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The Final Private Push: Anthropic Secures $65 BillionAnthropic has closed a monumental Series H funding round, raising $65 billion at a $965 billion post-money valuation. This capital injection represents the startup's largest private fundraising effort to date and signals that the company is likely in its final pre-IPO stage. The round brings the company's total capital raised to a staggering level, positioning it as a heavyweight contender in the generative AI sector just as public markets begin to open up to high-growth technology companies.The Infrastructure and Investor EcosystemThe funding round was co-led by a consortium of elite institutional investors, including Altimeter Capital, Dragoneer, Greenoaks, and Sequoia Capital. Notably, the round saw participation from major infrastructure partners such as Samsung, SK Hynix, and Micron, highlighting the critical role hardware manufacturers are playing in the AI supply chain.Strategic Backing: Hyperscalers committed $15 billion, including a significant $5 billion from Amazon.Investor Demand: The round was highly competitive, with one institutional investor reportedly pledging up to $5 billion just to secure a meeting with the CFO.Use of Funds: Proceeds will be directed toward advancing safety research, expanding compute infrastructure, and scaling enterprise products.Valuation Wars and Revenue TrajectoryThis funding round places Anthropic at the epicenter of a fierce valuation war in the AI industry. The company's massive valuation comes as it reports a $47 billion revenue run rate and expects a 130% revenue surge to achieve its first operating profit. This financial performance contrasts sharply with the broader tech sector, illustrating the intense demand for high-performance AI models.Competitive Landscape: Anthropic's valuation rivals OpenAI, which raised $122 billion in March at an $852 billion valuation.Market Positioning: The company is reportedly preparing to launch models comparable to its powerful cybersecurity model, Mythos, which has been limited due to safety concerns.The Strategic Shift Toward Enterprise SafetyThe inclusion of infrastructure partners like Samsung and SK Hynix suggests a strategic pivot toward vertical integration. By securing hardware support, Anthropic ensures a stable supply chain for the compute-intensive models it is developing, such as the newly released Claude Opus 4.8. This model emphasizes agentic tasks, advanced coding, and self-correction capabilities, addressing a critical need for enterprises seeking reliable and safe AI solutions.The IPO Countdown and Market DominanceWith this massive capital raise and the release of advanced models, Anthropic is poised to lead the next phase of AI innovation. The company's ability to attract top-tier institutional investors and secure hardware partnerships positions it uniquely ahead of its IPO. As the race for AI dominance heats up, Anthropic's valuation and growth trajectory suggest it will be a key player in shaping the future of the public AI market.

Interviewing Mouse on Mars: A Conversation Like No Other Interviewing Mouse on Mars is no easy feat. Not because the duo are hard to find, even though their current studio is hidden in a courtyard deep in Berlin’s Kreuzberg district. Nor because they continue to be notoriously busy, particularly since one half of the band, Jan St Werner (born Jan Stephan Werner), is now a professor in pop music, at the Folkwang University of the Arts in the western German city of Essen. The Collaboration with Lee 'Scratch' Perry After a five-year silence, they are about to release Spatial, No Problem, a collaboration with Lee “Scratch” Perry recorded during the late dub and reggae legend’s whirlwind visit to their former Berlin studio in 2019, two years before his death aged 85. The meeting had been set up by mutual friends, though it was not clear whether it would really happen until Perry arrived at Berlin’s airport – the former Bob Marley producer had a reputation for unpredictability, and dates kept shifting. The Making of Spatial, No Problem The result is a collage-esque fever dream of a record, marrying Perry’s signature free-flowing vocals with a strange, yet warm mix of countless instruments played by friends, all held together by glitchy electronics. They had the idea to record the session as spatial audio, a technology used to mimic a more “natural” hearing experience in 3D. Asking about his familiarity with the technique, Perry answered with a wide grin, and the sentence “Spatial? No problem”. The title to the album was born, which includes recordings that are said to be some of Perry’s last. The Impact of the Collaboration Their reverence for Perry is obvious, every attempt to steer the conversation towards other topics brings the trio back to their time with him. They paint a picture of a creative frenzy: technicians installing microphones whichever corner Perry ended up standing and performing in, friends popping in and out of the sessions, NKishi being proclaimed “God” by Perry in a graffito on the studio’s walls, a general sense of a meeting of minds between artists with a similarly anarchic approach to life and craft. The Future of Mouse on Mars At a moment when the music industry is becoming ever more algorithmic, more optimised, more relentlessly targeting fickle attention-spans on social media, Mouse on Mars remain a genuinely anomalous proposition: a band whose greatest asset is their refusal to be legible. And they have been doing this for 30 years, ending up somewhere entirely different than originally planned – and making it sound, against all odds, exactly where they meant to be.

