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Scientists have made a groundbreaking discovery, identifying a distinct 'neural fingerprint' produced by psychedelic drugs in the human brain when users experience their mind-altering effects.This breakthrough finding emerged from a comprehensive study that combined 11 brain imaging datasets from around the world, involving over 500 brain scans from 267 people in five countries. The research focused on five psychedelic substances: LSD, psilocybin, DMT, mescaline, and ayahuasca.The study revealed that these substances have a shared impact on the brain's behavior, dissolving the usual hierarchy of brain systems and flattening the hierarchy, which may underlie the raw access to one's own consciousness that some people describe during psychedelic experiences.Dr. Danilo Bzdok, a senior author on the study from McGill University in Montreal, Canada, explained that all five drugs change brain function in common ways, despite some differences in how they alter brain activity. The most striking effect was stronger communication between brain networks that engage in higher-level thinking and more primitive networks linked to vision and sensation.The research, published in Nature Medicine, provides a solid foundation for psychedelic research, which is crucial if these drugs are to become widespread therapies for mental health conditions such as depression, schizophrenia, and post-traumatic stress disorder.Dr. Emmanuel Stamatakis, a senior co-author on the study from the University of Cambridge, emphasized the importance of large-scale, coordinated evidence in the field of psychedelic research, which is moving quickly and needs to mature responsibly.

At Augusta National, Justin Rose’s name appears twice on the bronze winner’s list beside the victories of Sergio García (2017) and Rory McIlroy (2025) – both wins coming after playoffs that Rose lost. Only Ben Hogan shares the dubious distinction of losing two Masters playoffs, though Hogan later won the tournament twice outright.Rose’s record also includes a second‑place finish in 2015, four strokes behind Jordan Spieth. The only player with more runner‑up finishes without ever winning is Tom Weiskopf, who was second four times in seven years.Now 45 years old and entering his 21st Masters, Rose cannot predict if he will ever get as close again as he did last year, when McIlroy’s birdie putt on the 18th sealed a one‑stroke playoff defeat.“When you realise you’re that close, you can taste the victory,” Rose says. “I lived it as if I’d won, but without the real positive emotion – I sensed everything.” He acknowledges the mental rehearsal of the “what‑if” scenario while maintaining that he “did everything he could” and can live with the result.Rose explains his mental formula: “You can’t make a major win too important in the moment,” because a career inevitably includes “a little bit of heart‑ache and heartbreak.” He believes that to win, a player must also be prepared to be on the losing side.Despite the setbacks, Rose feels he has already demonstrated the necessary skill set. “I’ve pretty much done what it takes to win. I just haven’t walked over the line,” he asserts, emphasizing that he does not feel the need to change his approach.Recent form offers optimism. Earlier this year Rose set a new course record at Torrey Pines and became the first player in 71 years to win the Farmers Insurance Open wire‑to‑wire. He notes that eight players have captured the Masters after finishing second the previous year, suggesting his odds improve when the field is considered.Rose is also mindful of external narratives. “People are wishing me well and thinking it’s my year,” he admits, adding that he must manage expectations and craft his own story rather than buying into others’ predictions.

Tadej Pogacar, the winner of the Tour of Flanders for a record-equalling third time, is among the riders under investigation for allegedly running a red light at a railway crossing during the race on Sunday. The incident occurred when Pogacar, along with a group of riders, proceeded through the crossing without stopping, while most of the peloton behind them had to halt before the railway. Belgian officials have confirmed that an investigation is underway into the riders who allegedly ran the red light. Although no further details were provided immediately, local media reports suggest that the riders could face fines ranging from €320 to €4,000 (£279 to £3487) and a driving ban of eight days if found guilty. Pogacar, who rides for UAE Team Emirates-XRG, explained after the race that the signal to stop came too late for them. He described the situation, saying, “Suddenly three guys jump on the middle of the road and start waving to stop. How can you stop in one second? I think they could prevent this by stopping us before, no? Not 10 metres before the crossing. I was thinking: ‘Maybe it’s like some protesters or something crazy is going on.’” The Belgian newspaper Het Laatste Nieuws reported that the East Flanders public prosecutor’s office intends to prosecute the riders. Riders could face significant penalties, including fines and a driving ban, if convicted. Race officials ordered the riders who went through the red light to slow down so the rest of the peloton could catch up. The Tour of Flanders, also known as De Ronde (the Tour), is one of cycling’s most challenging one-day races and a “monument” of the sport. This year’s 278km route featured 16 short but punishing climbs and several cobblestone sections. Pogacar’s victory was notable, but the incident has overshadowed his achievement.

