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Sam Neill, the veteran actor celebrated for his memorable performances on screen, is set to answer readers' questions in an upcoming interview with The Guardian. Neill's iconic roles include his portrayal in Jurassic Park, where he famously removes his sunglasses and gazes at a towering Brachiosaurus, a scene that has become etched in cinematic history.Born in Northern Ireland and raised in New Zealand, Neill's diverse filmography showcases his versatility as an actor. He has appeared in a range of films, from period dramas like My Brilliant Career to thrillers such as Dead Calm, which is set to be released in 4K later this year. His recent projects include Godzilla x Kong: Supernova, alongside Kaitlyn Dever and Matthew Modine.Neill's career has been marked by his ability to take on idiosyncratic, director-led projects, often playing characters with a unique blend of gruffness and warmth. His performances in Sweet Country and Rams have been particularly noted for their depth and nuance.In addition to his film work, Neill has also made headlines for his memoir, Did I Ever Tell You This?, in which he openly discusses his experience with stage-three blood cancer and his journey towards remission. When asked about his mortality, Neill expressed a pragmatic view, stating, “I’m not afraid to die, but it would annoy me”.Readers are invited to post their questions for Sam Neill by 6pm BST, Thursday 16 April, and The Guardian will publish his answers in their reader interview series. This provides a unique opportunity for fans to engage with one of cinema's most beloved actors and gain insight into his life and career.

Recent CDC data reveal a dramatic 1,200% increase in kratom‑related poisonings across the United States over the last ten years, with the most pronounced surge recorded in 2025. Researchers link this rise to the growing presence of 7‑hydroxymitragynine (7‑OH), a synthetically produced compound that mimics kratom’s effects but carries opioid‑like risks. Walter Prozialeck, pharmacology professor at Midwestern University, said the trend was expected, noting that the synthetic alkaloid has entered the market through energy drinks and other products since 2024. Christopher McCurdy of the University of Florida warned that marketing 7‑OH as “enhanced kratom” blurs the line for consumers, turning poison‑control calls into a conflated metric for both natural and synthetic products. By contrast, natural kratom (Mitragyna speciosa)—a Southeast Asian plant used for centuries as a pain reliever—has demonstrated a relatively favorable safety profile in animal and human studies. A 2018 statement from then‑HHS Secretary Brett Giroir rejected the DEA’s push to schedule kratom as a Schedule I substance, citing insufficient evidence of harm. Despite the scientific distinction, several states have moved to implement or propose blanket bans on all kratom products, prompting concern from clinicians and patient advocates. A recent user survey indicated that about 50% of respondents rely on kratom for chronic pain, while roughly 40% use it during addiction recovery. Personal testimonies underscore the plant’s therapeutic role. Jeff Maslan, a 68‑year‑old Californian with severe osteoarthritis, credits kratom with easing opioid withdrawal after multiple surgeries. Similarly, “Steven,” a disabled California resident, describes how kratom eliminated unbearable oxycodone withdrawal symptoms without producing the euphoric “warm fuzzy” feeling typical of opioids. Researchers emphasize that 7‑OH carries genuine opioid hazards, including addiction, severe withdrawal, and respiratory depression that can lead to fatal overdose. In animal models, 7‑OH demonstrated the same respiratory‑depression risk as classic opioids, whereas kratom’s primary alkaloid did not. Prozialeck and colleagues explain that kratom’s pharmacology is more nuanced: it partially activates opioid receptors while also engaging adrenergic and serotonin pathways, resembling a hybrid of a weak opioid and an SNRI‑type antidepressant. This multimodal action likely accounts for its lower euphoric potential and the reported boost in energy among users. Nevertheless, experts caution that kratom is not without risk. Fatal poisonings often involve co‑ingestion of potent opioids such as fentanyl, suggesting that some users may cycle between kratom and stronger substances, raising overdose danger due to reduced opioid tolerance. Additionally, heavy‑metal contamination has been detected in certain kratom batches, though the source—soil, processing, or storage—remains unclear. Given these complexities, the consensus among scholars like Austin Zamarripa (Johns Hopkins) is that natural kratom should remain accessible, while concentrated 7‑OH products merit stricter regulation. “These products may offer meaningful benefits to some individuals, and those benefits could be lost if access is restricted too broadly,” Zamarripa said, urging a differentiated policy approach. As the debate unfolds, patients like Steven worry that a sweeping ban would ignore the nuanced safety profile of the plant. “There’s corn on the cob, there’s high‑fructose corn syrup, there’s whiskey— all derived from corn but fundamentally different,” he remarked, highlighting the need for targeted, evidence‑based regulation rather than a one‑size‑fits‑all prohibition.

