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Residents of Tehran and much of Iran are breathing a sigh of relief after a two-week ceasefire was announced, bringing an end to daily bombardments. The ceasefire, agreed upon by Iran and the US with mediation from Pakistan, has allowed some traffic to return to the streets of the Iranian capital during daylight hours.Despite the temporary reprieve, Tehran remains far from its usual bustling state, having been targeted by several thousand munitions since February 28. The Iranian capital is home to more than 10 million people. Air defence systems were activated for short periods several times since the ceasefire was announced overnight, but there were no reports of impacts or any official explanation for the activations.People across Tehran are debating whether the ceasefire will hold and what the future may hold for them. A young man noted, “Looks like the ceasefire will continue. I heard the Israelis are opening up their airspace more,” referring to an announcement by Israeli authorities that flights will resume from Ben Gurion Airport.However, others are more pessimistic, especially after two critical islands off southern Iran were attacked on Wednesday morning, hitting oil facilities. It is unclear who was behind the attack. The Islamic Revolutionary Guard Corps (IRGC) said it shot down a drone in the southern province of Fars.Saudi Arabia, the United Arab Emirates, Qatar, Kuwait, and Bahrain also reported attacks on their territories by missiles and drones from Iran, with Iranian state television confirming this was in retaliation for the post-ceasefire oil attacks. Tehran said it was ready to restart military operations if attacked again.On Tuesday, Iranians had been worried about the targeting of critical civilian infrastructure, such as power plants and bridges, after a threat from US President Donald Trump to end “civilisation” in a country with one of the world’s oldest civilisations. The ceasefire was announced shortly before the midnight GMT deadline that Trump had set for an agreement to be reached.The Israeli military intensified its attacks in the hours preceding the ceasefire, hitting electricity outposts, bridges, and the railway network. Warplanes also struck the Iranian Aluminium Company in Arak, damaging the country’s largest aluminium production facility.Even after the ceasefire, Israel continued attacking Lebanon, killing more than 250 people in a devastating day of attacks on Wednesday. Israel said it was targeting Iran’s ally Hezbollah, but civilian locations across Lebanon were hit.Trump hailed what he described as a decisive victory against Iran while announcing the ceasefire, but his top general emphasised that the deal only signifies a pause and combat operations could start once again if no final deal is reached. The US military said it struck 13,000 targets across Iran in less than six weeks of war.In Iran, similar proclamations of victory and celebrations were broadcast from Iranian state television. A statement from the Supreme National Security Council urged supporters of the government to trust in the system and refrain from making “divisive commentary”.The council also stressed that affairs were being overseen by Mojtaba Khamenei, who was declared Iran’s supreme leader after his father, Ayatollah Ali Khamenei, was killed on the first day of the war on February 28.

Israeli forces have carried out a devastating bombardment across Lebanon, killing at least 254 people and wounding 1,165 others in air strikes that targeted areas in Beirut, the Bekaa Valley, Mount Lebanon, Sidon, and several villages in southern Lebanon.The Israeli military said that the attack was its largest coordinated assault on Lebanon since it started a new military operation in the country on March 2, “targeting more than 100 Hezbollah command centres and military sites”.The attacks have sparked widespread international condemnation, with leaders from around the world calling for an end to the violence. Lebanon’s Parliament Speaker Nabih Berri called the attacks a “full-fledged war crime,” while Hezbollah said it had a “right” to respond to the attacks.International Reactions:• Iran: The Iranian Revolutionary Guard Corps (IRGC) warned that it will respond to the attacks on Lebanon if Israel does not stop the assault.• US: President Donald Trump said Lebanon was not part of the ceasefire deal with Iran due to Hezbollah.• Qatar: The foreign ministry condemned the “brutal series” of Israeli attacks on Lebanon, calling them a “dangerous escalation and a flagrant violation of the sovereignty of the sister Lebanese Republic.”• Egypt: The Ministry of Foreign Affairs called Israel’s attacks on Lebanon had a “premeditated intent” to undermine regional and international efforts to reduce escalation.• UN: The United Nations strongly condemned the strikes by Israel across Lebanon that resulted in significant civilian casualties.