Sha’Carri Richardson, the Olympic 100m silver medallist and world‑ranked sixth‑fastest woman, delivered a thrilling victory at the 144th Stawell Gift on Easter Monday, crossing the finish line in a record 13.15 seconds to claim the $40,000 top prize.The 26‑year‑old American entered the historic Australian event – the nation’s oldest and richest running race – as a scratch runner, meaning she started from the zero‑metre mark while rivals enjoyed handicaps based on prior performance.In the women’s final, Richardson edged out Charlotte Nielsen (13.20s) and Chiara Santiglia (13.36s) after a false start by 17‑year‑old Grace Crowe forced the latter to move her blocks back a metre, effectively shortening Richardson’s target.Her semi‑final had been a nail‑biter; Richardson eased up at the line and won by a razor‑thin seven thousandths of a second over Halle Martin, prompting her coach Dennis Mitchell to stress the need for a stronger finish.“I think I realised I was going to win right past 90 metres,” Richardson said post‑race, adding, “The love, the support, the true enjoyment that I had on the track … you all made this moment happen. Thank you.”Richardson’s triumph makes her the third woman ever to win the Stawell Gift from scratch, underscoring the event’s growing international stature and the lucrative incentive for elite sprinters.In the men’s 120‑metre final, Australian Olufemi Komolafe – a 21‑year‑old medical student – secured victory in 11.93 seconds from a five‑metre handicap, with Jake Ireland second in 12.07 seconds. Komolafe expressed disappointment at not facing his idol, fellow American sprinter Christian Coleman, who failed to qualify for the final, finishing fifth in his semi‑final off scratch.Coleman reflected, “I gave it everything I got. You give them that much of a margin, it’s pretty tough. I hope everybody continues to watch and support athletics. I’m looking forward to a strong season and improving my 40‑to‑100 metre transition.”

Martin Ho arrived at Tottenham in July, inheriting a side that had slumped to 11th place the previous season. Within months the club has risen to fifth in the Women's Super League, just three points shy of matching their record 32‑point tally from 2021‑22. With three league games remaining, Spurs are set to face Chelsea in an FA Cup quarter‑final, while a recent League Cup exit saw them lose 2‑1 to Manchester United. Ho, who began coaching at 17 after an unfulfilled stint at Everton’s academy, describes the campaign as a success so far, noting the progress from a “rudderless” squad to a more cohesive unit. He acknowledges the boldness of such a claim before the season ends, especially after consecutive 5‑2 defeats to Manchester City and Arsenal, but stresses that the club’s trajectory is positive. Only two new signings – Norway forward Cathinka Tandberg and Japan defender Toko Koga – joined the roster in the summer, a deliberate move by Ho to assess the existing squad first. "I needed to see the players with my own eyes and apply my coaching methodology," he explained. Ho’s approach draws on his experience as an assistant at Manchester United under Casey Stoney and Marc Skinner, and his earlier head‑coach role at Norwegian side SK Brann. He spent time learning the club’s culture, fanbase and values before implementing changes. Key to the transformation was a psychological reset. Ho told his players that the team must look forward and abandon the disappointment of the previous season. "We asked them to play bravely, press higher and accept that mistakes are part of growth," he said. The 5‑1 loss to Manchester City early in the season became a catalyst. Ho observed that the squad’s response demonstrated a shift in mentality, prompting him to reinforce belief and challenge the players to improve. Consistency has been elusive – three wins from eight league matches – but the side has shown signs of potential, and January brought additional reinforcements. Looking ahead, Ho warns against over‑inflated expectations. "If we promise Champions League football now and fail, it harms everyone," he cautioned, noting that European competition would be premature for a club still building its foundation. He emphasizes the need for steady, sustainable progress rather than a flash‑in‑the‑pan surge. "We must evolve the squad, staff, processes and investment together," Ho said. With a limited pool of elite talent, attracting and retaining players remains a challenge. Ho stresses creating an authentic environment that offers clear development pathways, saying, "When players see their value and a clear route forward, they stay and improve." Born in Liverpool to a Chinese father and English mother, Ho credits his upbringing for his holistic coaching philosophy. He often remarks that coaches are like thieves, constantly borrowing ideas from one another, and strives to adapt those influences into a style that reflects his own vision for Tottenham Women.

