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The Revolutionary GeneticistCraig Venter, the pioneering geneticist who revolutionized genome sequencing and challenged traditional scientific approaches, has died at age 79. His announcement at the 2001 BioVision conference that humans possess only about 30,000 genes—far fewer than the previously estimated 100,000—shattered scientific assumptions about genetic determinism. "We simply do not have enough genes for this idea of biological determinism to be right," Venter declared, emphasizing that human diversity is shaped primarily by environmental influences rather than hard-wired genetic code.The Breakthrough in Genome SequencingVenter's most significant contribution was developing the revolutionary whole genome shotgun sequencing technique, which allowed for faster, more efficient genome mapping. In 1995, his team achieved the remarkable feat of sequencing the first genome of a living organism, the bacterium Haemophilus influenzae. This breakthrough led to the founding of Celera Genomics in 1998, which aimed to sequence the entire human genome using Venter's innovative methods.The competition between Venter's privately funded Celera and the publicly funded Human Genome Project, spearheaded by the US government and UK's Wellcome Trust, created what scientists described as "testosterone-driven" rivalry. Despite tensions, this competition dramatically accelerated progress in genomics research, culminating in the announcement of the first draft human genome sequence at a White House ceremony in June 2000.The Scientific MaverickVenter was as famous for his bold personality as for his scientific achievements. A brilliant entrepreneur and unapologetic self-promoter, he enjoyed showcasing his success, private plane, yacht, and luxury watches. This flamboyant approach made him both admired and controversial. James Watson, co-discoverer of DNA's double-helix structure, compared Venter to Hitler for attempting to patent human genes, while others nicknamed him "Darth" Venter after the Star Wars villain.His tendency to break scientific protocols became evident when he revealed that much of the DNA used in Celera's human genome sequencing came from his own cells—a decision that annoyed scientists who felt he had subverted standard processes. "I've been accused of that so many times, I've got over it," Venter responded, noting that the analysis revealed he had an abnormal fat metabolism and elevated risk of Alzheimer's disease.A Life Shaped by Science and WarBorn in Salt Lake City, Utah, Venter had an unconventional path to scientific greatness. Growing up in California, he had a poor academic record and initially pursued "pursuits that involved drink, girls and bodysurfing" rather than education. His life took a dramatic turn during the Vietnam War, where he served as a senior corpsman in a naval hospital's intensive care unit in Da Nang."I witnessed several hundred soldiers die, more often than not while I was massaging their hearts – at times with my bare hand – or attempting to breathe life into them," Venter recalled. "Vietnam would teach me more than I ever wanted to know about the fragility of life." This experience sparked his interest in life sciences, leading him to study at the University of California, San Diego, where he earned a PhD in physiology and pharmacology in 1975.The Legacy of a Scientific PioneerAfter being dismissed as head of Celera in 2002, Venter used his substantial payoff to endow the J. Craig Venter Institute with $100 million. There, he pursued ambitious projects including designing energy-producing microbes and synthesizing bacterial genomes. He later founded Human Longevity and Diploid Genomics, companies that aim to combine artificial intelligence with advances in aging research and gene sequencing to extend human lifespans and improve disease diagnosis.While some of Venter's claims about the primacy of environmental influences over genetics have been questioned, his impact on genomics research remains undeniable. His revolutionary sequencing techniques transformed the field, and his competitive approach accelerated what would have otherwise been a much slower process of mapping the human genome. As the scientific community remembers Craig Venter, it acknowledges a complex figure who was simultaneously a brilliant innovator, a controversial competitor, and a transformative force in our understanding of life's fundamental building blocks.

