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A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

Oil tanker workers stuck in the Gulf for six weeks are reaching their limit, with mental health concerns escalating due to the prolonged standoff. A crew member, who spoke to the Guardian, revealed that the situation is becoming increasingly unbearable.The worker, one of 20,000 seafarers trapped by Iran's chokehold on the Strait of Hormuz, expressed frustration and despair, stating that any hope of being freed had evaporated. The crew member's tanker is anchored near dozens of loaded tankers, with many feeling unwilling and unable to traverse the strait, even if a ceasefire allowed them to do so.90% of the crew on the tanker want to exercise their right to refuse to sail, citing safety concerns. The situation has taken a toll on the crew's mental health, with one member suffering a 'mental breakdown' and being checked on regularly by colleagues.The International Transport Workers' Federation (ITF) has received about 1,000 inquiries from seafarers on 300 different vessels, with 20% seeking repatriation. The union and other organizations are trying to provide support, but the situation remains dire.The shipping companies are expected to find new crew members willing to work in hazardous areas, offering double pay and promotions. However, the workers stuck on the tankers hope that their vessel will be taken to anchorage to allow new crew to take their places.The situation has reignited calls for shipowners to replace their crews with mariners willing to offer relief, highlighting the human cost of the conflict.

The Darts Regulation Authority (DRA) announced that Noa‑Lynn van Leuven is barred from competing in any Professional Darts Corporation (PDC) women‑only events with immediate effect, after the governing body ruled that only biological females may participate in women’s tournaments.Under the new policy, van Leuven – a 29‑year‑old who has claimed six titles in the PDC Women’s Series – will be ineligible for the series and the Women’s World Matchplay, a competition she was on track to qualify for this summer.The DRA justified the decision by referencing a report commissioned from Dr Emma Hilton, a developmental biologist who has published extensively on sex categories in sport. The study concluded that darts is a "gender‑affected sport" and identified several physical differences that give males an advantage, including greater height, longer limbs, broader shoulders, increased muscle mass and stiffer tendons. These attributes, the report argued, enhance reach, stability and throwing mechanics, thereby influencing consistency and precision.This ruling arrives shortly after the International Olympic Committee announced a ban on transgender women from female Olympic events, set to take effect at the 2028 Los Angeles Games.Van Leuven responded on Instagram, describing the decision as a forced retirement. She wrote, "I just got an email… apparently I’m retired, not by choice, but because I am no longer allowed to compete." She added, "This isn’t just about me; it’s another huge hit for the trans community. Every day it is getting harder for trans people just to exist, to compete. If you think this stops with me, it doesn’t. We just want to be."While barred from women‑only events, van Leuven could still aim for the open professional tour, which is gender‑neutral. Currently, Beau Greaves is the sole female player on the tour, and former women’s world champion Lisa Ashton held a two‑year tour card in 2020‑2021.

Rebecca Solnit's latest book, 'The Beginning Comes After the End', serves as a powerful reminder that change is inevitable and that we have the power to shape our future. Drawing on her previous work, Hope in the Dark, Solnit emphasizes the importance of hope and resilience in the face of uncertainty.In her 2004 book, Hope in the Dark, Solnit offered a vision of solidarity and tenacity in response to the war in Iraq. The book experienced a surge in popularity after the 2016 election of Donald Trump, and its message of hope and humility continues to resonate today. As Solnit notes, 'Hope is not a door, but a sense that there might be a door at some point, some way out of the problems of the present moment even before that way is found or followed.'Solnit's new book picks up this thread, arguing that 'you do not have to picture the destination to reach it or at least draw closer to it, you just need to choose a direction and keep on walking'. She draws on a wide range of sources, including history, philosophy, and contemporary writing, to explore moments of reparation and progress.One of the key takeaways from Solnit's work is the importance of acknowledging the enormous gains that have been made in recent decades in areas such as women's rights, racial justice, and environmental protections. As she notes, 'Our world has changed more than almost anyone imagined, in ways both wonderful and terrible, often in ways no one anticipated'. By focusing on these successes, Solnit encourages readers to adopt a more optimistic and forward-thinking mindset.Solnit also explores the idea of interconnectedness and independence, arguing that this worldview has the power to shape our future. She writes, 'whether or not it is true, a lot of us want it to be true, and that desire says a lot about who we are right now'. By embracing this idea, readers can begin to see the world in a new light and work towards creating a better future.While some readers may be disappointed by the lack of policy prescriptions or organizing strategies, Solnit's book is a deliberate exercise in reframing our approach to change. As she notes, 'change happens so subtly, so slowly, that only a milestone lets you know that it has been taking place all along'. By adopting a more nuanced and hopeful view of the world, readers can begin to see the small changes that add up to a large one.

