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President Donald Trump has taken a significant step to push for pharmaceutical deals by signing an executive order that could impose tariffs of up to 100% on some patented drugs. This move is part of his administration's effort to secure lower prices for medicines.Under the executive order, companies that have signed a 'most favoured nation' pricing deal and are actively building facilities in the US will have a zero-percent tariff. For those that don't have a pricing deal but are building such projects in the US, a 20 percent tariff will apply, but it will increase to 100 percent in four years.A senior administration official stated that companies still have months to negotiate before the 100 percent tariffs kick in. Bigger companies will have 120 days, and 180 days are offered for everyone else.The administration has already reached 17 pricing deals with major drugmakers, 13 of which have signed. The executive order aims to address the threatened impairment of national security posed by imports of pharmaceuticals and pharmaceutical ingredients.Critics, pharmaceutical leaders, and medical groups have warned of the consequences the new tariffs could bring, including increased costs and potential jeopardy to billions in US investments. The pharmaceutical company trade group PhRMA has expressed concerns that taxes on cutting-edge medicines will increase costs and could jeopardize investments.

Several ships have successfully navigated the Strait of Hormuz, a vital waterway that has been effectively closed since the start of the war in Iran. The development comes as shipping companies and international leaders work to ensure the passage of critical cargo, including oil and gas supplies that account for about a fifth of the world’s total. A French container ship owned by CMA CGM, the CMA CGM Kribi, which sails under the flag of Malta, is reported to have passed through the strait with cargo. This marks a significant development as it is believed to be the first ship owned by a western shipping line to make the journey. The blockade has led to increased oil and gas prices globally and growing concerns about food security, as a third of the global trade in raw materials for fertiliser normally passes through the strait. International leaders are expected to meet next week to discuss possible solutions, including clearing sea mines and rescuing trapped ships. The UK’s Foreign Secretary, Yvette Cooper, has stated that coordinated action is needed to pressure Iran into reopening the strait. The US President, Donald Trump, has claimed that the US could “easily” open up the strait but that it would require “a little more time”.

The US government has taken legal action against Illinois for attempting to regulate the rapidly growing online prediction market industry. The lawsuit, filed in Chicago federal court, claims that Illinois' efforts to shut down so-called designated contract markets regulated by the Commodity Futures Trading Commission (CFTC) are unlawful.Online prediction markets allow users to bet on a wide range of events, from Oscar winners to military conflicts. These platforms classify their offerings as 'event derivatives,' which fall under federal commodities law and are overseen by the CFTC. This classification allows them to operate in all 50 states for users 18 and older.Illinois introduced legislation earlier this year that would impose strict regulations on prediction markets, including an effective ban on sports-related trades, advertising restrictions, and age verification measures. The CFTC argues that this legislation intrudes on its exclusive authority to regulate national swaps markets.The lawsuit is the first by the CFTC to block state gaming regulators from policing operators of prediction markets. It cites cease-and-desist letters sent by the Illinois gaming board to companies like Kalshi, Polymarket, and Crypto.com, alleging violations of Illinois gambling laws.The federal lawsuit names Illinois Governor JB Pritzker and Illinois Attorney General Kwame Raoul as defendants. The case highlights the ongoing debate over the regulation of prediction markets, with some arguing they are essentially gambling operations and others seeing them as federally regulated financial exchanges.Congress is also considering federal measures to regulate prediction markets, including a bipartisan bill introduced by US senators that would ban federally regulated platforms from allowing wagers on sporting events.

President Donald Trump has announced a new policy threatening to impose 100% tariffs on US pharmaceutical companies that do not agree to lower their drug prices. This move is part of his effort to address the high cost of prescription medications in the US.The tariffs will specifically target branded drugs and their active ingredients, while generic drugs, which account for over 90% of medicines sold in the US, will be exempt for at least one year. Additionally, certain specialty drugs, such as orphan, veterinary, and other specialty drugs, will be exempt if they are from countries with which the US has a trade deal or meet urgent public health needs.Drugmakers that enter into pricing agreements with the White House and onshore drug production will be exempt from the tariffs. Companies planning to increase their domestic manufacturing will face a 20% tariff that will escalate to 100% over four years.The policy has been met with criticism from industry groups, such as the Midsized Biotech Alliance of America (MBAA), which argues that it creates an "unfair two-tiered system" that benefits large companies with diversified portfolios.Trump has been under pressure to lower drug prices, with US patients often paying nearly triple what patients pay in other developed nations. The announcement comes as the White House faces pressure from consumers to address rising costs amid other tariff-related price increases and high gas prices triggered by geopolitical tensions.