The prosecution: MelanieI want to live a healthier life too, but removing all plastics is unrealistic and unaffordableMy girlfriend, Amy, has become increasingly concerned about microplastics and environmental toxins, and it is starting to feel a little too much. It all began after she watched online content about how plastics affect fertility, and has escalated into a broader effort to remove anything she considers “toxic” from our home.We have thrown out hundreds of pounds’ worth of cleaning products and replaced toothbrushes and dental floss. I came home from work to find all our plastic food containers had been binned, and now she wants to discuss replacing furniture, like swapping our white plastic dining table for an oak one.In principle, I understand it will be better for us. I share her desire to live a healthier lifestyle, especially as we are trying for a baby using a donor and I will be the one carrying the pregnancy. However, the pace and the intensity of the change feels a bit unmanageable.If I pick up a plastic bottle of water, Amy will snatch it from my hands and say it’s poisonousWe can’t realistically eliminate all plastics and find alternatives overnight. Unfortunately, the world is full of plastic and so is our home: we have polyester cushions, plastic shoes and appliances that I’m not prepared to chuck out. Attempting a total removal feels financially and emotionally unsustainable. Buying a new dining table won’t be easy on our wallets.We are both self‑employed and saving for a baby, so we need to be frugal. Plastic‑free products are often deemed as specialist and it’s hard to get cheap alternatives. When I found Amy had splurged on all these organic cleaning products I was shocked, because they cost about £200.At the moment, it feels as if any “normal” behaviour is deemed to be unsafe by her. If I pick up a plastic bottle of water, Amy will snatch it from my hands and say it’s poisonous.I support her decision to live with fewer toxins, but her level of vigilance is harming our wellbeing. I want us to make healthier choices, but to do so gradually and realistically, rather than through sweeping changes that leave us feeling anxious and restricted.The defence: AmyI’m conscious of what we’re exposed to as we’re trying for a baby and I want the best for themPlastics and chemicals are everywhere. I’m not pretending we can eliminate them all, but I’d like to make some changes. I don’t think the only rational response when presented with all the information about toxins and plastics is to shrug and accept it without question.It’s not that hard to make some changes. Mel says: “Microplastics are everywhere, so where does it end?” But she should be saying: “What can we do to start?”Small changes help improve our health. I watched a documentary and it really scared me: I learned that just brushing my teeth with my normal toothbrush was releasing hundreds of thousands of microplastics into my mouth every day. These are linked to illness and altered brain functionality.Mel hasn’t heard all of the facts. If she watched the same documentary, she would feel the sameI didn’t start looking into endocrine disruptors and microplastics because I wanted to overhaul our home overnight. It was because we’re trying for a baby and that makes me more conscious of what we’re exposed to. If we have a child, I want them to have the best start in life and be as healthy as possible.Sometimes Mel acts as if I’m trying to dismantle our entire life, but I’m just trying to make things better. Switching cleaning products and replacing plastic food storage with glass will benefit us for years. When I threw our cleaning products away, it was because I had done the research and knew how much better nontoxic ones would be for us. That wasn’t a gradual adjustment, but I don’t regret it.I feel overwhelmed sometimes, but being told to “calm down” or “take it slow” doesn’t help. I don’t want to make our lives miserable. I want us to make informed choices together.Not drinking from plastic bottles is an easy change we can make, as is using better cleaning products. Mel and I need to work together on this, and active participation is important to me. If my decisions seem rash, it’s only because Mel hasn’t heard all of the facts. If she watched the same documentary she would feel the same. I don’t want to scare her, but making our home safer for our unborn child is a priority.The jury of Guardian readersGetting rid of plastic won’t make Amy and Melanie’s