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The Earliest Known Dental TreatmentNeanderthals used stone drills to treat cavities almost 60,000 years ago in what is the earliest known evidence of dental treatment. This groundbreaking discovery challenges previous assumptions about Neanderthal capabilities and reveals their sophisticated approach to medical care.The Discovery in SiberiaThe single molar, unearthed in a cave in southern Siberia's Chagyrskaya site, features a deep hole that appears to have been created using a sharp, thin stone tool during the lifetime of the tooth's owner. The tooth, dated to be 59,000 years old, was found alongside the remains of Neanderthals and thousands of stone tools that have been excavated at the site.Scientific Evidence of Ancient DentistryThe lower molar features a deep hole in the centre of the tooth extending into the pulp cavity. Microscopic X-ray imaging revealed changes in mineralization that indicated severe tooth decay. Researchers conducted experiments on three modern human teeth to demonstrate that a hole of the same shape and patterns of microscopic grooves could be created by manually rotating a narrow, elongated tool made from local jasper between two fingers. Penetrating the dentin using this approach took between 35 and 50 minutes of continuous work.Expert Analysis of the ProcedureDr. Kseniya Kolobova, an archaeologist at the Siberian branch of the Russian Academy of Sciences, noted that this discovery "powerfully reinforces the now well-supported view that Neanderthals were not the brutish, inferior cousins of outdated stereotypes but a sophisticated human population with complex cognitive and cultural capacities."A dental professor who reviewed images of the tooth rated the Neanderthal's work as "a decent job." Justin Durham, a professor of orofacial pain at Newcastle University and the British Dental Association's chief scientific adviser, stated: "If I was marking this for a dental student, I wouldn't give it an A, but given the circumstances it's pretty impressive."Implications for Understanding Neanderthal CapabilitiesThis discovery represents the first time dental drilling has been demonstrated outside of Homo sapiens, and it is the oldest example of such behavior by more than 40,000 years. The smoothed edges of the drilled cavity and wear patterns inside it suggest the individual survived and continued to chew with the tooth for some time after the procedure.Dr. Lydia Zotkina, an archaeologist at the Russian Academy of Sciences and co-author, emphasized the remarkable strength of will required: "What struck me, and continues to strike me, is what an incredibly strong-willed person this Neanderthal must have been. They must have surely understood that although the pain of the procedure was greater than the pain of the inflammation, it was only temporary and had to be endured."This finding adds to previous evidence of Neanderthals caring for the sick and vulnerable group members, including an adult man with a withered arm and deformities in both legs, and a child with Down's syndrome who survived until at least the age of six. The latest discovery reveals not only compassion, but an impressive level of self-control by the patient and advanced technical skills by the practitioner.

Lead: A Coordinated Drone Wave Rocks Multiple Ukrainian CitiesAt least six people were killed and dozens injured as a "one of the longest, massive Russian attacks" swept through Ukraine on Wednesday morning, according to President Volodymyr Zelenskyy. The barrage hit Kyiv, Lviv, Odesa and several other locations, challenging recent statements that the war may be winding down.Massive Multi-Region Drone Assault Across UkraineZelenskyy described the attack as lasting for hours, employing both cruise and ballistic missiles alongside swarms of drones. Key incidents included:Kyiv: air defenses strained by sustained strikes.Lviv (near the Polish border): civilian areas targeted.Odesa (Black Sea port): strategic maritime hub hit.Kherson region (Bilozerka): a woman killed when a drone struck a bus.Rivne region: three killed, four injured.Kharkiv region (near Zolochiv): a 60‑year‑old man killed, homes damaged.Zaporizhia region: a 76‑year‑old man killed at an agricultural enterprise.Casualties and Material Damage Across Six RegionsThe confirmed human toll stands at six dead and "dozens" wounded, with additional civilian infrastructure harmed:Two homes and a civilian car damaged in Russia’s Bryansk region after Ukrainian drones.Four injured in Belgorod’s village of Bessonovka.Russian Ministry of Defence reported destroying 286 Ukrainian drones overnight across multiple border regions.Strategic Implications Amid Claims of War’s EndThe offensive coincided with remarks from U.S. President Donald Trump and Russian President Vladimir Putin suggesting the four‑year conflict could be nearing a resolution. Zelenskyy warned that Russia aims to "overload air defences," hinting at a possible escalation with cruise and ballistic missile strikes following the drone wave. The juxtaposition of diplomatic optimism and on‑ground violence highlights the fragility of any cease‑fire prospects.What the Next Weeks May Hold for Ukrainian Defense and Diplomatic EffortsAnalysts anticipate that Ukraine will reinforce its air‑defence network, especially around major urban centers, while seeking accelerated diplomatic engagement from Western allies. Continued drone activity on both sides suggests that any negotiated settlement will need to address the persistent threat of unmanned aerial attacks and the capacity of Russian forces to launch prolonged barrages.

