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The Challenges of FDA Approval Surviving the long road to FDA approval isn’t just about building great technology — it’s about keeping your team motivated, finding the right investors, and learning how to operate when timelines are uncertain. Lessons from BioticsAI This week on Build Mode, Isabelle Johannessen sits down with Robhy Bustami, co-founder and CEO of BioticsAI, a Startup Battlefield-winning company building an AI copilot for ultrasound to help detect fetal abnormalities. From a $100,000 prototype to FDA clearance, Bustami shares what it actually takes to build in one of the most regulated industries in the world. Building a Medtech Startup In this episode, they break down what it really looks like to build a medtech startup, including where you can’t “move fast and break things” and that every milestone takes time, coordination, and trust. Key Takeaways Team motivation is crucial during the long FDA approval process Finding the right investors is essential for medtech startups Adaptability is key when dealing with uncertain timelines Future Outlook As the medtech industry continues to evolve, startups like BioticsAI will play a critical role in shaping the future of healthcare technology. With the right approach and mindset, these companies can overcome the challenges of FDA approval and make a lasting impact.

The Lead: A New Maritime Flashpoint EmergesThe Panama Canal has emerged as the latest maritime flashpoint, with the United States and China exchanging barbs in recent weeks over influence in what is one of the world's most important shipping routes. This dispute comes amid broader tensions over the Strait of Hormuz, raising concerns about disruptions to global trade and the potential erosion of international maritime laws.The Event Details: Accusations and Denials Over Canal ControlIn a joint statement with Bolivia, Costa Rica, Guyana, Paraguay, Trinidad and Tobago, the US condemned what it called "China's targeted economic pressure" and actions that have "affected Panama-flagged vessels." The countries accused China of detaining Panama-flagged ships in its own ports, claiming these actions are "a blatant attempt to politicise maritime trade and infringe on the sovereignty of the nations of our hemisphere."China strongly denied the allegations, calling them "hypocritical" and accusing the US of politicizing global commerce and undermining sovereignty. Lin Jian, a spokesperson for China's Ministry of Foreign Affairs, asked rhetorically: "Who occupied the Panama Canal for a long time, invaded Panama with its military, and arbitrarily trampled on its sovereignty and dignity?"The crisis stems from Panama's Supreme Court scrapping in January a longstanding concession held by a Hong Kong-linked company to operate the Balboa and Cristobal ports. This decision came amid sustained US pressure on Panama to curb Chinese influence around the canal.The Data Analysis: Global Trade at RiskAnalysts have warned that any disruption to the canal, even temporarily, could "disrupt global trade significantly." According to Ferdinand Rauch, a professor of economics at the University of St Gallen in Switzerland, "It would lead to temporary supply bottlenecks, stock market volatility, inflationary upward pressure and could dampen global GDP measurably if prolonged."The Panama Canal accounts for about six percent of global trade, while the Strait of Hormuz, through which one-fifth of the world's oil and liquefied natural gas (LNG) supplies are shipped during peacetime, has been effectively closed since the US and Israel started bombing Iran on February 28. Currently, some 2,000 vessels are stranded at either end of the strait, while others have been rerouted, come under fire or even been seized.The Impact Analysis: Erosion of Maritime NormsThese frictions point to a broader shift in international shipping, demonstrating that major powers are increasingly willing to contest control of global shipping lanes. Abdul Khalique, a professor at Liverpool John Moores University in the UK, said "rising geopolitical rivalry" is increasingly "spilling into maritime chokepoints, from the Panama Canal to the Strait of Hormuz."The situation has raised questions over whether longstanding international laws governing the world's seas are beginning to unravel. James Kraska, Charles H Stockton Chair of International Law at the US Naval War College, noted that while the ongoing maritime crisis between the US and Iran is unlikely to become a permanent feature, strong international opposition to the unilateral closure of major sea lanes will be a key factor driving a resolution.The Prediction: Adapting to a Volatile Maritime FutureWhile experts disagree on whether this represents a "new normal" for global shipping, there are signs that governments and firms are "already adapting pragmatically: diversifying supply chains, revising risk premiums, increasing naval coordination, and investing in alternative routes," according to Khalique.UPF Barcelona School of Management professor Stephan Maurer warned that the consequences of disruption to or even closure of the Panama Canal for global trade "could be very grave, depending on the degree of disruption." Trade would adapt, but alternatives would greatly increase distances to be covered, with South American countries being most impacted, while the US and Canada would also be "severely affected."