home healthier if they replace it with pressure and resentment. Amy’s pursuit is noble, but her cold‑turkey approach risks alienating Melanie from the cause.Estelle, 27They both want to live with fewer toxins, but Amy shouldn’t decide the pace at which they do this without agreement from Melanie. Amy throwing out all plastic containers and cleaning products without any discussion contradicts her claim that she wants “to make informed choices together”.Val, 68Life’s too short to make it hard for yourself. Carrying containers everywhere and only going to specialist retailers? No one’s got time for that when there’s work and chores to be done. Changing your life after one documentary is extreme, and Amy should consider the benefits of plastic.Ivan, 29We can’t live perfect lives, but that doesn’t mean we shouldn’t try to make better choices. I think they plan together what can change now and what can wait, Melanie might feel part of it instead of feeling it is something being done to her.Michael, 39Amy is valiant in trying to live a healthier lifestyle, but not making it a joint decision with Melanie seems to be detrimental to their relationship, and they need to be working together when they have a child. I wonder if Amy’s obsession might be masking a deeper issue.Jon, 50Now you be the judgeIn our online poll, tell us: should Amy bin her hatred of plastics?The poll closes on Wednesday 3 June at 9am BSTLast week’s resultsWe asked, should Martin stop telling his wife how to mop the floor?98% of you said yes – Martin is guilty2% of you said no – Martin is innocent

The Lead: China's Bold Leap into Long-Duration SpaceflightChina has launched its Shenzhou-23 mission in which an astronaut will spend a full year in orbit for the first time, a crucial step in Beijing's ambition to send humans to the moon by 2030. The Long March 2-F rocket lifted off from the Jiuquan launch centre in north-western China on Sunday, carrying three astronauts to the Tiangong space station.The Mission Details: Historic Crew CompositionThe mission marks the first spaceflight ever undertaken by an astronaut from Hong Kong: Lai Ka-ying, 43, who previously worked for the territory's police. The other crew members are the space engineer Zhu Yangzhu, 39, and the former air force pilot Zhang Zhiyuan, also 39, who will be travelling into space for the first time.The Scientific Objectives: Preparing for Deep SpaceThe crew is expected to undertake numerous scientific projects in life sciences, materials science, fluid physics and medicine. A key experiment will be the full-year stay in orbit by one of the crew to study the effects of a long stay in microgravity, part of China's preparations for future lunar and possible Martian missions.Richard de Grijs, an astrophysicist and professor at Macquarie University in Australia, said the main challenges would be long-term effects on humans, including bone density loss, muscle wasting, radiation exposure, sleep disturbance and behavioural and psychological fatigue. He also underlined the importance of reliable water and air-recycling systems and the ability to manage potential medical emergencies far from Earth.The Lunar Ambitions: China's Moon RoadmapThe Shenzhou-23 mission is part of China's goal to land astronauts on the moon before 2030 in a race with Nasa's Artemis programme. Beijing is also testing the equipment required to reach its goal, with an orbital test flight of its Mengzhou spacecraft set for 2026. It will replace the ageing Shenzhou line and will carry China's astronauts to the moon.China hopes to have built the first phase of a manned scientific base, known as the International Lunar Research Station, by 2035. It also plans to welcome its first foreign astronaut, from Pakistan, to the Tiangong station by the end of this year.The Global Context: China's Space Program EvolutionBeijing has significantly expanded its space programmes over the last 30 years, injecting billions of dollars in a push to catch up with the US, Russia and Europe. It landed the Chang'e-4 probe on the far side of the moon, a world first, in 2019, and a rover on Mars in 2021.China has been formally excluded from the International Space Station since 2011, when the US banned Nasa from collaborating with Beijing, prompting it to develop its own space station project. This isolation has accelerated China's indigenous space capabilities, making the Shenzhou-23 mission a milestone in both scientific achievement and geopolitical space competition.