The economic consequences of an Iran war could have devastating effects on global poverty, with 32 million people at risk of being pushed into poverty worldwide. The United Nations Development Programme (UNDP) warns that developing countries will bear the brunt of this impact. In a report released amid concerns over a fragile ceasefire, the UNDP highlights a 'triple shock' affecting energy, food, and economic growth. This conflict is reversing international development gains, with uneven regional impacts expected. Alexander De Croo, UNDP administrator and former Belgian prime minister, emphasizes that even if the war ends, its impact will persist, especially in poorer countries where people may be pushed back into poverty. He notes that those who had previously escaped poverty are now at risk of falling back into it. The report outlines three scenarios for the war's impact. In the worst-case scenario, involving six weeks of major disruption to oil and gas production and eight months of higher costs, 32.5 million people globally could fall into poverty. The UNDP uses the upper-middle-income poverty line, an international standard defined as income below $8.30 per person per day, calculated by the World Bank. To mitigate these effects, the UNDP suggests targeted and temporary cash transfers to protect vulnerable households in developing nations, estimating a cost of about $6 billion to neutralize the shocks for those falling below the poverty line. The agency also recommends interventions like temporary subsidies or vouchers for essential services. The news comes as Western governments face criticism for cutting aid spending amid economic pressures and increased defense spending. The UNDP and other international agencies stress the importance of maintaining or increasing development aid to support countries hardest hit by the economic fallout.

Three Very Large Crude Carriers (VLCCs) successfully navigated the Strait of Hormuz on Saturday, marking a rare movement of oil cargoes amid the fragile truce between the United States and Iran.The vessels – the Liberia‑flagged Serifos, and the China‑flagged Cospearl Lake and He Rong Hai – each can transport about 2 million barrels of crude, collectively representing a significant volume for a waterway that channels roughly 20% of the world’s oil and LNG shipments.According to data from the London Stock Exchange Group (LSEG) and analytics firm Kpler, the Serifos is chartered by Thailand’s state‑owned energy firm PTT. Loaded with Saudi and UAE crude in early March, it is slated to dock at Malaysia’s Malacca Port on April 21.The other two carriers, Cospearl Lake and He Rong Hai, are chartered by Unipec, the trading arm of Chinese energy giant Sinopec. Cospearl Lake, carrying Iraqi oil, is expected to reach China’s Zhoushan port on May 1, while the destination for He Rong Hai remains undisclosed.Earlier, a tanker named Ocean Thunder, chartered by a Petronas subsidiary, also transited the strait, underscoring a gradual, albeit limited, resumption of traffic.Despite these movements, hundreds of tankers remain stranded in the Gulf, awaiting clearance during the two‑week ceasefire. Their prolonged idling continues to pressure global energy prices, which have surged since Iran’s blockade began in late February.In addition to the loaded vessels, three empty tankers – Mombasa B, Agios Fanourios I, and Shalamar – were observed heading into the strait on Sunday to load fresh cargoes. Notably, Agios Fanourios I signaled a route to Iraq’s Basrah fields to pick up crude destined for Vietnam.Management firms such as Eastern Mediterranean Maritime, Cmb.Tech NV, and Pakistan National Shipping have not provided comments on the recent transits.While the passage of these three supertankers offers a modest relief to the global oil supply chain, the overall situation remains precarious. The continuation of the ceasefire and the resolution of Iran’s blockade will be critical determinants of oil market stability in the weeks ahead.

