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The Plant That Changed MedicineGoat's rue or French lilac, Galega officinalis, is a wild plant often grown in gardens for its clusters of attractive lilac or white flowers. For centuries, the plant was used to treat diabetes. Its key ingredient was later identified as galegine, which lowers blood glucose levels but has toxic side-effects.From Natural Remedy to Synthetic SolutionEventually, galegine led to the development of the synthetic drug metformin, now the classic treatment for diabetes by controlling blood sugar. Metformin has none of the toxic side effects of galegine and is now one of the most prescribed drugs in the world. For many years, however, metformin was vilified and banned in many countries because of its association with galegine.The Emergence of a Medical MultitaskerMetformin is now becoming something of a super drug for its anti-cancer effects, cardiovascular protection, delaying the onset of diabetes, and helping some people lose weight. It may even lower the risks for cognitive decline, dementia, strokes, slow aging and increase life expectancy.Understanding the MechanismExactly how metformin achieves all these remarkable wonders is not entirely understood, but it is not bad for a drug that originally came from an attractive wild plant. The scientific community continues to research the multiple pathways through which this simple compound derived from a garden plant can have such profound effects on human health.

A court in Islamabad handed down a death sentence to Umar Hayat, 23, for the murder of 17‑year‑old TikTok and Instagram influencer Sana Yousaf, a case that has revived nationwide discussions on women’s safety and honour‑based violence. Death Sentence Delivered in High‑Profile TikTok Murder The verdict, announced on May 19, 2026, was described by the victim’s father, Hassan Yousaf, as a “lesson for all such criminals in society.” Police arrested Hayat in Faisalabad within 20 hours of the June 2, 2025 killing. In a recorded statement, Hayat admitted a one‑sided obsession after online interactions, travelled to Islamabad on May 28‑29 to wish Yousaf a happy birthday, and later returned with a rented Toyota Fortuner and a 30‑bore pistol. Rising Toll of Honour‑Related Killings in Pakistan 2024: 346 women killed in the name of “honour”. 2023: 324 women killed under the same pretext. Increase of 6.8% year‑on‑year. These figures come from the Human Rights Commission of Pakistan (HRCP) and illustrate a growing pattern of gender‑based violence linked to cultural notions of honour. Broader Implications for Women’s Safety and Online Harassment Experts, including Nighat Dad, executive director of the Digital Rights Foundation, argue that Yousaf’s murder is part of a wider misogynistic culture where women’s online visibility is punished. The case highlights gaps in legal enforcement, societal attitudes that grant men entitlement over women’s bodies, and the role of social‑media platforms in amplifying risk. Looking Ahead: Legal and Social Responses to Gender‑Based Violence The death sentence may set a judicial precedent, but activists warn that without systemic reforms—stronger protective laws, education campaigns, and platform accountability—similar tragedies will persist. Observers anticipate increased pressure on Pakistani lawmakers to tighten honour‑killing statutes and on tech companies to improve safety tools for female creators.

The Cannon's RediscoverySixty years after Clint Eastwood used a cannon to fell a fleeing Eli Wallach in The Good, the Bad and the Ugly, the iconic weapon has been found in a museum in south-east Spain. The artillery piece, a 75mm cannon made in Manchester by Whitworth in 1873, was lent to Sergio Leone's production team by the Spanish military and was returned to the army museum in Madrid after filming.The Cannon's HistoryThe Sad Hill Cultural Association, a group of volunteers dedicated to restoring the graveyard near Burgos, northern Spain, built for the climax of the film, tracked down the cannon. They came across images of the cannon in a book on the film and set about trying to trace some of the weapons used in preparation for the 60th anniversary of the movie's release later this year.The Data AnalysisThe cannon was made in Manchester by Whitworth in 1873.The cannon is now on display at the military history museum in Cartagena, south-east Spain.The Impact AnalysisThe rediscovery of the cannon has generated significant interest, with the city council using its fame to draw more visitors to the museum. The museum's director, Lt Col Ernesto Terry, said the cannon's fame was already causing a stir, with many people ringing to ask about it.The PredictionWhile the Sad Hill Cultural Association would love to borrow the cannon and temporarily reinstall it in the Burgos landscape, where it last stood 60 years ago, its protected heritage status means that will not be in time for the anniversary. However, they plan to try to get hold of the piece and bring it to Burgos in the future.

