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A recent Cochrane review analyzing 17 clinical trials involving over 20,000 people with mild cognitive impairment or dementia has concluded that anti-amyloid drugs have a 'trivial' effect on cognition and dementia severity over 18 months.The review, which assessed seven anti-amyloid drugs, found that improvements in functional ability were 'small at best' and that the drugs caused more swelling and bleeding in the brain than the placebo.The findings are a blow to the new wave of drugs designed to slow Alzheimer's by clearing clumps of amyloid protein that build up in the brain. Despite initial hype, with some regulators approving drugs like lcanemab and donanemab, many countries have stopped short of providing them through public health services due to concerns over their effectiveness and cost.Critics of the review argue that it combines results from older, failed drugs with those from newer, more effective medicines, which may skew the conclusions. However, the review's authors defend their approach, stating that all the drugs aimed to remove amyloid from the brain and assessed the impact on patients in a similar way.The review's lead author, Edo Richard, notes that the effect sizes are too small for patients and caregivers to notice, and that the drugs are also 'burdensome' due to the need for regular intravenous drug infusions and MRI scans.Experts in the field, such as Robert Howard, express concerns that the drugs may not truly alter the course of Alzheimer's, and that it's unfair to raise expectations in patients. Meanwhile, Alzheimer's Research UK argues that the review's conclusions are limited by its methodology and that anti-amyloid treatments will not be the whole answer to curing Alzheimer's.

Average private rents across Great Britain have halted their near‑decade‑long climb, with the typical advertised rent outside London remaining at £1,370 per month during the first quarter of 2026, according to Rightmove data.That flat reading marks the first time since 2017 that rents have not risen in the opening three months of a year compared with the end of the previous year, signalling a potential easing of the chronic affordability squeeze that has plagued tenants.Rightmove warned that many renters are now hitting the “ceiling” of what they can afford, a trend compounded by broader cost‑of‑living pressures. Estate agent Jeremy Leaf noted that the Iran war that began on 28 February has heightened tenants’ financial anxieties.Conversely, the conflict has spurred a modest influx of migrants from the Middle East, bolstering demand in the “prime” rental segment, according to Chestertons.Rightmove’s property expert Colleen Babcock cautioned that the war’s immediate impact is an increase in borrowing costs for landlords, which could later translate into higher rents.In response to the softening market, landlords are “positioning rents correctly for the current market.” About 26 % of rental listings have been reduced in price while advertised – the highest proportion recorded since Rightmove began tracking this metric in 2012.After years of demand outstripping supply, the market now shows signs of balance: the number of homes available for rent is 3 % higher than a year ago, and supply is at its strongest level for this time of year since 2021.London’s average advertised rent rose modestly by 0.7 % to £2,736 per month, still below the record peak reached in the summer of 2025.The sector is also bracing for regulatory change. The Renters’ Rights Act, effective 1 May 2026, will abolish Section 21 of the Housing Act, ending “no‑fault” evictions. Charities have warned of a potential surge in last‑minute evictions ahead of the deadline, but Rightmove reported no noticeable increase in newly listed rentals before the law takes effect.Analysts view the pause in rent growth as a temporary relief for tenants, yet warn that higher financing costs for landlords and the upcoming tenancy reforms could reignite upward pressure later in the year.

The production of sugar has long been associated with exploitation and harsh labor conditions. Workers in the sugar industry often face grueling working conditions, with many suffering from serious health issues.The sugar industry's environmental impact is also significant, with large-scale deforestation and water pollution being major concerns. The article aims to expose the bitter truth behind sugar production, revealing the human cost and environmental damage.

Sudan, one of the world's most impoverished countries, has been ravaged by a civil war that began in 2023. The conflict, driven by a power struggle between the army and the paramilitary Rapid Support Forces (RSF), has left the nation unrecognizable. Over 40,000 people have been killed, and about 14 million – a quarter of the population – have been forced to flee their homes. Civilian infrastructure across the country has been extensively damaged.“We are not just facing a crisis – we are witnessing the systematic erosion of a country’s future,” Luca Renda, the United Nations Development Programme’s (UNDP’s) resident representative in Sudan, told Al Jazeera. A report by the UNDP and the Institute for Security Studies highlights the scale of Sudan’s economic collapse. Even under the most optimistic scenario of peace being achieved in 2026, Sudan would still lose an estimated $18.8 billion in gross domestic product (GDP) by 2043.The war has had a devastating impact on Sudan's infrastructure and basic services. $6.4 billion was lost in GDP in 2023 alone, reflecting a simultaneous collapse across all major parts of Sudan’s economy. The destruction of infrastructure has triggered displacement and made it difficult for people to secure adequate housing or access basic services. Up to 40 percent of power generation capacity has been lost, and key water infrastructure has been destroyed or seized, cutting communities off from clean water and sanitation.The labor market has also been severely affected, with agriculture – once the backbone of Sudan’s economy – severely hit. Cultivated land has shrunk, adversely impacting rural livelihoods. Average incomes have fallen back to levels last seen in 1992. About 90 percent of manufacturing activity has been destroyed in key economic hubs, eliminating thousands of jobs.The oil industry has suffered significantly, with oil output falling amid widespread instability and infrastructure damage. The Khartoum refinery, which previously processed up to 100,000 barrels per day, has been out of operation since July 2023. Key infrastructure, including pipeline routes carrying crude to Port Sudan, has been hit.The collapse of the Sudanese pound and supply chains has caused a sharp rise in living costs. Food prices have surged, with four pieces of bread now costing about 1,000 pounds, an amount that had previously bought six pieces. Wages have failed to catch up with inflation, leaving many households without access to necessities. Nearly half the population is now experiencing acute food shortages.The economic collapse has had a profound impact on Sudan's people, with 34 million people in need of assistance and 19 million facing acute food shortages. The war has caused death, trauma, and profound loss, casting a long shadow over Sudan’s future and dimming the prospects of a generation whose lives are being shaped by violence. If the conflict continues to 2030, Sudan’s economy in 2043 would be about $34.5 billion smaller than it would have been without the war, and GDP per capita would drop by roughly $1,700.

