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Paul Dano has had a remarkable career in Hollywood, taking on a wide range of roles in films like Little Miss Sunshine, Love & Mercy, and Swiss Army Man. In a recent interview, Dano shared his experiences working with Brian Wilson in Love & Mercy, and how he spent time with the legendary musician before filming.Dano discussed the challenges of playing a character who doesn't speak in Little Miss Sunshine, and how it felt to break his vow of silence in the second half of the film. He also talked about his experience working on the BBC's War and Peace adaptation, and how he read the book before filming to prepare for his role.When asked about his role as the leader of the Animal Liberation Front in Okja, Dano admitted that it changed his relationship to food, but only for a short time. He also discussed his experience working with the Daniels and Daniel Radcliffe on Swiss Army Man, calling it a fun and creative experience.Dano emphasized the importance of staying kind and grounded in the intense film industry, and how it helps him approach difficult characters with empathy. He also shared that he would most like to hang out with his characters Dwayne from Little Miss Sunshine and Brian Wilson from Love & Mercy.Looking ahead, Dano discussed his role in The Wizard of the Kremlin, a film about modern politics and power. He was drawn to the project because of its compelling and intelligent storytelling, and its relevance to current events.

A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

Oil tanker workers stuck in the Gulf for six weeks are reaching their limit, with mental health concerns escalating due to the prolonged standoff. A crew member, who spoke to the Guardian, revealed that the situation is becoming increasingly unbearable.The worker, one of 20,000 seafarers trapped by Iran's chokehold on the Strait of Hormuz, expressed frustration and despair, stating that any hope of being freed had evaporated. The crew member's tanker is anchored near dozens of loaded tankers, with many feeling unwilling and unable to traverse the strait, even if a ceasefire allowed them to do so.90% of the crew on the tanker want to exercise their right to refuse to sail, citing safety concerns. The situation has taken a toll on the crew's mental health, with one member suffering a 'mental breakdown' and being checked on regularly by colleagues.The International Transport Workers' Federation (ITF) has received about 1,000 inquiries from seafarers on 300 different vessels, with 20% seeking repatriation. The union and other organizations are trying to provide support, but the situation remains dire.The shipping companies are expected to find new crew members willing to work in hazardous areas, offering double pay and promotions. However, the workers stuck on the tankers hope that their vessel will be taken to anchorage to allow new crew to take their places.The situation has reignited calls for shipowners to replace their crews with mariners willing to offer relief, highlighting the human cost of the conflict.

On 23 June 2016, the United Kingdom’s electorate shifted from party‑centric voting to a binary choice between staying in or leaving the European Union. A decade later, about 60 % of the population still define themselves by the side they chose in that single referendum, turning a one‑off political decision into a lasting personal identity.While analysts often focus on the policy fallout—economic turbulence, party infighting, and shifting trade relations—the real impact runs deeper. The referendum ignited a civil‑war‑like split that continues to shape elections, media narratives, and everyday conversations across the country.Before the global upheavals of the George Floyd protests and the Covid‑19 vaccine rollout, Brexit was Britain’s most potent form of identity politics. It spawned new media outlets, such as GB News, and programmes like The Rest Is Politics, while also marginalising older cultural tropes like the “centrist dad” or “gammon” heckler on Question Time. Figures such as Nigel Farage and Zack Polanski now occupy the political fringe rather than the mainstream.The analysis draws on the new book Tribal Politics: How Brexit Divided Britain by political scientists Sara Hobolt and James Tilley. Their longitudinal surveys reveal a simple yet striking pattern: the referendum transformed a previously lukewarm public attitude toward the EU into a powerful, identity‑based habit.Prior to 2016, most Britons held only a mild Euroscepticism and gave the EU little thought. Even former Prime Minister David Cameron tried to silence the issue in 2006, believing it failed to engage voters. The sudden elevation of a niche concern to a national obsession forced ordinary citizens to pick a side, discuss it in pubs, and embed it into their self‑image—a process James Clear describes as building “identity‑based habits”.Data from Hobolt and Tilley show that emotional attachment to the Brexit identity was modest before the vote, rose sharply as the referendum approached, and surged dramatically after the result was announced. The post‑vote period saw a flood of EU‑themed merchandise, street rallies, and even flag‑clashes at cultural events such as the 2017 Last Night of the Proms.Crucially, the tribal divide has not faded. By 2025, only around 40 % of “Leavers” feel comfortable discussing politics with “Remainers”, and the sentiment is reciprocated. This goes beyond mere disagreement; it reflects a level of social discrimination where individuals on opposite sides would hesitate to share a home or marry into each other’s families.The authors note that the split now extends to perceptions of reality itself. Even in 2024, Remainers and Leavers disagreed on basic economic indicators, illustrating how the referendum reshaped not just policy preferences but fundamental worldviews.Class‑based voting, which dominated the 20th‑century British political landscape, has been largely supplanted by this new cultural cleavage. A previous study co‑authored by Tilley showed that the Labour Party’s turn toward the political centre in the 1990s eroded traditional working‑class loyalty. Today, leader Keir Starmer’s working‑class credentials appear largely symbolic, offering little substantive change.With class politics receded, culture wars have taken centre stage. The Brexit campaign’s vague promises about trade left the nation with a protracted, messy adjustment period. Immigration, famously dubbed the “baseball bat” issue by Dominic Cummings, remains the most polarising policy divide, followed by foreign aid and even the death penalty.Hobolt and Tilley’s most striking chart shows that while Remainers and Leavers clash over immigration, they share little disagreement on economic equality, workers’ rights, or public ownership—issues that directly affect household incomes. This suggests that the political battle is driven more by symbolic identity than by material concerns, benefitting those already financially secure.In sum, the United Kingdom’s post‑Brexit reality is one of entrenched tribalism, where a single referendum has reshaped social bonds, political discourse, and perceptions of truth itself. The nation continues to grapple with the legacy of a vote that turned a policy decision into a lasting cultural fault line.