The Papal Warning on AI's Ethical Crisis Pope Leo XIV has denounced the "culture of power" driving the rapid rise of artificial intelligence while warning that the technology must be subject to the "most rigorous" ethical constraints as it infiltrates everything from work to war. In his first major encyclical of his papacy, titled Magnifica Humanitas (Magnificent Humanity), the Pope presented the document himself during an event at the Vatican, marking a significant papal intervention in the global AI debate. The Encyclical's Core Ethical Framework The encyclical represents one of the highest forms of teaching from a pope to the Catholic church's 1.4 billion members, outlining his priorities while highlighting what he considers society's major issues. Pope Leo, who has previously identified AI as the biggest threat to humanity today, called for the "disarming" of AI, stating that some autonomous weapons systems are "practically beyond any human reach" to control. "Disarming AI means freeing it from the mentality of 'armed' competition," the Pope wrote. "To disarm does not mean rejecting technology, but preventing it from dominating humanity," adding that the technology should be "human-friendly", accessible to all and opened to discussion and debate. AI's Role in Modern Warfare In a significant warning about military applications, Leo referred to "a troubling revival of war as an instrument of international politics" and said AI was helping to facilitate the "normalization of war." He emphasized that "the development and use of AI in warfare must be subject to the most rigorous ethical constraints, to guarantee respect for human dignity and the sanctity of life and to avoid a race to develop such arms." The Concentration of Digital Power In a passage that appeared to be targeted at Silicon Valley, the Pope warned that power over digital systems, infrastructure and data "does not rest with states but with major economic and technological actors." He cautioned that when such power is concentrated "in the hands of the few" it tends to "become opaque and evade public oversight, increasing the risk of distorted forms of development that give rise to new dependencies, exclusions, manipulations and inequalities." The Vatican's Engagement with Tech Industry The Vatican has been seriously engaged on questions surrounding AI for several years, including having regular dialogues with Microsoft, Google and other big technology firms. Christopher Olah, a co-founder of Anthropic who attended the Vatican event, supported the need for greater oversight, stating that "the development of AI cannot be left solely to technology companies, urging greater oversight from religious leaders, governments and civil society." Olah warned there was "a real possibility" that AI would displace human labor "at very large scale," adding that "if that happens, supporting those displaced will be a moral imperative of historic proportions." Historical Reflections and Digital Slavery In a notable historical reflection, Pope Leo apologized for the Catholic church's long delay in condemning slavery, describing it as "a wound in Christian memory." He also spoke of the "new forms of slavery" due to the digital economy, particularly noting his family history includes both enslaved people and enslavers. "It is impossible not to feel deep sorrow when contemplating the immense suffering and humiliation endured by so many in stark contrast to their immeasurable dignity as persons infinitely loved by the Lord," the Pope wrote. "For this, in the name of the church, I sincerely ask for pardon." The Future of AI Regulation and Oversight The Pope emphasized that the Catholic church wanted to work with AI developers to discuss proper use of the technology. According to Christopher White, a senior fellow at Georgetown University's Initiative on Catholic Social Thought and Public Life, "Leo has done in this document is put the full weight of his office behind the Catholic church's efforts to be in dialogue with big tech." White noted that the Pope "is clearly approaching AI from a position of humility and making it clear that the church doesn't have all of the answers when it comes to what sort of policies are necessary for AI regulation. But he is being clear-eyed that AI development can't simply be the wild west like some of its advocates would like to see."

