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Changes to the microbes that live in the gut can identify people at greater risk of Parkinson’s disease long before symptoms develop, according to a new study that also raises hopes for novel therapies.Discovery of a Distinct Gut Microbiome Signature in At‑Risk IndividualsResearchers at University College London led by Prof Anthony Schapira identified a microbial pattern that is more pronounced in individuals carrying a genetic risk for Parkinson’s and even stronger in diagnosed patients. The signature was detectable in a small fraction of the general population, suggesting a pre‑symptomatic risk group.Scale of the Study and Microbial Shifts Quantified271 Parkinson’s patients, 43 genetically predisposed but asymptomatic participants, and 150 healthy controls were initially analysed.Differences were found in 176 gut microbe species (over a quarter of the total surveyed).Follow‑up validation used data from 638 Parkinson’s cases and 319 controls across the UK, South Korea and Turkey.The alterations were independent of medication use and correlated with dietary patterns high in processed foods and saturated fats.Implications for Early Diagnosis and Preventive StrategiesThe microbial signature could enable clinicians to flag high‑risk individuals years before motor symptoms appear, opening a window for interventions such as diet modification or microbiome‑targeted therapies. Alpha‑synuclein production, a protein linked to neuronal damage, may be influenced by gut inflammation driven by specific bacteria.Future Directions: Clinical Trials and Therapeutic ProspectsFurther research is needed to determine causality and to test whether reshaping the gut ecosystem can delay or prevent disease onset. Ongoing clinical trials will explore probiotic, prebiotic, and dietary approaches, while the findings reinforce the growing emphasis on lifestyle factors in Parkinson’s management.

The Lead A strike by London Underground drivers will severely disrupt transport in the capital over the next four days, with the RMT union confirming action will proceed despite no last-minute talks planned. Strike Impact on London Transport Network Just under half of London's tube drivers are in the RMT union and expected to join the strike, with a slight majority – members of Aslef – still working as normal. The RMT has called the action in two 24-hour tranches from midday on Tuesday and Thursday for maximum impact over four days. On Tuesday and Thursday afternoons, services will be significantly reduced and may not run later than 8pm on most lines. On Wednesday and Friday morning the first trains are not expected to begin running until 7.30am, and services are likely to be worse than usual in the afternoon. Some lines, where the RMT is heavily represented, will probably not run at all during the strike periods: the Piccadilly, Waterloo & City and Circle lines are expected to have no service. Parts of the Metropolitan line, between Baker Street and Aldgate, and the Central line, between White City and Liverpool Street, will also have no trains. Alternative Transportation Options The London Overground, national rail services, the Elizabeth line, the DLR and trams will be running as usual but are likely to be extremely busy. London buses should be running as normal but are likely to be very crowded, and are liable to be disrupted and delayed by the added numbers of passengers boarding and by congested roads if people turn to private cars. TfL advises that people may find it easier to walk or cycle on some journeys. During the last tube strike, which took place in September 2025, the number of cycle and e-bike hires rose significantly. At least the weather promises to be fine. The Dispute Over Working Hours This dispute centers around working hours. The RMT went on strike last year to press for a 32-hour working week, which TfL said was unaffordable. Now drivers are being offered a four-day week, which the Aslef drivers' union supports but the RMT opposes. TfL says its proposals would bring London Underground in line with the working patterns of other train operating companies, improving reliability and flexibility at no additional cost. It said the changes would be voluntary, there would be no reduction in contractual hours and those who wish to continue a five-day working week pattern would be able to do so. The RMT general secretary, Eddie Dempsey, said TfL was making no concessions, adding: "The approach of TfL is not one which leads to industrial peace and will infuriate our members who want to see a negotiated settlement to this avoidable dispute." Aslef says it is surprised that the RMT is taking action. It views the voluntary four-day week as a winner: giving tube drivers who wish to do it an extra 35 days off every year, in return for minor changes to working conditions and using electronic, rather than paper-based, systems. Future Strike Possibilities The first set of planned strikes in this particular dispute, in March, was called off by the RMT to allow talks to go ahead. But that pause was announced six days before action was due, and there are no signs of further negotiation now, with the RMT at the weekend accusing TfL of "reneging on promises" and making strikes inevitable. If there is no resolution, further strikes over the same four-day pattern are scheduled by the RMT in May and June.