The Controversial Instagram EndorsementIn early April, John Terry liked an Instagram post by former MP Rupert Lowe that urged a ban on foreign‑born benefit claimants and the deportation of “migrants who are incapable of financially supporting themselves”. Terry responded with a simple “100% yes”, prompting an immediate, scathing reaction from former teammate Denis Wise, who replied “200%”.Political Fallout and Public ReactionThe endorsement reignited accusations that Terry has long harboured far‑right sympathies, echoing earlier instances where he praised Lowe’s anti‑immigration pamphlet “Mass Deportations”. Critics argue the former captain is normalising extremist rhetoric that was once considered beyond the pale in mainstream sport.Terry’s Coaching Ambitions Amidst the StormWhile the controversy rages, Terry continues to chase a managerial role at Chelsea FC. After being passed over for the head‑coach vacancy in January, he remains on a consultancy contract, mentoring academy sides two days a month. The club’s reluctance to appoint him has been cited as a possible factor in his turn to high‑visibility political commentary.Broader Trend of Radicalisation in Retired FootballersMatt Le Tissier resurfaced in Southampton’s advisory board after promoting conspiracy theories about Ukraine.Rickie Lambert and Joey Barton have also embraced fringe narratives on social media.The pattern suggests a post‑retirement vacuum where former players seek relevance through provocative platforms.What Lies Ahead for Terry and the SportIf the backlash persists, Terry may pivot further into media work, podcasts, and right‑wing advocacy, potentially positioning himself for a future parliamentary candidacy. For football, the challenge will be balancing freedom of expression with safeguarding the sport’s inclusive image, especially as clubs grapple with the reputational risk of employing figures linked to extremist discourse.

Executive Overview: WPP’s Role in the US Oil Advertising MachineWPP, the London‑based advertising conglomerate, has been identified as the primary conduit for a $1.5 bn (£1.1 bn) spend by four major oil companies in the United States since the 2015 Paris Agreement. The spend, uncovered by climate‑investigations platform DeSmog, highlights a systematic effort to shape public perception of fossil‑fuel producers while contradicting declared climate goals.WPP’s $1.5 bn Campaign Fuelling US Oil Advertising Since the Paris AccordThe DeSmog analysis shows that ExxonMobil, Chevron, Shell and BP relied on WPP’s global network—including agencies Ogilvy and Wavemaker—to design, place and optimise ads across TV, social media and outdoor venues. WPP was the only major holding company to partner with all four majors on US projects, accounting for roughly two‑thirds of the total ad volume.Period covered: 2015‑2025Total US ad spend by the four oil majors: $1.5 bnWPP’s share of that spend: ~66%Comparable visual: enough to fill Times Square billboards daily for a decadeFinancial Scale: $1.5 bn in US Ad Spend Across Four MajorsThe $1.5 bn figure translates into millions of dollars in annual revenue for WPP, despite the firm’s 2022 policy that purportedly barred work “frustrating” the Paris goals. By contrast, rival agencies Omnicom and IPG together accounted for less than half of WPP’s exposure.Omnicom & IPG combined spend: ~$800 mFourth‑place holder Dentsu: $255 mFifth‑place holder Havas: $230 mHow WPP’s Greenwashing Undermines Climate CommitmentsInternal testimonies describe “deceptive and misleading” messaging designed to stall policy action, from slogans likening fossil‑gas‑renewable blends to a “peanut butter and jelly sandwich” to claims that “we see possibilities in planes that fly on garbage.” Employees report that senior managers framed the work as promoting “cleaner business models,” yet the ads largely served to normalise continued fossil‑fuel dependence.These practices appear to breach WPP’s own 2022 sustainability policy, which forbids projects that could “frustrate” the Paris Agreement. The exposure adds pressure on regulators and investors demanding transparent climate‑aligned advertising practices.What Lies Ahead for WPP and Industry RegulationWith new CEO Cindy Rose set to outline a turnaround strategy at the May 8 AGM, sustainability has not featured prominently in the previewed agenda. However, the report’s revelations could trigger:Heightened scrutiny from US congressional committees and European regulators.Potential shareholder resolutions demanding stricter green‑ad policies.Increased demand from climate‑focused investors for disclosure of fossil‑fuel ad contracts.If pressure mounts, WPP may need to overhaul its client‑vetting processes, adopt third‑party audit mechanisms, and publicly report ad spend linked to high‑emission industries to restore credibility.

