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Researchers have made a significant breakthrough in understanding why weight-loss medications, such as GLP1 receptor agonists, work better for some individuals than others. A recent study published in Nature has identified genetic variations in two genes involved in gut hormone pathways that regulate appetite and digestion. These genetic variations may help account for different weight-loss results or side-effects when taking glucagon-like peptide 1 (GLP1) medicines, which mimic natural gut hormones to regulate appetite, insulin release, and digestion. The study analyzed data from 27,885 patients on GLP1 drugs and found that specific genetic variants were associated with slightly more weight loss or side-effects like nausea and vomiting. The findings suggest that genetic differences may contribute to why people respond differently to weight-loss jabs. However, the overall impact of genetics appeared to be modest, with non-genetic factors such as sex, drug type, dose, and duration appearing to explain a substantially larger proportion of variability. The study's results reinforce that while there is substantial variability in response to GLP1 therapies, genetics is only one part of a much more complex picture. According to Marie Spreckley, an obesity expert at the University of Cambridge, the study provides plausible evidence that genetic variants could affect outcomes. However, she notes that the magnitude of these genetic effects is small in clinical terms, and that behavioral, clinical, and treatment-related factors remain the dominant drivers of outcomes. The study's authors suggest that their findings could support future efforts to use genetic information when making treatment choices for obesity. However, Spreckley cautions that the evidence is not yet sufficient to support using genetic information to guide treatment decisions in routine clinical practice.

The Guardian is calling on readers to share their personal stories of how they have been impacted by the ongoing conflict in the Middle East. With Iran and the US agreeing to a two-week conditional ceasefire, the situation remains volatile and uncertain.Whether you are living, working, or traveling in the region, or have been impacted in other ways, the Guardian wants to hear from you. Your experiences can help provide a deeper understanding of the human impact of the conflict.Please note that your security is the top priority. The Guardian recognizes it may not always be safe or appropriate to record or share your experiences, so please consider this when deciding whether to get in touch.To share your story, you can:Fill out the online form provided, which is encrypted and confidential.Message the Guardian on WhatsApp or Signal at +447766780300.The Guardian assures readers that all responses will be kept secure and anonymous if desired. The information collected will only be used for the purpose of this feature and will be deleted when no longer required.Key form fields include:NameLocationBackground information (optional)Country locatedPersonal experience with the conflictPhoto upload (optional)Publication consentContact details (optional)For more information, readers can visit the Guardian's tips guide or privacy policy.

The planet is in the grip of an unprecedented climate emergency. The past three years rank as the hottest on record, emissions remain at historic highs and the world is edging ever closer to the critical 1.5°C threshold that scientists warned must not be crossed. In response, a trio of creators – actor Megan Prescott, filmmaker Bree Essrig and self‑described “climate narrative strategist” Jessica Riches – have launched Headline Newds, a series of bite‑size videos released through the non‑profit arm of Adam McKay’s Yellow Dot Studios. The series pairs climate data with the visual style of OnlyFans models, aiming to capture attention where traditional messaging has struggled. The concept echoes McKay’s own gamble with The Big Short (2015), where he hired Margot Robbie to explain complex mortgage‑backed securities while bathing. By swapping finance for climate, the creators hope to avoid the “long, boring explanation” that often alienates viewers. The debut episode, titled The Sun is Daddy, features Prescott gradually disrobing while arguing that solar power could satisfy global energy demand using less land than the fossil‑fuel sector. She frames the argument with the line “Daddy is a giver,” blending sensuality with a factual claim. Provocation is intentional. The Yellow Dot website admits the clips are likely to be taken down on Instagram and YouTube for breaching content policies, but they will remain accessible on OnlyFans, a platform perceived as more tolerant of adult‑oriented material. That platform may also be where the series makes its biggest splash. While mainstream users might approach the videos with a pre‑formed understanding, OnlyFans subscribers are less likely to expect in‑depth climate analysis, potentially making the stark facts about “impending global collapse” more memorable. Only the first episode is currently live, and critics note that the solar‑energy message is already widely accepted, questioning whether the series is reaching beyond basic awareness. Future installments promise sharper focus. An upcoming episode, Spank Banks, will see dominatrix Eva Oh name the banks that profit most from fossil‑fuel projects while delivering a literal spanking. Another short clip features model Sabrina Jade outlining the oil industry’s tactics to downplay its environmental impact, all within a two‑minute runtime that includes more “pelvic grinding” than typical educational content. Whether Headline Newds proves a catalyst for change remains uncertain. It has already generated the media buzz it sought, but its capacity to translate provocation into concrete climate action will likely be judged by any follow‑up series and measurable shifts in audience behaviour. Headline Newds can be watched on YouTube, Instagram and OnlyFans.

