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Retatrutide Delivers Up to 28% Body‑Weight Reduction in Phase 3 StudyA new weight‑loss drug has helped participants in a sizable trial lose much more weight than other obesity drugs already on the market – up to an average of 28% of their body weight, Eli Lilly announced on Thursday. Phase 3 Trial Design and Dosing RegimenThe Indiana‑based company randomized 2,339 adults with obesity or overweight and at least one weight‑related comorbidity (no diabetes) to receive Retatrutide at 4 mg, 9 mg, 12 mg, or placebo for 80 weeks. The drug is a once‑weekly triple hormone receptor agonist targeting GLP‑1, GIP, and glucagon. Quantitative Outcomes and Safety ProfileAverage weight loss: 70.3 lb (28.3%) at the 12 mg dose.Average loss at 9 mg: 64.4 lb (25.9%).Average loss at 4 mg: 47.2 lb (19.0%).45.3% of 12 mg participants lost ≥30% of body weight.65.3% reduced BMI below 30; 37.5% of those starting with BMI ≥ 40 achieved this.Side‑effects increased with dose: nausea (28.6%‑42.4%), diarrhea (25.2%‑34.1%), vomiting (up to 25%).For comparison, Zepbound yields 15‑20% loss over 72 weeks and Wegovy 14‑19% over 64‑72 weeks. Implications for the Obesity‑Drug LandscapeThe magnitude of loss positions Retatrutide as the most effective pharmacologic option to date, potentially shifting prescriber preference away from existing GLP‑1 monotherapies. Its triple‑agonist mechanism adds glucagon, a hormone absent from current products, which may enhance metabolic control and appetite suppression. Future Outlook: Approval Path and Market PotentialAnalysts expect regulatory submissions within the next year, with a likely U.S. FDA review in 2027. If approved, Retatrutide could capture a sizable share of the rapidly expanding obesity‑treatment market, prompting competitors to explore multi‑agonist formulations.

The Diplomatic Warning The high representative overseeing the United States-founded Board of Peace for Gaza, Nickolay Mladenov, has warned that the deteriorating status quo in the devastated Palestinian enclave risks becoming "permanent." Speaking to the United Nations Security Council (UNSC), Mladenov presented a roadmap detailing obligations for Israel and Hamas to implement a permanent ceasefire. "Let me say this clearly: the implementation cannot advance through Palestinian obligations alone," Mladenov said, speaking via video call. "The continued killings and Israeli restrictions affecting humanitarian flows are not abstract issues." He urged the UNSC to use "every means at its disposal" to press Hamas to disarm, while also saying that Israel must uphold its commitment under a ceasefire agreed in October. The Humanitarian Crisis The war that Israel launched following the October 7, 2023 attacks on southern Israel by Hamas and other armed Palestinian groups was halted by a ceasefire in October 2025. More than 72,775 Palestinians have been killed in the conflict. But the Israeli military maintains a strict security regime, and many hundreds more have been killed in the past seven months. Conflict monitors warn that since the ceasefire in the US-Israel war on Iran was struck last month, Israeli bombardment of Gaza has accelerated. Violent raids by settlers and the military in the occupied West Bank have also been increasing. On Thursday, an Israeli drone attack killed a 26-year-old in Gaza's al-Mahatta area, east of Deir el-Balah city, according to Wafa news agency. The Stalled Peace Process In January, the US announced that the Gaza "ceasefire" was moving to phase two, which is supposed to focus on Hamas's disarmament, long-term governance and the establishment of a panel of Palestinian technocrats to lead post-war Gaza. It also calls for the gradual retreat of the Israeli army, which still controls more than 50 percent of the Palestinian territory, and the deployment of an international stabilizing force. But with the war in Iran drawing the world's attention amid a global energy crisis, the transition to the second phase has been stalled for weeks. Mladenov, a veteran Bulgarian diplomat, warned of the risks of inaction by both parties. The Regional Implications "The risk is that the deteriorating status quo becomes permanent: a divided Gaza, Hamas holding military and administrative control over two million people across less than half the territory," Mladenov said. "Those people are likely to remain trapped in the rubble, dependent on aid with no meaningful reconstruction, because reconstruction financing will not follow where weapons have not been laid down." "And the result? Another generation growing up in tents in fear, with despair as the most rational thing for them to feel." This, he said, is a scenario that Israelis, Palestinians and the region "should all fear and mobilize to avoid."

