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The United States and Iran left Islamabad without a peace deal, ending the most senior diplomatic encounter between the two nations since the 1979 Islamic Revolution. Vice President JD Vance, who led the U.S. delegation, told reporters that Tehran "refused to accept our terms" after a marathon 21‑hour session. Vance emphasized that the United States requires a "fundamental commitment" from Iran not to pursue nuclear weapons or the associated delivery systems. "We need an affirmative pledge that they will not seek a nuclear weapon, and they will not seek the tools that would enable them to quickly achieve a nuclear weapon," he said. Iran’s Ministry of Foreign Affairs, represented by spokesperson Esmaeil Baghaei, cautioned that no one expected a single‑session resolution. "Naturally, from the beginning, we should not have expected to reach an agreement in a single session," he told state broadcaster IRIB, adding that Tehran remains "confident that contacts with Pakistan and other regional friends will continue." Pakistan called on both parties to honor the ceasefire and pursue a durable peace. Foreign Minister Ishaq Dar expressed gratitude for the mediation efforts, stating, "We hope the two sides continue with a positive spirit to achieve durable peace and prosperity for the entire region and beyond." The stalled talks occur against the backdrop of a war that began on February 28, when the United States and Israel launched a campaign against Iran. The conflict has since spread across the Middle East, causing over 2,000 fatalities and extensive damage to both military and civilian infrastructure. One of the war’s most destabilizing effects has been a global energy crisis, as Iran tightened control over the Strait of Hormuz—a chokepoint through which roughly 20 % of the world’s oil and gas exports flow. The delegations, led by Vance for the United States and Iranian Parliament Speaker Mohammad Bagher Qalibaf, also discussed how to sustain a ceasefire that is already under strain from deep disagreements and Israel’s ongoing attacks on Hezbollah in Lebanon.

On April 12, 2026, relatives and neighbors in Afghanistan assembled to pay their respects to those killed in a deadly shooting. The gathering, marked by solemn chants and the display of photographs, underscored the deep grief felt across the community. While details about the incident remain scarce, the presence of dozens of mourners demonstrated a unified response to the tragedy, with many expressing hopes for peace and security in the region. Local leaders urged authorities to investigate the circumstances surrounding the shooting and to provide support for the bereaved families, emphasizing the need for justice and prevention of future violence.

“The world is grown so bad that wrens make prey where eagles dare not perch,” wrote Shakespeare in *Richard III*. The line now echoes a hopeful development: the iconic golden eagle could once again soar over England after more than a century and a half of absence. The golden eagle, a bird with a wingspan of roughly 2 metres, was a common sight in Shakespeare’s England, yet it has been effectively extinct in the country since the death of the last native individual in 2015. Centuries of persecution by gamekeepers and farmers, who feared predation on lambs and game birds, drove the species to the brink. A feasibility study commissioned by Forestry England and released on Sunday pinpoints eight potential “recovery zones”—predominantly in northern England—where the habitat could sustain a viable eagle population. The report cautions that establishing breeding pairs may take **more than a decade**. In response, Environment Secretary Emma Reynolds announced an additional £1 million in species‑recovery funding. The money will underwrite a programme that could see juvenile eagles, aged six to eight weeks, released into the wild as early as next year. Reynolds said, “This government is committed to protecting and restoring our most threatened native wildlife – and that includes bringing back iconic species like the golden eagle. Backed by £1 million of government funding, we will work alongside partners and communities to make the golden eagle a feature of English landscapes once again.” Across the border, golden eagle numbers in southern Scotland have surged to record levels thanks to a major restoration project. Satellite tracking shows that some translocated Scottish birds are already venturing into northern England, offering a natural source of future colonisers. The new funding will support these cross‑border movements and enable targeted reintroductions. While experts anticipate that golden eagles could be regularly observed across northern England within 10 years, establishing a self‑sustaining breeding population will require a longer horizon. Mike Seddon, chief executive of Forestry England, explained, “The detailed findings of our feasibility study will guide us, with our partners at Restoring Upland Nature, to take the next steps toward recovering golden eagles in northern England. This DEFRA funding means we can build on the good work we have begun, engaging local communities, landowners and conservation organisations.” The £1 million allocation forms part of a broader £60 million species‑recovery fund announced by DEFRA. It aligns with the UK’s legally binding commitment to halt the decline in species abundance by 2030 and to reduce extinction risk by 2042 relative to 2022 levels.

