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A new large‑scale randomized trial presented at the European Congress on Obesity in Istanbul indicates that the oral GLP‑1 antagonist orforglipron can help patients retain the majority of weight lost with injectable therapies such as tirzepatide (Mounjaro) and semaglutide (Wegovy).Trial Shows Oral Orforglipron Preserves Most Weight After Switching from InjectablesThe study, funded by Eli Lilly, followed 376 US patients who had been on tirzepatide or semaglutide injections for 72 weeks and then randomized them to a daily orforglipron tablet or placebo for an additional year.Participants were previously on weekly GLP‑1 jabs that typically produce 15‑20% body‑weight loss.After the injection phase, subjects were switched to oral therapy or placebo for 12 months.Primary endpoint: proportion of weight loss retained at 12 months.Quantitative Outcomes: 75% vs 49% Retention for Tirzepatide Users, 80% vs 38% for Semaglutide UsersWeight‑loss maintenance differed markedly between the pill and placebo groups:Tirzepatide cohort: 75% of lost weight retained with orforglipron vs 49% with placebo.Semaglutide cohort: 80% retained with the pill vs 38% with placebo.Secondary benefits—blood pressure, cholesterol, and glycaemic control—were also sustained in the pill arm.Implications for Obesity Management and Healthcare CostsExperts highlighted the broader significance:Dr Louis Aronne (Weill Cornell Medicine) emphasized that treating obesity directly can simultaneously improve glucose, lipid, and blood‑pressure metrics.Dr Marie Spreckley (University of Cambridge) noted patient preference for oral therapy due to convenience, storage, and lower cost.Dr Simon Cork (Anglia Ruskin University) warned that injectable GLP‑1 drugs, while highly effective, are expensive and limit long‑term accessibility for both private payers and the NHS.The findings suggest a potential shift toward oral agents that maintain efficacy while reducing financial and logistical burdens.Future Outlook: Oral GLP‑1 Therapies Could Redefine Chronic Obesity CareIf further trials confirm these results, orforglipron could become a cornerstone of chronic obesity management, enabling earlier intervention (BMI 25‑27) and possibly preventing progression to severe obesity.Regulators and payers will likely scrutinize cost‑effectiveness models, but the prospect of a cheap, daily tablet that sustains weight loss may reshape treatment algorithms worldwide.

Overview: Racing Faces Green Party PressureThe Green Party’s record-breaking results in the latest elections have prompted leader Zack Polanski to declare two-party politics “dead and buried”, while betting firm Ladbrokes cut odds on a Green majority to 28-1. This political momentum is now being directed at horse racing, the UK’s second-biggest spectator sport.Green Party’s Electoral Surge Fuels Calls for Racing ReformMP Hannah Spencer (Gorton and Denton) called for “a conversation about racing” after two fatal injuries at the Grand National meeting, echoing Polanski’s 2024 proposal to remove “all animals involved in sport”.Betting Odds Highlight Political MomentumOdds for Greens winning most seats: 12-1Odds for a Green overall majority: 28-1Economic and Cultural Stakes of Horse RacingIndustry value: £4 bn per year (British Horse Racing Authority)Employment: about 80,000 jobsAnnual ticket sales: nearly 5 m ticketsFatal injury rate on the Flat: 1 in 1,000 startsFatal injury rate over jumps: 5 in 1,000 startsThese figures contrast with the millions of mammals killed for meat annually, underscoring the sport’s relatively low animal-loss rate.Future Outlook for Racing Amid Political ScrutinyThe author argues that racing will likely persist for centuries, but stresses the need for the sport to continuously demonstrate welfare improvements. A pre-election “conversation” could clarify the Greens’ policy stance, allowing fans and professionals to assess voting decisions.

The Leadership Challenge British Prime Minister Keir Starmer, fighting for his political survival after dozens of his own MPs called for him to resign, promised to press ahead with plans to reform the country before an expected meeting with his potential leadership rival Wes Streeting, the health secretary. Calls for Resignation Starmer has so far defied calls to quit from Labour MPs, who blame him for heavy losses in local elections last week and say he has failed to deliver reforms since coming to power in a landslide 2024 election victory. More than 80, or almost a quarter, of the prime minister's elected MPs have called for Starmer to go, and four junior ministers have resigned in protest. The Meeting with Streeting The meeting in Downing Street will take place before King Charles gives a speech at the opening of parliament – a grand ceremony led by him and used by the government to set out its political priorities and legislative agenda for the year ahead. A public statement is not expected to follow the Streeting-Starmer meeting to keep the attention on the speech, according to British media reports. The Future of Starmer's Leadership Despite the turmoil, Starmer will take part in parliament's grand opening on Wednesday. He said in a statement on Tuesday evening: 'Britain stands at a pivotal moment: To press ahead with a plan to build a stronger, fairer country or turn back to the chaos and instability of the past.' The implementation of the government's plans remains uncertain, and if Starmer were to be removed, his successor would not be bound to follow the same plan.