The LeadEleven weeks after the start of the Iran war, the Strait of Hormuz has remained closed to naval traffic, bleeding the global economy far beyond the Gulf. Iran's Islamic Revolutionary Guard Corps (IRGC) maintains an iron grip over this narrow, strategic waterway, while a corresponding United States naval blockade on Iranian ports has failed to reopen it.Before the war began, between 120 and 140 ships travelled through the strait each day, about half of them oil tankers carrying some 20 million barrels of oil between them. Now, only a few vessels whose owners have negotiated with the IRGC are permitted to pass.The Strategic Control of HormuzOn Wednesday, Iran said it coordinated the transit of 26 vessels through the Strait of Hormuz in 24 hours, two days after announcing the formation of the Persian Gulf Strait Authority (PGSA), a new body to provide "real-time updates" on operations in the strait.Since the announcement of a temporary ceasefire between the US and Iran in April, Iran has been working on formalising a mechanism to charge a transit fee from ships crossing the critical chokepoint, through which 20 percent of the world's oil and liquefied natural gas (LNG) are shipped during peacetime.Tehran has reportedly already charged fees as high as $2m per ship for transit since the war started. Even though countries opposing Tehran say this is illegal, it may still be less expensive than the overall cost of the closure of the strait each day.The Economic Cost of BlockadeNearly one-fifth of global oil and LNG exports were shipped by Gulf producers through the Strait of Hormuz before the US and Israel bombed Iran on February 28, triggering the Iranian closure of the waterway. The strait is the only waterway linking Gulf producers to the open ocean – there is no other route through which they can ship exports.About 20.3 million barrels per day of oil passed through the Strait of Hormuz in peacetime – nearly 27 percent of global maritime oil trade. The lion's share of that crude went to Asian markets.Global LNG trade has been similarly hard hit. On the day before the war broke out, Brent crude – the global benchmark for oil prices – closed at $72.48 per barrel. After Iran closed the waterway on March 4 and began attacks on vessels attempting to sail through, traffic came to a standstill, stranding about 2,000 ships on either side of the strait.In terms of lost oil revenues, this amounts to $114.8bn of losses per day. About 10 billion cubic feet of LNG per day also used to pass through the strait, worth a further $7.8bn.The Cost-Benefit Analysis of Transit FeesFor hundreds of ships stranded in the Gulf with thousands of sailors on board, the cost of remaining anchored is steep, including crew wages, loan repayments, repair and management, coupled with inflated war risk premiums.In turn, Iran has reportedly been charging up to $2m for authorisation to pass. Experts say many will see this as worthwhile purely in terms of monetary cost."There is no doubt that paying Iran is cheaper than a continuous blockade because a sitting tanker bleeds money," said Nader Habibi, an Iranian American economist."It makes sense from an economic point of view, but it is not politically feasible," he added. "The companies are under pressure from the US sanctions and not to make arrangements with Iran. This is not just a purely economic cost-benefit analysis, but long-term considerations that are taken into account."International Legal PerspectivesInternational law protects free transit through strategic waters such as natural straits like Hormuz, barring countries from imposing passage tolls even where the waterways fall entirely into territorial waters, like in the case of Hormuz.However, services such as security controls, inspections and insurance regimes can be charged for. Chargeable fees also partly depend on whether a waterway is a man-made passageway or a natural one.These are three different precedents in maritime traffic flow:Panama Canal: An artificial waterway connecting the Atlantic and Pacific oceans. Vessels pass through a unique system of locks that raise and lower vessels across elevated terrain. Since Panama built, maintains and operates the canal, it can charge transit fees based on vessel size, cargo capacity and booking priority. These range from several hundred thousand dollars per transit to some slots sold for millions of dollars.Suez Canal: Another artificial canal, linking the Mediterranean and Red seas. Egypt charges transit fees for the use of canal infrastructure, maintenance and traffic management services through the narrow waterway. Container ships and oil tankers pay from several hundred thousand dollars to more than one million dollars per voyage.Turkiye's Bosporus Strait and Dardanelles: These are different because they are natural straits, rather than man-made canals. Turkiye charges for navigation-related services such as lighthouse operations, rescue readiness, medical support and traffic management – and tightly controls ship scheduling and navigation.Regional Cooperation PossibilitiesIran's newly-formed PGSA published a new map of Hormuz, stretching from Kuh-e Mubarak in Iran to south of Fujairah, in the UAE, at the eastern entrance