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GSK has revealed promising early results for its treatment for gynaecological cancers, Mocertatug Rezetecan (Mo-Rez), as its chief executive, Luke Miels, seeks to speed up drug development at the group.The company reported that in an early-stage trial, Mo-Rez shrank or eliminated tumours in 62% of patients with ovarian cancer where chemotherapy had failed, and in 67% of those with endometrial cancer.GSK acquired the Mo-Rez cancer treatment, an antibody-drug conjugate (ADC), from China’s Hansoh Pharma in late 2023, and has trialled it in 224 patients around the world, including the UK, over the past year. Few patients needed to stop treatment because of side-effects, the most common being nausea. It is administered every three weeks via intravenous infusion.Combined with data from a separate, intermediate trial in China, these results give GSK the confidence to go straight to late-stage trials, with five clinical studies planned globally in the next few months, including on patients in the UK.Presenting the results at the Society of Gynecologic Oncology’s annual meeting on women’s cancer in Puerto Rico, Hesham Abdullah, GSK’s global head of cancer research and development, said: “Treatment of gynaecological cancers remains a major challenge, with a pressing need for new therapies that offer improved response rates. With Mo-Rez we now have compelling evidence of a promising clinical profile.”Endometrial cancer affects 1.6 million women globally, with 417,000 new cases each year. Ovarian cancer affects 843,000 people, with 240,000 new cases annually.Abdullah described Mo-Rez as a “key asset” in the company’s growing cancer portfolio, expected to be a blockbuster drug with peak annual sales of more than £2bn, which GSK hopes will help it achieve its 2031 sales target of £40bn.

When a Toronto reader confessed to always using "please" and "thank you" with Alexa, the Guardian invited its audience to share their thoughts on the etiquette of speaking to artificial assistants.One camp warns against treating AI as sentient beings, arguing that these systems merely mimic social cues and that confusing imitation with reality can erode our language’s power to challenge dehumanisation. As User30000 put it, we should avoid both de‑humanising language toward people and humanising language toward machines.Conversely, several contributors argue that politeness serves as a useful human default. Lauk notes that courteous phrasing may reinforce positive behavioural cues for AI that learn from user input, while also keeping the speaker grounded in genuine social norms.From an ecological standpoint, extra words translate into measurable energy and water waste. Superspartan highlights that each unnecessary token adds processing load to already energy‑intensive models, and that the cumulative effect of polite phrasing across millions of daily interactions could be substantial.Academic research supports the idea that courteous language can improve AI performance. A linked study finds that polite prompts often elicit more helpful replies, treating modern models as "statistical parrots" that mirror the tone they receive. Yet Sam Altman has publicly estimated that responding to thank‑you notes costs OpenAI tens of millions of dollars, underscoring a tangible financial dimension to the debate.Some readers take a lighter view, extending politeness to elevators, SUVs and even low‑battery iPads, while others, like Martin from Dorset, argue that the practice protects the human soul rather than the machine.There is growing concern that habitual rudeness toward AI may spill over into real‑world interactions. Poridgeoates observes that younger users, who spend more time with technology than with people, risk weakening empathy and emotional‑intelligence muscles if they treat conversational agents dismissively.Louise adds that the way we speak to objects can shape broader social behaviour, especially where power imbalances exist. While AI itself may not feel insulted, the act of being rude can reinforce undesirable character traits in the speaker.Overall, the discussion reveals a split between those who see politeness as a harmless habit that can improve AI responses, and those who view it as an unnecessary drain on resources and a potential threat to human civility.

Springtime in a typical British suburb is a chorus of birds, buzzing insects and the occasional rumble of a mini‑digger. While sparrows spar and tits clash over territory, a crew of contractors is often busy erasing hedges, bushes and trees, leaving behind a stark trench of bare earth. In one April afternoon, a once‑lush front garden was reduced to a skip full of uprooted branches and a strip of exposed soil. Despite the nation’s reputation as a garden‑loving society, the trend toward concrete is accelerating. An RHS audit published last year found that 42% of domestic garden space in the United Kingdom has been paved over, with timber fences replacing wild privet and driveways smothering mossy lawns. The loss is not merely aesthetic; it erodes habitats that support a remarkable share of the country’s wildlife. According to the Royal Horticultural Society, over 50% of Britain’s butterflies, amphibians and reptiles, and more than 40% of its bird and mammal species rely on garden habitats. The new David Attenborough series Secret Garden underscores this, describing urban gardens as “almost as diverse as a tropical rainforest.” Yet, as the series aired, another garden was being stripped to the ground, highlighting the tension between media‑driven reverence and on‑the‑ground reality. Socio‑economic factors compound the issue. One in eight households in the UK has no garden at all, and lower‑income families and ethnic minorities are disproportionately deprived of green space. Even owners of gardens often lack the time, money, or confidence to cultivate biodiverse oases, viewing gardening as a burdensome chore. Experts suggest a radical, yet simple, alternative: do nothing. Allowing dandelions, thistles, and stray grasses to flourish provides nectar for pollinators, while bare patches become nesting sites for bees and birds. Unraked leaves serve as winter shelters for insects, and dead stalks become food for aphids, which in turn feed higher‑up predators. The “negative space” of an untended garden can therefore become a hotbed of ecological activity. Conservationists argue that embracing this messiness could reverse the decline of urban biodiversity. As one commentator mused, “If Sir David Attenborough could return for a bonus episode, he might show us that a tangled, overgrown garden is not a failure but a vibrant ecosystem in its own right.” By Emma Beddington, 12 April 2026