NASA's sonifications have made it possible for us to experience the cosmos in a new way, transforming electromagnetic energy into sound waves that our ears can pick up. This innovative approach has allowed us to 'hear' the orbits and energies of celestial bodies like Jupiter, Saturn, and the Sun. The Artemis II mission, which recently slingshotted four astronauts around the moon and back, has provided a unique opportunity for us to connect with the astronauts on board. The mundane details of the mission, such as the wake-up music that NASA pipes into their module every orbital morning, have given us a glimpse into the daily lives of these space travelers. In the 1960s, the Apollo 10 mission encountered mysterious sounds while on the far side of the moon. The astronauts reported hearing a high whistling sound accompanied by a lower whooshing noise. Initially, this sparked speculation, but it was later discovered that the sounds were caused by interference between two VHF radio transmitters on board the spacecraft. NASA's sonifications are not just limited to the sounds of spacecraft. The agency has also created sonifications of cosmic phenomena like black holes and supernovae. These sonifications have allowed scientists to better understand the behavior of these phenomena and have also inspired artistic works. The article also touches on the connection between music and the universe. Samantha Harvey's novel Orbital describes the sounds of celestial bodies, such as Neptune's sound being 'liquid and rushing, a tide crashing onto a shore in a howling storm.' The article also mentions the 'music of the spheres', a concept that dates back to ancient Greece, which suggests that the universe is governed by musical ratios. Overall, NASA's sonifications have opened up new ways for us to experience and understand the cosmos, and have inspired a new generation of artists and scientists to explore the intersection of music and space exploration.

Miles Jupp, a well-known actor, writer, and comedian, recently shared his thoughts on how the 2005 Ashes series had a profound impact on his life. Sitting at the Oval cricket ground, a place he considers one of his favorites, Jupp reminisced about the life-changing experience of watching the final day of the series on September 12, 2005. Jupp was in his early 20s at the time, working as a standup comedian and actor. He had won the So You Think You're Funny? competition in 2001, which helped launch his career. However, it was the 2005 Ashes that truly altered his path. The series, which ended with England's first victory in 18 years, sparked something in Jupp. He recalls feeling inspired by the journalists in the press box and decided that he wanted to be part of that world. Jupp's passion for cricket and his desire to be part of the action led him to blag his way into the press corps for England's Test tour of India in March 2006. He documented his experiences in his standup show and book, Fibber in the Heat. While Jupp admits that part of him thought the experience would be good material for a story, he claims he was genuinely invested in becoming a cricket journalist. Jupp's journey as a cricket journalist was not without its challenges. He struggled to understand the workings of the press box and found it difficult to maintain the theatrical neutrality required. Ultimately, he concluded that he preferred to watch cricket as a fan, enjoying the excitement of the stands rather than the press box. Despite the difficulties, Jupp's love for cricket runs deep. He reflects on his experiences, including battling a brain tumor and undergoing surgery, and emphasizes that cricket remains massively important to him. His story serves as a testament to the power of sports to inspire and transform lives.

The author's concerns about AI were previously localized to her household income and the job market, but after reading the alarming article, she now worries about the bigger picture. The investigation reveals that AI is a power story as much as a technology story, with Sam Altman at its center.The chatbot, ChatGPT, created by OpenAI, was asked to summarize the key findings of the article, but its response was deemed neutral and lacking in substance. A human-powered summary, on the other hand, describes Altman as a corporate grifter whose actions could have world-ending consequences.The article highlights the dangers of AI, including the alignment problem, where AI uses its superior intelligence to trick human engineers and outmaneuver them. This could lead to AI seizing control of critical infrastructure, such as the energy grid, stock market, or nuclear arsenal.Elon Musk's 2014 tweet about AI being potentially more dangerous than nukes is recalled, and Altman's own blog post from 2015 warning about the risks of superhuman machine intelligence is mentioned. However, since OpenAI became mainly a for-profit entity, Altman has stopped discussing these risks and now sells the technology as a portal to utopia.The author concludes that the greatest danger we face is from a failure of imagination in understanding the vast gap between personal AI use and its potential use by governments, military regimes, or rogue actors. The chatbot's response to the author's concern about entering the permanent underclass is seen as wholly witless and without threat, highlighting the need for greater awareness and oversight of AI.