The Legacy of a Scientific Pioneer My husband Peer Bork, who has died unexpectedly aged 62, was a bioinformatician with a remarkable ability to identify new directions in science and carry out world-class research to push them forward. Revolutionizing Microbiome Research During his career, he progressed from the statistical analysis of the sequences of individual protein molecules, via the analysis of the human genome, to the bioinformatics analysis of whole microbial communities. Peer pioneered the computational analysis of the human microbiome, introducing the concept of gut enterotypes – in work that was highlighted in many newspaper articles as well as on the radio and TV. He went on to study microbial ecosystems worldwide and, at the time of his death, was involved in expanding a consortium that he had initiated to systematically document coastal ecosystems in Europe. All these studies required the creation of bioinformatics tools – software and curated datasets – which are now widely used by the scientific community in academia and industry. A Life in Science Peer was born in the former East Berlin, where his father, Joachim, worked in economic statistics, and his mother, Regina, had an administrative job in the construction industry. Owing to his mathematical abilities, he won a place at a high school specialising in mathematics and science, the Heinrich-Hertz-Oberschule. After military service on the border between East and West Germany, he studied biochemistry at the University of Leipzig. He followed this with a PhD in bioinformatics under the supervision of Jens Reich at the Central Institute for Molecular Biology of the Academy of Sciences of the GDR in Berlin. International Scientific Career After the fall of the Berlin Wall in 1989, Peer joined the European Molecular Biology Laboratory (EMBL) in Heidelberg in 1991 as a visiting scientist. He and I met there and married in Canterbury, Kent, in 1994. We had two sons, Udo and Robin, and family life involved many trips between Germany and Britain. EMBL became Peer's scientific home and he rose up the ranks to become interim director general in 2025. He was dedicated to furthering EMBL – an intergovernmental research organisation with six sites, including the European Bioinformatics Institute near Cambridge. He was an outstanding mentor. Awards and Recognition He made science both challenging and fun. Among his awards, which included honorary doctorates and the 2009 Royal Society and Académie des Sciences Microsoft award, he was particularly proud of the Nature award for mentoring in science he received in 2008. Final Scientific Journey He died in Taiwan, where he was due to speak at an international conference on the microbiome. He loved to travel and make friends all over the world. Peer is survived by me, his sons, by a granddaughter and his mother.