After serving in Afghanistan, Army Ranger Jesse Gould developed PTSD and turned to drinking to cope. Seeking an alternative to lifelong medication, Gould discovered psilocybin in Peru, which significantly alleviated his symptoms.Gould founded the Heroic Hearts Project, a non-profit hosting ayahuasca and psilocybin retreats for veterans. The organization has helped over 1,500 veterans and their spouses without any psychotic episodes.State lawmakers are taking notice of psilocybin's potential health benefits, with Colorado, New Mexico, and Oregon legalizing it for therapeutic use. At least eight states are considering similar legislation, despite some arguing that the FDA should approve it first.Research suggests psilocybin can be safe and effective when administered with psychological support. A 2025 study found it was associated with symptomatic improvement in adults with PTSD. Clinical psychologist Joseph Zamaria notes that psilocybin can disrupt the brain's default mode network, allowing people to detach from harmful narratives.However, some experts, like Albert Garcia-Romeu, are skeptical about state-led legalization without FDA approval, citing potential unknown risks. Gould counters that the suicide rate among veterans is a pressing issue, with 35 deaths per 100,000 people in 2023, more than double the general population's rate.

Zappa Montag walks through a 76‑hectare (189‑acre) forest of redwoods, madrones and oaks that he co‑manages with five other Black residents at Black to the Land in Boonville, California. Powered by solar panels and supplied by a well, the off‑grid ecovillage embodies Montag’s goal to “reverse‑gentrify the country” by creating a self‑sufficient sanctuary for Black people. Intentional communities—small groups united by shared values—have long served Black and Indigenous peoples, ranging from urban co‑housing to rural ecovillages. In the post‑slavery era, tightly knit Black networks relied on mutual aid for business and farming, a tradition that is resurfacing in places like Alabama, Massachusetts and California as a way to revive ancestral agricultural knowledge. Montag and his daughter Bibi Sarai first imagined Black to the Land in 2015, frustrated by the rapid gentrification of Oakland. After a 2021 introduction to the declining Emerald Earth Sanctuary in Mendocino County, the nonprofit transferred stewardship of the property to their group through a verbal and written agreement. Montag describes the hand‑over as a form of reparations—instead of cash, they invest time learning land stewardship. Tragedy struck in February 2023 when Bibi Sarai died unexpectedly. Yet, reports that visitors felt uplifted after summer stays convinced Montag to stay permanently, turning grief into a catalyst for the community’s growth. Today, the community—members ranging from their late 20s to mid‑50s—funds land maintenance through grants, workshops and fundraising. They host classes on building, gardening and foraging, while some members work remotely to cover personal expenses. African plant‑medicine practitioners prepare herbal remedies, and a partnership with Ghanaian ecovillage leaders introduces natural‑building techniques. In addition to cultivating vegetables, the residents construct clay dwellings, practice yoga, and collectively manage chores such as fire‑wood gathering and trench‑building to prevent driveway flooding. Self‑reliance is the guiding principle, especially amid today’s economic uncertainty. The BIPOC Intentional Community Council, founded in 2020, supports Black and brown groups in establishing similar settlements by providing funding, nonprofit‑formation workshops and land‑trust guidance. Board member Crystal Byrd Farmer notes a growing “back‑to‑the‑land” movement as people seek rural roots. While mainstream media sometimes label intentional communities as radical, Farmer argues they echo millennial human practices of mutual support. Most U.S. intentional communities remain majority‑white due to historic capital access, leaving people of color to feel culturally alienated in those spaces. In Alabama, the Ekvn‑Yefolecv ecovillage—run by Indigenous Maskoke families—reclaimed 3,105 hectares (7,674 acres) of ancestral land. Governed matriarchally, residents speak their language daily, practice traditional foraging, reintroduce buffalo and sturgeon, and share land title, offering a model of ecological sustainability and cultural preservation. Massachusetts hosts the Solidarity Arts & Education Decolonial Initiatives (SAEDi) collective, a communal home for women of color that blends art, food sovereignty and reparations work. Rent is adjusted to ability, and members contribute childcare, meals and chores. Plans include a garden, orchard, and a “green residency” program that will archive elders’ agricultural stories online, aiming to boost security for immigrant families amid rising xenophobia. The modern roots of Black intentional living trace back to 1969’s New Communities in Georgia, a civil‑rights‑era farming settlement that pioneered the nation’s first community land trust. Although federal opposition led to its collapse, a 2009 $12 million settlement acknowledged USDA discrimination. Today, the organization runs workshops on land stewardship and mentors new generations of Black farmers. For Montag, the land also serves as a personal memorial. A clay bench honors his late daughter Bibi Sarai, allowing him to “connect with humanity” and keep her spirit alive. Future plans include grief‑focused rituals and a memorial garden, underscoring the belief that joy and healing are essential components of communal living. Increased security and safety Marginalized groups view intentional communities as safe havens for preserving cultural practices and passing knowledge to youth. Elders’ expertise is documented for future generations, reinforcing resilience against systemic oppression. Empowering collective action From the civil‑rights farms of Georgia to contemporary ecovillages in California and Alabama, these settlements illustrate how shared land ownership, communal labor and cultural affirmation can counter gentrification, foster economic independence, and nurture intergenerational healing.