The Lead United States President Donald Trump said he postponed a planned attack on Iran after requests from the leaders of Qatar, Saudi Arabia and the United Arab Emirates, adding that “serious negotiations are now taking place” behind the scenes. Iran's Stance on Negotiations Iranian President Masoud Pezeshkian defended Tehran’s participation in talks while rejecting suggestions that the country was backing down under pressure. “Dialogue does not mean surrender,” he said, adding that Iran had entered negotiations “with dignity, authority, and the preservation of the nation’s rights”. Escalating Tensions in the Region Meanwhile, there is no letup in Israeli attacks on Lebanon as the death toll crossed 3,000, with at least seven people reported killed on Monday, according to local reports, despite a US-brokered extension of the “ceasefire”. Iranian Military Actions The Islamic Revolutionary Guard Corps (IRGC) said its forces struck groups linked to the US and Israel in the western province of Kurdistan, near the border with Iraq. The IRGC said fibre-optic cables passing through the Strait of Hormuz could be brought under a system of permits as Tehran tightens control over the waterway. Mohsen Rezaei, a member of Iran’s Expediency Discernment Council, mocked Trump for setting and then cancelling a deadline for a military attack on Iran, saying Tehran would not surrender under pressure. Major-General Ali Abdollahi, commander of Iran’s Khatam al-Anbiya Central Headquarters, warned the US and its allies against making another “strategic mistake or miscalculation”. Diplomatic Efforts Pakistan has been playing a central role in indirect negotiations between Washington and Tehran, with Iran saying it delivered its response to the latest US proposal through Islamabad. Qatar’s Prime Minister Sheikh Mohammed bin Abdulrahman bin Jassim Al Thani has also expressed support for Pakistan’s mediation efforts aimed at resolving the crisis through diplomatic means. US Response and Reactions The US president touted a “very positive development” in talks with Iran, which convinced him to postpone a planned military attack. Treasury Secretary Scott Bessent said the US has extended its sanctions waiver for Russian oil cargoes already at sea by 30 days. Matt Duss, executive vice president at the Center for International Policy, said Trump’s insistence that Iran accept zero uranium enrichment had made a deal impossible. Regional Impact Israeli strikes have killed more than 3,000 people in Lebanon since March 2, the Ministry of Public Health said. Hezbollah’s drone attack on Israeli troops: The Lebanese group said it attacked Israeli soldiers with drones in the southern town of Rachaf in retaliation for deadly Israeli strikes on villages in the south. Iraqi forces carried out large-scale sweeps in western desert areas following unconfirmed reports of covert Israeli military sites in the region.

A Dark Revival of Shaffer’s Controversial ClassicThe Menier Chocolate Factory presents a stripped‑down, thrust‑stage version of Peter Shaffer’s Equus, directed by Lindsay Posner. The narrative follows Noah Valentine as the disturbed 17‑year‑old Alan Strang, whose obsession with horses culminates in the blinding of six stallions and a courtroom‑driven psychological showdown with psychiatrist Toby Stephens as Martin Dysart.The Physicalisation of Desire: Men as HorsesPosner abandons traditional mechanical horse heads, opting for six bare‑chested men whose bodies become the embodiment of the stallions. Paul Pyant’s lighting accentuates the muscular silhouettes, turning the ensemble into a living, breathing animal that mirrors Alan’s sexual reverence and inner turmoil.Six male performers serve as the equine presence.Movement direction by James Cousins creates a fluid, herd‑like choreography.Lighting design highlights the tension between humanity and animality.Critical Reception and Box‑Office OutlookEarly reviews praise Valentine’s “mature intensity” and the production’s “solid, satisfyingly plotted script.” While the show offers no “bad seat,” its most compelling moments arise during the visceral horse sequences, suggesting strong word‑of‑mouth potential. The run continues until 4 July, with ticket availability indicating steady demand.What This Means for Modern British TheatrePosner’s choice to foreground raw physicality over elaborate set pieces reflects a broader trend toward minimalist, actor‑driven storytelling in London’s fringe venues. By confronting themes of sexual obsession, authority, and the value of a life lived with “world‑burning devotion,” the revival re‑engages audiences with the moral ambiguities that made the original controversial.Future Prospects for Equus ProductionsIf the current run maintains its momentum, a West End transfer or international tour could follow, capitalising on the renewed interest in psychologically charged dramas. The production’s innovative staging may also inspire other directors to reinterpret classic works through embodied, non‑literal symbolism.

