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Israeli and U.S. forces launched a series of air strikes on Tuesday that struck Tofigh Daru Research and Engineering Company, one of Tehran’s largest producers of anaesthetics and anti‑cancer medicines. The state‑run firm, owned by the Social Security Investment Company, saw its drug‑production line damaged, according to an official post on X. In the north‑western city of Zanjan, a separate strike hit the Husseiniya Azam, a Shia congregation hall adjacent to a mosque. Iranian Red Crescent teams rescued two people from the rubble; one of the victims died and several others were injured. Further attacks were reported in the western province of Kermanshah, where a civilian contracting company in Qasr‑e Shirin – a border town with Iraq – was hit. One person was killed and eight injured, the Mehr news agency said. Heavy bombing was also confirmed in Isfahan, a strategic hub for Iran’s defence industry and home to key nuclear facilities such as Natanz. Local officials indicated that the strikes may have targeted “military sites,” though the exact locations and damage assessments remain unclear. Iranian officials condemned the operations. Former foreign minister Javad Zarif denounced the targeting of the pharmaceutical plant as a deliberate attack on a medical facility, calling the aggressors “desperate” and accusing them of “diabolical delusions.” Governor‑level security official Akbar Salehi echoed these concerns, noting that the strikes appeared aimed at military installations without specifying which ones. The broader conflict has already claimed 1,937 Iranian lives since the joint U.S.–Israeli campaign began on 28 February, while 20 Israelis have been killed. Recent Israeli interceptions using the Iron Dome and David’s Sling systems have limited damage on Israeli soil, but impact sites were reported in Tel Aviv, Bnei Brak and Petah Tikva. Amid the escalating violence, diplomatic channels remain active. U.S. Secretary of State Marco Rubio told Al Jazeera that communications between Washington and Tehran continue, primarily through intermediaries, and that the U.S. aims to achieve its war objectives “in weeks, not months.” Pentagon chief Pete Hegseth added that negotiations to end the conflict are “very real, ongoing and gaining strength.” Iran’s Islamic Revolutionary Guard Corps (IRGC) claimed a retaliatory strike, saying it hit an Israeli container ship in the Gulf with a ballistic missile and that Iranian drones targeted a group of U.S. Marines near a UAE military base. Public sentiment in Iran has turned sharply hostile, with pro‑state demonstrations erupting in Tehran as citizens protest the continued air raids. The atmosphere, described by Al Jazeera’s Tohid Asadi as a “cloud of mistrust,” reflects growing frustration over diplomatic dead‑ends and the relentless cycle of attacks.

Islamabad became the focal point of a new diplomatic track when the foreign ministers of Saudi Arabia, Turkey and Egypt arrived this weekend, joining Pakistan’s Deputy Prime Minister and Foreign Minister Ishaq Dar. The quartet pledged to channel U.S. and Iranian confidence in Pakistan’s ability to host direct talks aimed at a comprehensive settlement. At the close of the meeting, Dar announced the creation of a Committee of Four—senior officials from each foreign ministry tasked with ironing out the procedural details of the peace process. The gathering marks the evolution of a broader Arab‑Islamic consultative effort that began in Riyadh on March 19 into a focused four‑nation push, with Pakistan positioned as the primary conduit between Washington and Tehran. In a candid interview with the Financial Times, U.S. President Donald Trump declared his “favourite thing is to take the oil in Iran,” hinting at a possible seizure of Kharg Island, which handles roughly 90 % of Iran’s crude exports. He reiterated an April 6 deadline for Tehran to accept a deal or face U.S. strikes on its energy infrastructure, yet on Air Force One he added, “I do see a deal in Iran, yeah. Could be soon,” describing the negotiations as “extremely well” progressing. Analysts stress that these mixed signals underscore the central tension confronting Pakistan’s initiative. While Islamabad and its partners are building a multilateral framework to curb escalation, Israeli strikes continue and the U.S. military presence in the region expands. Key diplomatic insights came from former Pakistani officials. Former information minister Mushahid Hussain Sayed highlighted the meeting as the first institutional Muslim‑world effort to open a dialogue pathway, noting that Pakistan and Turkey are among the most credible interlocutors—one a nuclear power, the other a NATO member. He cautioned, however, that the steps are “baby steps” in a war that is rapidly complicating. Former ambassador Masood Khan described the Committee of Four as a structured back‑channel enabling a “step‑by‑step, layered, and calibrated process.” He outlined four potential stages: trust‑building measures, cease‑fire negotiations, direct talks on the nuclear programme and the Strait of Hormuz, and finally reciprocal commitments. Khan warned that Iran’s demands for war reparations and sovereignty over the Strait could prove the toughest hurdles. High‑level outreach extended beyond the region. Pakistan’s Prime Minister Shehbaz Sharif held a 90‑minute call with Iranian President Masoud Pezeshkian, while China’s Foreign Minister Wang Yi pledged full backing for the initiative. A senior Pakistani diplomat confirmed Dar’s planned visit to China on March 31, underscoring the strategic weight of the Pakistan‑China relationship. On the economic front, Iran’s agreement to allow 20 Pakistani‑flagged vessels through the Strait of Hormuz represents the most immediate confidence‑building measure. The strait remains effectively closed to regular shipping, prompting the International Energy Agency to label the disruption as the “worst oil shock in history,” surpassing the crises of 1973 and 1979. Brent crude surged above $116 per barrel, up more than 50 % since the war began on February 28, while WTO Director‑General Ngozi Okonjo‑Iweala warned of the “worst trade disruptions in the past 80 years.” Nevertheless, experts argue that the Strait should not become the centerpiece of any settlement. The long‑term resolution will likely involve all eight littoral states under UNCLOS and established legal precedents, with the immediate priority being a broader halt to hostilities. Military dynamics remain volatile. U.S. Central Command reported that an amphibious task force of roughly 3,500 Marines and sailors aboard the USS Tripoli arrived in the region, with an additional 2,200 Marines and 2,000 soldiers from the 82nd Airborne Division slated to deploy. Trump affirmed that military options are still on the table, and reports suggest the Pentagon is preparing for potential ground operations. Iran’s leadership remains skeptical. A spokesperson for Iran’s Ministry of Foreign Affairs described the U.S. 15‑point plan—calling for a one‑month cease‑fire, handover of highly enriched uranium, a halt to enrichment, missile curbs, and an end to proxy support—as “unrealistic, illogical and excessive.” Tehran’s counter‑proposal, aired on Press TV, demands a halt to aggression, concrete guarantees against recurrence, reparations, and formal recognition of Iranian sovereignty over the Strait of Hormuz. Analysts such as Reza Khanzadeh of George Mason University argue that the burden of compromise falls on Washington, noting that Iran will not sacrifice regime survival. Meanwhile, former diplomat Masood Khan identified the most decisive confidence‑building measure as a U.S. commitment to halt Israeli attacks on Iran and Lebanon—a step he admits is “easier said than done.” In sum, Pakistan’s diplomatic corridor offers a glimmer of hope, but deep mistrust, divergent demands, and an accelerating military buildup render the path to a lasting settlement precarious.

Former US President Donald Trump has stated that Iranian leaders are eager for a deal, but are hesitant due to fear of US retaliation. Trump's comments come amid ongoing tensions between the US and Iran. The Iranian government has been seeking a new agreement, but fears of potential US sanctions and military action have complicated negotiations.The situation remains complex, with Iranian leaders walking a tightrope between economic needs and geopolitical risks. Trump's remarks highlight the deep-seated concerns and mistrust that continue to characterize US-Iran relations.