In a night that felt more theatrical than competitive, Paris Saint‑Germain secured a 2‑0 victory over Liverpool at the Parc des Princes, leaving the English champions questioning their own identity ahead of the second leg.While Liverpool’s players showed resilience by refusing to abandon the fight, the result underscores a deeper issue: the team has lost five of their last eight matches and currently sits fifth in the Premier League, just three points clear of Everton in eighth place. The margin is razor‑thin and the pressure is mounting.PSG’s performance was a masterclass in flair and efficiency. Their first goal set the tone, but it was the second strike at the 66‑minute mark that captured headlines. Georgian winger Khvicha Kvaratskhelia received a swift pass from João Neves, surged past two Liverpool defenders with remarkable balance, evaded Ryan Gravenberch’s challenge, and finished with a composed right‑footed shot that left the Anfield side scrambling.The goal highlighted PSG’s technical edge: their movement was fluid, their ball control assured, and their finishing clinical. In contrast, Liverpool’s pressing strategy, orchestrated by manager Arne Slot, appeared tentative. Slot’s early enthusiasm has given way to a more nervous demeanor, as reflected in his subdued sideline presence.Beyond the scoreline, the match exposed Liverpool’s structural deficiencies. The team’s lack of a clear pattern and the absence of a recognizable “Liverpool goal” raise questions about the effectiveness of Slot’s tactical overhaul, often dubbed “Slot 2.0”.Adding to the narrative, midfielder Dominik Szoboszlai walked off the tunnel alone, a symbolic gesture that contrasted sharply with the collective pursuit of the manager by his teammates. The moment, while minor, hinted at a growing disconnect within the squad.PSG’s dominance was not limited to the goals. Their pre‑match spectacle—flashing lights, dramatic sound cues, and a flamboyant PA announcer—set a tone of confidence that translated onto the pitch. The French side’s control of possession and spatial awareness suggested they could have added another goal with more ruthless finishing.For Liverpool, the defeat is a sobering reminder of the challenges ahead. After a heavy loss to Manchester City in the FA Cup, the Reds entered Paris with evident apprehension. The 2‑0 result, while disappointing, may serve as a catalyst for introspection before the return leg at Anfield.Looking forward, the upcoming fixture at Anfield will test whether Liverpool can summon the “deep Anfield voodoo” that fans often cite as a turning point. The stakes are high: a positive result could revive their European ambitions, while another setback may cement doubts about their season trajectory.

