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Donald Trump's military approach against Iran has backfired, emboldening the country rather than weakening it. The 16-hour talks in Pakistan, led by JD Vance, failed to extract a quick accord, highlighting the complexity of issues between Washington and Tehran. The Israeli Prime Minister, Benjamin Netanyahu, had sold the war to Trump as an opportunity for regime change. However, Trump's plan had no clear strategy beyond killing senior Iranian officials, which only strengthened hardliners within the regime. Trump's goal of destroying Iran's military capacity has also failed. US intelligence indicates that Iran's ability to replenish its missiles and drones remains considerable. Furthermore, Iran is causing significant damage to Gulf states. The main issue remains Iran's nuclear program. The 2015 accord, negotiated by Barack Obama, had required Iran to limit its nuclear activities, but Trump withdrew from the deal in 2018. Today, Iran has nearly 900lb of highly enriched uranium, which could be further refined into a nuclear bomb. Trump's aggressive approach has handed Iran a new weapon: the ability to close the Strait of Hormuz, a critical waterway for international shipping. This move could wreak havoc on the world economy and give Iran significant revenue through tolls. The article concludes that diplomacy is the only viable solution to the conflict. Negotiation requires compromise and give-and-take, which Trump has so far resisted. The stakes are high, with the potential for genocide and massive war crimes. The door to a deal remains open, but it demands a willingness to negotiate in good faith.

Metabolic liver disease, or MASLD, is projected to affect 1.8 billion people worldwide by 2050, according to a recent study. This significant increase is primarily driven by rising obesity and blood sugar levels globally.MASLD, previously known as non-alcoholic fatty liver disease (NAFLD), is one of the most prevalent and rapidly growing liver conditions worldwide. The condition's prevalence has already seen a 143% increase in just three decades, from 500 million people in 1990 to 1.3 billion people in 2023.The study, published in the Lancet Gastroenterology & Hepatology journal, highlights that high blood sugar is the leading driver of MASLD-related health problems globally, followed by high BMI and smoking. These factors are strongly linked to type 2 diabetes and obesity.Regional disparities exist, with north Africa and the Middle East having disproportionately higher rates of MASLD. However, there have been sharp increases in the number of people affected in countries across the world, including the UK, Australia, and the United States.Despite the growing number of cases, the overall impact on health has remained stable, suggesting that advances in treatment and care are helping people live longer and healthier lives. However, the increasing number of cases still poses a risk of serious complications such as liver cirrhosis or cancer in the future.

Goldman Sachs's chief executive, David Solomon, has expressed heightened awareness of the capabilities of Anthropic's Mythos AI model and is collaborating closely with the tech firm following warnings about the cybersecurity risk it poses.The US bank has been closely monitoring the rapid advancements in artificial intelligence, including large language models (LLMs), as part of broader efforts to protect itself from hackers.“Obviously the LLMs are making rapid progress and we’re hyper-aware of the enhanced capabilities of these new models with the help of the US government and the model publishers,” Solomon told analysts on an earnings call on Monday.Anthropic, the company behind the Claude family of AI tools, claimed last week that its latest model, Mythos, posed an unprecedented risk due to its ability to expose flaws in IT systems. The company warned that AI models have reached a level of coding capability where they can surpass all but the most skilled humans at finding and exploiting software vulnerabilities.Solomon emphasized that Goldman Sachs is working closely with Anthropic and all of its security vendors to harness frontier capabilities. “We are very focused on supplementing our cyber and infrastructure resilience. And this is part of our ongoing capabilities that we have been investing in, and are accelerating our investment in.”The news comes after the US Treasury secretary, Scott Bessent, summoned Solomon and other big American bankers to Washington to discuss the Mythos model last week. The meeting focused on heads of so-called systemically important banks, where regulators believe that a major disruption to their operations, or their potential collapse, would put financial stability at risk.On Monday, the UK government’s AI Security Institute (AISI) warned that Mythos was a “step up” over previous models in terms of the cyber threat it posed. AISI said Mythos could carry out attacks that required multiple actions and discover weaknesses in IT systems without human intervention.