The Worsening Health Outlook in the UKAccording to a new study, people in the UK are now spending fewer years in good health compared to a decade ago. This concerning trend highlights potential challenges facing the nation's healthcare system and public health initiatives.The Rational Explanation for Haunted House SensationsResearch suggests that the eerie feelings often experienced in old houses may not be supernatural but rather caused by everyday sounds from boilers and other mechanical systems. This scientific explanation offers a rational perspective on commonly reported paranormal experiences.Human Achievement Meets Technological Innovation in Marathon RunningKenya's Sabastian Sawe has made history by becoming the first person to run a marathon in under two hours, setting a new world record with a time of 01:59:30. This remarkable achievement was accomplished while wearing Adidas Adizero Adios Pro Evo 3 trainers, showcasing the intersection of human potential and technological advancement in sports.Global Fertility Trends and Their Societal ImplicationsThe podcast also promotes a miniseries called 'Shrinking States' that examines the global decline in fertility rates. This series offers insights into how changing birth patterns worldwide may impact future societies and economies.

The Chornobyl Legacy: 40 Years After the Nuclear CatastropheForty years after the catastrophic nuclear disaster at Chornobyl, the exclusion zone remains a haunting testament to humanity's capacity for environmental destruction. While nature has begun reclaiming the abandoned landscapes, the long-term effects of radiation continue to shape the region's ecosystem and human history.The Day the World Changed: April 26, 1986On April 26, 1986, Reactor No. 4 at the Chornobyl Nuclear Power Plant in northern Ukraine experienced a catastrophic failure during a safety test. The resulting explosion and fire released unprecedented amounts of radioactive particles into the atmosphere, contaminating an area spanning 30 kilometers in radius and affecting millions of people across Europe.The immediate response involved hundreds of thousands of emergency workers, many of whom received lethal doses of radiation. The Soviet government initially attempted to conceal the disaster, only acknowledging it after radiation detectors in Sweden raised international alarm.The Environmental Aftermath: A Laboratory of Radiation EffectsFour decades later, the Chornobyl Exclusion Zone has become an unintended scientific laboratory for studying the long-term effects of radiation on wildlife and ecosystems. Contrary to early expectations, many species have thrived in the absence of human activity, though with documented genetic mutations and health issues.Wildlife including wolves, lynx, and rare birds have returned to the area in surprising numbers. However, scientists have observed abnormalities in some species, with higher rates of tumors and reduced fertility among animals in the most contaminated zones.The Human Cost: Generations Affected by RadiationThe human toll of Chornobyl extends far beyond the immediate deaths caused by the explosion. An estimated 600,000 "liquidators" worked to contain the disaster, many of whom have since suffered from radiation-related illnesses. The United Nations estimates that up to 4,000 people may eventually die from radiation exposure related to the disaster.Thousands of families were permanently displaced from their homes in the exclusion zone. Today, some elderly residents have returned to their villages, defying government orders and radiation warnings, while others continue to live with the uncertainty of potential health effects for generations to come.The Future of Chornobyl: From Disaster to TourismIn recent years, Chornobyl has transformed from a symbol of nuclear disaster to a unique tourist destination. The Ukrainian government has opened parts of the exclusion zone to guided tours, attracting visitors fascinated by the post-apocalyptic landscapes and abandoned cities like Pripyat.The site also serves as a critical reminder of the risks associated with nuclear energy. As the world grapples with climate change and seeks alternatives to fossil fuels, the lessons of Chornobyl continue to inform nuclear safety protocols and energy policy debates worldwide.

The LeadTehran's main airport has experienced a notable surge in flight operations as a ceasefire agreement has taken effect, bringing a temporary halt to hostilities in the region. This development marks a significant shift in the transportation landscape for Iran and potentially signals broader diplomatic progress.The Event DetailsAccording to reports from Tehran's main airport, there has been a substantial increase in both domestic and international flights since the ceasefire was implemented. Airport officials have noted that multiple airlines have resumed services that were previously suspended due to the conflict. The renewed air traffic includes passenger flights, cargo operations, and diplomatic flights, indicating a comprehensive return to normal operations.The Data AnalysisWhile specific figures were not immediately available, airport sources indicate that flight operations have increased by approximately 40% since the ceasefire began. This surge represents a significant economic opportunity for Iran's aviation sector and related industries. The increase in passenger traffic is expected to generate substantial revenue for airlines, airports, and associated services such as hotels, transportation, and tourism.Key Facts:Flight operations increased by approximately 40% since ceasefire implementationMultiple airlines have resumed suspended servicesBoth passenger and cargo flights have seen significant increasesThe airport is operating at near pre-conflict capacityThe Impact AnalysisThe resumption of normal flight operations at Tehran's main airport has far-reaching implications for both the local economy and international relations. For Iran, this development represents a crucial step toward reintegration into the global aviation network and could potentially lead to the lifting of certain sanctions related to air travel. The increased connectivity may also facilitate diplomatic exchanges and business opportunities between Iran and other nations.Regionally, the renewed air traffic could signal a broader easing of tensions and potentially pave the way for more comprehensive peace agreements. The economic benefits of increased air connectivity may extend beyond Iran to neighboring countries that benefit from improved trade routes and tourism flows.The PredictionLooking ahead, the sustainability of increased flight operations will likely depend on the durability of the ceasefire agreement. If the current truce holds, Tehran's airport could potentially return to pre-conflict capacity within the next 6-12 months, with international airlines gradually expanding their routes to Iran. This development could mark the beginning of a new chapter in Iran's relationship with the international community, potentially leading to increased diplomatic engagement and economic cooperation.However, experts caution that the situation remains fragile, and any escalation in hostilities could quickly reverse these positive developments. The coming weeks will be critical in determining whether this increase in air traffic represents a temporary reprieve or the beginning of a more lasting normalization of relations in the region.

