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GSK has revealed promising early results for its treatment for gynaecological cancers, Mocertatug Rezetecan (Mo-Rez), as its chief executive, Luke Miels, seeks to speed up drug development at the group.The company reported that in an early-stage trial, Mo-Rez shrank or eliminated tumours in 62% of patients with ovarian cancer where chemotherapy had failed, and in 67% of those with endometrial cancer.GSK acquired the Mo-Rez cancer treatment, an antibody-drug conjugate (ADC), from China’s Hansoh Pharma in late 2023, and has trialled it in 224 patients around the world, including the UK, over the past year. Few patients needed to stop treatment because of side-effects, the most common being nausea. It is administered every three weeks via intravenous infusion.Combined with data from a separate, intermediate trial in China, these results give GSK the confidence to go straight to late-stage trials, with five clinical studies planned globally in the next few months, including on patients in the UK.Presenting the results at the Society of Gynecologic Oncology’s annual meeting on women’s cancer in Puerto Rico, Hesham Abdullah, GSK’s global head of cancer research and development, said: “Treatment of gynaecological cancers remains a major challenge, with a pressing need for new therapies that offer improved response rates. With Mo-Rez we now have compelling evidence of a promising clinical profile.”Endometrial cancer affects 1.6 million women globally, with 417,000 new cases each year. Ovarian cancer affects 843,000 people, with 240,000 new cases annually.Abdullah described Mo-Rez as a “key asset” in the company’s growing cancer portfolio, expected to be a blockbuster drug with peak annual sales of more than £2bn, which GSK hopes will help it achieve its 2031 sales target of £40bn.

Nottingham Forest and Aston Villa played out a 1-1 draw at the City Ground, a result that significantly boosts Forest's chances of avoiding relegation. Neco Williams's low strike cancelled out Murillo's own goal, securing a precious point for Forest.The match was marked by Villa's dominance, with Morgan Rogers and Ollie Watkins missing clear chances to score. Forest goalkeeper Matz Sels made crucial saves, including one from Ross Barkley's low shot. The draw moves Forest three points clear of the relegation zone.Despite Villa's pressure, Forest's defense held firm, with Matty Cash seeing an effort blocked late in the game. The result comes as a relief for Forest, who could have faced a more challenging situation had they lost.The draw also highlights Villa's inconsistent form, as they failed to capitalize on their chances. Unai Emery's side now looks to their upcoming Europa League semi-final against Forest.

After serving in Afghanistan, Army Ranger Jesse Gould developed PTSD and turned to drinking to cope. Seeking an alternative to lifelong medication, Gould discovered psilocybin in Peru, which significantly alleviated his symptoms.Gould founded the Heroic Hearts Project, a non-profit hosting ayahuasca and psilocybin retreats for veterans. The organization has helped over 1,500 veterans and their spouses without any psychotic episodes.State lawmakers are taking notice of psilocybin's potential health benefits, with Colorado, New Mexico, and Oregon legalizing it for therapeutic use. At least eight states are considering similar legislation, despite some arguing that the FDA should approve it first.Research suggests psilocybin can be safe and effective when administered with psychological support. A 2025 study found it was associated with symptomatic improvement in adults with PTSD. Clinical psychologist Joseph Zamaria notes that psilocybin can disrupt the brain's default mode network, allowing people to detach from harmful narratives.However, some experts, like Albert Garcia-Romeu, are skeptical about state-led legalization without FDA approval, citing potential unknown risks. Gould counters that the suicide rate among veterans is a pressing issue, with 35 deaths per 100,000 people in 2023, more than double the general population's rate.