Global Study Quantifies Gender Attractiveness Gap Across AgesThe research team led by Dr Eugen Wassiliwizky at the Max Planck Institute for Empirical Aesthetics compiled the world’s largest dataset on facial attractiveness, drawing from 52 studies across 76 countries.Numbers Behind the Gap: 1.5 Million Ratings Reveal 60% Preference1.5 million attractiveness ratings17,000 distinct faces evaluated30,000 individual ratersAverage female face rated more attractive than 60% of male facesGap strongest in Western cultures, present across all sexual orientationsWhen participants rated themselves, the gender gap vanished, underscoring the role of external perception.Implications for Evolutionary Theory and Social PerceptionThe findings revive debate over Darwinian sexual selection. While Darwin noted male ornamentation in many species, he considered humans an exception where male competition dominated. This study suggests a universal bias toward rounder, more feminine facial structures, which may be linked to infant‑like features rather than purely cultural norms.Historical language—"the fairer sex", "le beau sexe"—reflects a long‑standing perception that the research now quantifies.Future Research Directions and Societal ShiftsAs the attractiveness gap diminishes after age 80, researchers hypothesize that facial structural differences shrink with age, reducing perceived bias. Ongoing work will explore:Neuro‑cognitive responses to facial roundness across agesCross‑cultural variations beyond the current datasetPotential impacts on age‑related social dynamics and media representationThe study, published in Proceedings of the Royal Society B, calls for cautious interpretation but highlights a robust, global pattern that challenges purely cultural explanations.

The British Solving Championship: An Opportunity for Chess Enthusiasts This week’s puzzle is a chance to enter an annual national competition in which Guardian readers ­traditionally perform well and in ­considerable numbers. White in the diagram, ­playing as usual up the board, is to play and checkmate in two moves, against any black defence. The Event Details The puzzle is the first stage of the annual Winton British Solving Championship, organised by the British Chess Problem Society and sponsored by the investment ­managers ­Winton. This competition is only open to ­British ­residents and entry is free. To take part, simply send White’s first move by post to Nigel Dennis, Boundary House, 230 Greys Road, Henley-on-Thames, Oxon RG9 1QY, or by email to [email protected]. Entry Requirements and Deadline All entries must be postmarked or emailed no later than 31 July 2026. Entrants must provide their name and home address. Juniors under 18 on 31 August 2025 must also give their date of birth. The Competition Structure The best 15-20 players from the postal round, plus the best juniors, will be invited to the final at Harrow school on Saturday 13 February 2027, where the prize money is expected to be at least £1,600. The winner of the final will have the right to represent Great Britain at the 2027 world ­solving championships, an event where GB are often medal contenders. A Note on Chess and Professionals Back in the 1950s most top English players were amateurs, often civil servants or teachers, who competed in tournaments during their vacations. After the 1970s Fischer boom and English successes brought an influx of sponsors, chess professionals could earn a decent living, but the tide turned again during the 1990s. The breakup of the Soviet Union brought harder international competition, while Nigel Short’s world title defeat and the move to screen rather than print marketing drove sponsors away. A New Grandmaster: Harry Grieve Harry Grieve became England’s latest grandmaster on Tuesday when the 25-year-old, who was British champion in 2022 and helped CSC/Kingston finish second in this season’s UK 4NCL League, won first prize in Budapest with a 7/9 total.

The Inevitable Relegation West Ham's relegation to the Championship has been confirmed, a bitter pill to swallow for the London club. Despite a convincing 3-0 victory over Leeds, the team's fate was sealed by Tottenham's win over Everton. This marks a disappointing end to the season, with the club's struggles on the pitch reflecting a deeper malaise. The Executive Failure The root cause of West Ham's downfall lies in its executive leadership. The club's ownership, led by David Sullivan, has been criticized for its complacency and lack of vision. The team's failure to adapt to changing circumstances and improve its performance has led to this point. The Financial Implications The financial implications of relegation are significant, with estimated losses of £100m in the first season alone. This will likely lead to job losses and a reduction in staff, as well as a decrease in the club's overall value. The Way Forward As West Ham looks to the future, it is clear that changes are needed. The club will likely undergo a period of restructuring, with potential changes to its management and playing staff. The appointment of a new manager and the departure of key players, such as Jarrod Bowen and Mateus Fernandes, are already on the cards. A New Era for West Ham? The relegation of West Ham presents an opportunity for the club to rebuild and rebrand itself. With a new approach and a renewed focus on developing young talent, the club may be able to recover and return to its former glory. However, this will require a fundamental shift in its approach to the game and its relationship with its fans.