Scientists at London's Institute of Cancer Research and the RCSI University of Medicine and Health Sciences in Dublin have announced a new AI-driven approach to identify how patients with advanced bowel cancer will respond to bevacizumab, a drug recently introduced by the NHS. The method uses PhenMap, an AI tool that integrates complex data on the genetic makeup of tumors, allowing researchers to track patterns of how different patients react to the drug. This development aims to spare potentially thousands of patients from being given drugs that would be ineffective in fighting their cancers. In the UK alone, nearly 10,000 cases of advanced bowel cancer are identified every year, with young adults seeing a particular rise in diagnoses. Bowel cancer has the second-highest mortality rate of any cancer, behind only lung cancer. While survival rates can be as high as 98% when caught early, the five-year survival rate for advanced bowel cancer can be as low as 10%. The study tracked 117 European bowel cancer patients who had been treated with chemotherapy and bevacizumab. Researchers identified a group of patients who all had the same gene mutation and were at a high risk of having negative reactions. The scientists behind the tests now hope to expand the number of patient samples and see if the results can be used in treatments for other types of cancer. Anguraj Sadanandam, a professor in stratification and precision medicine at the ICR, said: “Once bowel cancer spreads to other parts of the body, there are very few treatment options available for patients. It is therefore positive that patients can now access the targeted drug bevacizumab on the NHS. However, we know that the majority of patients won’t benefit from the drug, meaning thousands of people in England could be facing unpleasant side effects unnecessarily.” Sadanandam added that while the findings were encouraging, the tool would need to be tested on a larger cohort to be validated. “In future, I hope this approach will lead to a test that can be used by clinicians, to ensure patients receive personalised care that has the highest chance of working against their cancer.”

The recent ceasefire talks between the United States and Iran have ended without a breakthrough, with Iran's chief negotiator, Mohammad Bagher Ghalibaf, blaming the US for the failure of the talks held in Islamabad, Pakistan. The talks, which were the first direct engagement between the two countries at this level since the 1979 Iranian Revolution, exposed deep divisions on core issues.The US framed the lack of a breakthrough primarily around Iran's alleged refusal to meet its core demand: a firm commitment not to develop nuclear weapons. US Vice President JD Vance said Washington had made its 'red lines' clear and presented what he described as a 'final and best offer'. However, Iran downplayed expectations and blamed the US for making unreasonable demands.The main sticking points between Tehran and Washington are:Iran's nuclear programme: The US wants a clear and enforceable commitment that Iran will not develop nuclear weapons – or even the capability to do so quickly. Iran has consistently rejected accusations that it seeks to build nuclear weapons but said it is willing to negotiate limits on its nuclear activities if sanctions are removed.Strait of Hormuz: Who gets to control this strategic waterway, through which almost all of the oil and natural gas exports from the Gulf nations pass, has become a major flashpoint. Iran has floated the idea of charging transit fees to allow ships to pass through the strait, while the US is adamant the strait is reopened free of any tolls.The near shutdown of shipping through the strait has sent global energy prices soaring with many countries, especially in Asia, forced to implement unprecedented austerity measures to soften the impact of fuel shortages. Experts said the near-closure of the strait has caused the worst economic shock since the 1973 oil embargo.

Day 44 of the US‑Iran war ended without a peace deal as a marathon 21‑hour session in Islamabad collapsed, jeopardising the fragile cease‑fire that has held since the conflict began over six weeks ago.Vice President JD Vance, leading the US delegation, told reporters that the lack of an agreement was "bad news for Iran much more than it’s bad news for the United States of America," before departing Pakistan.Pakistan’s Foreign Minister Ishaq Dar pledged that Islamabad would continue to facilitate dialogue between the two longtime adversaries.In Iran, officials downplayed expectations, noting that no one anticipated a settlement in a single session. State‑run IRIB quoted ministry spokesperson Esmaeil Baghaei saying the talks were never expected to conclude quickly. Meanwhile, Tehran residents expressed a mix of scepticism and hope after weeks of air attacks that have left a nation of 93 million people reeling; more than 2,000 Iranians have been killed in the US‑Israel‑Iran conflict.In the United States, Vance reiterated that the delegation left with a "final and best offer" for Iran, emphasizing that Washington had communicated its position repeatedly during the talks. He cited multiple conversations with President Donald Trump, Secretary of State Marco Rubio, Treasury Secretary Scott Bessent, and Central Command head Brad Cooper. Trump, however, maintained that the US had already "won" on the battlefield by eliminating Iranian leaders and key infrastructure, stating that a deal would not alter the outcome.The US military reported that two destroyers transited the Strait of Hormuz ahead of planned mine‑clearing operations – a first since hostilities began – though Iran’s state media claimed the joint command denied the movement.Academic David Des Roches of the Thayer Marshall Institute told Al Jazeera that while Washington clarified its stance, it did not shift its core demand: preventing Iran from acquiring a nuclear weapon.In Lebanon, Israel continued strikes, claiming to have hit a "loaded and ready‑to‑launch rocket launcher" in Jouaiya, southern Lebanon. Protests have erupted in Beirut against any direct Israel‑Lebanon negotiations. The Lebanese Ministry of Public Health reported at least 2,020 deaths and 6,436 injuries from Israeli attacks since March 2.In Israel, Channel 12 reported that a drone launched from Lebanon triggered sirens in the Upper Galilee before being intercepted.The stalemate has kept global oil and gas prices soaring, underscoring the broader economic ripple effects of a war that shows no sign of abating.