Arsenal's title ambitions took a significant hit as they were stunned 2-1 by Bournemouth at The Emirates on Saturday. Alex Scott's 74th-minute goal proved to be the decisive blow, handing Manchester City a lifeline in the Premier League title race.The defeat left Arsenal with a nine-point lead over City, but Pep Guardiola's side have played two games fewer and can close the gap if they beat Chelsea on Sunday. Arsenal's first defeat in nine league games means they have 70 points from 32 games, while City have 61 points from 30 games.Bournemouth were the better side in the first half and took the lead through Eli Junior Kroupi's 17th-minute goal. Kroupi has now scored 10 times in the top flight this season, becoming the first teenager to reach that mark in his debut campaign in the Premier League since Robbie Keane for Coventry City in the 1999-2000 season.Arsenal equalized in the 35th minute through Viktor Gyokeres' penalty, but they were unable to find a winner. Bournemouth's victory moved them into ninth place and boosted their hopes of European qualification.The result was a significant upset, given Arsenal's recent form and their four-match winning run in the Premier League prior to the game. The Gunners had not been in league action for almost a month, having suffered a League Cup final defeat by City and a shock FA Cup quarterfinal exit at the hands of second-tier Southampton.

The United States and Iran have initiated direct talks in Islamabad, Pakistan, in an effort to bring an end to their six-week conflict. These face-to-face discussions, confirmed by the White House, follow a recent fragile ceasefire agreement and separate bilateral meetings with Pakistani Prime Minister Shehbaz Sharif. The US delegation, led by US Vice President JD Vance, includes special envoy Steve Witkoff and Jared Kushner, son-in-law of President Donald Trump. The Iranian delegation, comprising over 70 people, is headed by parliamentary Speaker Mohammad Bagher Ghalibaf and Foreign Minister Abbas Araghchi. According to Iranian state media, the talks proceeded after Iranian preconditions were met, including a reduction in Israeli attacks on Lebanon. Iran had insisted on the inclusion of Lebanon in the ceasefire and the lifting of US sanctions as prerequisites for the negotiations. Pakistani Prime Minister Sharif expressed hope that these talks would serve as a stepping stone toward durable peace in the region. Despite earlier assertions from Tehran that they would not engage without commitments on Lebanon's inclusion and US sanctions, the negotiations have moved forward. Sources indicate some progress on basic conditions, including the need for a ceasefire in Lebanon, with reports of a possible understanding to limit strikes to southern Lebanon. There are also indications of potential movement on the unfreezing of Iranian assets. US President Donald Trump posted on social media that the only reason Iranian officials were alive was to negotiate a deal, stating that Iran had no cards other than short-term extortion. Vance expressed optimism about a positive outcome but warned that the negotiating team would not be receptive if Iran tried to play them.

The new academic term began in Gaza in late March, but the usual bustle of students catching buses to campus has been replaced by the stark reality of displacement.Israel’s relentless campaign has turned most university buildings into rubble and shelters, forcing a shift to online learning that many students in tents cannot access due to lack of electricity, water, food and reliable internet.Against this backdrop, a glimmer of hope has emerged. In the overcrowded al‑Mawasi district of Khan Younis, the US‑based NGO Scholars Without Borders has erected a makeshift “University City,” a wooden and metal structure designed to bring students back into a real lecture hall."Our mission is to bring education closer to students in a better environment," said Hamza Abu Daqqa, the organisation’s Gaza representative.The facility houses six halls that can accommodate up to 600 students each day. Powered by solar panels, it offers internet access, improvised green spaces and even a small business incubator to help students explore entrepreneurial ideas.University City operates on a rotating weekly schedule, allocating each day to a different institution so that multiple universities can share the limited space. Priority is given to courses that require hands‑on instruction, such as practical labs and discussion‑based classes.Prominent Gaza institutions—including the Islamic University, Al‑Azhar University and the Palestine College of Nursing—have already begun using the site.For many students, this is the first time in years they have set foot in a space that feels like a real university. "When I saw this place, I was amazed," said 20‑year‑old nursing student Mariam Nasr, who fled Rafah and now travels four kilometres on foot to attend classes.Another first‑year student, Amr Muhammad, echoed the sentiment: "Being here with other students, discussing and engaging in class makes a huge difference."The broader picture remains grim. UN experts have labeled Israel’s systematic targeting of Gaza’s academic sector as “scholasticide.” More than 7,000 university students and staff have been killed or injured, and over 60 university buildings have been completely demolished, according to the Euro‑Med Human Rights Monitor.Materials for University City were sourced entirely within Gaza, a testament to the community’s resilience amid soaring costs and scarce resources. Yet the initiative is hampered by the same blockade that restricts reconstruction supplies, fuel and safe transport.Students still face daily hurdles: damaged roads, limited cash, and unreliable transport—often relying on worn‑out vehicles, donkey carts or long walks. "My father could only give me eight shekels (about $2.64) for a ride," Mariam explained, highlighting the economic strain.Even once inside the halls, challenges persist. Power outages and unstable internet make it difficult to print materials or follow online lectures, forcing many to rely on old phones and intermittent connections.Nevertheless, the atmosphere inside University City is one of determination. "For medical education, in‑person learning is essential," said Dr Essam Mughari of the Palestine College of Nursing. "Seeing students gather again restores something vital."For students like Mariam, the drive to continue studying is deeply personal. "My cousin, a nurse, was killed when an airstrike destroyed her family’s house. I study to heal others and honor her memory," she said.While University City now serves hundreds daily, thousands of Gaza’s students remain without comparable facilities. Abu Daqqa stresses that the project is only the beginning: "We have built dozens of makeshift schools, but the need is far greater. Imagine what could be done if the needed resources were allowed through."