Israel's heaviest and deadliest air attacks on Lebanon in years have left the country reeling, with at least 254 people killed and over 1,160 injured. The strikes, which occurred in dozens of locations across Beirut, its suburbs, the south, and the eastern Bekaa Valley, have sparked fears of a rising toll as more victims are recovered from the rubble.The attacks came hours after a Pakistani-negotiated ceasefire between the US and Iran took effect, but Israel and the US argued that Lebanon was not included in the agreement. US President Donald Trump described Lebanon as a 'separate skirmish,' while Israeli Prime Minister Benjamin Netanyahu claimed the ceasefire 'does not include Lebanon.'Netanyahu's goal appears to be taking advantage of the fluid situation to maximize operational achievements in Lebanon, according to Dania Arayssi, a senior analyst at New Lines Institute for Strategy and Policy. 'He must take into account that a US-Iran deal might include ceasing the war on Iranian proxies, which would greatly complicate the Israeli war effort against Hezbollah in Lebanon.'The conflict escalated in early March when Israel intensified its war on Lebanon, following a salvo of rockets launched by Hezbollah. Since then, over 1,700 people have been killed and more than 1.2 million displaced. Hezbollah has claimed its right to respond to the attacks, affirming that it will resist occupation and respond to aggression.The airstrikes, which included over 100 attacks in fewer than 10 minutes, targeted Hezbollah headquarters and military targets, but many strikes were in densely populated residential areas. Hospitals were overwhelmed, and people were forced to flee their homes, with some attempting to return to their homes in the south amid confusion over Lebanon's inclusion in the ceasefire.'People are afraid,' said Najib Merhe, owner of a restaurant in the Manara neighborhood. 'This kind of situation no one can afford nor endure.'

Israel's devastating bombardment of Lebanon in the hours after a US-Iranian ceasefire was announced has been widely condemned amid global efforts to salvage the truce. The bombing, which killed more than 200 people, including strikes with heavy munitions on densely populated areas, drew outrage from the International Committee of the Red Cross and other international humanitarian organisations.Benjamin Netanyahu insisted Lebanon was not included in the Tuesday night ceasefire agreed by Donald Trump, and vowed the Israeli military would continue to strike Hezbollah targets “wherever necessary”. The Israeli prime minister said his forces had killed the secretary to Hezbollah’s leader, Naim Qassem.The US vice-president, JD Vance, backed Netanyahu, claiming the US had never agreed to the inclusion of Lebanon in the truce. However, Iran’s president, Masoud Pezeshkian, said that further Israeli strikes on Lebanon would render negotiations “meaningless”. Iran would not abandon the Lebanese people, he said.Pakistan, which led the efforts to broker a ceasefire after Trump threatened a civilisation-ending onslaught, has said Lebanon had been part of the agreement. Robert Malley, a former American envoy who led earlier US-Iranian negotiations, said: “I would trust the Pakistani mediator that Lebanon was included.The EU foreign policy chief, Kaja Kallas, said on Thursday: “Hezbollah dragged Lebanon into the war, but Israel’s right to defend itself does not justify inflicting such massive destruction.” France’s foreign minister, Jean-Noël Barrot, condemned the Israeli strikes as “unacceptable” and his British counterpart, Yvette Cooper, described them as “deeply damaging”, adding that failure to include Lebanon in the ceasefire would “destabilise the whole region”.

Israeli airstrikes devastated Lebanon on Wednesday, killing more than 300 people and wounding 1,165 in a span of just 10 minutes. The strikes, which targeted over 100 sites across the country, have been described as one of the deadliest mass killings in Lebanon since the end of the civil war in 1990.Omar Rakha, a survivor, recounted his terrifying experience: he was bleeding and face down on the street when he realized a building next to his in Beirut's Barbour neighborhood had been destroyed by two Israeli bombs. The neighborhood, once considered safe, felt like a war zone.The Israeli military claimed it had targeted Hezbollah 'command and control centers' in the bombing campaign dubbed 'Operation Eternal Darkness.' However, residents and Lebanese officials argue that the strikes mainly killed civilians. Lebanon's prime minister, Nawaf Salam, accused Israel of targeting 'densely populated residential neighborhoods' and killing unarmed civilians in breach of international law.Dr. Ghassan Abu-Sittah, a surgeon at the American University of Beirut Medical College, described the overwhelming influx of wounded, including children pulled from under the rubble. 'The youngest was an 11-month-old. I had to operate on him just to relieve some pressure in the head,' he said.The airstrikes have escalated tensions and raised concerns about the potential for further conflict. The war in Lebanon, which started after Hezbollah launched rockets at Israel on March 2, has left around 1,800 people dead and 5,873 wounded.