In the aftermath of the most recent US‑Iran diplomatic round, which concluded without a formal agreement, Senator JD Vance addressed the media to outline his perspective on the stalled negotiations. Vance highlighted that the failure to secure a deal underscores the challenges facing the current administration’s Middle‑East strategy. He warned that the absence of a binding accord could prolong regional instability and complicate efforts to curb Iran’s nuclear ambitions. While refraining from detailed policy prescriptions, the senator called for a clearer approach to diplomatic engagement, urging policymakers to consider both the strategic risks and the domestic political ramifications of continued deadlock. The remarks come at a time when U.S. officials are reassessing their diplomatic posture toward Tehran, with analysts noting that the lack of progress may influence future sanctions and security calculations across the region.

The United States and Iran left Islamabad without a peace deal, ending the most senior diplomatic encounter between the two nations since the 1979 Islamic Revolution. Vice President JD Vance, who led the U.S. delegation, told reporters that Tehran "refused to accept our terms" after a marathon 21‑hour session. Vance emphasized that the United States requires a "fundamental commitment" from Iran not to pursue nuclear weapons or the associated delivery systems. "We need an affirmative pledge that they will not seek a nuclear weapon, and they will not seek the tools that would enable them to quickly achieve a nuclear weapon," he said. Iran’s Ministry of Foreign Affairs, represented by spokesperson Esmaeil Baghaei, cautioned that no one expected a single‑session resolution. "Naturally, from the beginning, we should not have expected to reach an agreement in a single session," he told state broadcaster IRIB, adding that Tehran remains "confident that contacts with Pakistan and other regional friends will continue." Pakistan called on both parties to honor the ceasefire and pursue a durable peace. Foreign Minister Ishaq Dar expressed gratitude for the mediation efforts, stating, "We hope the two sides continue with a positive spirit to achieve durable peace and prosperity for the entire region and beyond." The stalled talks occur against the backdrop of a war that began on February 28, when the United States and Israel launched a campaign against Iran. The conflict has since spread across the Middle East, causing over 2,000 fatalities and extensive damage to both military and civilian infrastructure. One of the war’s most destabilizing effects has been a global energy crisis, as Iran tightened control over the Strait of Hormuz—a chokepoint through which roughly 20 % of the world’s oil and gas exports flow. The delegations, led by Vance for the United States and Iranian Parliament Speaker Mohammad Bagher Qalibaf, also discussed how to sustain a ceasefire that is already under strain from deep disagreements and Israel’s ongoing attacks on Hezbollah in Lebanon.

Iran’s attempt to impose tolls on vessels passing through the Strait of Hormuz has been labeled illegal by Arsenio Domínguez, the head of the United Nations’ International Maritime Organization (IMO). In an interview with Al Jazeera, Domínguez stressed that such charges would set a dangerous precedent for global shipping. Tehran has asserted its right to levy fees even after the conflict ends, while U.S. President Donald Trump floated the idea of a joint U.S.-Iran venture to collect the payments. Both proposals clash with established maritime conventions. "Countries do not have the right to introduce tools or payments or charges on these straits," Domínguez said, adding that any toll system would be contrary to international law and could cripple the free flow of trade. The remarks came as marathon cease‑fire negotiations between U.S. and Iranian officials in Pakistan concluded without an agreement. U.S. Vice President JD Vance noted that Tehran rejected Washington’s terms, which included a commitment to forgo nuclear weapons development, prompting the American delegation to depart Islamabad after presenting its "final and best offer." Iran’s state‑run Press TV blamed the stalemate on what it called the United States' "excessive demands," citing the toll issue and the nuclear programme as major points of contention. Despite a two‑week cease‑fire announced earlier in the week, maritime traffic remains severely limited. Only 22 vessels with active AIS signals exited the strait between the truce’s start and Friday, a stark drop from the pre‑conflict average of about 135 daily transits, according to S&P Global. The bottleneck is throttling oil and natural‑gas exports from the Gulf. The U.S. military reported that two warships had navigated the waterway to clear Iranian mines, a move Iran denied. President Trump later insisted the strait would reopen "fairly soon," with or without Tehran’s cooperation. Domínguez emphasized that ending the hostilities is the fundamental solution to restoring safe passage. He warned that any resumption of traffic must be accompanied by thorough de‑mining and safety checks to protect both vessels and crews. He also dismissed calls for new legal frameworks, noting that the 1968 traffic‑separation agreement between Iran and Oman—which splits the strait into north‑ and south‑bound lanes—had functioned effectively before the war and does not require revision. Humanitarian concerns feature prominently in Domínguez’s statements. He highlighted that roughly 20,000 seafarers are stranded in the Gulf due to the blockade, warning that prolonged isolation would not only harm these workers but also have a negative ripple effect on the global economy.