Argentina's congress has approved a bill promoted by President Javier Milei that authorizes mining in ecologically sensitive areas of glaciers and permafrost, sparking widespread environmental protests. The bill, which was already approved by the senate in February, will make it easier to mine for metals such as copper, lithium, and silver in frozen parts of the Andes mountains.The chamber of deputies approved the amendment with 137 votes in favor, 111 against, and three abstentions after nearly 12 hours of debate. Environmentalists argue that the legislative changes will weaken protections for crucial water sources, with thousands protesting outside parliament, holding banners with slogans such as “Water is more precious than gold!” and “A glacier destroyed cannot be restored!”Seven Greenpeace activists were arrested earlier in the day after scaling a statue outside parliament and unfurling a banner urging lawmakers “not to betray the Argentine people”. The passage of the amendment is a new coup for Milei, who pushed through looser labor laws in February despite repeated street protests.Environmental activists, such as Flavia Broffoni, argue that there is no possibility of creating a 'sustainable mine' in a periglacial environment. Argentina has nearly 17,000 glaciers or rock glaciers, with glacial reserves in the north-west shrinking by 17% in the last decade due to climate change.Milei, a free-market radical who does not believe in human-made climate change, says the bill is necessary to attract large-scale mining projects. The Central Bank of Argentina estimates that the country could triple its mining exports by 2030. Supporters argue that the bill will provide legal certainty and clear definitions, while critics, such as Enrique Viale, warn that it threatens the water supply for 70% of Argentinians.

Michael Jordan, the legendary basketball player, has found a new winning formula in Nascar. His team, 23XI Racing, has stormed to the top of the Cup series standings in 2026, with Tyler Reddick claiming four wins in the first six events, including a victory in the Daytona 500.Jordan's foray into Nascar ownership began in 2021 with a joint venture with Denny Hamlin, a prominent driver and Jordan Brand ambassador. The team's rapid rise to prominence has been fueled by Jordan's competitive drive and leadership style, which he attributes to his basketball background. "I'm cursed with this competitive gene, that anything I do is from a competitive lens," Jordan explained in an interview with CBS's Gayle King.The team's success has not been limited to Reddick, with Bubba Wallace, the No 45 car driver, consistently finishing in the top 11 through the first five races. Jordan's leadership approach, which emphasizes performing at the highest level and taking calculated risks, has drawn comparisons to his basketball career. "He emphasizes doing what you need to do to make sure you're performing at your highest level and taking that game-winning shot," said Dave Rogers, 23XI's senior director of competition.Jordan's entry into Nascar was not without controversy. In October 2025, 23XI Racing filed an antitrust lawsuit against Nascar, challenging the sport's charter system and revenue distribution model. The lawsuit led to the resignation of Nascar commissioner Steve Phelps in January 2026 and ultimately resulted in a settlement between Jordan and Nascar.Jordan's impact on Nascar extends beyond his team's on-track success. He has been instrumental in promoting diversity and inclusion in the sport, launching 23XI Racing with Bubba Wallace, a trailblazer for racial equality in Nascar. Jordan has also engaged with fans and artists, including rappers Fat Joe and Jadakiss, to help bring Nascar into the 21st century.As Jordan told King, "I'm excited that I'm connected to this sport. I feel like I watch it through the lens of my father, or with my family – and that matters to me." With 23XI Racing's impressive start to the season, it's clear that Michael Jordan has found a new passion and a winning formula in Nascar.

