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The Lead: Rubio's Diplomatic Mission to IndiaUnited States Secretary of State Marco Rubio will travel to India on Saturday for a three-day visit taking in Kolkata, Agra, Jaipur and New Delhi. He will discuss energy security, trade and defence cooperation with senior Indian officials, US State Department spokesperson Tommy Pigott said in a statement on Tuesday.The visit comes as relations between US President Donald Trump and India's Prime Minister Narendra Modi continue to fluctuate, making Rubio's diplomatic mission particularly significant in the current geopolitical landscape.The Quad Context: Strategic Alignment in the Indo-PacificRubio is spending a few days in India ahead of a meeting of foreign ministers from the informal Quad security forum comprising the US, Japan, Australia and India in New Delhi on May 26. The Quad, or the Quadrilateral Security Dialogue, has been referred to as "the Asian version of NATO". It was formed as a response to the rising power of China and has carried out joint military and naval exercises in the Indo-Pacific region.Rubio's meeting with other leaders of the Quad will also be seen as a sign of the US reaffirming its commitment to the Indo-Pacific region, which has become increasingly important in global geopolitics.The Economic Leverage: Adani Case and Russian Oil SanctionsRubio's visit comes days after the Trump administration moved to dismiss US criminal fraud charges against Indian billionaire Gautam Adani in a case in which he is accused of bribing Indian officials with as much as $265m to secure contracts and of lying to US investors to secure a solar energy project in India, allegations that his company has long denied.The case was dropped by the US Department of Justice (DOJ) after Adani pledged a $10bn investment in the US. In an X post on Monday, US Treasury Secretary Scott Bessent announced another 30-day extension of a sanctions waiver allowing purchases of Russian seaborne oil to aid "energy-vulnerable" countries hit by the Iran war, reversing plans not to grant an extension.This extension has temporarily eased pressure on major Russian oil buyers such as India, which has previously faced US criticism for its reliance on discounted Russian crude.The Regional Impact: US Balancing Act Between India and PakistanRubio's visit comes after months of improving relations between the US and Pakistan, India's arch enemy. In April last year, India and Pakistan became embroiled in armed conflict after attackers killed 26 people in Pahalgam, a popular tourist spot in Indian-administered Kashmir. Following the Pahalgam attack, New Delhi scaled back diplomatic ties with Islamabad and suspended the Indus Waters Treaty.On May 7, India struck nine sites in Pakistan and Pakistan-administered Kashmir with missiles, which Islamabad said killed dozens of civilians. A ceasefire – for which Trump claimed credit – was eventually brokered on May 10. However, tensions between the South Asian neighbours continue to simmer."PM Modi told President Trump clearly that during this period, there was no talk at any stage on subjects like India-US trade deal or US mediation between India and Pakistan," Indian Foreign Secretary Vikram Misri said last June.The Future Outlook: Navigating Complex Geopolitical WatersAnalysts say that Rubio's visit to India is part of Washington's attempt to mend bilateral ties with New Delhi following tension between Trump and Modi last year. Sadanand Dhume, senior fellow for India, Pakistan and South Asia at the Council on Foreign Relations (CEFR), wrote in an article for the CEFR website on Thursday that Rubio is going to India in "repair" mode.Last October, Indian Foreign Secretary Shyam Saran told The Wire: "The 25-year upward trajectory of India-US relations has certainly plateaued, if not started declining". The coming months will be crucial in determining whether Rubio's visit can successfully reset the relationship or if the current tensions will continue to define US-India relations.