On 15 May, **BioOrbit** launched its compact **Box‑E** payload aboard a **SpaceX** rocket, beginning a six‑week orbital trial to grow ultra‑pure protein crystals for self‑injectable cancer therapies. Box‑E’s Orbital Test: Microgravity Enables Ultra‑Pure Protein Crystals The microwave‑sized unit will float aboard the International Space Station, where microgravity eliminates the disruptive effects of Earth’s gravity on crystal formation. The resulting crystals are more stable, allowing drug formulations that are impossible to achieve on the ground. Mission duration: ~6 weeks in orbit Target output: thousands of litres of fluid per box per year Goal: Produce cancer‑drug crystals that can be stored in a fridge and self‑injected £9.8 Million Funding Round and UK Space Agency Contract Last month **BioOrbit** closed a **£9.8 million** Series A round led by **LocalGlobe** and **Breega**, earmarked for the orbital test and scaling of the hardware. Earlier in March the company secured a **£250,000** contract from the UK Space Agency to manufacture drugs in microgravity. Potential Disruption of Cancer Treatment Delivery Current immunotherapies such as Merck’s **Keytruda** require lengthy IV infusions in hospitals. By crystallising the active protein, **Box‑E** could enable high‑concentration, low‑viscosity formulations suitable for pen‑injectors, reducing treatment time from hours to minutes and extending shelf‑life. Roadmap to Commercialisation and Market Size **BioOrbit** projects that, if orbital tests succeed, multiple **Box‑E** units could be stacked to meet the demand of a blockbuster drug within a handful of boxes. The company estimates a market of **$22.7 trillion** for in‑space manufacturing across sectors, with pharmaceuticals a key segment. Clinical trials and regulatory approval are expected to take at least five years before the new formulations reach patients. Future Outlook for Space‑Based Pharma Beyond cancer, the crystallisation platform could be applied to the roughly 70 % of top‑selling drugs that are currently administered intravenously. Partnerships with major pharma groups are already being explored, and competitors such as **Varda Space Industries** are also pursuing in‑orbit drug processing, signaling a burgeoning industry.

The LeadAdam Root’s invention represents a tangible shift in consumer technology designed to mitigate ocean pollution. By installing a compact device above a standard washing machine, homeowners can now intercept billions of microfibres before they enter the water system. The technology, developed by Root’s Bristol-based company Matter Industries, has already proven its efficacy in the field, capturing a surprising amount of waste that often resembles a "dinner-plateful" after just a few weeks of use.From Garage Prototype to Global Solution: The Matter Industries BreakthroughThe core of this innovation is a filtration system that claims to capture 97% of microfibres. What distinguishes Root’s device from previous iterations is its self-cleaning mechanism; after each wash cycle, the filter rinses itself to prevent blockage, ensuring continuous flow and efficiency. This breakthrough was born from humble beginnings. Root, a former mechanical engineer and product innovator at Dyson, began the project with a mere £250 investment on a wet garage floor. After several precarious attempts with a broom handle and a temperamental machine, he successfully demonstrated the capture of microfibres. The invention has since gained significant traction, earning Matter Industries a runner-up position in the oceans category of the Earthshot Prize in 2025.Origin Story: Started with £250 investment on a garage floor.Key Feature: Self-cleaning mesh that rinses after each cycle.Recognition: Runner-up in the Earthshot Prize 2025 (Oceans category).Availability: Currently sold in more than 30 European markets and the UK.Quantifying the Invisible Threat: The Scale of Microfiber PollutionThe necessity for such technology is underscored by alarming statistics regarding textile shedding. An estimated 69% of all clothing contains fossil fuel-based plastic textiles like polyester, nylon, and acrylic. These synthetic materials shed billions of fibres during every wash cycle. In the UK alone, domestic washing machines discharge between 6,000 and 87,000 tonnes of clothing fibres into rivers and oceans annually. The impact is profound: microfibres are the most ubiquitous type of microplastic in the environment, constituting more than 90% of the microplastics marine animals consume. Furthermore, these fibres are not just plastic; they carry chemical dyes and additives that pose additional environmental risks.Rethinking the Supply Chain and PolicyThe industry is beginning to recognize that filtration must happen at multiple stages. Anja Brandon, director of plastics policy at Ocean Conservancy, notes that the filter captures not only plastic fibres but also other textiles laden with chemicals and colorants. Currently, Matter Industries is targeting the consumer market, but Root has a broader vision for systemic change. The company is actively campaigning for legislation to mandate microfibre filters in all washing machines within the UK. This move would transition the solution from a voluntary consumer choice to a regulatory standard, ensuring that the burden of pollution reduction falls on manufacturers and policymakers rather than individual households.The Future of Textile FiltrationLooking ahead, the trajectory for microplastic filtration is moving toward municipal infrastructure. Root aims to see his filters integrated into wastewater treatment plants to capture fibres before they ever reach the sea. Simultaneously, the company is preparing to expand its footprint into the US market, capitalizing on the country's larger population and higher frequency of washing. As the global community moves toward a comprehensive plastics treaty, the success of Matter Industries suggests that the next generation of environmental solutions will likely be small, high-tech devices integrated into everyday household appliances.