On 23 June 2016, the United Kingdom’s electorate shifted from party‑centric voting to a binary choice between staying in or leaving the European Union. A decade later, about 60 % of the population still define themselves by the side they chose in that single referendum, turning a one‑off political decision into a lasting personal identity.While analysts often focus on the policy fallout—economic turbulence, party infighting, and shifting trade relations—the real impact runs deeper. The referendum ignited a civil‑war‑like split that continues to shape elections, media narratives, and everyday conversations across the country.Before the global upheavals of the George Floyd protests and the Covid‑19 vaccine rollout, Brexit was Britain’s most potent form of identity politics. It spawned new media outlets, such as GB News, and programmes like The Rest Is Politics, while also marginalising older cultural tropes like the “centrist dad” or “gammon” heckler on Question Time. Figures such as Nigel Farage and Zack Polanski now occupy the political fringe rather than the mainstream.The analysis draws on the new book Tribal Politics: How Brexit Divided Britain by political scientists Sara Hobolt and James Tilley. Their longitudinal surveys reveal a simple yet striking pattern: the referendum transformed a previously lukewarm public attitude toward the EU into a powerful, identity‑based habit.Prior to 2016, most Britons held only a mild Euroscepticism and gave the EU little thought. Even former Prime Minister David Cameron tried to silence the issue in 2006, believing it failed to engage voters. The sudden elevation of a niche concern to a national obsession forced ordinary citizens to pick a side, discuss it in pubs, and embed it into their self‑image—a process James Clear describes as building “identity‑based habits”.Data from Hobolt and Tilley show that emotional attachment to the Brexit identity was modest before the vote, rose sharply as the referendum approached, and surged dramatically after the result was announced. The post‑vote period saw a flood of EU‑themed merchandise, street rallies, and even flag‑clashes at cultural events such as the 2017 Last Night of the Proms.Crucially, the tribal divide has not faded. By 2025, only around 40 % of “Leavers” feel comfortable discussing politics with “Remainers”, and the sentiment is reciprocated. This goes beyond mere disagreement; it reflects a level of social discrimination where individuals on opposite sides would hesitate to share a home or marry into each other’s families.The authors note that the split now extends to perceptions of reality itself. Even in 2024, Remainers and Leavers disagreed on basic economic indicators, illustrating how the referendum reshaped not just policy preferences but fundamental worldviews.Class‑based voting, which dominated the 20th‑century British political landscape, has been largely supplanted by this new cultural cleavage. A previous study co‑authored by Tilley showed that the Labour Party’s turn toward the political centre in the 1990s eroded traditional working‑class loyalty. Today, leader Keir Starmer’s working‑class credentials appear largely symbolic, offering little substantive change.With class politics receded, culture wars have taken centre stage. The Brexit campaign’s vague promises about trade left the nation with a protracted, messy adjustment period. Immigration, famously dubbed the “baseball bat” issue by Dominic Cummings, remains the most polarising policy divide, followed by foreign aid and even the death penalty.Hobolt and Tilley’s most striking chart shows that while Remainers and Leavers clash over immigration, they share little disagreement on economic equality, workers’ rights, or public ownership—issues that directly affect household incomes. This suggests that the political battle is driven more by symbolic identity than by material concerns, benefitting those already financially secure.In sum, the United Kingdom’s post‑Brexit reality is one of entrenched tribalism, where a single referendum has reshaped social bonds, political discourse, and perceptions of truth itself. The nation continues to grapple with the legacy of a vote that turned a policy decision into a lasting cultural fault line.

The UK's reliance on glyphosate, a widely used herbicide, has come under fire from campaigners who argue that its use has spiralled out of control. Glyphosate, known for its effectiveness in killing weeds, has been linked to various health risks, including cancer, and environmental damage.Originally pioneered by Scottish farmers in the 1980s to dry crops before harvest, the use of glyphosate has expanded globally. In the UK, over 2,200 tonnes of glyphosate were applied in 2024, with more than half used on wheat and other cereals. This represents a 10-fold increase in usage over the past three decades.Despite the World Health Organization classifying glyphosate as 'probably carcinogenic to humans' in 2015, its use has remained high. Bayer, the manufacturer, maintains that its herbicides do not cause cancer, but this stance is contested by many health and environmental organizations.Campaigners, including Nick Mole of Pesticide Action Network UK, are urging the government to phase out and ultimately ban glyphosate, citing its links to a range of cancers and other life-threatening diseases, as well as its impact on the environment. They argue that safer, more sustainable alternatives are available and should be adopted by farmers and local councils.However, some agricultural experts, like Helen Metcalfe of Rothamsted Research, suggest that glyphosate is used differently in the UK compared to the US, where genetically modified crops are involved. The shift towards 'regenerative' farming practices has contributed to the increased use of glyphosate, as it helps protect soil health and prevent erosion.The debate over glyphosate's safety and environmental impact continues, with the EU banning its use in pre-harvest desiccation in 2023 due to concerns about food accumulation. In the US, Bayer has offered $7.25bn to settle lawsuits alleging that Roundup, which contains glyphosate, can cause cancer. The UK government maintains that pesticide use is strictly regulated and only approved if it does not harm human or animal health or the environment.

The little corella infestation on Kangaroo Island has reached critical levels, with the birds causing widespread destruction and disruption to daily life. Despite a recent culling effort that resulted in the death of 2,640 little corellas, authorities acknowledge that it won't be enough to mitigate the problem.The birds, which are not native to the island, have been covering a local school in faeces, tearing up infrastructure, damaging crops, and causing mental distress to residents with their screeching. They have also been spotted using the nesting hollows of the endangered glossy-black cockatoo, smashing their eggs and killing their nestlings.Past attempts to control populations by shooting, scaring, trapping, or gassing them have failed, with the highly intelligent birds learning how to survive or just moving to cause havoc somewhere else. The Kangaroo Island Landscape Board's general manager, Will Durack, says that night-time shooting was more efficient, with the roosting birds easier to kill in large numbers, but it is not clear how much of a dent they made in the population.The little corellas have created a perfect environment for themselves on the island, with a predictable water supply from stock troughs and dams, and food from grain crops. Residents have expressed concerns about the physical and mental health impacts of the infestation, including the spread of diseases such as ornithosis and the disruption to daily life caused by the birds' loud shrieks.Coordination with other agencies and more resources are needed if the trial is to be expanded, according to the landscape board. A resident, Rodney Bell, has four grandchildren at the school and says: “They poo all over the yard, then the kids are playing in it.” He also mentions that “near the school, they would drive anyone insane from the sheer noise.”