Pakistan is scrambling to keep diplomatic lines open between the United States and Iran as both sides intensify rhetoric and military posturing. Interior Minister Mohsin Naqvi arrived in Tehran for a two‑day visit, but recent U.S. threats and regional drone attacks highlight the limits of Islamabad’s mediation.Pakistan’s Diplomatic Push Amid Rising Iran‑US RhetoricNaqvi met President Masoud Pezeshkian, Interior Minister Eskandar Momeni and Parliament Speaker Mohammad Bagher Ghalibaf, who also serves as Iran’s chief negotiator with Washington. At the same time, Donald Trump warned Iran on Truth Social that “the clock is ticking.” The U.S. delegation, including Vice President JD Vance and Secretary of State Marco Rubio, convened in Washington, underscoring the high‑stakes environment.Numbers Behind the Negotiations: Proposals, Uranium and Missile ReadinessIran submitted a 14‑point counterproposal calling for a permanent cease‑fire within 30 days and the release of frozen assets.The U.S. plan demanded a 20‑year moratorium on uranium enrichment and the transfer of roughly 400 kg (882 lb) of 60% enriched uranium.Iran’s missile force is estimated at 70 % of pre‑war levels, with operational access to 30 of 33 sites along the Strait of Hormuz.Drone strikes hit the UAE’s Barakah nuclear plant perimeter and Saudi forces intercepted three drones launched from Iraq.Regional Stakes: How the Standoff Threatens the Strait of Hormuz and Global TradeThe Strait of Hormuz remains a critical chokepoint for worldwide oil shipments. Tehran’s preconditions include recognition of its sovereignty over the strait, while Washington seeks to keep a naval blockade as leverage in any future nuclear talks. Recent drone attacks and the restoration of Iranian missile sites raise the risk of a direct naval clash that could disrupt global energy markets.What’s Next? Scenarios for Pakistan’s Role and Potential EscalationAnalysts warn that if the U.S. and Iran shift to alternative channels (e.g., Oman or Qatar), Pakistan could become a peripheral conduit. Conversely, some experts argue Islamabad’s on‑the‑ground contacts remain indispensable for de‑escalation. The near‑term outlook hinges on whether both sides can agree on sequencing—first a cease‑fire, then nuclear negotiations—or whether military pressure escalates within the “next 48 to 72 hours,” as warned by regional security analysts.