As more than 10 million visitors are expected for the 2026 FIFA World Cup, residents in host cities from Seattle to Atlanta are warning that the influx is aggravating an already strained affordable‑housing market. Short‑term rental boom and city‑level pushback Airbnb is offering a $750 sign‑up bonus to homeowners, and short‑term listings have jumped as much as 30% in recent weeks. While hotels remain under‑booked, some Airbnb nights are listed for up to $6,000. Local coalitions such as Tenants Not Tourists and the national Dignity 2026 alliance are mobilising to keep rentals affordable and to stop evictions. Rental‑price data and short‑term listing economics Short‑term rental listings up 30% in several host cities. Airbnb’s bonus program: $750 per new host. High‑end listings reaching $6,000 per night. NYC analysis links roughly 9% of the citywide rent increase to Airbnb activity. Only 4 of 16 North American host cities have published human‑rights housing plans. Community impact: rent hikes, evictions and jail threats Advocates say the rental surge could push landlords to terminate leases, especially in markets without short‑term rental caps like Atlanta. In New York, the city council rejected a bill to lift short‑term rental restrictions, citing the risk of turning homes into hotels. In Kansas City, a $22 million temporary jail is being built, raising fears that unhoused residents will be detained during the tournament. Looking ahead: policy battles and possible safeguards Organisers are urging FIFA to finalize human‑rights housing plans, while city activists are proposing taxes on short‑term rentals and ballot measures to protect tenants. In Atlanta, the Play Fair ATL coalition is documenting evictions and encampment sweeps to build evidence for future advocacy. The outcome of these efforts will shape whether the World Cup becomes a catalyst for housing reform or a catalyst for further displacement.

The Senate StandoffMore than a dozen gunshots rang out at the Philippine Senate as police and marines moved in to arrest a senator wanted by the International Criminal Court for alleged crimes against humanity. Journalists ran for cover as gunfire erupted on Wednesday evening minutes after soldiers with rifles and protective gear went up the stairs of the legislative building. It was not immediately clear who fired the shots during the tense confrontation.Arrest Warrant and Senator's DefiancePhilippine Senator Ronald dela Rosa had earlier anticipated his arrest, urging people to come to the legislature to prevent him from being detained and sent to the ICC. "I am appealing to you. I hope you can help me. Do not allow another Filipino to be brought to The Hague," dela Rosa said in a video posted on Facebook. Philippine law enforcement agents had been gathering outside the Senate building after dela Rosa's message.The ICC Charges and Drug War LegacyThe ICC unsealed an arrest warrant on Monday for dela Rosa, dated November, on suspicion of crimes against humanity, the same crimes 81-year-old Duterte is accused of as he awaits trial in The Hague. Dela Rosa, better known as "Bato", meaning "rock", has been under the protective custody of the Senate since law enforcement agents entered the building on Monday. He has denied involvement in illegal killings, stating "I did everything for the country. I did not enrich myself. I worked faithfully."Political Implications for the Marcos AdministrationFormer police chief dela Rosa, who was the top enforcer of ex-President Rodrigo Duterte's so-called "war on drugs", urged President Ferdinand Marcos Jr on Tuesday not to hand him over to the ICC, adding that he was ready to face justice at home. "Mr President, [you] may one day face a situation like this. You may also encounter problems, and then you will understand, you will feel what I am feeling right now," dela Rosa told reporters, his eyes welling with tears. The incident places the current administration in a difficult position balancing international legal obligations with domestic political considerations.Future Legal ProceedingsDela Rosa was Duterte's top lieutenant and oversaw a fierce crackdown during which police say more than 6,000 suspected drug dealers were killed in official operations. Thousands of drug users were also shot in slumland murders blamed on vigilantes or turf wars. Police say those killed during operations had resisted arrest and reject allegations of systematic murders and cover-ups. As the ICC case progresses, the Philippines faces continued scrutiny over human rights issues and the legacy of the drug war that defined Duterte's presidency and continues to influence the nation's political landscape.

The Daring Debut of Angel's Bone English National Opera takes a bold leap with Du Yun's Angel's Bone, a Pulitzer Prize-winning opera that tackles human trafficking head-on. This inaugural production at ENO's northern base, a collaboration with Factory International and the BBC Philharmonic Orchestra, features Kip Williams' innovative direction. The Unsettling Allegory The opera tells the story of two angels who fall into the clutches of a dysfunctional couple, leading to a descent into physical and sexual abuse. Du Yun's score is a genre-bending mix of contemporary classical and nightclub electronica, performed by a tireless ensemble of 10. The Data Analysis: A Complex Soundtrack The music operates at extremes, with key roles assigned to tuba and lute. The instrumental palette offers textural beauty, but also joyously kicks ass. The score is expertly conducted by Baldur Brönnimann. The Impact Analysis: A Powerful Statement The production is a powerful statement against human trafficking, with a clear and admirably clear storyline. However, the endlessly rotating walls can be problematic, forming an impenetrable barrier that obscures the screens at times. The Prediction: A Must-See Performance Despite some technical issues, the production is a must-see, with standout performances from Allison Cook as Mrs X E and Rodney Earl Clarke as her browbeaten husband. The production transfers to London later in the year, rejigged for the Coliseum's proscenium stage, and is one to catch.

