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A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

Iran and the United States each declared a triumph after agreeing to a two‑week ceasefire that was announced just before President Donald Trump’s deadline to force Tehran’s surrender. The conflict, which began on 28 February, has already claimed 2,076 lives in U.S.–Israel strikes on Iran and has caused thousands more deaths across the region. The fighting has also shocked global energy markets, stranding oil tankers and pushing prices to unprecedented levels. Trump announced on Truth Social that the United States would halt bombing Iran after receiving a “workable” 10‑point ceasefire proposal, adding that “almost all of the various points of past contention have been agreed to.” Iran, for its part, said it would reopen the Strait of Hormuz to commercial traffic, even as some citizens denounced the government’s perceived capitulation. Both parties are set to resume Pakistan‑mediated talks in Islamabad on Friday, though analysts warn that earlier red lines may resurface. Key terms of the Tuesday agreement: the United States will suspend air strikes for two weeks, citing that it has already achieved its military objectives and is close to a “definitive agreement concerning long‑term peace.” Iran’s foreign minister, Abbas Araghchi, pledged to halt “defensive operations” and to allow safe passage through the Strait of Hormuz, while also indicating willingness to fund reconstruction from fees collected on transiting ships. Domestic reaction in Iran remains volatile. University of Tehran professor Foad Izadi noted that the public’s pessimism stems from two prior escalations—June’s 12‑day war and the February 28 strikes—both of which occurred amid ongoing negotiations. Earlier demands: The United States had presented a 15‑point plan on 25 March, calling for a 30‑day ceasefire, immediate reopening of the Strait, Iran’s de‑commissioning of its nuclear facilities, a total ban on uranium enrichment, handover of nuclear stockpiles to the IAEA, cessation of support to regional proxies, strict limits on ballistic missiles, and a full lift of sanctions, among other items. Iran responded with a 10‑point proposal that emphasized a non‑aggression commitment from the United States, controlled passage through the Strait, acceptance of its enrichment programme, comprehensive sanctions relief, withdrawal of U.S. combat forces, compensation for war damages via shipping fees, and a binding UN Security Council resolution. Both sides have already made concessions. Iran moved from demanding a permanent ceasefire to accepting a two‑week pause, and it shifted from insisting on reparations to proposing reconstruction funding from Strait fees. The United States, meanwhile, has softened its demand for an “unconditional” Iranian surrender and has not reiterated its earlier insistence on dismantling Iran’s missile capabilities. One of the most contentious issues remains the status of Lebanon. While Pakistan’s prime minister said the ceasefire would extend to Lebanon, Israeli Prime Minister Benjamin Netanyahu denied any such inclusion, and Israel launched a major bombing campaign in Beirut shortly thereafter, killing hundreds. Looking ahead, analysts highlight that the United States is unlikely to concede on the complete withdrawal of its roughly 50,000 troops stationed across 19 Middle Eastern sites—a demand Tehran has placed on the table. The outcome of the upcoming talks will hinge on whether Washington can accommodate Tehran’s broader political and economic requests without compromising its strategic objectives.

The recent two-week ceasefire announced by US President Donald Trump in the war on Iran has sent shockwaves through Israel. The move has been met with criticism from Israel's opposition leader, Yair Lapid, who called it one of the greatest 'political disasters in all of our history'. Prime Minister Benjamin Netanyahu's office issued a statement supporting the US decision, claiming that 'Iran no longer poses a nuclear, missile and terror threat to America, Israel, Iran's Arab neighbours and the world.' However, Netanyahu's war aims of preventing 'Iran from developing nuclear weapons' and creating 'the conditions for the Iranian people so they can remove the cruel regime of tyranny' remain unachieved.Despite significant military successes over the past 40 days of attacks on Iran, neither of Netanyahu's goals has been achieved. The Iranian regime is still in place, its ballistic missile programme could be rebuilt quickly, and it still has 440kg of enriched uranium at 60 percent purity, enough for 10 bombs.Analysts say that Iran has emerged stronger as a result of the war, with key victories including the survival of the Iranian government and its decision to close the Strait of Hormuz, one of the world's key energy arteries. The ceasefire has also given Iran an opportunity to continue with newly imposed levies on ships for safe passage through the Strait.Criticism of Netanyahu's handling of the war has been swift, with Ofer Cassif of the left-wing Hadash party saying that the prime minister has 'failed politically, failed strategically, and didn't meet a single one of the goals that he himself set'. Ahron Bregman, a senior teaching fellow at the Department for War Studies at King's College London, said that 'Israel achieved almost nothing tangible' and that the ceasefire has 'strained the US relationship'.