On May 22, 2026, Russian officials announced that a Ukrainian drone attack on a five‑storey student dormitory in the occupied city of Starobilsk, Luhansk, killed at least four people and left dozens injured, prompting the Kremlin to label the incident a “monstrous crime.” The Drone Strike on a Luhansk Student Dormitory Regional governor Leonid Pasechnik said the UAV struck a dormitory belonging to Luhansk Pedagogical University during an overnight raid, causing the building to collapse to its second floor. The attack targeted a structure that housed roughly 86 children and teachers at the time. Casualties and Immediate Response Deaths: at least 4 confirmed. Injured: at least 35, including 3 critically, many trapped under rubble. Victims’ ages: between 14 and 18 years old. Rescue crews, despite warnings of further UAV attacks, continued extracting survivors and bodies. Al Jazeera’s Moscow correspondent Yulia Shapovalova reported ongoing rescue operations. Political Reactions and Accusations Kremlin spokesman Dmitry Peskov called the strike “a monstrous crime” and demanded accountability for those responsible. Foreign Ministry spokesperson Maria Zakharova described the attack as a “deliberate” assault on children. Russia’s Investigative Committee alleges that four Ukrainian UAVs were used in the operation. Both Moscow and Kyiv maintain that they do not target civilians, a claim that remains contested amid the broader war that began with Russia’s February 2022 invasion. Potential Ramifications for the Conflict The incident arrives amid heightened tensions following President Volodymyr Zelenskyy’s pledge to respond to a recent Russian raid on Kyiv that killed 24 people. Russia’s Defence Ministry reported shooting down 217 Ukrainian drones nationwide overnight, underscoring the intensity of aerial exchanges. Analysts warn that repeated attacks on civilian infrastructure could exacerbate humanitarian crises in occupied territories and strain Russia’s domestic oil and petrol production, potentially influencing the war’s economic sustainability.

What is Immunotherapy? Immunotherapies are biological treatments that harness the immune system to prevent, control and fight diseases and other conditions. The most familiar are vaccines, which train the immune system to recognise targets such as invading pathogens. Other immunotherapies boost immune responses when they are too weak, or dampen them down when they are out of control. Still others draw on engineered immune cells or lab-made antibodies to disrupt disease processes. The Evolution of Immunotherapy Efforts to prevent disease by boosting the immune system date back thousands of years, but advanced therapies for a wide range of illnesses have come to the fore in the past two decades. A global registry of clinical trials listed 1,257 trials of immunotherapies between 2006 and 2016. The figure leapt to 4,591 in the past decade. How Do Cancer Immunotherapies Work? Cancer patients have seen great benefits from immunotherapies and dozens are now approved for more than 30 types of cancer. Some tumours evade the body’s defences by switching off immune cells, but antibody-based drugs – called checkpoint inhibitors – reactivate them so they can recognise and attack the malignancies. The Future of Immunotherapy: Beyond Cancer Researchers are now testing whether existing immunotherapies can help a broader range of patients. This includes treating allergies, infections, brain diseases, and autoimmune disorders. Some of the most exciting new immunotherapies draw on recent Nobel prizewinning work on regulatory T-cells, or Tregs, which can be used to dampen down immune responses. The Potential of Tregs in Immunotherapy Tregs are unusual immune cells that stand the immune system down once the threat has been dealt with. Therapies are in the pipeline for dementia and autoimmune diseases from type 1 diabetes and rheumatoid arthritis to lupus and chronic inflammation. The potential for Tregs is vast, and researchers believe that half of all deaths have a component that is immunological.

Palantir Accuses Mayor of Prioritising Politics Over SafetyPalantir says London mayor Sadiq Khan is “politicising procurement” by blocking a two‑year, £50 million AI contract for the Metropolitan Police, arguing the move jeopardises public safety.Mayor Blocks £50m AI Procurement Deal with Met PoliceKhan’s office cited a “clear and serious breach” of procurement rules and rejected the plan for the Met to use Palantir’s AI to process intelligence in criminal investigations. The decision was first reported by the Guardian on 21 May 2026.Financial Stakes: £50m Contract and Wider Government Deals£50 million – value of the blocked Met Police contract.£330 million – NHS England deal with Palantir.£240 million – Ministry of Defence agreement.Less than £500,000 – earlier separate AI pilot with the Met to detect rogue officers.Political Fallout and Policing Implications in LondonThe move has split Labour MPs: Rosena Allin‑Khan and Clive Lewis praised the block, while Stella Creasy condemned Palantir’s CEO for “using sexual‑abuse allegations to attack the mayor”. The Metropolitan Police Federation called the AI system “big brother”. Business Secretary Peter Kyle defended Palantir’s capabilities and urged Khan to explain his decision.Future of AI Procurement and Domestic Tech AlternativesKhan’s stance may encourage a shift toward British‑owned AI solutions, echoing Kyle’s call for more investment in domestic firms. Ongoing debates about foreign AI providers could reshape how UK public services adopt advanced technology, with potential impacts on policing effectiveness and public trust.

