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The End of Purdue Pharma Purdue Pharma, the manufacturer of OxyContin, is slated to be dissolved by the end of the week as a comprehensive legal settlement takes effect. This settlement resolves thousands of lawsuits filed against the company for its role in the opioid crisis, which has claimed over 900,000 lives in the US since 1999. Terms of the Settlement As part of the deal, Purdue Pharma will admit to not having an effective program to prevent its powerful painkillers from being diverted to the black market. The company will also admit to paying doctors to prescribe the drugs and providing information to encourage more opioid prescriptions. The settlement includes $8.3 billion in forfeitures, fines, and penalties, although the company will only pay $225 million to the federal government. Victims' Reactions Many victims of the opioid crisis expressed frustration with the settlement, arguing that it does not provide them with real justice. Some asked the judge to reject the negotiated sentence, stating that it does not hold individual members of the Sackler family accountable. Over 54,000 people with personal injury claims voted to accept the settlement, while about 200 rejected it. The Sackler Family's Role Members of the Sackler family, who own Purdue Pharma, will contribute up to $7 billion over 15 years to fight the opioid crisis. Most of the funds will go to government entities. The settlement also shields family members from lawsuits over opioids for those who agree to the payments. A New Era for Purdue Pharma Under the settlement, Purdue Pharma will cease to exist and be replaced by Knoa Pharma, a new company with a board appointed by states and a mission to combat the opioid crisis. Millions of internal Purdue documents will be made public, and the Sackler family has agreed not to object to having their names removed from institutions they have supported.

East Darfur, Sudan — Hawa Adam did not expect a childhood illness to kill her son. Ali was two years old when he fell sick on February 25 in Labado, in Sudan’s East Darfur state. He died two days later.“I thought it was one of the ordinary childhood diseases,” the 37-year-old told Al Jazeera. “I never imagined I would lose my child to this epidemic.”Hawa attributes his death to the absence of basic medical care – no vaccination, no qualified doctors. “Most doctors”, she says, “left the area after the war broke out, forcing those with means to seek treatment abroad, in South Sudan or Uganda.”The Collapse of Routine Immunization in East DarfurA measles outbreak has struck several Labado districts since March, killing approximately 70 people and infecting about 1,000 others across 12 residential neighbourhoods, in a population of roughly 12,000, which includes displaced people who arrived during the war, according to Mohamed Abdel Aziz, 32, coordinator of the Labado crisis unit.Those numbers were disputed by East Darfur’s health director, Dr Jabir al-Nadeef, who confirmed to Al Jazeera that measles has struck four districts of the state, but only reported 300 cases and 26 deaths, figures that diverge substantially from those documented by the Labado emergency room.“Vaccines only arrived on April 11 from Chad via UNICEF [United Nations Children’s Fund ], after a prolonged period with no supply, and a vaccination campaign is scheduled to run from April 18 to 24 across the state,” he said.Measles is one of the world’s most contagious diseases, spread by contact with infected nasal or throat secretions or breathing in air that was breathed out by someone with measles, according to the World Health Organization (WHO). Outbreaks can result in severe complications and deaths, especially among young, malnourished children.Transmission: Contact with infected secretions or airborne particles.Current Coverage: Measles vaccination has fallen to 46 percent.Routine Immunization: First dose of diphtheria, tetanus, and pertussis dropped to 48 percent in 2024.Quantifying the Human Cost: Disputed Death Toll and Economic BarriersThe first measles cases in Darfur in the current outbreak were recorded in January, according to UNICEF. It is unfolding against the backdrop of a near-total collapse of public health infrastructure across Darfur, where war has gutted facilities, halted routine vaccination and driven out medical personnel.