Celebrations erupted in Tehran after officials announced a two‑week ceasefire with the United States, creating a window for diplomatic talks aimed at de‑escalating the regional conflict.Iran consented to suspend hostilities, with negotiations slated to begin on Friday in Pakistan. President Donald Trump pledged to halt military operations provided Tehran fully reopens the Strait of Hormuz, a vital maritime corridor. Iran’s foreign minister added that safe passage through the strait will be coordinated with Iranian armed forces throughout the truce.The breakthrough followed a direct appeal by Pakistan’s Prime Minister Shehbaz Sharif, who urged Trump to extend his negotiation deadline and called on Iran to restore strait access.Iranian officials framed the ceasefire as a “victory”, asserting that their preconditions for talks were accepted and that Trump’s acknowledgment of progress on key disputes validates Tehran’s stance. They emphasized that national unity, patience, and military resilience were decisive factors.In their assessment, the earlier U.S.–Israeli strategy of targeting Iranian leadership failed, while the ensuing conflict demonstrated Iran’s capacity to sustain prolonged military operations.Trump, speaking to AFP, described the agreement as a “total and complete victory”, insisting that Iran’s uranium stockpiles would be “perfectly taken care of” under the deal and crediting China for facilitating the negotiations.Despite the truce, Democratic lawmakers announced they will continue impeachment efforts against Trump, condemning his rhetoric toward Iran as “genocidal” and “unhinged.”

The administration has confirmed a two‑week suspension of any imminent strikes on Iran, signaling a short‑term pause in hostilities. This move reflects a tentative step toward reducing immediate tensions, though officials did not elaborate on the conditions that would trigger a resumption of operations.

The Guardian is calling on readers to share their personal stories of how they have been impacted by the ongoing conflict in the Middle East. With Iran and the US agreeing to a two-week conditional ceasefire, the situation remains volatile and uncertain.Whether you are living, working, or traveling in the region, or have been impacted in other ways, the Guardian wants to hear from you. Your experiences can help provide a deeper understanding of the human impact of the conflict.Please note that your security is the top priority. The Guardian recognizes it may not always be safe or appropriate to record or share your experiences, so please consider this when deciding whether to get in touch.To share your story, you can:Fill out the online form provided, which is encrypted and confidential.Message the Guardian on WhatsApp or Signal at +447766780300.The Guardian assures readers that all responses will be kept secure and anonymous if desired. The information collected will only be used for the purpose of this feature and will be deleted when no longer required.Key form fields include:NameLocationBackground information (optional)Country locatedPersonal experience with the conflictPhoto upload (optional)Publication consentContact details (optional)For more information, readers can visit the Guardian's tips guide or privacy policy.

UK house prices experienced a decline in March, as the housing market lost momentum due to uncertainty surrounding the conflict in the Middle East and its potential impact on the economy and interest rates. Figures from Halifax showed a 0.5% dip in property prices compared to the previous month. As a result, the average price of a home slipped back below £300,000 to £299,677, after initially crossing the £300,000 milestone in January. The pace of annual property price growth also eased to 0.8%, down from 1.2% the previous month. Halifax cited uncertainty over the conflict in the Middle East as a factor that has dampened the initial momentum in the market seen at the start of the year. Concerns about higher energy prices have pushed up inflation expectations, leading to a rise in mortgage rates. Expectations that the Bank of England could raise interest rates several times this year have driven up the cost of fixed-rate mortgages. However, City traders adjusted their forecasts for rate rises after the US and Iran agreed to a two-week conditional ceasefire. The choice of mortgage deals has shrunk in recent weeks, with hundreds of mortgage products pulled from the market. The average two-year fixed residential mortgage rate moved upwards to 5.84% by the end of March, the highest since July 2024. Amanda Bryden, head of mortgages at Halifax, noted that the effect on house prices will largely depend on how long-lasting these pressures prove to be and the wider implications for the economy and unemployment. She emphasized that mortgage rates are a key factor for buyers, particularly those getting on the ladder for the first time.