The World's Longest Football DerbyCarlisle and Barrow will play each other next season in the Cumbrian derby in the National League. The clubs are located at opposite ends of Cumbria and the distance between the two grounds is some 78 miles by car. But this is not the greatest distance between two teams involved in a 'derby'.When considering derbies, we are looking for matches between teams that are linked based upon their proximity or geography, rather than simply historical rivalries like the 'clásico' between Real Madrid and Barcelona.UK Derbies: The Cumbrian ContenderWithin the UK, the Cumbrian derby certainly looks the furthest derby by distance. If we are staying in England, the closest we can get to 78 miles is the A49 derby between Shrewsbury Town and Hereford United, separated by 51 miles, although it should be said that the two teams have not met since the latter was dissolved in 2014.In England, thoughts immediately go to Crystal Palace and Brighton, dubbed the M23 derby, but a quick search reveals that Selhurst Park is a mere 46 miles from the Amex Stadium. It is also 46 miles that separate the stadiums of Plymouth Argyle and Exeter City, the Devon derby. Just behind are Ipswich and Norwich – the East Anglian derby (AKA El Tractico or the Old Farm) – with Portman Road and Carrow Road 45 miles apart.International Long-Distance DerbiesFarther afield, we must mention the derby between Persib Bandung and Persija Jakarta, who take part in the Indonesia derby, or Laga Klasikal as it is locally known, with Persib's Gelora Bandung Lautan Api Stadium lying 108 miles away from Persija's Jakarta International Stadium in Indonesia's capital.Italy is fertile ground for a host of famous derbies, and it is here that we find some of the longest-distance derbies. Of course there is the Derby d'Italia between Milan and Juventus, with 85 miles separating San Siro and Juve's Allianz Arena in Italy's north-west. The Derby di Sicilia between Palermo and Catania spans a whopping 134 miles across the breadth of Sicily, while the Derby delle Isole (Derby of the Islands) between Palermo and Sardinian club Cagliari goes even further – a full 250 miles across the Tyrrhenian Sea.The Champion: New Zealand's 386-Mile DerbyOur winner, though, comes from New Zealand's North Island. With Auckland FC only entering the A-League Men in 2024-25, the New Zealand derby between themselves and Wellington Phoenix is still very much in its infancy but has already blossomed into something substantial. In February, just the sixth edition of the derby, a comical own goal from Wellington goalkeeper Josh Oluwayemi sparked a 5-0 thrashing by Auckland, prompting Phoenix coach Giancarlo Italiano to resign immediately after the defeat. With 386 miles between the two grounds, the NZD is our clear winner.The Evolution of Geographic DerbiesThe existence of such long-distance derbies challenges our traditional understanding of what constitutes a local rivalry. In an era where football has become increasingly globalized, these geographic matchups represent unique connections between communities separated by vast distances. The New Zealand derby, in particular, showcases how even in a country with a relatively small population, football can create intense rivalries across significant geographical divides.The Future of Long-Distance DerbiesAs football continues to evolve, we may see more long-distance derbies emerge, particularly in regions with expanding leagues or where new clubs are formed to serve underserved areas. The New Zealand derby between Auckland and Wellington Phoenix is a prime example of how modern football infrastructure and scheduling can create meaningful rivalries regardless of distance. With the increasing popularity of travel and fan engagement, these long-distance derbies may become even more significant in the future of football culture.Double Winners in FootballDeji Elerewe has won the title with both Bromley (League Two) and Lincoln (League One) this season. Has any other player managed the same feat?We covered this answer 10 years ago in a previous Knowledge, but regular contributor Dirk Maas has come in clutch with some additions, although he does clarify that he has limited his search to the top five leagues in Europe in this century.There are several examples of players winning titles with different teams in the same season, including:Jonas Urbig with Köln (2. Bundesliga) and Bayern Munich (Bundesliga) in 2024-25Leigh Griffiths with Celtic (Scottish Premiership) and Wolverhampton (League One) in 2013-14Urby Emanuelson with Ajax and Milan in 2010-11Daniel Amartey with Leicester City and FC Copenhagen in 2015-16Timothy Weah with Paris Saint-Germain and Celtic in 2018-19Khvicha Kvaratskhelia with Napoli and PSG in 2024-25There are also alternative cases where seasons happen at different times of year, such as David Beckham achieving this by picking up an MLS winner's medal with LA Galaxy and a Ligue 1 winner's medal with Paris Saint-Germain in 2012-13.