The Latest Escalation in Lebanon Israeli attacks have killed at least 11 people in southern Lebanon, including several healthcare workers. The attacks occurred on Friday in the Tyre district and are the latest in a long line, questioning the durability of the shaky United States-mediated ceasefire between Israel and Lebanon. Details of the Attacks At least 11 people killed in Israeli attacks in southern Lebanon Several healthcare workers among the dead, including paramedics and a child Attacks occurred in the Tyre district, including in the municipality of Deir Qanoun en-Nahr and the town of Hannaouiyah The Humanitarian Impact More than 400 people have been killed by Israeli fire since the ceasefire came into force in mid-April. Israel insists it will continue to target the Hezbollah armed group, which opposed the Lebanese government’s agreement on the ceasefire. At least 2,896 people killed in Lebanon since Israeli attacks began More than 8,824 injured and over 1.6 million displaced – about one-fifth of the country’s population The Systematic Destruction of Health Facilities The Israeli military has repeatedly attacked health facilities and medical teams in Lebanon, accusing Hezbollah of using them to conceal weapons and fighters. The Lebanese government rejects that claim. 116 healthcare workers killed since the latest escalation in early March 16 hospitals damaged and 147 ambulances attacked The Future Outlook A ceasefire brokered by the United States came into effect in mid-April, but the violence has continued, and Hezbollah has continued to trade attacks with Israel. The US has imposed sanctions on individuals with links to Hezbollah, including Iran’s ambassador to Lebanon.

The Lead: Russia's Escalation and Ukraine's Counteroffensive Russia's attempts at escalation via Belarus, where it has delivered more nuclear weapons and held highly publicized joint war games, come as its ground war falters in Ukraine. Ukrainian commander-in-chief Oleksandr Syrskii reports that Ukraine has seized the tactical initiative, with Ukrainian offensive assaults now outnumbering Russian assaults on Ukrainian positions. Russia's Soldier Shortage and Recruitment Crisis Ukraine's forces have gained the upper hand because Russian forces are running out of soldiers to conduct offensive operations. According to Syrskii, "Since the beginning of 2026, the total losses of the enemy have already exceeded 141,500 people, of which more than 83,000 are irreversible." Ukraine's Foreign Intelligence Service believes Russia is unable to replenish these losses of more than 1,000 people a day, and this year is recruiting at a rate of 800-930 a day, suffering a net decrease of battlefield strength. In response, 40 Russian regions have increased sign-up bonuses by between 30 and 100 percent. Putin has also simplified citizenship procedures for Russian speakers in the Transnistrian region of Moldova, which Ukrainian President Volodymyr Zelenskyy described as "Russia looking for new soldiers." Economic Impact: Ukraine's War on Russian Oil Infrastructure Russia's economy is fraying, having run up a $78.4bn deficit in the first four months of 2026 after budgeting for a $50.5bn deficit for the entire year. "Oil dealt the main blow. Revenues from hydrocarbons fell by 38.3 percent," according to Ukraine's Foreign Intelligence Service. Ukraine has scaled up its long-range campaign against Russian refineries and oil export terminals, depriving Moscow of windfall profits from high oil prices. International Energy Agency (IEA) data shows Russia has curtailed production by 460,000 barrels per day (bpd) in April 2026 compared with April 2025. Reuters estimates that Ukrainian drone attacks knocked out about 700,000 bpd of refining capacity between January and May across 16 refineries, accounting for a quarter of Russia's refining capacity. Shift to Asymmetric Warfare: Ukraine's Strategy Evolution "Given our limited resources, to effectively resist a much larger enemy, we are trying to shift from a 'war of attrition' to an asymmetric strategy," Syrskii told the European Union Military Committee. "Our main tasks are to stop the enemy's advance and effectively counterattack, strike at the Russians' rear, including deep within their territory." Ukraine has attacked military-industrial targets in a 100km radius around Moscow, including the Angstrem semiconductor plant, the Solnechnogorsk oil pumping station, and the Moscow Refinery. Ukraine has also targeted refineries in Ryazan, Yaroslavl, Kstovo, and Sizran, as well as military hardware including helicopter gunships, amphibious craft, and anti-aircraft missile systems. Belarus Front: Russia's Nuclear Escalation and Ukraine's Warning Russia has put pressure on Belarus President Alexander Lukashenko to open a new front in the war against Ukraine. Zelenskyy stated that Russia would launch a simultaneous attack from its neighboring region of Bryansk against Chernihiv. "We know that there have been additional contacts between the Russians and Alexander Lukashenko aimed at persuading him to join new Russian aggressive operations," Zelenskyy said. Russia involved Belarus in a joint nuclear exercise with 64,000 personnel, more than 200 missile launchers, 140 aircraft, 73 surface ships and 13 submarines. Russian President Vladimir Putin confirmed that the two countries would launch ballistic and cruise missiles as part of the exercise. Russia has parked its new Oreshnik tactical nuclear missile in Belarus since last year and has threatened to attack European arms manufacturing and military sites with it.