The collapse of talks between the US and Iran has sent shockwaves through global markets, fuelling fears of a prolonged energy crisis and rising inflation. The failure to reach a peace deal has left large numbers of oil tankers stuck in the Persian Gulf, with oil prices fluctuating wildly in response to the uncertainty.US Vice-President JD Vance has blamed the collapse of the talks on Tehran's refusal to abandon its nuclear weapons programme, while Iranian sources have hit back at what they describe as 'excessive' demands from Washington. The stalemate has raised concerns about the long-term impact on the global economy, with governments and central banks warning of higher inflation and interest rates.Mohamed El-Erian, an adviser to Allianz, has cautioned that uncertainty will continue to dominate assessments of the financial impact from the conflict. 'Absent a swift resumption of negotiations, the immediate reaction of financial markets when they open for the trading week will be to push oil prices higher and borrowing costs higher,' he said.The International Monetary Fund and World Bank's spring meetings in Washington will focus on the war's impact on the global economy, with the IMF's managing director, Kristalina Georgieva, indicating that the fund will present three scenarios predicting lower economic growth and higher inflation. The IMF is also expected to highlight the impact on vulnerable economies.In the short term, oil prices have ended the week lower, with Brent crude at $94.26 a barrel and West Texas Intermediate crude at $95.63 a barrel. However, global stock markets have rebounded after a temporary ceasefire was announced, with the S&P; 500 close to its level before the US-Israeli attacks on Iran began.

Brian Cox’s latest live show, ‘Emergence’, draws its spark from Johannes Kepler’s 1609 treatise ‘The Six‑Cornered Snowflake’. Cox explains that Kepler’s wonder at the symmetry of snowflakes, written during a Prague snowstorm, embodies the modern scientific quest to understand the origins of patterns we observe.He says the show explores three realms: what we know, what we don’t know, and what may remain unknowable. This framework sets the stage for his reflections on the biggest unanswered questions in science.If he could answer any scientific mystery, Cox would choose the existence of life beyond Earth. He points to current missions—two spacecraft heading to Jupiter’s moons and the James Webb Space Telescope probing exoplanet atmospheres—as promising avenues that might soon reveal a biosignature.When asked about the future of technology, Cox warns that the trajectory of artificial intelligence is still opaque, making it both thrilling and potentially hazardous. He adds that quantum computing is another frontier with wildly divergent timelines—some experts see breakthroughs within five years, others doubt they’ll arrive in a lifetime—highlighting the revolutionary yet unpredictable nature of these tools.Cox also reflects on his shifting stance toward social media. He admits moving from early optimism about its democratizing power to a more critical view of its noise and misinformation, while acknowledging its complex impact on politics and public discourse.On personal advice, Cox stresses the importance of following one’s passion: “Do what you most enjoy,” he says, recalling his own journey from a teenage musician to a celebrated astronomer, supported by parents who encouraged his interests.He shares a memorable fan encounter: at an ELO concert, a man introduced himself as Paul McCartney after asking a question about Saturn’s moon Enceladus—an encounter that left Cox “overwhelmed” as a lifelong Beatles fan.When asked about a pop‑culture stance, Cox admits he is largely out of touch, but notes that musical innovation seems to have plateaued since the 1980s, contrasting the rapid evolution of earlier decades.One of his favorite astronomical facts is the staggering number of observable galaxies: about two trillion. He highlights how, within a century, humanity moved from debating whether other galaxies existed to quantifying an immense cosmos, also measuring its age at roughly 13.8 billion years.Brian Cox will tour ‘Emergence’ across Australia from 5 to 30 May 2026.