Israel's High Court has begun hearing petitions that seek to remove Ben-Gvir from his position. The petitions, filed by various groups, argue that Ben-Gvir's actions and policies are detrimental to the country's stability and democratic values.The hearing comes amid heightened tensions in Israel, with many questioning Ben-Gvir's suitability to hold office. The court's decision is expected to have significant implications for the country's political landscape.

Arab Barghouti has made a compelling appeal to human rights groups, urging them to step up their support for Palestinian prisoners. The call to action comes as a significant development in the ongoing efforts to address the plight of Palestinian detainees.While specific details about the current situation of Palestinian prisoners are scarce, Barghouti's statement underscores the urgency for enhanced advocacy and assistance from rights organizations. This appeal is likely to resonate with various human rights groups that have been actively involved in Middle Eastern issues.The situation of Palestinian prisoners has been a longstanding concern in international relations, particularly within the context of the Israeli-Palestinian conflict. Efforts to improve their conditions and ensure their rights are protected have been a focal point for many human rights organizations.

Bayern Munich is set to host Real Madrid at the Allianz Arena in Munich, Germany, for the second leg of their highly anticipated Champions League quarterfinal matchup. The German side will look to build on their 2-1 advantage secured in last week's game, as they aim to progress to the next stage of the competition.The match is scheduled to kick off at 9pm local time (19:00 GMT), promising an exciting encounter between two of Europe's top football clubs. Real Madrid will be eager to overturn the deficit and advance, making for a compelling second leg.

In the midst of Israel's ongoing attacks on Lebanon, which have resulted in the displacement of at least one million people, migrant workers are taking initiative to support their communities. Myra Aragon, a Filipino migrant, runs a community center called Tres Marias in a Beirut suburb, providing meals to around 200 people daily, mostly migrant workers.Aragon's efforts are part of a larger trend of migrant solidarity in Lebanon. With many migrant workers facing restrictions and discrimination due to the country's kafala labor system, they are organizing themselves to help those in need. Tres Marias is one of at least three food kitchens run by migrant workers in Lebanon, serving not only migrants but also occasionally Lebanese families.The war has exacerbated existing challenges for migrant workers, with many facing displacement, discrimination, and limited access to shelters. However, Aragon and others like her are working to provide food and a sense of community to those affected. As Aragon notes, 'Food is unifying... It is a way for people to learn about food from the Philippines, and it makes people feel cared for and seen.'Despite the danger and uncertainty posed by the war, Aragon remains committed to her work, stating, 'This war is a lot worse than the last one... But as the war carries on, I will continue to cook and distribute food to those who need it.'

Israel has intensified its military campaign in southern Lebanon, conducting deadly strikes on several towns, resulting in significant casualties. The attacks occurred just a day after Lebanese and Israeli envoys held rare talks in Washington, DC, facilitated by US Secretary of State Marco Rubio. These talks marked the first direct contact between the two countries in decades.According to Lebanon's state-run National News Agency (NNA), Wednesday's attacks killed at least 13 people, including a family of four in the town of Jbaa. The strikes also targeted other towns, including Ansariyeh, Qadmus, Saadiyat, and Jiyeh. The escalation has sparked anger among the Lebanese population, with many questioning the government's decision to engage in diplomatic talks with Israel while attacks continue.Al Jazeera's Zeina Khodr, reporting from Beirut, noted that residents are demanding an end to the attacks and expressing frustration over the government's handling of the situation. The Lebanese government has faced criticism for its concessions and perceived weakness in dealing with Israel. Hezbollah lawmaker Hassan Fadlallah accused the government of squandering Lebanon's political and military strength and criticized its decision to withdraw the army from the south.The conflict between Israel and Hezbollah, an Iran-aligned group, has resulted in over 2,000 deaths in recent weeks. The situation remains volatile, with ceasefire talks being a key point of contention. Hezbollah is seeking a comprehensive ceasefire, while Israel has ruled out discussions on a ceasefire in the latest war.