Donald Trump’s demand that Iran reopen the Strait of Hormuz has an immediate impact on U.S. gasoline prices, but analysts warn that a prolonged conflict will push energy costs higher across the globe, far beyond the fuel pump. Systemic increases in power prices and disrupted supply chains are set to compress margins for industries worldwide; in the United States, the effect could be especially damaging to the fragile economics of the AI boom. Oil‑importing nations in the Global South are already feeling the strain: Egypt has imposed curfews, Indonesia is trialling work‑from‑home Fridays, and the Philippines has declared a national energy emergency. While the United States, as a major oil exporter, can partially insulate itself, the country cannot escape the global rise in energy costs. Experts predict that price pressure will linger for months even if the strait reopens within days. Companies are revisiting cash‑flow forecasts, and the AI sector—characterised by energy‑intensive model training and debt‑laden expansion—faces a particularly acute risk. OpenAI chief Sam Altman attempted to downplay environmental concerns, likening the energy required to train an AI model to the cumulative food intake over a human’s 20‑year development. The Bank of England’s Financial Policy Committee warned that rising energy costs could depress AI share prices, noting that investors were already uneasy about the sector’s heavy reliance on debt financing and uncertain return prospects before the war began. "The conflict could increase these concerns, particularly given the energy‑intensive nature of the supply chain for key components and the operation of datacentres," the committee said. World Trade Organization chief economist Robert Staiger echoed this view, cautioning that a prolonged period of high energy prices could "crimp" AI investment. He highlighted that AI‑related goods accounted for 70% of U.S. investment growth in the first three‑quarters of last year. A forensic note from US law firm Quinn Emanuel revealed that the AI sector generated roughly $60 billion in revenue last year while committing $400 billion to capital expenditure. The financing structure mirrors the 2008 crisis, with off‑balance‑sheet special purpose vehicles and asset‑backed securities playing a central role. Leading "hyperscalers" and infrastructure providers such as CoreWeave are borrowing enormous sums to build out datacentres, although some analysts argue that many projects lag behind their lofty promises. Much of this borrowing comes from private‑credit lenders, making total liabilities opaque and challenging for regulators—an issue the Bank of England has repeatedly flagged. Complex financing arrangements see datacentres owned by special purpose vehicles, debt pooled and sold to pension funds, and other layered structures that obscure true exposure. Quinn Emanuel estimates that $120 billion of datacentre debt has been moved off‑balance sheets in the past two years. The firm warns that distress at any single node could cascade through the tightly interconnected AI ecosystem. Extended higher energy costs, combined with volatile interest rates and weaker consumer demand—both likely fallout from the Middle East war—could trigger that distress. The fundamental question remains: can the AI sector generate sufficient revenue to justify its sky‑high valuations? Even modest energy price hikes may force a market rethink, with potential spill‑over effects across U.S. markets and beyond. As the article concludes, the economic fallout may be yet another unintended consequence of Trump’s aggressive stance on Iran, unleashing forces beyond his control.

Major League Soccer (MLS) Commissioner Don Garber has expressed his approval of FIFA's dynamic pricing strategy for the upcoming World Cup, which has significantly raised ticket prices across all games. The tournament is set to take place in the US, Mexico, and Canada this summer. Garber made these comments in Miami, where he attended the inaugural fixture at Inter Miami's Nu Stadium. He suggested that the high prices resulting from FIFA's dynamic pricing model are justified by the event's exclusivity, stating that Americans are accustomed to such pricing for major events. “FIFA has been smart. They have variable ticket pricing and I'm hoping they'll be providing access to anybody that wants to buy a ticket,” Garber said. “It's not really for me to comment on pricing. [MLS] has nothing to do with that, it's FIFA's decision. But I think it's going to be a premier event and premier pricing Americans are used to.” FIFA's dynamic pricing model has been met with criticism, with some labeling it as “price gouging”. US politicians have also weighed in, writing to FIFA President Gianni Infantino. Supporters' groups have expressed outrage over the rising costs. Recently, FIFA raised the top price of a World Cup final ticket to $10,900, up from $8,600 after the finals draw in December. This represents a significant increase from the $1,600 top price for a World Cup final ticket in Qatar four years ago. Despite the controversy, Garber emphasized that MLS is working to capitalize on the tournament to showcase its growth. Many of MLS' top players, including Lionel Messi and Rodrigo de Paul, are expected to represent their nations during the World Cup. “We're going to be present during the games,” Garber added. “We've just finalized the last shoot for major advertising campaigns. It's the first time we've ever produced anything like that. We'll be advertising in the final and semi-finals with some of our biggest stars that we think will resonate around the world.”