The Artemis II crew has just returned from a ten‑day journey that looped around the Moon, marking only the second launch of the Artemis system and the first with humans aboard. NASA admits that the limited data from this mission makes risk assessment difficult.To date, the Artemis programme has consumed almost $100 billion (≈£75 billion). The U.S. Congress’s 2025 "one big beautiful bill" earmarked $9.9 billion for the upcoming Artemis IV and V flights, with even larger sums projected for a permanent lunar base.The scientific case for lunar exploration remains compelling: studying the Moon can illuminate the Solar System’s formation and provide a pristine platform for telescopes, especially on the far side where radio interference is minimal.However, the article questions whether human presence is essential. While astronauts still offer unique capabilities, the author suggests that within a decade robots—already proven on Mars by Curiosity and Perseverance—will outperform humans in cost, endurance, and operational flexibility.China’s lunar ambitions underscore the geopolitical stakes. After successful robotic orbiters and landers, Beijing retrieved the first far‑side soil samples in 2024 and plans a 2025 mission to the south pole with an orbiter, lander, and "mini‑hopper". By 2028, China aims to test equipment for a lunar base, potentially mirroring the U.S. push for crewed landings.Advances in AI, sensor technology, and autonomous navigation could soon enable robots to conduct near‑self‑directed scientific surveys and even construct infrastructure, diminishing the practical advantage of astronauts.Historical examples, such as the Hubble Space Telescope’s on‑orbit repairs, are revisited. The article cites Riccardo Giacconi’s view that, without the human element, multiple Hubble‑class telescopes could have been launched for the same budget, illustrating how crewed interventions may no longer be cost‑effective.The launch of the James Webb Space Telescope in 2021—operating far beyond the reach of routine astronaut servicing—demonstrates that complex, high‑value missions can succeed without crewed support, reinforcing the argument that human spaceflight now serves more as a prestige project than a scientific necessity.In conclusion, while the awe of viewing Earth from lunar orbit endures, the article contends that the future of space exploration will be defined by robots and private sponsorship, not by the costly and risky deployment of astronauts to the Moon or beyond.

The Artemis II mission is set to make a profound impact on the world, inspiring future generations to pursue careers in science, technology, engineering, and mathematics (STEM). The crew's journey represents a significant milestone in space exploration, uniting people across the globe in their quest for knowledge and discovery.As the world watches, the Artemis II mission is poised to ignite a sense of wonder and curiosity about the vastness of space and the possibilities that lie beyond our planet. By pushing the boundaries of human exploration, the crew is embodying the spirit of adventure and cooperation that defines humanity's pursuit of excellence.

Britain’s recent reversal of the on‑shore wind ban, announced by Energy Secretary Ed Miliband, has set in motion a wave of proposals to install more than one hundred colossal turbines across the Cambrian Mountains of mid‑Wales. The Cambrians, a 500‑square‑mile stretch of moorland and high ground that remains the most extensive wilderness south of Scotland, could soon host turbines reaching 220–230 metres – roughly 50% taller than any existing on‑shore turbine in England and Wales and more than twice the height of Big Ben. Each turbine would sit on a 2,000‑tonne concrete foundation and require at least 100 tonnes of steel. The scheme also envisions over 200 km of new pylons to link the farms to the National Grid, alongside roads, repair bays and storage depots. Analysts note that the construction phase would generate a substantial carbon footprint, especially given the turbines’ relatively short operational life of 20–25 years. Environmental organisations, including the Wild Wales Trust and the Campaign for the Protection of Rural Wales, have rallied against the plans, warning that they would "degrade and industrialise huge areas of the uplands and valleys" and could encroach on Wales’s sole UNESCO biosphere reserve in the Dyfi valley. Local opposition is hampered by the region’s sparse population, but activists have been posting hand‑drawn notices on the Glaslyn uplands and highlighting the visual impact of proposed turbine clusters – for example, a hilltop site slated for 26 turbines that would dominate the skyline across the country, and a location dubbed “Artists Valley” that could be renamed after a row of 37 similar structures. Critics argue that Wales, which is moving toward renewable self‑sufficiency and already exports surplus power, does not need these installations for its own energy security. Instead, the turbines appear designed to feed the broader UK grid, echoing historic instances where Welsh resources were harnessed for the benefit of other regions, such as the 1960s water transfers to Liverpool. With the Cambrian Mountains lacking any national‑park protection – a status denied in the 1950s due to local farming opposition – the landscape remains vulnerable to large‑scale industrialisation. The proposed developments raise a fundamental question: should a politician’s ambition for renewable credentials outweigh the preservation of one of Britain’s most pristine natural areas?