“We discovered the outbreak by accident,” Abdel Aziz, the coordinator, told Al Jazeera. The teams had been conducting home visits for a fire-prevention workshop when they saw the scale of the outbreak, with almost half of the homes visited having measles cases.In the al-Nil neighbourhood, Ismail Issa, 38, lost his two-year-old daughter Makarem on March 11. His brother Ahmed lost an 18-month-old son, Issa, on March 25. Then Hasan, the three-year-old son of Ismail’s sister Medeeha, died on March 23. All three families live in adjoining homes, and the infection passed between them.Abdel Aziz traced much of the death toll directly to a supply failure. Medicines ran out at the government health centre on February 23. Drugs remain available at private pharmacies, but most residents cannot afford them.Intravenous fluids: 8,000 Sudanese pounds ($20.50).Antibiotics: 10,000 to 15,000 pounds ($25.60 to 38.40).A Public Health Catastrophe UnfoldingAsmaa Jalaluddin, 28, lives in the Dar al-Naim West neighbourhood of Labado with her three children. Her three-year-old daughter, Mashaer Rajab al-Sheikh, fell ill on April 5 with fever, diarrhoea and persistent vomiting. She stopped eating and kept her eyes shut for four days.On April 8, Asmaa took her to the Labado health centre, where she was told her daughter had measles. With no medicines available, she was directed to travel to Shuairiya, 40 kilometres north. There, on April 10, Mashaer received fever reducers and vitamins and slowly began to open her eyes again. She was discharged two days later.Local doctors are now calling for intervention from international health organisations, noting that diseases that had been eliminated are returning.UNICEF spokesperson for Sudan, Eva Hinds, told Al Jazeera that “measles cases continue to be reported across Darfur, with insecurity, displacement, damaged health facilities, and prolonged disruption to routine immunisation all constraining the response.”UNICEF says that a measles-rubella vaccine catch-up campaign has been completed across all localities in Central Darfur and West Darfur, as well as parts of North and South Darfur, reaching approximately 2.1 million children aged nine to 14. Vaccination in remaining areas, including East Darfur, is scheduled for mid to end of April, aiming to reach close to 750,000 children across all nine of the state’s localities.The Long Road to RecoveryFor the families of Labado, the calendar offers little comfort. In the al-Nil neighbourhood, three siblings buried their children within days of one another over the Eid holiday. In Dar al-Naim West, a mother counts the days until her daughter’s 14-day isolation ends. In the Safaa neighbourhood, Hawa Adam has already buried hers.“They could have still been alive,” Hawa Adam said. “Those without money die in Darfur.”

Thai Police Capture Indonesian Romance‑Scam Operator in PhuketThai police announced the arrest of a 33‑year‑old Indonesian man suspected of defrauding Americans out of $10 million through romance‑scam schemes. The suspect was taken into custody at a luxury resort on Phuket and will be extradited to the United States.Cross‑Border Tip‑Off Triggers Arrest at Luxury ResortThe operation was launched after a direct tip‑off from the U.S. Federal Bureau of Investigation (FBI). According to Suriya Poungsombat, a spokesperson for Thailand’s national immigration police, the suspect arrived in Thailand from Dubai on a Wednesday before being detained on Friday.Arrest location: Luxury resort, PhuketArrest date: 2026‑04‑26Detention: Immigration centre, Bangkok pending extradition$10 Million Fraud Scheme: Scale and Modus OperandiInvestigators say the suspect used dating apps and social‑media platforms to lure victims, employing hired models to build trust before steering them toward fake investment platforms promising unrealistic returns.Victim pool: Primarily U.S. nationalsPeriod of activity: Reported from 2022 to 2026Financial loss: Approximately $10 millionSoutheast Asia’s Emerging Role as Cyber‑Fraud HubRecent reports highlight the region’s appeal to organized crime groups, which exploit casinos, hotels, and fortified compounds as operational bases. A 2025 UN Office on Drugs and Crime study noted that foreign workers in the UAE are being funneled into “scam work” in Southeast Asia, positioning Dubai as a recruitment hub for cyber‑enabled fraud.What the Arrest Means for International Cyber‑Fraud EnforcementThe case illustrates growing cooperation between Asian law‑enforcement agencies and the FBI. Analysts predict tighter cross‑border information sharing and increased pressure on Southeast Asian jurisdictions to dismantle safe‑havens for online fraud networks.