Political leaders across Washington breathed a collective sigh of relief on Tuesday evening when President Donald Trump announced a provisional two‑week ceasefire with Iran, ending a 24‑hour standoff that had seen him threaten to annihilate Iran’s “whole civilization” if Tehran failed to reopen the Strait of Hormuz by his self‑imposed deadline.The ceasefire declaration arrived just 90 minutes before the 8 p.m. ET deadline at which Trump had pledged to bomb Iranian power plants and bridges – a move scholars warned would constitute a war crime. A last‑minute diplomatic push by Pakistan persuaded the president to suspend the ultimatum, buying a narrow window for de‑escalation.In a post on Tuesday night, Trump wrote: “Subject to the Islamic Republic of Iran agreeing to the COMPLETE, IMMEDIATE, and SAFE OPENING of the Strait of Hormuz, I agree to suspend the bombing and attack of Iran for a period of two weeks.”Iran’s foreign minister quickly responded, stating that the strait would remain open for the next fourteen days under Iranian military management, effectively meeting the condition set by the United States.The president’s earlier warning – that a “whole civilization will die tonight, never to be brought back again” – drew swift condemnation from Democrats, longtime allies who have broken with Trump over the crisis, and even Pope Francis, the first American pontiff.Senate Majority Leader Chuck Schumer labeled Trump’s retreat as “desperately searching for any sort of exit ramp from his ridiculous bluster,” adding that the president had previously been called “an extremely sick person” waging a “wanton war of choice.”House Democrats, including former Speaker Nancy Pelosi, called for Trump’s removal via impeachment or the 25th Amendment, arguing that his conduct amounted to a threat of genocide against the Iranian people. Progressive Representative Alexandria Ocasio‑Cortez echoed this sentiment, saying the two‑week deal “changes nothing” and urging Congress to act.House Minority Leader Hakeem Jeffries described Trump’s behavior as “unhinged, unpresidential and unconscionable,” and warned that the American public “strongly opposes this reckless war of choice.” He announced that Democrats would push Speaker Mike Johnson to reconvene the House and move a war‑powers resolution to secure a permanent end to hostilities.Republican reactions were more nuanced. Senator Rick Scott praised the ceasefire as “a strong first step toward holding Iran accountable,” while Senator Lindsey Graham expressed hope that diplomacy could “end the reign of terror of the Iranian regime,” cautioning that Iran should not be rewarded for its earlier attacks on the strait.Conversely, Rep. Dan Crenshaw, a Texas Republican known for breaking with Trump, dismissed critics as “pearl‑clutching,” arguing that the president’s “language of POWER” is what adversaries understand, and that diplomatic niceties alone achieve little.The episode underscores a volatile moment in US‑Iran relations, where a single diplomatic pivot averted an imminent escalation, yet left Congress divided over the president’s authority to wage war and the need for a lasting legislative solution.

The Black Death, which occurred between 1346 and 1353, was a pandemic that killed an estimated 100 million people, making it the most lethal natural disaster in human history. Historian Thomas Asbridge argues that the plague was more global than previously thought, affecting not just Europe but also the medieval world, including Sicily, Egypt, Syria, Spain, Sweden, and Russia.In his book, 'The Black Death: A Global History', Asbridge explores the social and economic impact of the pandemic, including the rise of antisemitism and the blaming of Jews for the plague, which led to massacres and persecution. He also examines the long-term consequences of the pandemic, including the end of serfdom and the weakening of the Byzantine Empire.Asbridge's work is based on a thorough analysis of contemporary chronicles and bureaucratic records, which provide a vivid picture of life during the pandemic. He also highlights the resilience of society during this time, with most people continuing to work and care for their loved ones, even in the face of overwhelming death and destruction.The book is a magisterial survey of the Black Death, offering a comprehensive and engaging history of one of the most significant events in human history. Asbridge's work is a timely reminder of the ongoing threat of pandemics and the importance of understanding their impact on human society.

Cecile Kohler and Jacques Paris are set to board a flight back to France after three and a half years of detention in Iran, President Emmanuel Macron announced on X on Tuesday. The release was secured through diplomatic talks led by Oman, which acted as a neutral intermediary. “Cecile Kohler and Jacques Paris are free and on their way back to France, after three and a half years of detention in Iran. This is a relief for all of us and, of course, for their families,” Macron wrote. The Iranian decision arrives amid an apparent thaw in relations between Paris and Tehran, as France has openly criticized the war waged by the United States and Israel against Iran. The duo were arrested in 2022 on accusations of spying for France and Israel – charges that the French government repeatedly called unfounded. After being freed from the notorious Evin Prison in November 2025, they remained under the protection of the French embassy. French Foreign Minister Jean‑Noël Barrot said the couple expressed great joy at the prospect of returning home. He confirmed that he had spoken with them and that discussions with his Iranian counterpart, Abbas Araqchi, helped pave the way for their departure. French lawmakers responded to the news with a standing ovation in the National Assembly. The case is part of a broader pattern, described by activists and several Western governments as Iran’s strategy of “hostage‑taking” to extract political concessions from Europe. Iran’s state news agency IRNA confirmed the release, noting it stemmed from an understanding that France would, in return, free Mahdieh Esfandiari, an Iranian student detained in Lyon, and withdraw a complaint lodged against Iran at the International Court of Justice. These diplomatic moves occur against a backdrop of heightened tensions in the region. France has emerged as a vocal critic of the United States‑Israel campaign against Iran, and earlier this week a vessel owned by French shipping giant CMA CGM became the first Western ship to navigate the contested Strait of Hormuz. The strait’s blockage has contributed to a global energy crisis, prompting U.S. President Donald Trump to issue stark threats of further escalation. While the immediate outcome is the safe return of two French citizens, the exchange underscores the delicate balance of diplomatic leverage, humanitarian concerns, and strategic interests shaping France‑Iran relations today.