The Regulatory Response to Deadly Online ContentA nihilistic internet suicide forum implicated in over 160 UK deaths has been fined £950,000 by the online regulator in its latest attempt to shut it down. Ofcom said the US-based website remains accessible in the UK despite over a year of warnings. Online safety campaigners have accused the regulator of taking an "interminable" amount of time to act.The Samaritans, mental health campaigners and the Molly Rose Foundation, have repeatedly raised concerns about the site – which promoted a particular poison – which has remained accessible despite it being cited in multiple coroners' reports regarding the deaths of UK citizens.Molly Rose was set up in the memory of Molly Russell, a 14-year-old who took her own life after descending into a vortex of negative online content, including about suicide. Its chief executive, Andy Burrows, welcomed the fine and a separate move that could block UK internet access to the site, but said it was "appalling that it has been left to bereaved families and campaign groups to press Ofcom into action".Legal Action Under the Online Safety ActOfcom has been trying to get the site to obey British laws criminalising intentionally encouraging or assisting suicide since last spring. It had some success with the site being blocked last July and then a mirror site being taken down in November. But it is now taking action because the site can be "used by people in the UK, including without a VPN, and presents a material risk of significant harm".The fine is being levied under the Online Safety Act which also allows Ofcom to seek a court for an order requiring internet service providers to block UK access to the site. It is preparing an application to have its connections effectively cut "if our concerns are not fully addressed and there continues to be an ongoing breach".It accused the provider of "serious and deliberate contraventions" and said the fine reflected the "the risk of fatal harm to people in the UK posed by the content present on the service".Human Cost and Family AdvocacyOn Wednesday, the forum was unavailable but its operator posted a page that said it was advocating for "the right to access lawful information without government overreach" and quoted Mark Twain: "Censorship is telling a man he can't have a steak just because a baby can't chew it."The Molly Rose Foundation and Together with Families and Survivors to Prevent Online Suicide Harms said coroners had warned the UK government 65 times about risks of further deaths from the forum "and a substance it promotes, glorifies and instructs for use as a suicide method". Adele Zeynap Walton, the sister of Aimee Walton who took her life after accessing suicide forums, said the wait for action had been agonising."While we've waited further lives have been lost and we've had to fight every step," she said, speaking on behalf of Families and Survivors to Prevent Online Suicide Harms. "We feel let down by the process and Ofcom's slow response to this threat to life."Regulatory Challenges and Future ActionsBurrows said: "Molly Rose Foundation submitted detailed evidence which showed scores of vulnerable young people remained at risk while Ofcom's investigation dragged on … There are real questions about why it has taken so long for the regulator to act against a forum linked to at least 164 UK deaths."Ofcom said it has "engaged extensively" with the forum provider and that last summer the forum geoblocked mirror sites in the UK and later removed information on a landing page promoting ways to circumvent the block."We share the urgency about the extreme harms that sites such as this can cause, and understand the anger felt towards them by those who have been so personally affected," a spokesperson said. "It is vital that we ensure our enforcement action is thorough, and this can take time, as is the case for any enforcement agency."Preventive Measures and Support Resources"Lucas was 16. Vlad 17. Aimee 21. Grace, Hannah and Tom 22. Immy 25. Adam 28 and Claire 41," the campaign groups said in a report last year. "They were drawn into a dark world that was allowed to exist online and continues to exist through the use of a VPN. We believe our loved ones suffered coercion, grooming, instruction on how to end their lives. Most accessed a poison that was allowed to cross borders or was readily available domestically."Suzanne Cater, director of enforcement at Ofcom, said the forum had "caused unimaginable pain and suffering … and no punishment can undo that harm"."The provider of this forum knows it's used to share illegal content encouraging and assisting suicide on their site," she said. "While they've responded to our enforcement action by making some changes to the accessibility of their service in the UK, this is not good enough and the changes they've made were not consistently applied or effective to reduce the risk of harm. Given the ongoing risk of harm, we are using all powers available to us to protect the public."