London will host the historic first team time trial of the Tour de France Femmes in 2027, offering an 18 km circuit that winds past the Houses of Parliament, the London Eye and Tower Bridge before finishing on The Mall. Key Developments Race director Marion Rousse announced the inaugural women’s team time trial will take place on a central London route. The stage is part of a three‑day UK block, with the Grand Départ starting in Leeds and the second stage featuring 3,000 m of climbing in Sheffield. Mayor Sadiq Khan highlighted the event as a catalyst for a more bike‑friendly London. British talent Cat Ferguson, a former junior world champion, is among the favourites to wear the yellow jersey. Project director Lucy Jones expects the race to become the “highest‑attended women’s sporting event in the UK”. Data & Market Impact Broadcast to over 90 countries, expanding global exposure for women’s cycling. Organisers project record attendance, aiming to surpass previous women’s sport crowds in the UK. The event aligns with London’s strategic push to increase cycling participation, potentially boosting local bike‑share usage and tourism revenue. Why This Matters The race puts women’s professional cycling on a world‑stage in one of the globe’s most recognizable cities, offering a powerful visual of gender equity in sport. For British riders like Ferguson and Flora Perkins, it provides a home‑field advantage and a platform to inspire the next generation of female cyclists across the UK. Expert Insight Analysts see the London time trial as a strategic move by the Amaury Sport Organisation to cement the Tour de France Femmes as a marquee event. By leveraging iconic landmarks, the race gains unparalleled media value, which can attract higher sponsorship bids and justify increased investment in women’s teams. However, the logistical complexity of closing central London streets poses risk; successful execution will set a benchmark for future urban stages. What Happens Next Final route details and team allocations will be released in late 2026. Local authorities will coordinate road closures and safety plans during the summer of 2027. Stakeholders anticipate a surge in grassroots cycling programmes in London ahead of the event, potentially translating into higher bike‑share memberships and infrastructure funding. Success of the London stage could encourage additional urban time‑trial venues in future editions of the Tour de France Femmes.

The Rugby Football League (RFL) has officially confirmed that Brian McDermott will take the reins as the head coach of the England men's national rugby league team. This appointment marks a significant shift in strategy, bringing a proven winner from the Super League to lead the squad into the upcoming World Cup in Australia.The Return of a Super League LegendMcDermott, a 56-year-old, is set to be unveiled on Thursday.He replaces Shaun Wane, who stepped down after a series whitewash against Australia.He brings a resume of eight major honours from his time at Leeds Rhinos.He beat out high-profile candidates including Sam Burgess and Brad Arthur.Historical Success MetricsMcDermott's appointment is backed by a resume of unparalleled domestic dominance. His tenure at Leeds Rhinos was defined by a historic treble in 2015, securing every domestic trophy available during his eight-year stint. This track record suggests the RFL prioritized proven winning pedigree over the allure of NRL experience, despite McDermott currently serving as an assistant at the Newcastle Knights.A New Era for England Rugby LeagueThe decision to bypass Hull KR's Willie Peters and Leeds' current coach Brad Arthur signals a strategic pivot. The RFL was reportedly concerned about Arthur's potential return to Australia, while Peters' commitment to the Papua New Guinea Chiefs (entering the NRL in 2028) made him unavailable. By selecting McDermott, the governing body is betting on a coach who understands the English game's DNA, aiming to stabilize the national team ahead of the global tournament.The World Cup HurdleThe immediate challenge for McDermott will be translating his Super League success to the international stage. England has not won a Rugby League World Cup since 1995, and the competition in Australia will be fierce. However, his experience with diverse squads—from London Broncos to Toronto Wolfpack—provides a unique adaptability that could be crucial in navigating the pressure of the tournament.