As the clock ticked down to President Donald Trump’s 8 p.m. deadline to force the reopening of the Strait of Hormuz, the six‑week Middle East conflict teetered on the brink of a far more devastating escalation.Trump’s rhetoric had escalated dramatically, with his Truth Social posts warning that the United States would unleash strikes capable of “decimating every bridge and power plant in Iran” and that “a whole civilisation will die tonight.” Legal experts labeled the language as bordering on a genocidal threat.Amid the rising tension, a series of rapid developments unfolded on Tuesday:12:06 GMT – Trump announced a plan to target Iran’s civilian infrastructure, promising total destruction of bridges and power facilities.15:21 GMT – Iranian media confirmed that US strikes hit Kharg Island, the nation’s primary oil‑export hub, but reported no significant damage.15:40 GMT – In the UN Security Council, China and Russia vetoed a Bahraini resolution aimed at protecting commercial shipping in the Strait of Hormuz, arguing the draft was biased against Tehran.16:54 GMT – Qatar’s defence ministry reported a successful missile interception, while the United Arab Emirates warned of a barrage of missile and drone attacks.18:23 GMT – Iran’s envoy to Pakistan, Reza Amiri Moghadam, signalled a “step forward” after a “critical, sensitive stage,” praising Pakistan’s “positive and productive” peace efforts.19:17 GMT – Pakistani Prime Minister Shehbaz Sharif appealed to Trump to extend the deadline by two weeks, urging Tehran to keep the Strait open as a goodwill gesture.20:25 GMT – Iran warned it would target US and Gulf‑allied energy infrastructure, threatening to block regional oil and gas supplies for years.20:41 GMT – Joint US‑Israeli airstrikes struck the Amirkabir Petrochemical Plant in Mahshahr, Iran, prompting local assessments of damage.With less than ninety minutes remaining, diplomatic channels intensified. Pakistani officials, including the military chief Asim Munir, facilitated talks that culminated in a two‑week, double‑sided cease‑fire announced by Trump at 22:45 GMT. The United States claimed to have received a “workable” 10‑point proposal from Tehran.Iranian Foreign Minister Abbas Araghchi quickly confirmed the truce, stating Iran would honor it provided attacks on its territory ceased. Sharif then invited both Iranian and US delegations to Islamabad for further negotiations aimed at a permanent settlement.Early Wednesday, Trump’s tone shifted dramatically. In a Truth Social post he hailed the cease‑fire as a potential “Golden Age for the Middle East,” celebrating the pause in hostilities and the reopening of the Strait of Hormuz.The episode underscores how last‑minute diplomacy, spearheaded by Pakistan, averted a catastrophic escalation and opened a narrow window for a broader peace process in a region long mired in conflict.

Israeli air raids have torn through densely populated commercial and residential districts in central Beirut without warning, striking the heart of the capital just hours after a ceasefire was announced in the United States-Israeli war with Iran.Lebanon’s Ministry of Public Health reported that dozens of people had been killed and hundreds wounded, stressing that the figures were preliminary and likely to rise as rescue workers sifted through the rubble.Israel had already claimed that the truce did not apply to its conflict with Hezbollah in Lebanon, despite mediator Pakistan saying the agreement extended to that front as well.The Israeli military described the bombardment as the largest coordinated strike of the current war, with more than 100 Hezbollah-linked targets hit within 10 minutes in Beirut, southern Lebanon and the eastern Bekaa Valley.Several of the strikes landed in busy commercial areas, sending residents fleeing in panic as sirens wailed and glass and debris carpeted the streets.Lebanon’s National News Agency said at least five neighbourhoods in Beirut’s central and coastal districts were hit.The Israeli military said it had targeted missile launchers, command centres and intelligence infrastructure, and accused Hezbollah of using civilians as human shields.Residents and local officials, however, insisted that the buildings struck were not military sites.While Israel has regularly bombed southern and eastern Lebanon, as well as Hezbollah strongholds in Beirut’s southern suburbs, it had rarely carried out attacks in central Beirut since the latest round of fighting with the group began on March 2.Israeli air strikes in Lebanon have killed more than 1,530 people so far, and have forced at least 1.2 million people to flee their homes.

The Confederation of African Football (CAF) chief Patrice Motsepe arrived in Dakar this week, marking his first visit to Senegal since the body’s controversial decision to strip the nation of its Africa Cup of Nations (AFCON) crown and hand it to Morocco.Motsepe announced the itinerary at the end of March, pledging to meet leaders in both countries to stress the need for "working together to grow African football" as CAF confronts mounting criticism.President Bassirou Diomaye Faye is scheduled to receive Motsepe at the presidential palace, followed by a joint news conference intended to calm tensions.The visit comes in the wake of CAF’s surprise reversal of the January 18 final, where Senegal had defeated hosts Morocco 1‑0. Citing a breach of regulations concerning players leaving the field, CAF retroactively recorded a 3‑0 victory for Morocco on March 17.During the match in Rabat, Senegal’s squad, head coach Pape Thiaw and staff walked off after Morocco were awarded an added‑time penalty, which forward Brahim Diaz ultimately missed.In response, the Senegalese Football Federation lodged an appeal with the Court of Arbitration for Sport (CAS), while the Senegalese government demanded an international probe into alleged corruption within CAF.Motsepe, speaking late last month, affirmed that he would respect and implement the CAS ruling, adding that his personal view on the matter was “irrelevant.”

A daring escape attempt has unfolded in Namibia, where a prisoner has taken refuge on the roof of a shopping centre. The individual, whose identity has not been disclosed, managed to evade capture and hide on the rooftop, prompting a standoff with authorities. The incident has raised concerns about prison security and the measures in place to prevent such escapes. Details about the prisoner's motives and background are still scarce. Namibia's law enforcement agencies are working to resolve the situation safely, with negotiations and tactical operations underway to bring the escaped prisoner to justice.