Oil markets experienced a dramatic correction on Wednesday, with Brent crude falling 13.9% to $94.10 per barrel and U.S. WTI futures sliding almost 16% to $95, marking the steepest daily percentage drop since the COVID‑19 crash of April 2020. Despite the plunge, prices remain well above pre‑conflict levels, when Brent traded below $73.The price shock followed President Donald Trump's announcement of a two‑week, conditional ceasefire with Iran, contingent on Tehran reopening the strategic Strait of Hormuz for oil tankers. Iran’s foreign minister, Abbas Araghchi, confirmed the strait would be managed by the Iranian military during the grace period, while Iran’s national security council accepted the ceasefire on the condition that U.S. attacks be halted.Equity markets reacted positively. The pan‑European Stoxx 600 surged 4%, its biggest one‑day gain in over four years. In the UK, the FTSE 100 climbed nearly 3% to 10,646 points, its highest level since the early days of the Iran war. Travel and leisure stocks led the rally, with Air France up 14.5%, Lufthansa +11%, IAG +9.5% and TUI +12%.Oil majors were the notable laggards; BP and Shell each lost more than 5% as investors priced in continued supply uncertainty. Asian markets also posted strong gains: Japan’s Nikkei 225 rose over 5%, Australia’s S&P;/ASX 200 jumped 2.55%, South Korea’s Kospi surged 7.5%, Hong Kong’s Hang Seng added 3.1% and China’s CSI300 climbed 3.2%.Bond yields eased on the ceasefire news. The U.S. 10‑year Treasury yield fell to 4.24% from 4.30%, while the UK 10‑year gilt slipped to 4.7% from 4.9%.Safe‑haven assets rallied as well: gold rose more than 2% to $4,812 per ounce, and cryptocurrencies recovered, with Bitcoin up 2.9% to $71,327 and Ether gaining 5.6% to $2,234.Market strategists emphasized the provisional nature of the relief. Jim Reid, Deutsche Bank markets strategist, warned that “investors will be breathing a big sigh of relief, but the durability of the ceasefire remains the key risk.” He noted ongoing Israeli‑Iran strikes and unclear extensions to Lebanon could reignite volatility.Energy analyst Saul Kavonic (MST Financial) described the pause as “an off‑ramp for Trump’s bombastic ultimatum, but not yet an off‑ramp for oil markets or the war.” He expects a limited release of tankers from Hormuz in May, which would ease storage pressure without boosting production.Capital Economics chief economist Neil Shearing highlighted potential transit fees for Hormuz passage, estimating a $1‑2 million charge per tanker—equivalent to roughly $1 per barrel—would have a modest effect on global oil prices but could signal a de‑facto partial nationalisation of the route.TD Securities senior strategist Prashant Newnaha cautioned that “renewed escalation cannot be ruled out, but markets are treating this ceasefire as the real deal, and all parties will sell it as a major win.” He added that oil prices are unlikely to revert to pre‑war levels, keeping inflationary pressures alive.Earlier in the week, U.S. equities swung sharply, with the S&P; 500 dipping 1.2% before rebounding after Pakistan’s prime minister urged Trump to extend the deadline and keep the strait open.The conflict, which began after the U.S. and Israel struck Iranian targets in late February, has choked the Strait of Hormuz—through which about 20% of global oil and LNG supplies flow—fueling a worldwide energy crunch.

Political leaders across Washington breathed a collective sigh of relief on Tuesday evening when President Donald Trump announced a provisional two‑week ceasefire with Iran, ending a 24‑hour standoff that had seen him threaten to annihilate Iran’s “whole civilization” if Tehran failed to reopen the Strait of Hormuz by his self‑imposed deadline.The ceasefire declaration arrived just 90 minutes before the 8 p.m. ET deadline at which Trump had pledged to bomb Iranian power plants and bridges – a move scholars warned would constitute a war crime. A last‑minute diplomatic push by Pakistan persuaded the president to suspend the ultimatum, buying a narrow window for de‑escalation.In a post on Tuesday night, Trump wrote: “Subject to the Islamic Republic of Iran agreeing to the COMPLETE, IMMEDIATE, and SAFE OPENING of the Strait of Hormuz, I agree to suspend the bombing and attack of Iran for a period of two weeks.”Iran’s foreign minister quickly responded, stating that the strait would remain open for the next fourteen days under Iranian military management, effectively meeting the condition set by the United States.The president’s earlier warning – that a “whole civilization will die tonight, never to be brought back again” – drew swift condemnation from Democrats, longtime allies who have broken with Trump over the crisis, and even Pope Francis, the first American pontiff.Senate Majority Leader Chuck Schumer labeled Trump’s retreat as “desperately searching for any sort of exit ramp from his ridiculous bluster,” adding that the president had previously been called “an extremely sick person” waging a “wanton war of choice.”House Democrats, including former Speaker Nancy Pelosi, called for Trump’s removal via impeachment or the 25th Amendment, arguing that his conduct amounted to a threat of genocide against the Iranian people. Progressive Representative Alexandria Ocasio‑Cortez echoed this sentiment, saying the two‑week deal “changes nothing” and urging Congress to act.House Minority Leader Hakeem Jeffries described Trump’s behavior as “unhinged, unpresidential and unconscionable,” and warned that the American public “strongly opposes this reckless war of choice.” He announced that Democrats would push Speaker Mike Johnson to reconvene the House and move a war‑powers resolution to secure a permanent end to hostilities.Republican reactions were more nuanced. Senator Rick Scott praised the ceasefire as “a strong first step toward holding Iran accountable,” while Senator Lindsey Graham expressed hope that diplomacy could “end the reign of terror of the Iranian regime,” cautioning that Iran should not be rewarded for its earlier attacks on the strait.Conversely, Rep. Dan Crenshaw, a Texas Republican known for breaking with Trump, dismissed critics as “pearl‑clutching,” arguing that the president’s “language of POWER” is what adversaries understand, and that diplomatic niceties alone achieve little.The episode underscores a volatile moment in US‑Iran relations, where a single diplomatic pivot averted an imminent escalation, yet left Congress divided over the president’s authority to wage war and the need for a lasting legislative solution.