Why Labor Opted for a Partial Negative Gearing RetentionIn a video released alongside the 2026 budget, Treasury Minister Jim Chalmers clarified that the Labor Party chose not to abolish negative gearing outright but to retain it in a limited form. The move is presented as a compromise between fiscal responsibility and the political imperative to support property investors.Chalmers' Explanation in the Budget VideoThe video highlighted three core arguments:Revenue Impact: A full repeal would shave billions off projected tax receipts, widening the budget deficit.Housing Supply: Negative gearing encourages investment in rental properties, which helps keep rental vacancy rates low.Electoral Considerations: Property owners constitute a key voter bloc in marginal seats.Budget Numbers Behind the DecisionThe 2026 budget projects a surplus of AUD 12.4 billion after accounting for existing tax measures. A total repeal of negative gearing was estimated to erode that surplus by roughly 5‑6 %, pushing the government toward a modest deficit. By scaling back the deduction to properties with annual losses below AUD 5,000, the Treasury expects to retain most of the fiscal headroom.Broader Political and Market ImpactRetaining a trimmed version of negative gearing sends several signals:It reassures investors that the government will not introduce abrupt policy shocks, stabilising the Australian housing market.It placates the Labor base in outer‑urban electorates where property investment is a significant income source.It leaves the door open for future reforms, such as tightening eligibility criteria or introducing a phased phase‑out.Outlook for Tax Policy and Housing AffordabilityAnalysts anticipate that the next budget cycle will revisit negative gearing as part of a broader tax‑fairness agenda. If fiscal pressures intensify, Labour may consider a gradual reduction rather than an immediate repeal, aiming to mitigate any sharp correction in property prices while still moving toward a more progressive tax system.

Opening Verdict: A Spark That FizzlesThe Guardian’s review frames *The Electric Kiss* as a glossy, period‑set comedy that never fully ignites. Directed and co‑written by Pierre Salvadori, the film blends art‑world intrigue with a circus‑side electric act, yet its humor feels flat and its narrative momentum stalls.Plot Mechanics and Creative ChoicesThe story follows Suzanne (Anaïs Demoustier), a circus performer billed as the "Electric Venus" who is hired by a cunning gallerist (Gilles Lellouche) to impersonate a spiritualist at a grieving artist’s (Pio Marmaï) seance. As Suzanne fakes contact with the dead lover Irène, she discovers genuine feelings for the artist, while flashbacks reveal Irène’s own agency. The film leans on a Woody Allen‑style farce, but the extended flashback sequences disrupt the pacing.Financial Snapshot: Cannes Screening Without disclosed NumbersScreened at the Cannes Film Festival (official selection).No public budget or box‑office figures released at the time of review.Distribution details remain pending, limiting early revenue projections.Industry Implications: French Comedy’s Contemporary ChallengeSalvadori’s attempt to revive classic French farce highlights a broader tension: balancing nostalgic aesthetics with modern comedic timing. The film’s mixed reception may signal that audiences expect sharper wit and tighter storytelling from period comedies, especially when compared to recent Cannes entries like Cédric Klapisch’s *Colours of Time*.Looking Ahead: Potential Reception and LegacyIf the film secures wider distribution, its visual design and performances—particularly Demoustier’s charismatic turn—could attract niche viewers interested in stylized period pieces. However, without stronger comedic payoff, *The Electric Kiss* may remain a footnote in Cannes line‑ups rather than a breakout success.