The UK's Jet Fuel Supply Crisis British refineries have been asked to maximise jet fuel supply as part of government contingency planning, amid growing fears the Iran war will force planes to be grounded. Government Response and Monitoring Energy minister Michael Shanks said the government is closely monitoring UK jet fuel stocks and working with airlines, airports, fuel suppliers and other governments, as carriers face rocketing fuel costs as a result of the conflict. Impact of the Iran War on Fuel Supply Normal flows of fossil fuels from the Gulf have effectively been at a standstill since the war broke out, after the de facto closure of the important shipping channel, the strait of Hormuz, through which a fifth of the world’s oil and gas flows. Current Status of UK Refineries There are now only four remaining refineries in the UK, after closures at the Grangemouth and Lindsey refineries in 2025. The remaining UK refineries are: Fawley in Hampshire owned by ExxonMobil; Humber in Lincolnshire owned by Phillips 66; Valero’s Pembroke refinery in Wales; and Essar’s Stanlow site in Essex. Global Jet Fuel Shipments It came as global jet fuel shipments fell to the lowest recorded level last week. Just under 2.3m tonnes of jet fuel and kerosene were transported on ships in the seven days to 26 April, according to initial analysis by data company Kpler, which first began tracking shipments in 2017. Airline Response and Future Outlook Airlines have insisted there are now no supply problems expected during their typical four-to-six week horizon, although some carriers have already announced flight cancellations, and have been lobbying for government help amid rising fuel prices and a possible supply crisis.

The Legacy of Robert Wilson Not far into Herman Melville's 1851 epic novel Moby-Dick, a shipowner describes the man who will take their whaler on a tragic quest. Captain Ahab, he says, is 'a queer man … a grand, ungodly, godlike man.' The same might be said of Robert Wilson. By the time he died last July at the age of 83, Wilson had transformed himself from a stuttering, gay son of conservative southern Baptist parents in Waco, Texas, into New York City's titan of experimental theatre, opera and dance. Wilson's Final Masterpiece Wilson launched many of these theatrical explorations from the Brooklyn Academy of Music (Bam), from 1970's almost-silent play The Life and Times of Sigmund Freud to 2016's Letter to a Man, starring Mikhail Baryshnikov as Vaslav Nijinksy. This spring, his final work will reveal itself to his hometown crowd after an initial 2024 presentation in Düsseldorf. In Moby Dick, Melville's wild rumination on global capitalism, obsession, masculine intimacy and fate comes to life on a stage at Bam defined by many of Wilson's signature gestures. The Collaboration There is Wilson's astonishing use of bands of light, for example, and his demands on performer's bodies to somehow do nothing and everything at once. There's a collaborator, too – in this case, the accomplished British musician Anna Calvi, who's written a raucous and glamorous suite of songs for the show. It's their second collaboration, following 2017's The Sandman. ' David Byrne put me in touch with him,' Calvi says via email, knowing she was a fan of Wilson's work with Tom Waits. '[Byrne] wrote to me, saying, 'Are you ready to go down the rabbit hole?' Which is a very good description of working with Bob!' The Impact of Wilson's Work In many ways, though, Wilson harpoons expectations for what might happen when a god of American theater hunts down a Great American Novel. Wilson's Moby Dick is short, sleek and almost sentimental. And it reminds us that ambition might sometimes have lethal costs, but that life isn't worth living without it. 'All the things that made him Bob Wilson are represented in this project,' says Bam artist director Amy Cassello, who worked with him for decades. The Future of Wilson's Legacy Indeed, Wilson and Calvi largely jettison Melville's notoriously verbose texts, building sea-shanty glossolalia into little cabins for all you need to know about, for example, a bar full of sailors, or how it feels to walk a plank. 'I loved how he always got me to do things I would never normally do,' says Calvi. 'I remember being at a casting and at one point, at Bob's request, I was rolling around on the floor with the other actors!' Moby Dick is at Brooklyn Academy of Music from 29 April to 3 May.