The Historic Two-Hour Barrier Broken They call Sabastian Sawe the silent assassin. But it was impossible to ignore the beautiful destruction on the streets of London as the 30-year-old Kenyan became the first athlete to shatter the two-hour barrier in an official race. As Sawe crossed the line on the Mall, the clock showed that he had run 26.2 miles in a staggering 1 hour, 59mins and 30 seconds – 65 seconds faster than the previous best set by Kelvin Kiptum in 2023. The Record-Shattering Performance The world record had not just been destroyed. It had been obliterated. He came. He Sawe. He conquered. "I am feeling good, I am so happy," said Sawe. "It is a day to remember." Sawe's team had insisted their man was in shape, and that he would be helped by wearing the latest pair of Adidas Adios Pro 3 supershoes, which weigh in at just 97 grams – lighter than a baby kitten – and will retail for about £450. But no one expected this. Unprecedented Competition Not long behind him was Ethiopia's Yomif Kejelcha, who was 11 seconds back in his debut marathon. His time would have also shattered the world record. Uganda's Jacob Kiplimo, who came third in 2:00:28, was also inside it too. "I think today, it shows me a lot," Sawe told BBC Sport afterwards. "There is time for everyone. I think I was well-prepared because coming to London for the second time was so important to me." The Science Behind the Speed For the elite racers, the weather at the start was almost perfect for fast times: 11 degrees Celsius, sunny, and with a gentle tailwind over the crucial last few miles. And six men – including the favourites, Sawe and Kiplimo – were determined to take advantage. They hit the 10km mark, just before Cutty Sark, in 28 mins and 25 sec, a shade under world-record pace, and were through halfway in 60:29 secs, 12 seconds down. The Final Push to Glory At this point the men's race looked like being fast but not record-breaking. When the last pacemaker dropped out, though, Sawe and Kejelcha suddenly charged clear at a drinks station, surprising Kiplimo who found himself unable to fight back. By now they were pouring the pace on. Between 30-35km they ran an astonishing 13:54 5km. To put into context, the time is just 12 seconds slower than the world record for a 5km parkrun, set by the Irish international runner Nick Griggs. The Doping Question Addressed Naturally there will be questions about whether we can trust Sawe's record, given the chequered history of Kenyans failing doping tests in recent years. It should be noted, however, that before the Berlin marathon in September, Sawe's sponsors, Adidas, paid the Athletics Integrity Unit £50,000 to test him as many times as possible because they wanted to show he was clean. Not only was Sawe tested 25 times in a few weeks, but his samples were also scrutinised with top-end analysis, including isotope ratio mass spectrometry testing, which is much better at detecting tiny levels of banned drugs. The Women's Race Record The women's race turned into a three-way sprint down the Mall, with the Ethiopian Tigst Assefa defending her title after kicking from home in sight of Buckingham Palace. Her time of 2:15:41 was a women's only-word world record, which applies to races with only women's pace makers but is nearly five minutes slower than the official women's world record. In second place, 12 seconds back, was Kenya's Hellen Obiri, while her compatriot Joyciline Jepkosgei finished third. The Future of Marathon Running Sawe's achievement marks a new era in marathon running, pushing the boundaries of what was once considered humanly possible. With advancements in training techniques, equipment technology, and increasingly sophisticated doping detection methods, we can expect more records to fall in the coming years. The two-hour barrier, once thought to be an insurmountable milestone, has now been officially conquered, opening the door for even more ambitious targets in the sport.

Tom Wright’s latest theatrical offering, “Please Please Me”, turns the spotlight onto the often‑overlooked figure of Brian Epstein, the man who shepherded the Beatles to global fame. By weaving together the manager’s personal turmoil, his ambiguous bond with John Lennon, and a pivotal holiday in Torremolinos, the play asks whether the myth of Beatlemania can ever be fully disentangled from the private shadows of its architect.The Play’s Narrative Focus on Epstein’s Inner WorldThe production opens in Epstein’s father’s record shop, where a young Brian swaps classical violin concertos for Elvis’s “Hound Dog,” signalling the cultural rupture of the 1960s. Set designer Tom Piper employs rotating closets and dimly lit corridors to echo the manager’s sense of concealment, while the script delves into his identity as a Jewish gay man navigating a hostile industry. Central to the drama is the disputed Torremolinos encounter, a moment that, according to the play, intensified Epstein’s dependence on drugs and deepened his entanglement with Lennon’s volatile genius.Critical Reception and Box‑Office SnapshotVenue: Kiln Theatre, London (running until 29 May 2026)Lead Cast: Calam Lynch as Brian Epstein, Eleanor Worthington‑Cox in multiple roles including Cilla Black, Noah Ritter debuting as John LennonDirection: Amit SharmaCritical notes: Praise for Lynch’s “terrific, increasingly physical” performance and the production’s “mobile set of spinning closets” that visualise the era’s chaos.Reframing the Beatles’ Mythos Through Epstein’s LensBy centring Epstein rather than the band, the play challenges the conventional hero narrative that has long dominated popular culture. It foregrounds how the manager’s personal insecurities and hidden sexuality may have shaped key decisions—such as the timing of the Torremolinos trip—that in turn influenced the Beatles’ trajectory. This reframing invites audiences to reconsider the price of fame and the often‑invisible architects behind cultural revolutions.Future Prospects for Musical Biographies on Stage“Please Please Me” arrives at a moment when theatre is increasingly embracing biographical stories that blend music, politics, and personal identity. Its success could spur further productions that explore the backstage lives of iconic artists, especially those whose stories intersect with LGBTQ+ history and post‑war cultural shifts. Expect more investors to back daring, historically nuanced works that promise both critical acclaim and modest commercial returns.