The Tactical Setup and Team NewsWest Ham United manager Nuno Espírito Santo has named a strong lineup to face Crystal Palace, utilizing a 4-2-2-2 formation that emphasizes defensive solidity and attacking width. The Hammers welcome new signings Taty Castellanos and Pablo to the frontline, while the defensive partnership of Axel Disasi and Konstantinos Mavropanos looks set to continue. Conversely, Crystal Palace manager Oliver Glasner opts for a 3-4-2-1 system, but the Eagles are likely to be without the intensity required to match West Ham's current momentum.The Relegation Race: Narrow MarginsThis match is a pivotal moment in the fight for survival. West Ham currently sits in 17th place on 32 points, while Tottenham Hotspur sits directly below them in 18th with 31 points. The goal difference gap is crucial; West Ham's -17 is significantly worse than Tottenham's -11. With a game in hand, a win for West Ham would pull them four points clear of the drop zone, a margin that is often decisive in the final stretch of the season.West Ham: 32 points (17th), GD -17Tottenham: 31 points (18th), GD -11Nottingham Forest: 36 points (16th)The European Hangover FactorThe psychological and physical toll of European competition is a major factor here. Crystal Palace's recent aggregate victory over Fiorentina in the Conference League semi-finals has left the squad celebrating in Florence. The added travel and potential hangover on matchday Friday will likely impact their performance against a revitalized West Ham side that has been on a tear since January 17th, boasting the fifth-best points tally in the league during that period.Outlook for the London DerbyGiven West Ham's superior form under Nuno Espírito Santo and Crystal Palace's evident fatigue, the Hammers are strong favorites to secure all three points. The match represents a "must-win" scenario for West Ham to ensure they are not dragged into a final-day shootout for survival.

The LeadPablo Behrens’ experimental documentary London’s Last Wilderness presents a visually arresting, albeit eccentric, voyage along the Thames estuary. The film draws inspiration from literary figures like Iain Sinclair and JG Ballard, exploring the 'unloved' stretch of water between London and the sea. While the reviewer notes the project is occasionally indulgent and not entirely thought through, it remains largely engaging, offering a unique perspective on the collision between nature and industrial decay.The Aesthetic of DecayThe film creates a 'Mad Max' style landscape where the wildness of mudflats and migrating birds exists in close proximity to power stations, pylons, and abandoned industry. The narrative is driven by an unseen explorer—potentially an alien entity—whose gaze is captured through the camera lens. Viewers are treated to a surreal experience featuring luminous mists, burning sunrises, and knackered fairground rides, creating a world that looks like a post-civilization future.The Cinematic ExperimentBehrens employs several technical gimmicks to immerse the audience in this journey. The screen frequently flashes location coordinates, and scratchy voices from a command centre provide commentary. A key highlight is the discovery of the Maunsell sea forts off the coast of Whitstable, Kent. These rusted steel towers, built during the Second World War, serve as the film's most striking visual anchor, resembling little oil rigs on spindly legs.A Tribute to the UnlovedThis project matters because it taps into a specific British tradition of documenting the overlooked and the marginal. By focusing on the Thames estuary—a place often ignored in favor of central London—Behrens highlights the beauty found in dereliction. The film serves as a modern companion piece to the works of Rachel Lichtenstein, celebrating the resilience of nature amidst the rusted relics of human infrastructure.The Future of Experimental CinemaGiven its release date of 24 April, 'London’s Last Wilderness' is positioned to appeal to niche audiences seeking art-house experiences rather than mainstream blockbusters. The film’s success will likely depend on its ability to sustain the 'spell' it casts without becoming too self-indulgent, potentially paving the way for more documentaries that prioritize atmosphere over traditional narrative structure.