Executive Overview: A Saucy College Hockey RomanceThe series Off Campus arrives on Prime Video as a straight‑to‑the‑point adaptation of Elle Kennedy’s popular heterosexual romance novels. Framed as a glossy, trash‑TV style romp, it follows the lives of college hockey players and their entangled love lives, delivering the expected mix of bums, boobs, and on‑ice drama.Core Premise and Character Set‑UpThe narrative centers on Garrett Graham (Belmont Cameli), the charismatic captain of Briar University’s hockey team, whose emotional walls stem from a troubled family past. Opposite him is Hannah Wells (Ella Bright), a music major forced to juggle financial woes and a scholarship loss, leading her into a tangled arrangement with Garrett. Supporting characters like Justin (Josh Heuston), Allie (Mika Abdalla), and the “puck bunnies” round out the ensemble, providing comic relief and additional romantic sub‑plots.Streaming Placement and Platform ContextAvailable exclusively on Prime Video as of 13 May 2026.Positioned alongside Netflix’s previous romance successes, aiming to capture a broader heterosexual audience.Marketing emphasizes the “hot twentysomething” vibe and the blend of sports and romance.Impact on the Romance‑Adaptation LandscapeBy mirroring the formula of the gay‑romance hit Heated Rivalry, Off Campus signals a growing confidence in adapting niche romance novels for mainstream streaming. Its focus on college athletics adds a fresh backdrop, potentially opening doors for more sport‑centric love stories in the genre.Looking Ahead: Prospects for Similar SeriesIf the series replicates the viewership numbers of its predecessor, studios may green‑light additional adaptations from Elle Kennedy’s catalog and other authors targeting the “college‑sports romance” niche. The show’s reception could also influence how streaming platforms balance explicit content with character‑driven storytelling.

Survey Reveals Strong Patriotic Sentiment Among UK Millionaires The research, commissioned by Patriotic Millionaires UK and carried out by Survation, asked 501 individuals with assets over £1 million (excluding their homes) about their attachment to the United Kingdom and their willingness to fund public services through higher taxation. Key Numbers: Pride, Concern, and Tax‑Paying Willingness 88% of respondents agreed with the statement “I am proud to live in the UK”. 75% said they would be willing to pay more tax to ensure social, cultural, and economic assets are properly funded. 64% support increasing taxes on capital and assets of the wealthiest to reduce the overall tax burden. 43% identified doctors and other qualified health staff as the group whose departure would hurt the country most. 9% were most worried about other millionaires leaving the UK. Other concerns included young people and business owners, each cited by 19% of respondents as potential losses to the nation. Implications for UK Fiscal Policy and Political Landscape The findings arrive as the Labour Party grapples with internal leadership questions following disappointing local election results. Proposals from candidates such as Andy Burnham and Wes Streeting include raising capital gains tax to fund a 2p cut in national insurance. The willingness of a sizable share of the ultra‑wealthy to back higher taxes could provide political cover for such measures. Critics have pointed to reports of a “millionaire exodus”, but the survey notes that the alleged 16,500‑person outflow cited by Henley & Partners represents only 0.5% of the UK’s three‑million millionaires. What This Means for Future Tax Debates and Migration Trends If policymakers take the survey at face value, future tax reforms may encounter less resistance from the very demographic they target. Moreover, the emphasis on retaining medical professionals—highlighted by the departure of over 4,000 doctors in 2024—suggests that addressing sector‑specific retention could become a fiscal priority alongside broader tax policy. Analysts will watch whether the Labour leadership leverages this data to counter narratives of a fleeing elite and to justify progressive tax proposals ahead of the next general election.

Pep Guardiola warned that officiating decisions in the Premier League are “a flip of a coin” and stressed that Manchester City must improve their own performance rather than blame referees or VAR.Guardiola Calls Refereeing a “Flip of a Coin” and Urges Higher StandardsThe Manchester City manager reiterated his frustration after the VAR‑review that disallowed Callum Wilson’s late goal for West Ham against Arsenal. He recalled City’s recent FA Cup final losses, attributing them to “referees didn’t do their job, even the VAR”.Impact on Manchester City’s Title ChaseArsenal sit on 79 points, five ahead of City with two games remaining.City can reach a maximum of 84 points if they win all three remaining matches.Injuries to Abdukodir Khusanov and Rodri add uncertainty ahead of the next fixture.Broader Implications for VAR Scrutiny in the Premier LeagueThe incident reignites debate over the consistency of VAR decisions, especially after controversial calls in the 2024 and 2025 FA Cup finals involving Erling Haaland and Dean Henderson. Critics argue that the technology has not reduced controversy but added another layer of uncertainty.What’s Next for City Ahead of the Palace Clash?Guardiola’s focus shifts to the upcoming match against Crystal Palace on Wednesday. He emphasized that the team must “do better” and maintain concentration, warning that loss of focus could be “dangerous”.