The Executive Order That Changed Psychedelic PolicyIn a surprising move during the weekend celebrating 'Bicycle Day' – the anniversary of the first LSD trip – Donald Trump signed a landmark executive order to accelerate research into hallucinogens and increase access to them. The scene was surreal as Trump joked, 'Can I have some, please?' when discussing ibogaine, a lesser-known psychedelic known for its 12-hour trips that often provide visions of traumatic personal memories.Accelerated FDA Review ProcessThanks to the order, the US Food and Drug Administration (FDA) will fast-track the reviews of three incoming psychedelic drug candidate applications that have already received breakthrough therapy designations. These are likely to be psilocybin for two types of depression and MDMA for PTSD, a prior application for which was rejected by the FDA in 2024. This move represents the biggest greenlight the potential multibillion-dollar market has yet received, causing psychedelic company stocks to soar.Financial Implications of the Psychedelic MarketThe executive order has significant financial implications for the emerging psychedelic industry. Industry analyst Josh Hardman noted that the expected issuance of these vouchers shows just how much the White House has changed its mind on psychedelics in the last six months. The Department of Health and Human Services also announced a new $139m initiative to help spur new, effective therapies for behavioral health, including the safe use of psychedelics, with at least $50m earmarked to match state psychedelic research initiatives.Industry and Regulatory TransformationThis executive order marks a significant shift in the approach to psychedelic substances in the United States, which have been federally illegal since Richard Nixon passed the 1970 Controlled Substances Act. The order states that investigational psychedelic drugs will become available under 'right to try' legislation, which is typically reserved for terminally ill patients and those who have tried all approved treatment options. However, this sets up a potential clash with the Drug Enforcement Administration (DEA), which has previously stated that schedule I compounds are ineligible for right to try.Future Outlook for Psychedelic MedicineThe future of psychedelic medicine in the US appears to be accelerating, but with significant challenges remaining. While Trump indicated his administration is already working on rescheduling efforts, which would require approval from the DEA, concerns remain about pharmaceutical and commercial interests being the primary beneficiaries of the order. Indigenous communities that have stewarded psychedelics like ibogaine and psilocybin worry they won't be fairly compensated for their knowledge. As psychedelic reform advocate Ismail Ali noted, 'It is a substantial threshold moment,' but 'if you're looking at the US federal government for the full liberation of these plants, you're probably looking in the wrong place.' The coming years will determine whether this marks the beginning of a truly accessible psychedelic medicine future or another chapter in extraction and commercialization.

The Legal Basis for ProsecutionJudges at the International Criminal Court (ICC) have confirmed all three counts of murder as crimes against humanity against former Philippine President Rodrigo Duterte. The court determined there were 'substantial grounds' to believe the 81-year-old leader played a key role in the murders of 76 people and the attempted murder of two others. The ruling establishes that a 'common plan' existed between Duterte and his co-perpetrators to kill alleged criminals through violent means, including the creation, funding, and arming of death squads.The Human Cost of the 'War on Drugs'Prosecutors allege Duterte's campaign, spanning from 2016 to 2022, resulted in a catastrophic loss of life. While official police reports estimate the death toll at 6,000, human rights organizations have documented figures as high as 30,000. This disparity highlights the scale of the alleged systematic violence and the difficulty of accurately quantifying mass atrocities.A Watershed Moment for Global AccountabilityThe ruling has been hailed as a 'historic moment' by international human rights organizations. Maria Elena Vignoli of Human Rights Watch emphasized that the trial sends a powerful message: 'no one responsible for grave crimes is above the law, whether in the Philippines or elsewhere.' This case sets a precedent for holding high-ranking officials accountable for state-sponsored violence.The Road Ahead for Duterte's DefenseDespite the confirmation, the path to trial remains complex. Duterte's defense team has argued he is mentally too weak to proceed and claims he only instructed police to act in self-defense. With trials typically taking up to a year from charge confirmation, the international community watches closely to see if the former leader will face the tribunal in The Hague.

