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President Donald Trump told allies that Tehran does not need to negotiate a settlement for the hostilities to cease, estimating the conflict could be over in two to three weeks. Iranian Foreign Minister Abbas Araghchi, however, dismissed any hope of talks, stating that Tehran has zero trust in Washington.US‑Israeli air raids persist across Iran, hitting key industrial and civilian targets such as steel factories in Isfahan and Farokhshahr, pharmaceutical facilities, port infrastructure, meteorological stations and a residential complex. Iranian state media and the Red Crescent reported explosions in cities including Ahvaz, Shiraz, Isfahan, Karaj, Kermanshah and Bandar Abbas.An Iranian official said the Tofigh Daru pharmaceutical raw‑material plant in Tehran was struck, crippling its research and development wing and delivering a "blow to the national medical supply chain." In Bandar Abbas, the Shahid Haqqani passenger pier was bombed, though officials claimed no casualties.A desalination plant on Qeshm Island, crucial for water supply in the Strait of Hormuz, was knocked out of service by the strikes.Analyst Trita Parsi warned that the war is unlikely to end swiftly and that the Strait of Hormuz will remain closed, noting that it will not be easy for President Trump to simply walk away from the conflict.Casualties have surpassed 2,000 Iranians, with numerous civilian sites—including hospitals, schools, universities and pharmaceutical factories—targeted, raising concerns of potential war‑crime violations.On the diplomatic front, Spain, France and Italy have begun curbing U.S. military operations by closing airspace, denying base access and limiting logistical support. Meanwhile, China and Pakistan have tabled a five‑point cease‑fire proposal that calls for reopening the Strait of Hormuz.Regional leaders are also active: Qatar’s Emir Sheikh Tamim bin Hamad Al Thani and UAE President Sheikh Mohamed bin Zayed Al Nahyan have convened to discuss the Iran war, while Argentina, under President Javier Milei, officially labeled Iran’s Islamic Revolutionary Guard Corps as a “terrorist” organization.Pope Francis (Leo XIV) appealed directly to President Trump, urging an end to the violence and expressing hope that the U.S. leader is moving toward a resolution.In the Gulf, Iranian drones have repeatedly struck Kuwait’s airport, forcing the closure of its airspace since late February; Saudi Arabia has stepped in to provide transport for affected passengers. Bahrain sounded air‑raid sirens, and Saudi forces reported intercepting two additional drones.A merchant vessel north of Doha suffered damage from an "unknown projectile," though the crew remained unharmed and no environmental harm was recorded.U.S. officials remain divided: while Trump predicts a rapid end, Defense Secretary Pete Hegseth warned that the United States is "negotiating with bombs" and that the coming days are decisive. The war’s uncertainty has pushed oil prices higher, prompting U.S. Senator Chris Coons to warn that American families face rising grocery, utility and mortgage costs.Israel continues to face coordinated attacks from Iran and Hezbollah, with missile and drone incursions reported across northern and central regions. Despite these threats, Prime Minister Benjamin Netanyahu asserted that Iran’s regional allies no longer pose an "existential threat," yet Israel plans to maintain its offensive, including operations in Lebanon.In Lebanon, Israeli ground advances and heavy bombardments have resulted in over 1,200 deaths and displaced roughly 1.2 million people since early March. Iraqi militia Kata’ib Sayyid al‑Shuhada warned that any U.S. ground incursion into Iran via Kuwait could trigger an all‑out war.

Israeli and U.S. forces launched a series of air strikes on Tuesday that struck Tofigh Daru Research and Engineering Company, one of Tehran’s largest producers of anaesthetics and anti‑cancer medicines. The state‑run firm, owned by the Social Security Investment Company, saw its drug‑production line damaged, according to an official post on X. In the north‑western city of Zanjan, a separate strike hit the Husseiniya Azam, a Shia congregation hall adjacent to a mosque. Iranian Red Crescent teams rescued two people from the rubble; one of the victims died and several others were injured. Further attacks were reported in the western province of Kermanshah, where a civilian contracting company in Qasr‑e Shirin – a border town with Iraq – was hit. One person was killed and eight injured, the Mehr news agency said. Heavy bombing was also confirmed in Isfahan, a strategic hub for Iran’s defence industry and home to key nuclear facilities such as Natanz. Local officials indicated that the strikes may have targeted “military sites,” though the exact locations and damage assessments remain unclear. Iranian officials condemned the operations. Former foreign minister Javad Zarif denounced the targeting of the pharmaceutical plant as a deliberate attack on a medical facility, calling the aggressors “desperate” and accusing them of “diabolical delusions.” Governor‑level security official Akbar Salehi echoed these concerns, noting that the strikes appeared aimed at military installations without specifying which ones. The broader conflict has already claimed 1,937 Iranian lives since the joint U.S.–Israeli campaign began on 28 February, while 20 Israelis have been killed. Recent Israeli interceptions using the Iron Dome and David’s Sling systems have limited damage on Israeli soil, but impact sites were reported in Tel Aviv, Bnei Brak and Petah Tikva. Amid the escalating violence, diplomatic channels remain active. U.S. Secretary of State Marco Rubio told Al Jazeera that communications between Washington and Tehran continue, primarily through intermediaries, and that the U.S. aims to achieve its war objectives “in weeks, not months.” Pentagon chief Pete Hegseth added that negotiations to end the conflict are “very real, ongoing and gaining strength.” Iran’s Islamic Revolutionary Guard Corps (IRGC) claimed a retaliatory strike, saying it hit an Israeli container ship in the Gulf with a ballistic missile and that Iranian drones targeted a group of U.S. Marines near a UAE military base. Public sentiment in Iran has turned sharply hostile, with pro‑state demonstrations erupting in Tehran as citizens protest the continued air raids. The atmosphere, described by Al Jazeera’s Tohid Asadi as a “cloud of mistrust,” reflects growing frustration over diplomatic dead‑ends and the relentless cycle of attacks.