It's been 12 months since Donald Trump's 'liberation day' on April 2, 2025, when the US president introduced tariffs on nearly every country the US did business with. The move sent shockwaves through the global economy, causing chaos in Washington and beyond. Experts say that if Trump had spent the last 14 months on the golf course instead of in the White House, the US economy would be in a better place. The wholesale slashing of government jobs and defunding of US aid agencies had already signaled that Trump was in a hurry to upset institutions he considered profligate or useless. Investors quickly understood that chaos was an essential tool in Trump's armoury. Almost as soon as he was inaugurated, there was a steady decline in the value of the dollar against other currencies. Investors sold assets denominated in dollars and bought assets elsewhere: Europe, Asia, South America. Dario Perkins, the head of global research at the consultancy TS Lombard, said: 'If you think that discouraging investors from buying assets in the US is a victory, then you don’t believe in a growing economy.' He added that Trump's policies had led to a decline in US manufacturing jobs and a growing trade deficit. The data supports Perkins' claims. US companies stopped hiring almost as soon as liberation day was announced. Significant revisions in February to data covering 2025 pushed payroll employment down by 403,000 jobs, resulting in the addition of just 181,000 jobs last year. This small boost is set against the 163 million people who are employed in the US. Russ Mould, the investment director of the British stockbroker AJ Bell, said: 'America is still home to the world’s largest economy and its reserve currency, as well as the globe’s largest equity and bond markets, but investors continue to reassess their exposure one year on from liberation day.' The next few months of steadily increasing confidence levels followed probably the calmest period in the second Trump presidency. But sentiment began to fall again in the autumn as the White House battled with Congress over the federal budget deficit and much of the public sector was shut down. A poll by the University of Michigan showed consumer confidence at a near record low at the end of 2025. A six-month moving average produced by the Conference Board showed every generation, from baby boomers to gen Xers, had lost confidence in the economy over the past year. Trump’s liberation day executive order stated: 'The decline of US manufacturing capacity threatens the US economy in other ways, including through the loss of manufacturing jobs.' However, the US manufacturing sector shed 100,000 jobs between January 2025 and March 2026. The ratio of manufacturing workers to total nonfarm employment fell to the lowest point since 1939. Bryan Riley, the director of the National Taxpayers Union Foundation’s free trade initiative, said: 'One year after liberation day, the evidence is in. Tariffs failed even by the Trump administration’s own terms. They did not shrink the trade deficit, did not revitalise manufacturing and did not help farmers. It would be a mistake to replace one set of failed tariffs with another.' Some major US companies have redirected their investments to Europe, but China has proved to be one of the main beneficiaries. In the year to February 2026, China’s industrial profits increased by 15.2%. It's a boom that Beijing will struggle to repeat should Chinese companies face fuel and energy shortages and price hikes. But the decline of two major powers can only be to China’s gain.

When billionaire hedge‑fund manager Chris Rokos announced a £190 million contribution to the University of Cambridge, the move instantly became the largest single donation to any UK university in modern history. The funds will establish a new “school of government” aimed at bridging policy, science and emerging technologies. Rokos, a 55‑year‑old Oxford graduate, has amassed an estimated £2.6 billion fortune, primarily through his firm Rokos Capital Management (RCM), which he founded in 2015 after a high‑profile stint at Brevan Howard. RCM now oversees **over £22 billion** in assets, employs roughly 350 staff, and operates from offices in London, New York, Singapore and Abu Dhabi. In the most recent fiscal year ending March, Rokos paid himself nearly £500 million, according to Companies House filings, reflecting the firm’s strong performance amid volatile markets. Beyond finance, Rokos has kept a remarkably low public profile. He famously declined to provide a photograph when launching a £500 million fund in 2007, and he has avoided media attention despite owning one of England’s most expensive private residences. The £175 million refurbishment of the Grade I‑listed Tottenham House in Wiltshire – featuring a tennis pavilion, private cinema, basement squash court and a proposed “subterranean family link” to a pool house – has drawn local council scrutiny but stands as a tangible testament to his wealth. Rokos’s career trajectory began in banking at UBS and Goldman Sachs, moving to Credit Suisse where he was recruited by Alan Howard. He later joined the founding team of Brevan Howard in 2002, generating roughly $4 billion (≈£3 billion) in investor profits and about £600 million for himself before departing in 2012. His philanthropic philosophy emphasizes diversity of thought. In a video released by Cambridge, Rokos warned that a school populated only by “centrist, socially liberal” voices would be a failure, insisting on a broad spectrum of intellectual viewpoints. Earlier this year, RCM’s exploratory talks to bring former UK business secretary Peter Mandelson onto its advisory board collapsed after revelations about Mandelson’s connections to the late Jeffrey Epstein. Rokos also ranks among the UK’s biggest taxpayers and maintains a family office in Mayfair. A lingering legal dispute over a five‑year non‑compete clause with a former employer was settled out of court, clearing the way for his current venture. Overall, the record‑breaking Cambridge donation not only reshapes the university’s academic landscape but also underscores how hedge‑fund wealth is increasingly channeled into high‑impact philanthropy, blurring the lines between finance, education and public policy.