Match details: Chelsea host Manchester City at Stamford Bridge on Sunday, 12 April, 4:30 pm BST (15:30 GMT). Live coverage and pre‑match analysis will be available on Al Jazeera Sport from 12:30 GMT. City sit second in the Premier League, trailing league leaders Arsenal by nine points after Arsenal played one more game. A win at Chelsea could shrink the gap to six points, and a victory for Arsenal over Bournemouth on Saturday would widen the gap to twelve, putting immense pressure on Pep Guardiola’s side to collect maximum points. Chelsea, currently sixth, are desperate to reignite their push for a top‑five finish that guarantees Champions League football next season. They sit just one point behind Liverpool, who occupy the final European spot. Guardiola warns of zero‑margin for error Speaking on Friday, Pep Guardiola admitted City’s season has been “inconsistent” and stressed that the squad must win every remaining match to retain any chance of clinching the title. He highlighted the demanding run of fixtures ahead, beginning with the Chelsea trip and followed by a home clash with Arsenal on 19 April. “We need to win all of them; otherwise we won’t have a chance to fight until the end,” Guardiola said, acknowledging points dropped earlier in the campaign. Bernardo Silva’s future remains uncertain Midfielder Bernardo Silva, a six‑time Premier League champion with City, is in the final year of his contract. Guardiola expressed a personal desire to keep the Portuguese international at the club but admitted he does not know the player’s decision. “I’m a bit grumpy because I wasn’t informed of his plans,” the manager said, praising Silva’s competitiveness and importance in big‑match moments. Enzo Fernández excluded despite apology Chelsea boss Liam Rosenior confirmed that midfielder Enzo Fernández will remain on the bench for the Sunday fixture, even after the Argentine apologised for comments that questioned his future at Stamford Bridge. Rosenior emphasized the club’s collective values, stating, “Football is a team sport, not about individuals,” and hinted that Fernández could feature again after this match. Chelsea’s Champions League ambition Rosenior reiterated confidence in his squad’s ability to secure a top‑five finish, noting that despite a recent dip in form, the team has consistently created problems for opponents. Historical head‑to‑head The two clubs have met 181 times in competitive fixtures: Chelsea have won 71, City 68, with 42 draws. Notably, Chelsea have not beaten City since the 2021 Champions League final. Recent encounters (last 10): 04 Jan 2026 – Man City 1‑1 Chelsea (Premier League) 25 Jan 2025 – Man City 3‑1 Chelsea (Premier League) 18 Aug 2024 – Chelsea 0‑2 Man City (Premier League) 20 Apr 2024 – Man City 1‑0 Chelsea (FA Cup semi‑final) 17 Feb 2024 – Man City 1‑1 Chelsea (Premier League) 12 Nov 2023 – Chelsea 4‑4 Man City (Premier League) 21 May 2023 – Man City 1‑0 Chelsea (Premier League) 08 Jan 2023 – Man City 4‑0 Chelsea (FA Cup third round) 05 Jan 2023 – Chelsea 0‑1 Man City (Premier League) 09 Nov 2022 – Man City 2‑0 Chelsea (League Cup third round) Team news – Chelsea Rosenior confirmed centre‑back Levi Colwill has returned to training after a serious knee injury, though he remains a selection risk. Right‑back Reece James is training after a hamstring issue. Defender Trevoh Chalobah and winger Jamie Gittens are still sidelined. Predicted starting XI: Sanchez; Gusto, Fofana, Adarabioyo, Cucurella; Santos, Caicedo; Neto, Palmer, Estevao; Pedro. Team news – Manchester City Defender Rúben Dias continues to recover from a muscle problem and is unavailable. Josko Gvardiol remains out with a tibial fracture sustained in January. Predicted starting XI: Donnarumma; Nunes, Khusanov, Guehi, O’Reilly; Silva, Rodri; Semenyo, Cherki, Doku; Haaland. The outcome of this clash could dramatically reshape the Premier League title race and determine whether Chelsea can keep their Champions League aspirations alive.