The crew of Artemis II is preparing to return to Earth on Friday, following their historic 10-day lunar flyby mission. Nasa leaders have outlined the critical steps needed to ensure a safe splashdown off the coast of San Diego. The Orion capsule will travel at nearly 24,000mph before making a final splashdown several miles off the coast of San Diego. The operation requires multiple teams and careful coordination to safely extract the crew from the spacecraft. Nasa's associate administrator Amit Kshatriya emphasized the importance of the mission, stating, "To every engineer, every technician that's touched this machine, tomorrow belongs to you. The crew has done their part. Now we have to do ours." Jeff Radigan, lead flight director of the mission, highlighted the precision required for re-entry, noting the team has "less than a degree of an angle" to hit the correct flight path. "Let's not beat around the bush. We have to hit that angle correctly – otherwise we're not going to have a successful re-entry," he said. The splashdown is expected to occur at 5:07pm PT, with the USS John P Murtha ready to assist with recovery operations. The crew will undergo post-mission medical evaluations before being flown to Nasa's Johnson Space Center in Houston, Texas. Pilot Victor Glover, the first Black man to travel beyond low Earth orbit, reflected on the journey, saying, "We have to get back. There's so much data that you've seen already, but all the good stuff is coming back with us. There are so many more pictures, so many more stories."

In a stark address delivered as the cease‑fire in the Iran conflict teetered, IMF Managing Director Kristalina Georgieva warned that the war will leave a permanent scar on the global economy, slowing growth beyond the IMF’s original projections for 2026. Georgieva noted that, had the hostilities not erupted six weeks ago, the Fund would have been poised to raise its 2026 growth outlook. Instead, even the most optimistic scenario now entails a downgrade, and a swift return to pre‑war conditions appears unlikely. The uncertainty surrounding the cease‑fire—exacerbated by divergent positions of Washington and Tehran—has already pushed oil prices higher, reflecting fears of continued disruptions to shipments through the Strait of Hormuz, a vital conduit for world energy supplies. According to the IMF’s upcoming World Economic Outlook, the conflict’s “scarring effects” will translate into lower living standards worldwide. The Fund had previously forecast global growth of 3.1% in 2026, a modest slowdown from 3.2% in 2025, buoyed by a tech‑driven investment surge. Georgieva emphasized that the war arrived when the economy was riding “considerable momentum” from technology investment and supportive financial markets. She outlined the mechanisms of damage: damaged infrastructure, supply‑chain interruptions, eroded confidence, and prolonged uncertainty over oil and gas production in the region. These factors will depress growth regardless of whether a peace agreement is ultimately reached. Georgieva highlighted that the most vulnerable will be net oil‑importing nations, poorer economies and small island states, which stand to feel the brunt of higher energy costs and reduced trade flows. She urged governments to avoid unilateral measures such as export bans or price controls, warning that such actions could "pour gasoline on the fire" and further destabilise markets. With many countries already carrying elevated debt levels and higher borrowing costs, the IMF chief called for targeted, temporary assistance to protect the most at‑risk households. She cautioned against broad tax cuts or blanket energy subsidies, which could stoke inflation and strain fragile public finances. Central banks, she added, should keep policy rates steady while remaining ready to act against inflationary pressures. Bank of England Governor Andrew Bailey, who also chairs the Financial Stability Board, echoed the IMF’s concerns, describing the conflict as a "very big shock" that has heightened market volatility. He stressed that the situation remains fluid and that policymakers must stay vigilant. Overall, the IMF’s message is clear: the Iran war will reshape the global growth trajectory for the foreseeable future, and coordinated, prudent policy responses are essential to mitigate its lasting impact.

Paul Dano has had a remarkable career in Hollywood, taking on a wide range of roles in films like Little Miss Sunshine, Love & Mercy, and Swiss Army Man. In a recent interview, Dano shared his experiences working with Brian Wilson in Love & Mercy, and how he spent time with the legendary musician before filming.Dano discussed the challenges of playing a character who doesn't speak in Little Miss Sunshine, and how it felt to break his vow of silence in the second half of the film. He also talked about his experience working on the BBC's War and Peace adaptation, and how he read the book before filming to prepare for his role.When asked about his role as the leader of the Animal Liberation Front in Okja, Dano admitted that it changed his relationship to food, but only for a short time. He also discussed his experience working with the Daniels and Daniel Radcliffe on Swiss Army Man, calling it a fun and creative experience.Dano emphasized the importance of staying kind and grounded in the intense film industry, and how it helps him approach difficult characters with empathy. He also shared that he would most like to hang out with his characters Dwayne from Little Miss Sunshine and Brian Wilson from Love & Mercy.Looking ahead, Dano discussed his role in The Wizard of the Kremlin, a film about modern politics and power. He was drawn to the project because of its compelling and intelligent storytelling, and its relevance to current events.

A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.