Roberto De Zerbi diagnosed a deep‑seated lack of confidence as the core issue behind Tottenham’s recent struggles after his debut in charge ended in a 1‑0 loss to Sunderland. The defeat has dropped Spurs into the relegation zone, sitting 18th and two points shy of safety with only six games left.“We didn’t deserve to lose,” De Zerbi said, referring to the decisive second‑half goal that came from a Nordi Mukiele deflection. “We played well, but not well enough to win.” He added that while the players showed the right attitude, his priority now is to rebuild their mental resilience.The manager also raised concerns over captain Cristian Romero’s knee injury after a mid‑field collision. “I don’t know the extent yet, but we hope it’s not serious. He’s vital for the rest of the season,” De Zerbi remarked.Confidence, according to De Zerbi, is the missing ingredient for Spurs to unleash their quality. “When the squad believes in themselves, the football follows. A single win could change the narrative,” he asserted, emphasizing that his role is more about fostering belief than overhauling tactics.Looking ahead, Tottenham travel to face De Zerbi’s former club Brighton, a match De Zerbi hopes will serve as a catalyst for a confidence surge. He warned that the fear of relegation is palpable among the players and that a positive mindset is essential to reverse their fortunes.Brighton manager Régis Le Bris, meanwhile, was less concerned after his side’s victory, noting a strong finish after a slow start and expressing ambition for a top‑ten finish.

Roberto De Zerbi arrived on the pitch barely half an hour before kick‑off, his black padded gilet pulled up to the neck against a biting Wearside wind. By the final whistle the chill had eased, but Tottenham’s morale had plummeted.Sunderland’s 1‑0 victory not only cemented the visitors’ place in the league’s bottom three, it also lifted Régis Le Bris’s side to 10th place with six matches left in the campaign.Facing his third managerial appointment in a single season, De Zerbi urged his squad to rediscover the high‑risk attacking ethos of former boss Ange Postecoglou – a vision that remained frustratingly out of reach on a day dominated by low‑tempo play.Long‑time Tottenham midfielder Antonin Kinsky made a rare return after his brief, infamous cameo in a 5‑2 Champions League loss to Atlético Madrid. His comeback was cut short when a second‑half head clash forced his substitution for the inexperienced Brandon Austin.Goalkeeper Guglielmo Vicario, still recovering from hernia surgery, was expected to be tested. Sunderland’s Granit Xhaka delivered a sharply inswinging corner, but Kinsky calmly palmed the ball over the bar, keeping Spurs in the game.A potential penalty for Tottenham was overturned after VAR review; replays showed Omar Alderete had won the ball cleanly, while Randal Kolo Muani’s appeal proved unfounded.Richarlison offered brief flashes of quality but failed to convert his chances, and Dutch striker Brian Brobbey – described as a “human bulldozer” – was unable to capitalise on Enzo Le Fée’s incisive passes, despite a lone fine save from the Sunderland keeper.De Zerbi’s frustration was palpable. After Dominic Solanke’s weak finish allowed Sunderland’s Robin Roefs to deny a golden‑chance in stoppage‑time, the manager pulled his gilet up over his eyes, perhaps to shield himself from the disappointment.Mid‑second‑half, former Paris Saint‑Germain defender Nordi Mukiele, back from injury, struck a 20‑yard shot that deflected off centre‑back Micky van de Ven. The ball’s change of direction left the goal‑mouth ambiguous, sparking a debate over whether the goal should be credited to Mukiele or recorded as an own‑goal.The match’s physical intensity escalated when Brobbey’s challenge led to a painful collision between Kinsky and Cristian Romero, forcing both players off – Romero in tears with a leg injury. De Zerbi also expressed anger that Brobbey, already booked, escaped a second yellow card.Despite a flurry of substitutions, Tottenham struggled to pose serious questions to Sunderland’s defence, leaving the club’s relegation hopes hanging by a thread as the season draws to its final stretch.