NASA's Artemis II mission has achieved a major milestone with the successful return of its four astronauts to Earth, marking the end of a 10-day journey that took them farther into space than any human has gone before. The crew, comprising NASA astronauts Reid Wiseman, Victor Glover, and Christina Koch, along with Canadian astronaut Jeremy Hansen, completed a parachute landing in the Pacific Ocean off the coast of California at 5:07 pm Pacific time (00:07 GMT). This mission is a critical step towards future lunar exploration, particularly Artemis IV, which aims to land astronauts on the lunar surface for the first time since the Apollo era. The Artemis II mission tested essential technologies for deep space travel, including the performance of the Orion capsule's heat shield, navigation systems, and life-support technology. The mission also marked several historic firsts: Glover became the first person of color to travel around the moon, Koch the first woman, and Hansen the first non-American. During their journey, the crew witnessed a solar eclipse and meteorite impacts, and shared vivid descriptions of the lunar surface. Mission commander Wiseman reflected on the mission's significance, stating, "what we really hoped in our soul is that we could, for just a moment, have the world pause — and remember that this is a beautiful planet in a very special place in our universe".

The quiet evening in the Israeli kibbutz of Cabri, just five miles from the Lebanon border, was shattered by the sound of air raid sirens. The residents, including the Moria family, rushed to a reinforced safe room as Iron Dome interceptors were launched to counter incoming rockets from Hezbollah.The ceasefire-defying attack by Israel that killed over 300 people in Lebanon has reignited the conflict. Despite hopes that the Iran ceasefire might bring an end to Hezbollah's rocket fire, the situation remains fragile. 1,164 rockets have been fired into Israel since March 2, at a rate of about 30 a day, according to the Alma Center thinktank.Residents of Cabri describe a life of constant risk management, with every decision to leave home, work in the fields, or walk a dog influenced by the threat of attack. The conflict has resulted in over 1,700 recorded deaths in Lebanon since early March, with a smaller but significant number of civilian casualties in Israel.Moshe Davidovich, chief of the local Mate Asher Regional Council, supports Israel's continued war in Lebanon, citing the need to counter Hezbollah's threats. In contrast, Amir Yarchi, a kibbutz resident, argues that a military solution is unrealistic and could lead to an endless war.The situation highlights the complexity of achieving peace in the region, with international engagement and support for the Lebanese government seen as potential pathways to stability. However, with 79% of Israelis supporting continued strikes into Lebanon, finding a lasting solution remains a significant challenge.