Phyllida Barlow's Disruptor Exhibition at Wolterton Hall Phyllida Barlow's exhibition 'Disruptor' at Wolterton Hall in Norfolk is a thought-provoking showcase of her unconventional sculptures and installations. The exhibition challenges the traditional grandeur of the stately home, transforming it into a space for contemporary art. The Exhibition's Concept and Curation The exhibition is curated by Simon Oldfield, Wolterton's artistic director, who has reinvented the space to make room for new ideas. Barlow's works, which seem to take on a life of their own, are a perfect fit for this vision. Her exhibition begins at the entrance with the installation 'Untitled: Stacked Chairs', a cacophony of red plywood chairs that feels like a statement about throwing things out and starting again. Barlow's Sculptures and Installations Throughout the exhibition, Barlow's sculptures and installations are displayed in various rooms of the stately home. Her works are made from unconventional materials such as latex, cement, hessian scrim, plaster, and rope. One of her early works, 'Loaf', is a tar-black glass and paper coated with latex, resembling a loaf of bread. Her recent wall sculptures, cobbled together with cement, hessian scrim, plaster, and other materials, look like big gobs of bubblegum stuck rudely to the wall. The Impact of Barlow's Work Barlow's work is about what materials communicate. The house says, 'I am here, I'm important – Barlow says, everything is precarious, nothing goes as planned.' Her works are a commentary on the impermanence of things and the challenge to traditional notions of art and architecture. The Future of Wolterton Hall The exhibition is part of Wolterton Hall's ongoing transformation into a space for contemporary art. The hall's owners, the Ellis family, have been working to reinvent the space, and Barlow's exhibition is a key part of this vision. The exhibition runs until 31 October and is a must-see for anyone interested in contemporary art and the transformation of traditional spaces.

The Unconventional Auction Artists Hilary Powell and Dan Edelstyn are auctioning off their work from the past decade and a half to help fund a community-led renewable power station in Nigel Farage's Clacton constituency. The big-ticket item going under the hammer will be the remnants of a gold Ford Transit van containing £1.2m in fake banknotes that the pair blew up in London's Docklands in 2019. The Blown-Up Van The van wreckage and charred banknotes were gathered up and reconstituted as an Alexander Calder-like mobile that, for a while, hung in Cambridge's Fitzwilliam Museum. Now, for perhaps £100,000, this sculpture could be the centrepiece of your living room. Powell hopes that the exploded van will be bought by a public institution. The Fundraising Goal The pair hope to raise at least £250,000 for the project. Alongside the in-person auction, they are hosting an online iteration that will run until 31 May. They currently have £750 and need about 250 times that to fund the project. The Purpose Behind the Project The pair call what they do Method Art. They aim to build a community-owned renewable power station in Reform's first seat as a response to the party's donations from oil and gas interests, highly polluting industries, and climate science deniers. The Future of Community-Owned Renewable Energy The proceeds from the auction will bankroll the work the pair are doing to set up in Clacton and to make a film about the project. If they sell the blown-up van, the proceeds will be core funding for their not-for-profit production company. The funding for the power station will come from issuing shares and other fund-raising to create a community benefit society.

The Lead The Museum of Homelessness in London is hosting an exhibition titled 'Criminal: An Untold Story of Homelessness, Resistance and Survival', which explores the criminalization of homeless people and nomadic communities over the last 400 years. The Exhibition's Powerful Message The exhibition features an installation by Romany Gypsy poet, performance artist, and journalist Gemma Lees, which includes a trim caravan with china decorated with Sun newspaper headlines criticizing Gypsy and Traveller encampments. The installation highlights the stark contrast between the cozy interior of the caravan and the harsh realities faced by nomadic communities. The History of Criminalization The exhibition takes visitors on a chronological journey through the history of criminalization, from the Egyptians Act of 1530 to the 2022 Police, Crime, Sentencing and Courts Act. It showcases how laws have been used to marginalize and criminalize homeless people and nomadic communities. The Impact on Homelessness London is currently facing a record high level of homelessness, with over 13,000 people sleeping rough in 2024-2025, a 10% increase from the previous year and a 63% rise over the past decade. The exhibition aims to raise awareness about the issue and provide a platform for discussion. The Future of Homelessness Support The Museum of Homelessness not only serves as a museum but also provides community support and acts as a cold weather shelter in winter. The exhibition 'Criminal' is a timely and powerful reminder of the need for better solutions to address homelessness and the criminalization of vulnerable communities.