UK businesses are planning to raise their prices more rapidly in the coming months due to the escalating costs triggered by the Iran conflict. A recent survey conducted by the Bank of England among over 2,000 chief financial officers revealed that companies now anticipate increasing their prices by 3.7% over the next year. This marks an increase from 3.4% in February, while the expectation of inflation across the economy has also risen from 3% to 3.5%. The effective closure of the Strait of Hormuz has significantly driven up oil and gas prices, leading to predictions of wider price rises as these higher costs impact industries. The UK Chancellor, Rachel Reeves, has met with retail bosses to discuss the risks of supply shortages and price increases. There is also pressure on her to mitigate the impact of likely rises in household gas and electricity bills before next winter and to reconsider plans for a 5p per liter increase in fuel duty set to take effect by next March. Bank of England policymakers are closely monitoring UK companies' pricing intentions as they consider whether to raise interest rates in the coming months from their current level of 3.75%. Financial markets are currently pricing in two interest rate rises by the end of the year, reflecting a sharp turnaround from expectations of rate cuts before the conflict began. However, Bank of England Governor Andrew Bailey has cautioned that markets may be getting ahead of themselves, and weak consumer demand may prevent companies from passing on cost increases to their customers. He noted that businesses often report an absence of pricing power. Inflation on the consumer price index was steady at 3% in February but is now expected to rise.

Global markets were jolted on Thursday as oil prices skyrocketed and stocks sank following a televised address by Donald Trump, in which he vowed to take 'extremely hard' action against Iran in the coming weeks. This development has dashed investor hopes of a swift resolution to the conflict in the Middle East.Brent crude prices jumped by 8% to surpass $109 a barrel, reversing the previous day's decline when hopes of de-escalation had briefly pushed the international benchmark below $100 a barrel.Asian markets were particularly hard hit, with Japan's Nikkei index falling 2.4%, China's CSI 300 index dropping 1.36%, and South Korea's Kospi tumbling 4.8%. In Europe, Germany's Dax fell 2%, France's Cac 40 dropped 1.15%, and Italy's FTSE Mib was down 1.45%. The FTSE 100 in London initially opened 0.7% lower but later stabilized, buoyed by gains in fossil fuel companies BP and Shell, which rose 4.5% and 3.1% respectively.Government borrowing costs also increased, with the yield on 10-year UK gilts rising four basis points to 4.886% and the two-year UK bond yield rising six basis points to 4.36%, reflecting growing fears of inflation due to higher energy costs.Chris Beauchamp, chief market analyst at IG, noted that investors are betting on the impact of delayed oil supply deliveries from the Gulf, given Trump's failure to provide guidance on a potential end to the US-Israeli conflict with Iran. 'Instead of 'no more war', we got 'no, more war!', Beauchamp said, highlighting the market's concerns about hundreds of millions of barrels of oil that may not be delivered soon.The US dollar gained 0.6% against a basket of major currencies as investors sought safe-haven assets, pushing the pound down by almost a cent to $1.321. The market turmoil is already affecting consumers, with the Bank of England warning that 1.3 million more homeowners may see their mortgage payments rise due to financial shocks from the Iran conflict.Additionally, data from the RAC showed that petrol and diesel prices jumped by a record amount in March, with the average price of a litre of unleaded petrol rising by 20p to 152.83p by the end of the month, surpassing the previous monthly record.

Iranian government supporters have taken to the streets to celebrate the anniversary of the 1979 referendum that solidified the Islamic Republic's hold on power. The celebrations come as the United States and Israel continue their attacks on the country.President Masoud Pezeshkian and Foreign Minister Abbas Araghchi joined pro-establishment rallies in Tehran, marking Islamic Republic Day with 98.2 percent of the popular vote in favor of the Islamic Republic in 1979.The US and Israel targeted Iran's top steel manufacturing companies, threatening thousands of jobs and exacerbating economic hardship under harsh US sanctions. Other attacks hit civilian nuclear sites, a university, and military installations.The Iranian state remains defiant, with authorities saying their defenses are prepared for potential US military action. Ahmad Reza Pourdastan, head of the Iranian army's research center, warned of 'heavy casualties' in response to any aggression.Iranians face an unprecedented near-total internet shutdown lasting over a month, creating a black market for VPN access and raising concerns about the future.The authorities have issued calls to action for people to participate in group marches while waving flags, with religious singers and eulogists performing religious songs drawing on Shia Islam's influence.