Birmingham City defeated Wrexham 2-0 at St Andrew’s, a result that pushes the Red Dragons further from the Championship playoff places. The loss leaves Wrexham four points behind sixth‑placed Hull City with only four games remaining.After a 5-1 drubbing by Southampton, the defeat marks Wrexham’s first back‑to‑back losses since August. Manager Phil Parkinson tried to steady the mood, saying, “We’ve had a tough week, but we’re not down and out yet. People may write us off, but inside the dressing room we’re still fighting.”Goals came from Carlos Vicente, who headed in his third goal for Birmingham since joining in January, and Christoph Klarer, who added a second‑half strike to seal the win.Wrexham’s attack was virtually silent – they failed to register a single shot on target, and goalkeeper James Beadle had little to do. In contrast, Birmingham’s keeper Arthur Okonkwo made several first‑half saves, keeping the hosts in control.The victory gave Birmingham their first win in over a month and lifted them to 15th place in the league table. The hosts dominated possession, forcing early saves from Okonkwo and creating chances for Ibrahim Osman and August Priske, though those early efforts were thwarted.In the second half, a well‑timed delivery from Kai Wagner allowed Vicente to rise highest at the far post and head home. Later, a corner from Paik Seung‑ho found Klarer, who muscled past Max Cleworth and finished confidently.Substitutes Josh Windass and Nathan Broadhead were introduced by Parkinson in a bid to spark Wrexham’s attack, but the visitors could not muster any meaningful threat in the final quarter.Birmingham manager Chris Davies praised his side’s performance: “We were excellent throughout. When the opposition doesn’t have a shot on your goal and you score two – we could have scored five – that’s everything.”

GSK has revealed promising early results for its treatment for gynaecological cancers, Mocertatug Rezetecan (Mo-Rez), as its chief executive, Luke Miels, seeks to speed up drug development at the group.The company reported that in an early-stage trial, Mo-Rez shrank or eliminated tumours in 62% of patients with ovarian cancer where chemotherapy had failed, and in 67% of those with endometrial cancer.GSK acquired the Mo-Rez cancer treatment, an antibody-drug conjugate (ADC), from China’s Hansoh Pharma in late 2023, and has trialled it in 224 patients around the world, including the UK, over the past year. Few patients needed to stop treatment because of side-effects, the most common being nausea. It is administered every three weeks via intravenous infusion.Combined with data from a separate, intermediate trial in China, these results give GSK the confidence to go straight to late-stage trials, with five clinical studies planned globally in the next few months, including on patients in the UK.Presenting the results at the Society of Gynecologic Oncology’s annual meeting on women’s cancer in Puerto Rico, Hesham Abdullah, GSK’s global head of cancer research and development, said: “Treatment of gynaecological cancers remains a major challenge, with a pressing need for new therapies that offer improved response rates. With Mo-Rez we now have compelling evidence of a promising clinical profile.”Endometrial cancer affects 1.6 million women globally, with 417,000 new cases each year. Ovarian cancer affects 843,000 people, with 240,000 new cases annually.Abdullah described Mo-Rez as a “key asset” in the company’s growing cancer portfolio, expected to be a blockbuster drug with peak annual sales of more than £2bn, which GSK hopes will help it achieve its 2031 sales target of £40bn.

Nottingham Forest and Aston Villa played out a 1-1 draw at the City Ground, a result that significantly boosts Forest's chances of avoiding relegation. Neco Williams's low strike cancelled out Murillo's own goal, securing a precious point for Forest.The match was marked by Villa's dominance, with Morgan Rogers and Ollie Watkins missing clear chances to score. Forest goalkeeper Matz Sels made crucial saves, including one from Ross Barkley's low shot. The draw moves Forest three points clear of the relegation zone.Despite Villa's pressure, Forest's defense held firm, with Matty Cash seeing an effort blocked late in the game. The result comes as a relief for Forest, who could have faced a more challenging situation had they lost.The draw also highlights Villa's inconsistent form, as they failed to capitalize on their chances. Unai Emery's side now looks to their upcoming Europa League semi-final against Forest.

After serving in Afghanistan, Army Ranger Jesse Gould developed PTSD and turned to drinking to cope. Seeking an alternative to lifelong medication, Gould discovered psilocybin in Peru, which significantly alleviated his symptoms.Gould founded the Heroic Hearts Project, a non-profit hosting ayahuasca and psilocybin retreats for veterans. The organization has helped over 1,500 veterans and their spouses without any psychotic episodes.State lawmakers are taking notice of psilocybin's potential health benefits, with Colorado, New Mexico, and Oregon legalizing it for therapeutic use. At least eight states are considering similar legislation, despite some arguing that the FDA should approve it first.Research suggests psilocybin can be safe and effective when administered with psychological support. A 2025 study found it was associated with symptomatic improvement in adults with PTSD. Clinical psychologist Joseph Zamaria notes that psilocybin can disrupt the brain's default mode network, allowing people to detach from harmful narratives.However, some experts, like Albert Garcia-Romeu, are skeptical about state-led legalization without FDA approval, citing potential unknown risks. Gould counters that the suicide rate among veterans is a pressing issue, with 35 deaths per 100,000 people in 2023, more than double the general population's rate.