The Legacy of the White Hotel The White Hotel, a Salford venue housed in a former MOT garage, has been a generator for underground culture in the north-west for over a decade. Its programme has spanned classical music ensemble the Manchester Collective, a celebration of Bertolt Brecht, and Andy Weatherall's last ever DJ set. The Event Details The White Hotel will shut up shop in January due to its location in a flood-risk zone. The venue's artistic director, Austin Collings, and caretaker, Ben Ward, decided it was better to close on their own terms rather than risk becoming a museum. The Data Analysis The White Hotel has hosted sold-out gigs from notable acts such as Damo Suzuki and William Basinski. The venue has a 300-capacity space that was overwhelmed by a 2015 gig with Detroit legend DJ Stingray. The Impact Analysis The White Hotel's closure will erase a rare club built from the ground up, fueled by a spirit of experimentation and collaboration, disregarding the profit motive. However, its spirit will mutate, and the team behind the venue are celebrating its legacy with a new three-day festival, the Black Lights, in venues around Blackpool. The Prediction The team behind the White Hotel are launching a film production company, with Collings' directorial debut, a short titled Wild Bodies, set to go on the festival circuit with a soundtrack by the Coral. The future of the Black Lights festival is dependent on ticket sales, but it aims to continue the White Hotel's legacy of experimental and underground culture.

The Masterpiece of John Woo The title of this 1990 John Woo extravaganza might lead the uninitiated to expect a chillingly focused, targeted assassination. Actually, there are innumerable bullets and innumerable heads in this over-the-top gonzo spectacle. It is a crime thriller, a wartime action film set in Vietnam, but it offers something other than the usual Hollywood perspective; it is a parable of greed comparable to The Treasure of the Sierra Madre, and even a kind of romantic melodrama. The Symbolic Bullet There is, however, one key bullet in a head, a literal bullet lodged in the skull of someone who achieves a macabre zombie-like semi-survival, the bullet being symbolic of the way violence takes root in the brain, dehumanising its victim. The final “boardroom” scene disclosing this image is toweringly mad and strange. Yet in this movie, as in so many other Woo films, we can see how the director counterintuitively uses sad music – harmonica, woodwind – over grisly, brutal action sequences, as if what he wants us to register is not the violence or the shock but just how poignantly futile and pathetic it all is. The Plot Unfolds The setting is – initially – late 60s Hong Kong; Tony Leung plays Ben, a young guy getting married to his sweetheart Jane (Fennie Yuen), and on hand are his buddies Frank (Jacky Cheung) and Paul (Waise Lee). This trio are involved in a gang war with a rival mob who corner Frank when he has gone to get cash from the local moneylender to pay for the wedding. The confrontation ends in violence and, simply to get away and avoid the heat – Woo has a cameo as a police inspector – the three guys accept a crooked job from a local gang boss smuggling contraband pharmaceuticals in Vietnam. The Climax In Saigon, all their plans explode in pure anarchy; they are at first arrested under suspicion of working for the Vietcong, then upgrade their strategy to cynical arms smuggling for the North Vietnamese, and stealing the gold belonging to the local wiseguy who was supposed to be distributing their drugs. They make contact with a worldly fixer called Luke (Simon Yam), who has a Catherine Deneuve poster in his apartment, and also gallantly undertake to rescue a Hong Kong singer Sally (Yolinda Yam), who has been trafficked to Vietnam to sell sex. They end up on the spectacular field of battle itself (with helicopters, explosions, burning villages), where Paul, increasingly obsessed with the gold, finds himself at a key moment at mortal risk of detection if he cannot keep the wounded Frank quiet, whose cries of pain might alert the enemy to their position. The Legacy It’s an extraordinary, uninhibited barnstormer from Woo, who takes us from regular, domestic crime to military chaos with confidence and sweep. One moment, in which someone stands in front of a tank, even appears to echo the Tiananmen Square protests. No one else could have made it. The Release Bullet in the Head is in UK cinemas from 1 June, and on 4K UHD and Blu-ray from 22 June.