When Corentin Roudaut arrived in Paris a decade ago, he swapped his student‑era bike for a car, daunted by the city’s traffic and lack of cyclist protection. After a protected lane opened on Boulevard Voltaire in the 11th arrondissement, he reclaimed his two‑wheel commute and now volunteers with the cycling advocacy group Paris en Selle, witnessing a city that has shed its car‑centric image.Roudaut notes that the shift “started slowly but really accelerated in the last ten years,” with a growing network of bike routes that is becoming safe and nearly complete in many districts.Mayor Anne Hidalgo’s 12‑year agenda reshaped Paris’s urban fabric. Since taking office in 2014, her administration planted 155,000 trees, created several hundred kilometres of segregated bike lanes, pedestrianised 300 school streets, and banned cars from the banks of the Seine. Former parking spaces have been turned into green plazas and café terraces, reducing the risk of children being hit while walking to school.As Hidalgo departs on Sunday, her legacy is touted as a blueprint for progressive European cities, especially as some national governments retreat from green initiatives.Nevertheless, the reforms have sparked pushback. Motorists object to the loss of road space, and recent referendums on higher parking charges for SUVs and further school‑street pedestrianisation suffered low voter turnouts. Right‑wing mayoral candidate Rachida Dati described the new public‑space regime as “anxiety‑inducing,” though she stopped short of promising a reversal.In a candid interview, Hidalgo described the Seine‑bank pedestrianisation as “a tough battle” that, once won, left residents reluctant to revert to car traffic. She highlighted a generation of children who have never known cars on those riverbanks, prompting awe‑filled reactions from visitors.Urban scholars attribute the rapid change to Paris’s tight administrative boundaries, which limit suburban influence on city transport decisions, and to groundwork laid by previous mayors. Yet they stress that political courage was essential to implement measures that inconvenienced drivers while delivering social and environmental benefits.Environmental epidemiologist Audrey de Nazelle of Imperial College London, a Paris native, praised the transformation as “fabulous” and warned that many cities lack the bravery to pursue similar legacies.A recent report placed Paris among 19 global cities that cut two major toxic air pollutants between 2010 and 2024. While Brussels and Warsaw saw faster declines in fine‑particle matter, London outpaced Paris in reducing nitrogen‑dioxide levels.By contrast, Berlin—despite opening a new inner‑city motorway and scrapping 30 km/h speed limits on key streets—still records a higher share of cyclists than Paris.Transport researcher Giulio Mattioli argues that Paris simply needed to add bike lanes to unlock latent demand, noting that the city started from a lower baseline but quickly caught up with peers.However, the transformation remains uneven. The extensive suburbs continue to be dominated by cars, hemmed in by the 35 km Boulevard Périphérique ring road. Analyst Jean‑Louis Missika of think‑tank Terra Nova stresses that “as long as this motorway encircles Paris, the Greater Paris metropolis will remain an administrative construct devoid of urban reality.” He calls for dismantling or repurposing the ring road to achieve a truly post‑car metropolis.

Chelsea manager Liam Rosenior has sought to calm the storm surrounding Enzo Fernández's recent comments about his future at the club. Fernández had appeared to cast doubt on his Chelsea future during the international window, praising former Real Madrid players Toni Kroos and Luka Modrić and expressing a desire to live in Madrid. Rosenior took the decision to suspend Fernández from Chelsea's FA Cup quarter-final against Port Vale and the upcoming Premier League game against Manchester City, feeling his comments had 'crossed the line' and threatened the culture he is working to instill. However, Rosenior was pleased that Fernández was present at Stamford Bridge to watch the Vale match and sought to draw a line under the affair. “Enzo and I are in a very good place,” Rosenior said. “I saw him today, had a really good conversation with him today one-to-one and things aren’t what people maybe think they are.” Rosenior emphasized that he wants the team to focus on achieving their season goals, including winning the FA Cup and qualifying for the Champions League. The decision to punish Fernández drew an unhappy response from the player’s agent, Javier Pastore, who described it as 'completely unfair.' Rosenior remained firm, stating that Fernández knows his value to the team and that he was pleased to see him supporting the players.