The SpaceX IPO: A Historic Listing on Nasdaq Tech billionaire Elon Musk’s SpaceX is preparing to list its shares on the US-based Nasdaq in what will be the most hotly anticipated initial public offering (IPO) in years. What is SpaceX? Founded in 2002 by Musk, now the world’s richest man, SpaceX is best known for designing and launching rockets, spacecraft and reusable launch vehicles. Since 2006, the company has partnered with NASA to deliver cargo and crew to the International Space Station (ISS). The Texas-based company has also launched rockets, satellites and spacecraft for various private companies. As well as its aerospace business, SpaceX provides internet services and artificial intelligence platforms through its dedicated divisions, Starlink and xAI. The Significance of the SpaceX IPO The IPO will be listed under “SPCX” on the Nasdaq, which is home to such corporate behemoths as Nvidia, Apple and Microsoft. While SpaceX has not officially confirmed the date of its public debut, multiple media reports have said it is planning to do so as early as June. Following the IPO, members of the public will be able to buy and sell SpaceX shares on the stock exchange. Why is the SpaceX IPO such a Big Deal? It is widely expected to be the largest IPO in history, and is likely to make Musk the world’s first trillionaire. The firm is aiming to raise upwards of $80bn for a market valuation of between $1.75 trillion and $2 trillion, according to media reports. Twenty-three financial institutions, including Goldman Sachs, Morgan Stanley, Citigroup, JP Morgan and BofA Securities, are underwriting the deal. Financial Performance and Future Outlook SpaceX achieved revenue of $18.6bn in 2025, up from $14bn the previous year, but suffered a net loss of $4.9bn. In the first quarter of this year, the company reported $4.7bn in revenue but made a net loss of $4.3bn. Analysts have linked some of the losses to SpaceX’s decision to acquire xAI in 2025.

The Final Hour: Apply for Startup Battlefield 200 Today The application window for Startup Battlefield 200 closes today at 11:59 p.m. PT. This is the last chance for founders to apply or nominate a startup for a chance to compete for $100,000 in equity-free funding, gain global visibility, and connect directly with investors on the TechCrunch Disrupt stage. What Startup Battlefield 200 Offers Selected companies will showcase at TechCrunch Disrupt in front of 10,000+ attendees, leading venture capital firms, global media, and the broader TechCrunch audience. Founders gain direct investor access, live exposure, and the opportunity to prove they belong among the next generation of category-defining companies. Every selected company pitches live, whether on the Disrupt Stage or the Pitch Showcase Stage. Founders get direct investor access, live exposure, and the opportunity to prove they belong among the next generation of category-defining companies. The Impact of Startup Battlefield 200 More than 1,700 startups have participated in Startup Battlefield over the years. Together, they've raised over $32 billion and produced more than 250 exits, including acquisitions by Microsoft, Google, Salesforce, Uber, and Amazon. Eligibility and Application Applications are open globally across industries. Most selected startups are pre-Series A, though select Series A companies may qualify. To apply, startups should: Be building innovative, potentially category-defining products. Have a strong founding team. The Stakes Thousands apply every year. Only 200 are selected. Just 20 finalists pitch on the main Disrupt Stage. One startup wins $100,000 in equity-free funding. The Prediction If you're building something category-defining — or know a startup that deserves the spotlight — submit your nomination and complete your application before time runs out. The deadline closes tonight, 11:59 p.m. PT.