The Breakthrough in Addiction Treatment Results from a new clinical trial published in JAMA Network Open this month show that a single dose of psilocybin could be an effective treatment for cocaine addiction. The study found that 19 participants who received psilocybin were more likely to abstain from cocaine than 17 participants who received a placebo of diphenhydramine, a common antihistamine. Participants in both groups worked with therapists to process their experiences, highlighting the importance of the therapeutic context alongside the medication. The Urgent Need for Cocaine Addiction Treatments Dr. Peter Hendricks, a behavioral health professor at the University of Alabama at Birmingham and lead author of the study, emphasized the critical need for effective treatments. Currently, there are no FDA-approved medications for addiction to cocaine or other stimulants like methamphetamine. Overdoses involving stimulants are killing more Americans, and according to the latest UN global drug report, cocaine deaths are rising globally as cocaine production reaches an all-time high. Understanding the Mechanism Experts believe psilocybin works by increasing neuroplasticity and psychological plasticity – the ability to change thinking and behavior. Addictions inherently involve resistance to changing rigid, impulsive behaviors, which psychedelics may help overcome. Unlike traditional addiction medications that target the same neurochemical systems as the substance itself, psilocybin produces a profound altered state of consciousness within a structured psychotherapy context. It acts more like a catalyst within a therapeutic process rather than a maintenance medication. Addressing Cocaine Withdrawal Symptoms Cocaine withdrawal symptoms are primarily psychological rather than physically painful, including bad dreams, agitation, depression, and cravings. This psychological nature may make psilocybin particularly effective for cocaine addiction, as it can facilitate shifts in perspective and self-compassion that help people change their behavior. The therapeutic framework allows individuals to process their experiences and develop new insights about their addiction patterns, potentially breaking the cycle of craving and use. Diverse Clinical Trial Participation This study is notable as the first psychedelic clinical trial to include a majority of Black participants. While many spiritual rituals involving psychedelics originated in Indigenous societies in Latin America and Africa, US psychedelic culture today is often associated with Silicon Valley and elite, white personalities. Dr. Hendricks specifically recruited participants who were dependent on cocaine and wanted to stop, rather than advertising for psychedelic enthusiasts. This approach likely reduced the "expectation effect" and produced more generalizable results. Future Research Directions A critical commentary published alongside the study noted that the results might not be generally applicable because the study excluded people with comorbid depression and anxiety. However, experts point out that psilocybin shows promise for treating both conditions. The success of this trial is a clear indication that psilocybin for cocaine use disorder is a promising treatment that should proceed to larger-scale clinical trials. As research continues, the medical community may gain more insight into how psychedelics can be integrated into addiction treatment protocols.

The Rediscovery of a Forgotten VisionaryGordon Stevenson, a multifaceted artist who made significant contributions to New York's late-70s no wave scene, is about to experience a posthumous renaissance. Four decades after his death, Stevenson has been largely remembered as merely a footnote in other people's stories. However, this is about to change dramatically with the discovery of a storage unit filled with his lost work, including jewelry, collaborations with mail-art pioneer Ray Johnson, and even clues to the whereabouts of a surviving print of his notorious film, Ecstatic Stigmatic.The Early Life and InfluencesStevenson's story begins not in the gritty streets of New York, but 900 miles south in the small town of Dublin, Georgia. Born into a family of "emotionally repressed stoics," he was a maths prodigy with a taste for Flannery O'Connor, Nietzsche, and Sartre. His intellectual pursuits and unconventional lifestyle created a rift with his parents, who expected him to follow a more traditional path. Offered a maths scholarship at Georgia Tech, Stevenson instead chose the liberal arts campus of Eckerd College in St. Petersburg, Florida, further widening the divide with his family.The New York YearsIn 1977, Stevenson and his partner Mirielle Cervenka relocated to New York, a city that photographer Julia Gorton described as "a nihilistic playground for people with trauma." The city was "very destroyed by the drugs and violence," according to Maripol, a European émigré designer and filmmaker who later worked with Grace Jones and Madonna. "But there was freedom. That the city was bankrupt meant low rents. Creative people could afford to live there," Maripol recalls.The Artistic LegacyStevenson's artistic contributions were multifaceted. He and Cervenka founded the jewelry brand LHOOQ, which "repositioned the jewellery for the punk market" by upcycling vintage trinkets. His "memento mori" series focused on crosses and skulls, anticipating gothic fashion and showcasing a macabre sensibility. In music, he joined Lydia Lunch's Teenage Jesus and the Jerks, a band that was, according to Gorton, "really intense, abrasive, not friendly – just a perfect band." Jim Sclavunos, who later drummed for Sonic Youth and Nick Cave and the Bad Seeds, remembers Stevenson as "a very striking presence, depraved in the right ways." His most ambitious work was the film Ecstatic Stigmatic, a $5,000 production inspired by Catholic mysticism and the Jonestown massacre, which Sclavunos found "surprised by how good it was. A lot of no wave cinema looked juvenile. But Ecstatic Stigmatic was very shadowy, sleazy and sexual."The Impact on Contemporary CultureThe rediscovery of Stevenson's work comes at a time when there is renewed interest in the no wave movement and its influence on contemporary art and music. His story offers insight into the creative ferment of late-70s New York, a time when the city's financial struggles paradoxically created space for artistic experimentation. The letters Stevenson wrote to his parents, which his family has recovered, provide a personal window into this period, chronicling life in the downtown demimonde and his experiences as one of New York's first Aids patients. As his sister Barbara Stevenson notes, "Gordon always belonged in New York," and with this rediscovery, his rightful place in the city's artistic pantheon is finally being secured.