of the strait, and from the tip of Qeshm Island to Umm al-Quwain at the western entrance.Given how the Iran war has spilled over into the Gulf region – with the UAE taking the brunt of Iranian strikes – economist Mohammad Reza Farzanegan said "regional cooperation with Iran is the most realistic path to stable transit through the Strait of Hormuz."The UAE, Oman, Qatar and Iran will have to work together because their economies require it, he argued. A workable arrangement could include a joint maritime authority, shared monitoring, emergency coordination, environmental protection and service-based contributions for maintaining safe passage."This would give Iran a recognised role in the security of the waterway while giving Persian Gulf economies more predictability," Farzanegan added. "Such a framework is also more realistic than relying on external military enforcement, which has been more a source of trouble for these states."The Future OutlookWhile it may seem that the economics of the closure of the strait are currently skewed towards Iran, Aniseh Tabrizi, an associate fellow on the Middle East and North Africa Programme at think tank Chatham House, noted that "the economics by itself is not going to be the driver to change calculation or move from the current standpoint."She emphasized that Iran and the US need to reach a "diplomatic compromise, with other calculations linked in to the economic factor", before there can be an end to the energy supply crisis.Farzanegan added that if the world expects stable access to the Strait of Hormuz, then paying Iran could well be accepted as the price of keeping the vital waterway predictable. "From an economic perspective, a negotiated transit arrangement [with Iran] now makes more sense than continued closure," he concluded.

Rachel Reeves' Cost of Living Support Package Rachel Reeves will cut VAT to 5% on summer attractions such as theme parks and softplay centers during the school holidays, as she aims to ease the impact of the war in Iran on cash-strapped households. Key Measures Announced VAT cut from 20% to 5% during the summer on tickets for attractions and children’s meals Postponement of fuel duty increases due to take effect in September and December Suspension of import tariffs on some foods 10p increase in tax-free mileage rate for workers claiming back the costs of driving The Data Analysis The costs of these measures will be partly met by changes to the “foreign branch profits” regime, which determines how multinational oil firms pay tax on their UK operations. Reeves suggested the shift would raise several hundred million pounds. The Impact Analysis The chancellor said the summer attractions that would benefit from the temporary VAT reduction included zoos, museums, theme parks and softplay venues, as well as children’s theatre tickets and meals. This move is expected to support families and help them cope with the rising cost of living. The Prediction Reeves declined to say how she expected to support families in the upcoming winter, when utility bills are expected to rise sharply – but restated her intention to ensure any such scheme would be, “targeted and temporary”.

US Treasury Announces Removal of ICC‑Related Sanctions on AlbaneseThe Department of the Treasury updated its website on Wednesday, listing Francesca Albanese under “International Criminal Court‑related Designation Removal,” effectively ending the sanctions that had been in place since July 2025.Legal Battle and Judge Leon’s Injunction Prompt ReversalA federal judge, Richard Leon, issued a temporary injunction last week after Albanese’s husband and daughter sued, arguing the sanctions were a punitive response to her public advocacy. Leon found the Trump administration had sought to curb her speech because of the “idea or message expressed.”Sanctions Timeline and Financial ImplicationsJuly 2025: Treasury imposed sanctions following Albanese’s report accusing 48 companies, including Microsoft, Alphabet and Amazon, of complicity in Israel’s war on Gaza.May 14, 2026: Judge Leon blocks the sanctions with a temporary injunction.May 22, 2026: Treasury removes the designation, ending travel bans and asset freezes tied to the sanctions.No specific monetary penalties were disclosed, but the sanctions restricted Albanese’s ability to travel to the United States and froze any U.S.‑based assets.Broader Implications for US Policy on Human‑Rights AdvocacyThe reversal signals a potential shift in how the United States uses economic tools against UN human‑rights experts. Under the Trump administration, sanctions were employed to pressure advocates for Palestinians and other progressive causes, including climate‑change activists. Removing the sanctions may ease diplomatic friction with the UN Human Rights Council and the International Criminal Court.Future Outlook: Potential Shifts in US‑UN Relations and ICC PressureAnalysts expect the Biden administration to review the broader sanctions regime targeting ICC officials and activists. Continued legal challenges could further limit the U.S. government’s ability to weaponize sanctions against speech, while the ICC’s ongoing investigations into Israeli leaders may keep the issue in the spotlight.