The Lead: Demands for Transparency on £5m Gift The defence secretary, John Healey, has urged Nigel Farage to provide transparency about the £5m gift he received from a billionaire businessman, in particular over whether any of the sum could have been linked to Russia-connected profits. In a letter to the Reform UK leader, Healey also asked him to address the possibility that the war against Iran might boost the revenues of AML Global, an aviation fuel company owned by Christopher Harborne, who gave Farage the £5m in 2024. Farage initially supported the US-Israeli attacks on Iran. The Financial Inquiry: Scrutinizing the Gift's Origins The letter, seen by the Guardian, asked Farage to confirm that none of the sum was "derived from transactions with Russian state-linked energy companies", and to give assurances that AML Global had complied fully with all sanctions on Russian energy since the full-scale invasion of Ukraine in 2022. In a statement to the Guardian, AML Global said it had complied fully with all UK and international sanctions, and screened any business partners to ensure the same. The Political Fallout: Investigation and Disclosure The Guardian revealed last month that shortly before the 2024 general election, Farage was given £5m by Harborne, a British-Thai dual citizen based in Thailand. Farage did not disclose the money at the time, and it only emerged when the Guardian reported it. He has argued that because it was an unconditional gift, and received before he announced he would run for parliament, there was no need to declare it once he did become an MP. However, after a complaint from the Conservatives, Farage faces a formal investigation by the parliamentary standards watchdog, Daniel Greenberg, into whether he should have done. The Geopolitical Concerns: Russia and Iran Connections In the letter, Healey noted that AML Global supplies jet fuel through a network of "main and regional oil companies" covering more than 1,200 locations worldwide, including central Asia, the Gulf and eastern Europe. Healey asked Farage to confirm that none of the profits which helped finance the £5m gift came from transactions with Russian state-linked energy companies, that AML Global had fully complied with all Russia sanctions, and that "no fuel sourced from Russian-controlled refineries has passed through its supply chain". The Public Interest: Demands for Open Books Citing previous comments by Farage about Russia – for example, that Nato "provoked" Russia's invasion of Ukraine by expanding eastwards – Healey said this wider situation "places Reform UK under a Russian cloud that only transparency can lift". On Iran, the letter asked Farage to say whether he was aware of a potential benefit to Harborne's company from rising aviation fuel prices when he made supportive comments about the attack on Iran, which led to Iran blockading the strait of Hormuz. Healey added: "The public is entitled to ask whether your financial interests were impacting on your political positioning and your initial support for throwing the UK armed forces headlong into a war in the Middle East without a plan."