The Personal Connection to Stardust For Claire Danes and her family, Stardust has transcended its status as a simple film to become something of a cure-all. In a personal essay, Danes reveals how the movie has treated everything from bad days at work to an overdose of adult cynicism. Our Sunday nights followed a certain ritual, she recalls, with her and her two siblings sitting on the sofa, ignoring that school was on the next day, and watching their battered DVD copy of Stardust. The Film's Magic: Unashamedly Cheesy Stardust, adapted from a Neil Gaiman novel, works as a feelgood movie precisely because it's so unashamedly cheesy. The film tells the story of Tristan Thorn (Charlie Cox), a young man living in a quaintly twee version of England who sets out on a quest to retrieve a fallen star. Things take an unexpected turn when the star turns out to be Yvaine (Claire Danes), a person being hunted by three witches who want to eat her heart. The resulting adventure is big, romantic, and complete with a sweeping soundtrack as the pair travels across the mythical continent of Stormhold, eventually falling in love. Despite not making significant waves upon its 2007 release, the film found a special place in Danes's unapologetically nerdy household, where magic was the air they breathed. The Cultural Impact: A Modern Fantasy Classic Spiritually, Stardust feels like a successor to the 1987 classic The Princess Bride, though with Claire Danes's character given slightly more to do than Buttercup. The film's appeal extends beyond its fantasy elements—Danes highlights Michelle Pfeiffer's enthusiastic scenery-chewing as the lead witch Lamia, which goes beyond terrifying into pure camp. The entire film is an exercise in camp, featuring excessive world-building, magical inns, human stars, pirates harvesting lightning on sky ships, and sly jokes hinting at even more backstory. The cast reads like a who's who of big names: Claire Danes, Rupert Everett, Mark Strong, Michelle Pfeiffer, Sienna Miller, Ian McKellen, Robert De Niro as a tutu-wearing pirate, and a young Henry Cavill. The Lasting Appeal: Flaws and All Does Stardust stand up to a rewatch? Some elements have aged badly, Danes admits. The modern feminist perspective might balk at Tristan having to save Yvaine in the final act, or at Lamia being evil because she's terrified of aging. The entire film is also fearsomely naff—something that definitely didn't come from Gaiman's book. Yet that's part of its charm. When Danes revisited Gaiman's novel after university, she found it lacking the whimsy and breathless adventure that made the film such a delight. Where Gaiman's prose comes across as dry and detached, Stardust the movie is openhearted and warm—a story where good guys win and baddies get what's coming to them. The Comfort in Fantasy: An Antidote to Stress In a world that feels increasingly fractious and scary, Stardust offers comfort. Like a warm bath, it's an antidote to all things stressful. Danes concludes that the film's ability to provide this escape is what makes it special, transcending its flaws to become a beloved family tradition that continues to bring joy. Stardust is available on Peacock and Hoopla in the US, to rent digitally in the UK and on 10 in Australia