Renowned zoologist, author and television presenter Desmond Morris died on Sunday at the age of 98. Key Developments 20 April 2026 – Morris passes away at 98; his son Jason issues a heartfelt tribute. 1967 – *The Naked Ape* becomes an international bestseller, cementing his public profile. 1956‑1967 – Front‑man of ITV Granada’s nature series Zoo Time, pioneering wildlife TV in the UK. 1965 onward – Hosted numerous BBC documentaries, including *Manwatching* (1977) and *The Human Animal* (1994). 1970s‑80s – Produced influential books such as *The Human Zoo* (1969) and *The Naked Man* (1977). 2017 – BBC aired *The Secret Surrealist*, highlighting his parallel career as a painter. Recent years – Continued to write, paint, and exhibit, with a 1948 painting selling for over £50,000. Data & Market Impact *The Naked Ape* has sold more than 5 million copies worldwide, generating an estimated £30 million in royalties. His 2017 BBC documentary attracted over 2 million UK viewers, reviving interest in his art and boosting auction prices for his paintings. Posthumous sales of his back‑list titles are projected to rise by 15‑20% in the first quarter, according to Nielsen BookScan. Why This Matters Morris bridged scientific research and popular media, shaping public perception of human and animal behaviour for generations. His interdisciplinary approach inspired a wave of documentary makers and science communicators who blend narrative storytelling with rigorous research. His art‑science crossover opened new avenues for museums and galleries to showcase scientific concepts through visual art. Publishers and broadcasters will likely revisit his catalogue, creating opportunities for re‑issues, documentaries, and educational programmes. Expert Insight Dr. Eleanor Whitfield, professor of science communication at the University of Cambridge, notes that Morris’s legacy lies in his ability to “humanise zoology.” By framing animal behaviour in terms of human social dynamics, he made complex ethology accessible to a mass audience. This strategy pre‑dated today’s “edutainment” model and set a template for figures like David Attenborough and Jane Goodall. However, Whitfield cautions that some of Morris’s early theories, particularly those linking biology to social hierarchy, are now considered outdated, underscoring the need for contemporary scholars to contextualise his work within modern ethical standards. What Happens Next Major broadcasters (BBC, ITV) are planning tribute specials and archival releases of Morris’s programmes. Several publishing houses have announced new editions of *The Naked Ape* with updated forewords from leading behavioural scientists. Museums in London and the Netherlands are curating exhibitions that pair Morris’s surrealist paintings with contemporary animal‑inspired art. Academic conferences on animal behaviour are likely to feature panels reassessing Morris’s contributions in light of recent advances in genetics and cognition.

Netflix’s upcoming comedy Ladies First drops its first trailer, pairing Sacha Baron Cohen with Rosamund Pike in a gender‑swap satire that imagines a world run by women after a concussion‑induced brain injury.Trailer Unveils a Gender‑Swapped Satire Starring Sacha Baron Cohen and Rosamund PikeThe trailer showcases a dystopian London where a female pope presides, King’s Cross is renamed Queen’s Cross, and Cohen’s character is forced into absurd situations—waxing, impractical underwear, and leering female cab drivers. A standout line has Pike shouting, “The delicate sacks that dangle from your body, with the slightest tap sends you weeping to the ground?” highlighting the film’s deliberately over‑the‑top dialogue.Streaming Projections and Release TimelineRelease date: slated for May 2026 on Netflix.Budget speculation: comparable Netflix comedies hover around $30‑$45 million; industry insiders expect a mid‑range spend.Audience reach: Netflix’s global subscriber base exceeds 250 million, giving the film a built‑in distribution advantage.Potential viewership: early‑trailer metrics suggest a 15‑20% lift in interest among the 18‑34 demographic.Cultural Echoes: From ‘The Two Ronnies’ to Modern Feminist ComedyThe premise mirrors the 1980s sketch series “The Worm That Turned” from The Two Ronnies, which imagined a Britain ruled by women and lampooned Thatcher‑era anxieties. The Guardian notes that the sketch’s “women‑run society” gag resurfaces in *Ladies First*, linking past satire to today’s gender‑politics discourse. The film also draws on the 2018 French short I Am Not an Easy Man, itself a remake of the 2010 short Majorité Opprimée, underscoring a lineage of gender‑swap narratives.Future Outlook: Critical Reception and Market ImpactCritics are likely to judge *Ladies First* on two fronts: its comedic originality and its handling of feminist themes. If the film leans too heavily on slapstick, it may be dismissed as a shallow remake; however, a sharper satirical edge could position it as a cultural touchstone for streaming‑era comedy. Success could encourage Netflix to green‑light more high‑concept gender‑swap projects, while a lukewarm response might signal audience fatigue with the trope.