Mikel Artura tried to fire up the crowd before kickoff, urging fans to bring “your lunch, bring your dinner” for the 12.30 pm showdown. Players warmed up to a big screen looping Arsenal’s past triumphs, a psychological push meant to spark confidence. The opening half unfolded as many had predicted: a physical tussle in which Bournemouth exploited a right‑flank weakness to go ahead, only for Arsenal to level from a set‑piece penalty. The penalty was calmly slotted by Viktor Gyökeres, who seized the ball from Kai Havertz and demonstrated the composure that has underpinned Arsenal’s recent victories. Early in the second half, Arteta made a rare triple substitution nine minutes in, swapping an ineffective attacking trio for fresh legs. The change stalled Arsenal’s momentum; the new unit struggled to build immediate connections, allowing Bournemouth to seize control. In the 74th minute, Alex Scott delivered a clinical finish after a slick passing move on the edge of the Arsenal penalty area, restoring Bournemouth’s lead. Six minutes later, Gyökeres had another chance from a Max Dowman cross but sent his shot wide, underscoring Arsenal’s growing frustration. Throughout the closing stages, Artura repositioned Gyökeres deeper, turning him into a quasi‑centre‑half in a desperate search for an equaliser. The resulting play was slow and ponderous, reflecting a side unable to generate the quick combinations that had served them earlier in the season. Statistically, Arsenal produced 1.44 expected goals (xG) from set‑pieces, outpacing Bournemouth’s total of 1.2. However, all of Bournemouth’s chances came from open play, while Arsenal managed a paltry 0.19 xG from open play – the second‑lowest home figure since such metrics were recorded. This disparity highlights a reliance on dead‑ball situations and an inability to threaten opponents in regular play. Despite the loss, Arsenal remain nine points clear at the top of the Premier League. Yet the gap is vulnerable: if Manchester City maintain their winning run, the cushion could evaporate quickly. The defeat signals that Arsenal must evolve beyond sheer grit and set‑piece proficiency, finding ways to create and convert chances in open play if they are to withstand the challenge from serial winners.

Moldova is facing a severe environmental crisis after an oil spill in the Nistru river, which provides 80% of the country's drinking water. The spill was caused by Russia's attack on Ukraine's Novodnistrovsk hydropower complex on March 13. The attack has led to a significant contamination of the river, with oil slicks detected over 200 km downstream.The Moldovan government has declared an environmental alert and set up a crisis centre to monitor the spill and remove the pollutant. The government has also received support from European allies, including Romania and Poland, which have sent help to prevent the petrol from streaming downwards towards Chișinău.The oil spill has had a significant impact on local residents, with many struggling to access clean drinking water. Inflation in Moldova rose to 35% in 2022 and is currently around 5%, and the country has had to declare a state of energy emergency after Russia attacked the Isaccea–Vulcănești power line in Ukraine.The crisis has also highlighted the vulnerability of Moldova's water supply to attacks from Russia and the chaos caused by its war on Ukraine. Moldova's president, Maia Sandu, has laid the blame squarely on Moscow, saying Russia bears 'full responsibility' for the oil spill.The environmental disaster has sparked an information war between Moldova's pro-European and pro-Russian factions, with conflicting interpretations of the crisis. While Moldova's pro-European government holds Moscow responsible for the spill, pro-Russian propagandists claim the crisis was an accident caused by a Ukrainian truck.The Nistru oil spill has shown Moldova how exposed it is, and how fragile a society can become without access to clean drinking water. The war next door, combined with the climate crisis, give us little reason to think there won't be another ecological disaster like this.