Lead: A Historic Indictment Raises the Stakes in US‑Cuba RelationsActing US Attorney General Todd Blanche announced a criminal indictment against former Cuban leader Raul Castro for the 1996 downing of two civilian planes, marking the first time senior Cuban officials have faced US criminal charges for violence against American citizens.Indictment Unveiled: Charges and ContextThe indictment, delivered from Miami’s Freedom Tower, accuses Castro—then defence minister and now 94‑year‑old—of:One count of conspiracy to kill US nationalsFour counts of murderTwo counts of destroying an aircraftThe charges stem from the 1996 shoot‑down of two aircraft operated by the exile group Brothers to the Rescue, which killed four people: Carlos Costa, Armando Alejandre Jr, Mario de la Pena and Pablo Morales.Financial and Legal Stakes of the CaseBeyond the criminal counts, the indictment sits within a broader US pressure campaign that includes:A renewed $100m humanitarian assistance offer tied to political reform.Continued enforcement of the longest‑standing trade embargo, first imposed in the 1960s.Recent fuel blockades that have triggered island‑wide blackouts and deepened Cuba’s economic crisis.These measures collectively aim to force regime change or at least significant policy shifts in Havana.Geopolitical Ripple Effects Across the CaribbeanThe indictment is expected to:Escalate diplomatic tensions between Washington and Havana, with Cuban President Miguel Diaz‑Canel branding the shoot‑down as “legitimate self‑defence.”Complicate any ongoing or future negotiations, as US officials hint at possible military options while also courting Cuban private‑sector growth.Fuel migration pressures, as economic hardship drives more Cubans to seek refuge in the United States.Regional actors are watching closely, given the US’s recent actions against Venezuela’s Nicolas Maduro and the broader pattern of using legal mechanisms to pressure adversarial regimes.What the Indictment Signals for Future US‑Cuba RelationsAnalysts suggest the move reflects a dual‑track strategy:Legal pressure to hold Cuban leaders personally accountable for past violence.Economic leverage aimed at strengthening Cuba’s private sector while isolating state‑run entities.Experts such as journalist Javier Farje argue that Washington is more likely to pursue gradual economic transformation rather than outright regime change, using the indictment as a bargaining chip.Outlook: Potential Scenarios and RisksLooking ahead, three plausible paths emerge:Negotiated reforms: Cuba may accept limited economic concessions in exchange for reduced sanctions.Escalation: The US could intensify legal and economic actions, possibly extending to targeted sanctions on additional Cuban officials.Stalemate: Continued legal battles without substantive policy change, prolonging the humanitarian crisis and migration flows.Each scenario carries significant implications for regional stability, US domestic politics, and the future of US‑Cuba engagement.

The Indictment of Raul Castro: Legal Action Over 1996 ShootdownU.S. federal prosecutors have unsealed an indictment charging former Cuban president Raul Castro with conspiracy, murder, and aircraft destruction for the February 24, 1996 shootdown of two civilian planes operated by the exile group Brothers to the Rescue.Details of the Federal Indictment and Historical ContextThe indictment, released on May 20, 2026, alleges that Castro, then Cuba’s defence minister, directed fighter jets to fire on the aircraft over international waters. The planes, part of a humanitarian‑rescue operation founded by exile Jose Basulto, were shot down, killing four people and sparking worldwide condemnation.1996 incident: two civilian aircraft shot down on February 24.Victims: four Cuban‑American activists killed.Brothers to the Rescue: founded 1991 to aid rafters crossing the Florida Straits.Legal Charges and Historical Casualties: Numbers at a GlanceThe Justice Department’s filing lists:1 count of conspiracy to kill U.S. nationals.4 counts of murder.2 counts of destroying an aircraft.The indictment also references the four fatalities from the 1996 attack, underscoring the gravity of the alleged crimes.Geopolitical Ripple Effects for US‑Cuba RelationsAnalysts see the timing as part of a broader U.S. pressure campaign under the Trump administration. Recent diplomatic activity includes a CIA director visit to Havana and reports of Cuban interest in drone capabilities targeting U.S. assets. The indictment could:Intensify existing sanctions and diplomatic isolation of Havana.Bolster hard‑line factions within Cuba, who may portray the move as external aggression.Provide the Trump administration a narrative of “tough on Cuba” ahead of the November midterm elections, where President Trump’s approval sits at a historic low of 34 % according to a Reuters‑Ipsos poll.Potential Trajectories: Diplomatic Negotiations and Domestic PoliticsWhile the indictment may pressure Cuba toward a negotiated settlement, experts caution that it could also entrench the regime’s hardliners. Possible outcomes include:Limited diplomatic concessions from Havana in exchange for reduced legal pressure.Escalation of rhetoric and retaliatory measures from the Cuban government.Domestic political gains for Trump if a perceived “victory” is framed, though the likelihood of a tangible deal remains uncertain.As the case proceeds, both U.S. policymakers and Cuban officials will weigh the legal, diplomatic, and electoral stakes of this unprecedented move.