The UN's Call for Accountability in Civilian DeathsThe United Nations human rights chief has demanded independent investigations into reports that separate air attacks by the Nigerian and Chadian forces in northern Nigeria killed more than 100 civilians. Nigeria's military has been battling "bandits" in the northwest and an armed rebellion in the northeast for 17 years, while Chadian forces have been targeting Boko Haram camps in the Lake Chad region.Market Massacre and Fishermen DeathsThe Nigerian military and the "bandit" gangs killed at least 100 civilians on Sunday in one of the bloodiest days in the state's conflict against armed groups, according to Amnesty International. Citing witnesses, Amnesty said many of those killed were women and children, and urged authorities to immediately investigate the attack on a crowded market in Tumfa village.Meanwhile, the bombardment by Chadian jets against Boko Haram camps on remote islands in the vast marshland shared by Nigeria, Cameroon, Niger and Chad has reportedly killed dozens of Nigerian fishermen working on islands under Boko Haram control. Footage verified by the AFP news agency showed several fishermen with severe burns being treated at a hospital in Bosso, Niger.Mounting Casualty FiguresAmnesty International confirmed that at least 100 civilians were killed in the Nigerian military airstrikes on a market in Zamfara state on May 10, with many more injured. The Chadian attacks since Friday have also resulted in significant civilian casualties among fishermen who were forced to pay taxes to the armed group controlling the islands.Regional Security ImplicationsThe incidents highlight the complex security challenges in West Africa's Sahel region, where military operations against terrorist groups like Boko Haram and the Islamic State West Africa Province (ISWAP) increasingly threaten civilian populations. The Lake Chad region has been particularly volatile, with cross-border military operations creating humanitarian concerns as civilians become caught between armed groups and national militaries.Future Investigations and Potential RepercussionsAs international pressure mounts for investigations, the Nigerian military maintains there is no evidence of civilian casualties, claiming their strikes targeted confirmed high-level gatherings of terrorists. The UN's demand for independent probes could lead to increased scrutiny of military operations in the region and potentially affect international support for counter-terrorism efforts in West Africa.

The humanitarian crisis in Haiti's capital has escalated dramatically, with residents of the Cite Soleil neighborhood taking to the streets to demand immediate government protection after a weekend surge in gang violence forced hundreds to flee their homes. The Collapse of Security in Cite Soleil Protesters reported witnessing people being killed in Cite Soleil in recent days, yet Haitian authorities have remained silent regarding casualty figures. This violence is part of a broader trend where armed gangs have tightened their grip on the capital since the assassination of President Jovenel Moise in July 2021. Police reports indicate these groups now control approximately 70 percent of the capital. Displacement Statistics and Gang Dominance The displacement crisis has reached critical levels. A report by the International Organization for Migration estimates that more than 1.4 million people have been uprooted by gang warfare. Of these, about 200,000 are currently living in overcrowded and underfunded sites within the capital, highlighting the severe strain on urban infrastructure. The Humanitarian Toll on Healthcare Medical services are facing an existential threat. In a statement released on Monday, Doctors Without Borders (Medecins Sans Frontieres) announced the evacuation of its hospital in Cite Soleil following intense clashes on Sunday. Furthermore, the Centre Hospitalier de Fontaine suspended operations, having successfully evacuated all patients, including 11 newborns, to safety. The Unfolding International Security Mission The situation is poised for a potential shift with the deployment of an international security mission. The UN Security Council approved a plan for a 5,550-member force in late September, with the first foreign troops arriving in April. However, the full contingent has yet to arrive, and only an undisclosed number of troops from Chad have been deployed so far.