The latest offering from writer Theo Jamieson and director Adam Lenson is a boldly conceived musical that thrusts a turbulent romance into a sci‑fi framework. The story follows a young astronaut, Daniel, who vanishes from his shuttle with barely enough fuel, prompting a quest to uncover the motives behind his reckless flight.Stuart Thompson (as Daniel) and Poppy Gilbert (as Emily) anchor the piece with performances that are both visceral and nuanced. Their chemistry captures the push‑pull of a relationship scarred by childhood bullying, parental betrayal, and a shared history of trauma, delivering songs that soar and hit hard.Visually, the production leans heavily on interstellar projections that transform the stage into a shifting cosmos, while the score oscillates between Sondheim‑style wit and full‑blown symphonic passages. This combination creates an epic sense of strangeness that distinguishes Flyby from more conventional West End fare.However, the narrative’s fragmented structure hampers its emotional payoff. The non‑chronological storytelling leaves critical gaps, and the metaphor of being "stranded in space" feels over‑extended—especially with the protagonist’s surname, Defoe, a thin nod to Robinson Crusoe. The three narrators, played by Simbi Akande, Gina Beck, and Rupert Young, often drift into digressive asides that dilute the central arc.Despite these flaws, moments of brilliance emerge, particularly in the musical’s treatment of mental‑health themes. The show hints at the potential to join the ranks of modern theatre successes like Next to Normal and Dear Evan Hansen, should its structural rough edges be smoothed.The production is currently staged at Southwark Playhouse, Borough, London and will run through 16 May. Audiences seeking a daring blend of emotional intensity and cosmic spectacle will find Flyby a compelling, if imperfect, experience.

Protesters in Ireland and Norway have escalated demonstrations against rising fuel costs, turning major highways into blockades and prompting a convoy of lorries to converge on Oslo’s parliament. The unrest is linked to the broader spike in oil prices triggered by the conflict in the Middle East. In Dublin, hauliers, farmers and other groups have shut down motorways for the fourth consecutive day, causing fuel shortages, traffic chaos and warnings that essential supplies—food, clean water and animal feed—are at risk. The Irish police force, An Garda Síochána, described the blockades as unlawful and warned that continued defiance could lead to arrests. The Irish government has placed the army on standby to clear the obstructions, while the justice minister accused outside actors, including far‑right figures such as Tommy Robinson, of exploiting the protests for political gain. Fuel prices have surged dramatically: Irish diesel has risen from roughly €1.70 per litre to €2.17, and petrol from about €1.74 to €1.97. In Norway, despite a recent fuel‑tax cut on 1 April, diesel prices jumped 23.6 % from February to March, with overall fuel and lubricants up 17.9 %. Statistics Norway noted this as the steepest month‑on‑month increase on record, comparable only to the post‑Ukraine‑invasion spike of spring 2022. Irish Prime Minister Mícheál Martin warned that blockades of the Whitegate refinery and key depots in Galway and Foynes were pushing the country to the brink of turning away oil shipments. He called the situation “unconscionable and “illogical.” In response, Dublin unveiled a €250 million relief package that includes a temporary excise duty cut, an expanded diesel rebate for hauliers and bus operators, and an extended fuel allowance. Nevertheless, industry leaders remain skeptical about the measures’ ability to quell the unrest, and many protesters demand direct talks with ministers. Across the North Sea, Norwegian demonstrators—part of the “Dieselbrølet” (diesel roar) movement—marched a convoy of 70‑80 trucks toward the Storting. Their banners read “nok er nok!” (enough is enough). While only a few vehicles were permitted into Oslo, the show underscored hauliers’ demand for more predictable, lower fuel prices despite Norway’s status as an oil producer. Other nations have taken emergency steps: the Philippines declared a national energy emergency, and France authorized fuel tankers to operate on weekends and holidays until 11 May to stave off shortages. Back in Ireland, the blockade of the sole refinery and depots has left dozens of petrol stations empty, prompting a rush of motorists to fill up before supplies run out. Emergency services report slower response times, and the Irish Medical Organisation warns that delayed care could jeopardise patient health. Courier firm DPD has halted deliveries, and protesters have vowed to remain in Dublin for weeks, with spokesperson John Dallon stating, “If it takes a month, we are prepared to sit here.” The crisis has also forced the Irish Taoiseach to postpone a trade mission to Canada, highlighting the domestic political fallout of the fuel‑price turmoil.