UK Grants Indefinite Licence for Russian‑Refined Jet Fuel and DieselThe United Kingdom announced an indefinite trade licence, effective from Wednesday, that relaxes sanctions on Russian jet fuel and diesel processed in third countries such as India and Turkiye. The licence will be reviewed periodically and also covers a temporary waiver for liquefied natural gas from selected Russian plants.Economic Rationale Behind the Policy ShiftLondon says the decision is a “time‑limited” response to unprecedented fuel‑price pressure caused by the closure of the Strait of Hormuz and the ongoing Iran‑Russia war. By allowing cheaper Russian‑refined products, the government hopes to curb inflationary pressures on transport and aviation sectors.Fuel prices have surged across Europe, with diesel and jet fuel benchmarks up over 30% year‑to‑date.The licence applies to oil refined outside Russia, sidestepping direct imports of Russian crude.Review cycles are set to occur every few months, though the licence itself has no fixed end date.Potential Fiscal and Market ImpactWhile exact cost savings are not disclosed, analysts estimate that the policy could shave up to £200 million off annual fuel‑related expenditures for UK airlines and logistics firms. However, the move may also expose the UK to criticism for weakening the sanctions regime that has been a cornerstone of its Ukraine support strategy.Geopolitical Repercussions and Domestic OppositionEU economy commissioner Valdis Dombrovskis warned that easing pressure on Russia contradicts the collective G7 stance. Within Britain, opposition Conservative leader Kemi Badenoch denounced the licence as a betrayal of the “standing up to Putin” narrative.Outlook for UK Energy Policy and SanctionsFuture steps will hinge on the trajectory of global oil supply disruptions and the durability of the US sanctions waiver, which was recently extended for a second time. Treasury minister Dan Tomlinson emphasized that the licence is narrowly scoped and will be rescinded if market conditions improve, suggesting a cautious, reversible approach to energy security.

The US-Israel Plan for Regime Change The United States and Israel went into war on Iran intending to replace the regime’s leadership with hardline former President Mahmoud Ahmadinejad, The New York Times reported. Quoting US officials who were briefed on the “audacious plan”, the newspaper said things “quickly went awry”, and Ahmadinejad’s “current whereabouts and condition are unknown”. The Background on Ahmadinejad After the killing of Ayatollah Ali Khamenei, US President Donald Trump mused that it would be best if “someone from within” Iran took over the country, the Times reported. “To say that Mr Ahmadinejad was an unusual choice would be a vast understatement,” the newspaper said. “While he had increasingly clashed with the regime’s leaders and had been placed under close watch by the Iranian authorities, he was known during his term as president, from 2005 to 2013, for his calls to ‘wipe Israel off the map’. He was a strong supporter of Iran’s nuclear program, a fierce critic of the United States and known for violently cracking down on internal dissent.” The Plan Goes Awry The US-Israeli plan, which Ahmadinejad had been consulted about, “quickly went awry”, according to the US officials who spoke to the Times. Ahmadinejad was reportedly wounded on the first day of the war by an Israeli strike on his home in Tehran, which was intended to free him from house arrest, American officials told the Times. Ahmadinejad survived the strike, they said, but after the near-miss, he changed his mind about the regime change plan, and he has not been located since. The Aftermath An article in the Atlantic in March said the attack on the house was “in effect a jailbreak operation”, citing anonymous associates of Ahmadinejad. After that article, the Times said it received confirmation from an associate of Ahmadinejad that he recognised the air strike was an attempt to free him. The associate said the Americans believed Ahmadinejad could lead the country and had the ability to manage “Iran’s political, social and military situation”.