The Stumbling Blocks in US-Iran War Talks Future control over the Strait of Hormuz and a demand from Washington that Tehran export its stockpile of highly enriched uranium remain key stumbling blocks, as Pakistani mediators continued to seek a permanent ceasefire they believe is still within reach between the US and Iran. Escalating Tensions and Fear of Surprise Attacks Meanwhile, Israel and Iran each fear the other is about to launch a surprise attack on its territory while the US president, Donald Trump, continues to insist a fresh assault on Iran is an option available to him. Pakistani Mediation Efforts The Pakistani interior minister, Mohsen Naqvi, met the Iranian foreign minister, Abbas Araghchi, for the second time in two days in a bid to secure a breakthrough in talks, and it is still possible that a delayed visit to Tehran by Field Marshal Asim Munir, the commander of the Pakistani army, will signal progress is being made. Iran's Conditions for a Ceasefire Iran has emphasised it is seeking to postpone all talks on its nuclear program and focus instead on a permanent cessation of hostilities that it hopes will include a phased lifting of US sanctions, unfreezing of frozen Iranian assets, compensation for US-Israeli war damage, and commitments not to resort to force in future. The Strait of Hormuz Dispute The future management of the strategic Strait of Hormuz is a key point of dispute, with Pakistan floating plans for joint control under UN auspices. Tehran has also proposed that its recently created Persian Gulf Strait Authority take responsibility for the channel, in which fees would be charged and ships would have to follow instructions from over selected transit routes. International Response and Concerns Five Gulf states have written a letter to the International Maritime Authority, a global shipping watchdog, urging merchant and commercial ships not to engage with the PGSA. The list of signatories are Bahrain, Kuwait, Qatar, Saudi Arabia and the United Arab Emirates.

The End of an EraPep Guardiola will leave Manchester City at the end of the season after a decade in charge, the club has confirmed, bringing an end to one of the most successful eras in English football and one of the most influential managerial reigns of all time.The departure of the 55-year-old Catalan coach will close the book on a remarkable chapter that has seen City transform into a footballing juggernaut. Guardiola had arrived in Manchester with a resume already stuffed with silverware from Barcelona and Bayern Munich, taking over from Manuel Pellegrini in July 2016.The Trophy-Laden ReignGuardiola, who took charge of City in 2016, has won six Premier League titles – including four in a row – three FA Cups, five League Cups and the Champions League, but his side have not won the league in two years.Although City sealed the domestic cup double this season, Guardiola saw his dreams of a seventh Premier League crown dashed when they drew 1-1 at Bournemouth on Tuesday to hand Arsenal the title, with City set to finish second. His final game in charge is Sunday's home fixture against Aston Villa.The Tactical RevolutionAfter inheriting a successful club financed by the Abu Dhabi United Group, Guardiola will walk away having built a footballing empire after overseeing a paradigm shift in Premier League tactics. As Guardiola faced the challenge of adapting to England's famously fast-paced and physical league, possession became an art form and a defensive tool at City as his teams craved complete control.The result was not just utter dominance – evidenced by record-breaking campaigns like the 100-point 2017-18 season with 106 goals scored – but also relentless consistency year after year, including a record four league titles in a row. Guardiola's squads set new standards, forcing other teams to evolve, while City's financial muscle, combined with shrewd signings such as the much-sought-after striker Erling Haaland helped deliver the treble in 2022-23.The Changing LandscapeHowever, the spectre of the 115 charges of alleged breaches of the Premier League's financial rules looms large over his tenure at the club. His rivalry with former Liverpool manager Jurgen Klopp raised the bar in the Premier League so high that even 97 points proved insufficient for the Anfield side to claim the title in 2018-19.More recently, Guardiola has faced a challenge from his protege and former coaching assistant Mikel Arteta, who took charge at Arsenal and finished second behind City twice before ultimately winning the trophy this season.The Guardiola LegacyGuardiola looked back fondly at his time in Manchester, remembering how the city came together after the Manchester Arena attack while also describing how the club helped him through a tough period when he lost his mother to COVID."The fans, the staff, the people of Manchester, you gave me strength when I needed it most," he added. "Players don't forget – every single instant, moment, me, my staff, this club, everything. What we have done, we have done it for all of you. And you have been just exceptional. You don't know it yet, but you are leaving a legacy.""Don't ask me the reasons I'm leaving. There is no reason, but deep inside, I know it's my time," Guardiola said in a statement on Friday. "Nothing is eternal, if it was, I would be here. Eternal will be the feeling, the people, the memories, the love I have for my Manchester City."