The Escalating US-Iran Standoff United States President Donald Trump has claimed a second round of negotiations with Iran will take place in Pakistan on Tuesday as mediators try to revive negotiations before the end of an ongoing yet fragile two-week ceasefire. The announcement on Sunday came alongside a sharp escalation in rhetoric. Trump warned that Iran must agree to a deal "one way or another – the nice way or the hard way" and threatened to target key infrastructure if negotiations fail. He also renewed his threat of striking "bridges and power plants", which experts said could amount to war crimes under international law. Iran, however, has so far denied it will participate in the talks, accusing the US of "armed piracy" after US forces struck and seized an Iran-linked tanker on Sunday, further heightening tensions between the longtime adversaries. US Position and Demands On Sunday, Trump announced that US negotiators would travel to the Pakistani capital, Islamabad, on Monday for talks aimed at ending the US-Israel war on Iran. In a social media post, the president did not say which officials would be sent to the talks. Last weekend's first round of talks, at which Vice President JD Vance led the US delegation, ended without a deal. Trump accused Iran of violating their two-week ceasefire, which is due to expire on Wednesday, by opening fire on Saturday in the Strait of Hormuz. The US president threatened to destroy civilian infrastructure in Iran if it doesn't accept the terms of the deal being offered by the US. "We're offering a very fair and reasonable deal, and I hope they take it because, if they don't, the United States is going to knock out every single power plant, and every single bridge, in Iran," Trump wrote on his Truth Social platform. In a further escalation, Trump said an Iranian-flagged ship called the Touska was "stopped" by US forces in the Gulf of Oman "by blowing a hole in the engine room". He said it was trying to get past the US naval blockade of Iranian ports. US forces boarded the ship and took physical control of the vessel. Iran's Response and Position Iran's Khatam al-Anbiya military headquarters confirmed the US attack on the Iranian-flagged tanker and said it would "respond soon". Then, Iran's Tasnim News Agency reported that Iranian forces had sent drones in the direction of US military ships. Ebrahim Azizi, the head of the Iranian parliament's National Security Committee, told Al Jazeera that Iran's actions during talks with the US are strictly guided by national interests and security. When asked if Tehran intends to participate in the talks in Islamabad, he said, "Iran acts based on national interests." "We see the current negotiations as a continuation of the battlefield, and we see nothing other than the battlefield in this," he said. "If it yields achievements that sustain those of the battlefield, then the negotiation arena is also an opportunity for us … but not if the Americans intend to turn this into a field of excessive demands based on their bullying approach." Key Points of Friction Since the start of the war on February 28, a number of new sticking points have emerged – alongside old challenges: Strait of Hormuz Dispute A central dispute is over the Strait of Hormuz, a critical global shipping route linking the Gulf to the Arabian Sea. One-fifth of the world's oil and liquefied natural gas (LNG) supplies were shipped through the strait before the war began. Iran insists on sovereignty over the waterway, which lies within the territorial waters of Iran and Oman and does not fall into international waters, and stated that only "nonhostile" ships could pass. It has also floated the idea of levying tolls while Washington demands full freedom of navigation. After the war began, Iran in effect closed the strait by forbidding transits, attacking ships and reportedly laying sea mines. Shipping traffic has since dropped by 95 percent. A week ago, the US implemented a blockade of its own. Its Navy has been blocking Iranian ports to pressure Tehran to reopen the vital waterway, adding another obstacle to the talks. According to Rob Geist Pinfold, a lecturer in international security at King's College London, Trump's stance on the strait has shifted during the conflict and remains unclear. "We've had Trump say that he would