The Geopolitical Ripple Effect on UK MedicineThe ongoing conflict in Iran is creating a significant ripple effect across the UK healthcare sector, driving up the cost of essential over-the-counter medications and threatening supply chains. Community chemists are reporting that the war has pushed up the price of widely used medicines, including painkillers and hay fever medication, leading to a crisis for both patients and pharmacists.The Surge in Over-the-Counter Medication CostsCommunity chemists are charging customers 20-30% more for paracetamol than they did in February, according to the National Pharmacy Association (NPA). Over-the-counter prices for cetirizine tablets, a common hay fever medication, have also risen by the same margin. Furthermore, many pharmacies have run out of certain strengths of aspirin and co-codamol, with some temporarily halting sales of aspirin altogether due to supply constraints.The Supply Chain Shock: Fuel and FreightThe jump in petrol and diesel prices since the war began nearly eight weeks ago has increased manufacturing and transport costs for medicine suppliers by 40-50%. The conflict has also doubled air freight costs, as one in five NHS medicines comes in by air. Additionally, supplies of petroleum derivatives from the Gulf, essential for making common medications like paracetamol and aspirin, have been strangled.Paracetamol Price Spike: Purchase price for a pack of 100 500mg tablets jumped from 41p to £1.99 before easing back to £1.09.Reimbursement Gap: The government reimburses only 49p for a prescribed 32-pack of paracetamol, often forcing pharmacies to sell at a loss.Pharmacy Closures: Over 1,400 community pharmacies have closed since 2020, with one or two closing per week.The Crisis for Community Pharmacies and the NHSManufacturers of generic off-patent drugs operating on low margins have started to increase their prices, driving up the NHS medicines bill. While suppliers have long-term agreements with NHS hospitals, they have more leeway over drugs provided to pharmacies. This has led to a record 230 items on the price concessions list in March, compared to 90 in the same month last year. However, popular items like paracetamol and cetirizine remain excluded, meaning pharmacies are absorbing the cost.Looming Shortages and Future Price HikesAs manufacturers move to replenish stocks, transportation costs have risen by 700%, and some chemicals are in very short supply. Mark Samuels, chief executive of Medicines UK, warned that if the conflict continues, rising prices or shortages of essential medicines could occur as soon as the next few weeks. Patients are also warned that allergy sufferers could face more price increases by May or June, the peak of the hay fever season.

The Fallout of Theramex's Regulatory CollapseOne of the UK's largest producers of hormone replacement therapy (HRT) has been publicly reprimanded by the Prescription Medicines Code of Practice Authority (PMCPA) for "systemic failures" that directly jeopardized patient safety. The case against Theramex, the maker of popular drugs Evorel and Intrarosa, highlights a critical breakdown in compliance standards that regulators say has eroded trust in the pharmaceutical industry.Systemic Failures in HRT Safety ProtocolsThe PMCPA found that Theramex breached the Association of the British Pharmaceutical Industry (ABPI) code of practice 21 times. These failures were not isolated incidents but a pattern of negligence that included:Failing to update crucial prescribing information for years, including for Evorel patches.Not clearly warning that certain drugs, such as Yselty (linzagolix), must not be used during pregnancy.Ignoring internal whistleblower concerns regarding incomplete side-effect data.The Scale of Prescribed RiskThe impact of these failures is magnified by the sheer volume of prescriptions. Evorel patches, which contain estradiol, are among the most prescribed forms of transdermal HRT, with 250,000+ items issued in the last financial year. Overall, nearly 10 million items of estradiol were prescribed in the 2024/25 financial year, meaning thousands of patients may have been exposed to incomplete or outdated safety data.The Erosion of Self-RegulationThe decision by Theramex to leave the PMCPA's jurisdiction in January 2026 has sparked a debate on the efficacy of self-regulation. The PMCPA condemned the move, stating it inevitably delayed oversight. However, the Medicines and Healthcare products Regulatory Agency (MHRA) has stepped in, asserting that leaving the self-regulatory framework does not grant immunity. Dr Amit Aggarwal noted that Theramex has "brought discredit upon" the industry, signaling a potential shift toward stricter, government-led enforcement.Future Scrutiny and Industry ReformLooking ahead, the Theramex case is likely to trigger a comprehensive review of compliance frameworks across the pharmaceutical industry. With the MHRA retaining full legal powers to investigate and prosecute criminal offences, companies can no longer rely on voluntary self-regulation to shield them from liability. The industry faces a critical juncture where patient safety must take precedence over administrative efficiency.