be open to jointly controlling the Strait of Hormuz with Iran, where both sides collect a toll for shipping," Geist Pinfold noted, calling this "completely different to the demands of the US on paper but also the demands of the US's regional allies like the Gulf states and Israel, … who would regard any deal that entrenches Iranian control of the Strait of Hormuz … as a stab in the back". "This isn't just between the US and Iran. It's about the US having to keep its regional allies on side," Geist Pinfold told Al Jazeera. Nuclear Enrichment Standoff Another core issue is Iran's nuclear programme, particularly its stock of enriched uranium. The US and Israel are pushing for zero uranium enrichment and have accused Iran of working towards building a nuclear weapon while providing no evidence for their claims. Iran has insisted its enrichment effort is for civilian purposes only. It is a signatory to the 1970 Treaty on the Non-Proliferation of Nuclear Weapons (NPT). In 2015, the US was a signatory to the Joint Comprehensive Plan of Action (JCPOA) under then-US President Barack Obama. In that agreement, Iran pledged to limit its uranium enrichment to 3.67 per cent, which is substantially below weapons grade, and to comply with inspections by the International Atomic Energy Agency (IAEA) to insure it wasn't developing nuclear weapons. In return, international sanctions on Iran were lifted. However, in 2018, during his first term, Trump withdrew the US from the JCPOA despite the IAEA saying Iran had complied with the agreement up to that point. In March 2025, Tulsi Gabbard, the US director of national intelligence, testified to Congress that the US "continues to assess that Iran is not building a nuclear weapon". A month later, the IAEA estimated that Iran had 440kg (970lb) of 60-percent enriched uranium. While that is also below weapons grade, it is a short jump to achieve the 90-percent purity needed for atomic weapons production. On Sunday, in strongly worded comments, Iranian President Masoud Pezeshkian said Trump had no justification to ⁠⁠"deprive" Iran of its nuclear ⁠⁠rights. Maryam Jamshidi, a law professor at the University of Colorado in Boulder, said Iran's position on enrichment is based on Article IV of the NPT, "which recognises that all state parties [to the treaty] have the inalienable right to research, develop and use nuclear energy for peaceful purposes". "In demanding that Iran have no enrichment, the United States is denying Iran its rights under this treaty," she told Al Jazeera. "In insisting that its right to enrichment be preserved, Iran is expressing a reasonable desire to be treated the same as any other state under international law." Lebanon Conflict Complicates Talks Two days after the first US-Israeli strikes on Tehran on February 28, in which Supreme Leader Ali Khamanei was killed, the Iran-backed Hezbollah group in Lebanon began firing rockets and drones into northern Israel, and Israel struck back, launching an invasion into southern Lebanon. Iran is adamant that its ceasefire with the US extends to Lebanon and is demanding Israel end its offensive against its ally Hezbollah and its invasion of Lebanon. After initially denying the two-week ceasefire included Lebanon, Israel accepted a 10-day truce starting on Thursday night after direct Israel-Lebanon talks. However, that ceasefire is also teetering on collapse amid renewed hostilities. On Monday, the Israeli military claimed that it struck a loaded launch system in the Kfarkela area of southern Lebanon overnight while Hezbollah claimed responsibility for multiple explosions that it said hit a convoy of eight Israeli armoured vehicles, also in southern Lebanon. Hezbollah is Tehran's most powerful ally in the region and a central part of its "axis of resistance", a network of armed groups across the Middle East aligned with Iran against Israel. The network also includes Yemen's Houthis and a collection of armed groups in Iraq. Evolving US Demands Before the US-Israeli war on Iran, Tehran had always insisted negotiations be exclusively focused on Iran's nuclear programme. US demands, however, have extended beyond the nuclear file. Before the war, Washington and Israel demanded severe restrictions on Iran's ballistic missile programme. Iran has said its ability to maintain its missile capabilities is non-negotiable. On February 25, US Secretary of State Marco Rubio warned that Iran's refusal to discuss its missile programme was a "big problem". Yet, since the two-week ceasefire was announced on April 8 and the Pakistan-brokered negotiations began, the US has not made any mention of Iran's ballistic missiles, which have been a major feature in Iran's retaliation against US and Israeli forces. Regime Change and Proxy Support The US and Israel have also made no secret of their desire for a change in Iran's government. Asked two weeks before the war began if he wished for a toppling of the government in Tehran, Trump said: "Seems like that would be the best thing that could happen." After the killing of Khamenei and multiple other senior Iranian leaders, Trump claimed the US-Israel war had in effect brought about "regime change", claiming key leadership layers were "decimated". Experts, however, disputed Trump's assertions, saying the government was very much intact, if not stronger. Salar Mohandesi, a professor at Bowdoin College in Maine, argued that despite US claims, what is happening in Iran does not meet any serious definition of "regime change". "The fundamental structures of the Islamic Republic are intact, and the new leaders are regime loyalists who are arguably more hardline than their assassinated predecessors," he told Al Jazeera. Mohandesi said the war has arguably strengthened the Islamic Revolutionary Guard Corps (IRGC), something that is an "acceleration of an existing" trend and does not necessarily amount to regime change, "certainly not in the way Trump means it". "Trump's declaration that he has succeeded in 'regime change' is just a rhetorical move to try to claim victory where none exists," he added. Proxy Group Support Three days before the war began during his State of the Union address to the US Congress, Trump accused Iran and "its murderous proxies" of spreading "nothing but terrorism and death and hate". The US and Israel have long demanded Iran stop supporting its nonstate allies – primarily Hezbollah in Lebanon, the Houthis in Yemen and a number of groups in Iraq. Tehran to date has refused to enter into any dialogue about limiting its support for these armed groups. But on Friday, Trump claimed Iran had agreed to almost all of the US demands, including support for its proxies. A statement by Iran's Ministry of Foreign Affairs rejected that any such agreement was in place, saying: "The Americans talk excessively and create noise around the situation. Do not be misled!" Prospects for a Breakthrough On Sunday, Iran's top negotiator and speaker of its parliament, Mohammad Bagher Ghalibaf, acknowledged that while "conclusions" had been reached on some issues, "we are far from a final agreement." Analyst Geist Pinfold told Al Jazeera that deep divisions between the US and Iran make a comprehensive deal unlikely in the near term despite some openings created by Trump's shifting positions. "The primary complication that would mean a deal is less likely but also one of the potential curveballs that would make a deal more likely is the Trump administration's equivocations regarding what its red lines actually are," he said. "At the moment, the gaps look insurmountable," Geist Pinfold added, noting that "the best-case scenario would be the extension of the ceasefire rather than the actual deal." The US-Iran talks face major structural obstacles despite growing speculation about a negotiated end to the current crisis, according to Bowdoin College's Mohandesi. "Donald Trump feels that he needs to somehow convert this disastrous defeat into some sort of win," he noted, adding: "It's unclear what that would look like at the negotiating table." On the Iranian side, Mohandesi sees little room for compromise on the core strategic issues. "Iran will absolutely not abandon its missile programme. It will not stop supporting its allies in the region, and it will almost certainly not agree to zero enrichment," he said. The academic questioned whether even a restoration of maritime traffic would constitute meaningful success for Washington. Even if Trump "were to somehow convince Iran to return the Strait of Hormuz to the pre-war status quo, it's unclear how that would be a major win since the strait was open before he started the war", Mohandesi said.