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A 47‑year‑old woman who had endured three life‑threatening autoimmune diseases for more than a decade is now living a near‑normal life after an experimental CAR‑T cell therapy reset her immune system at University Hospital Erlangen in Germany.Before the procedure she had exhausted nine different treatments with no lasting benefit, relying on daily blood transfusions and continuous anticoagulation to manage her illnesses.Within weeks of the infusion, doctors observed rapid improvement in all three conditions—a world‑first outcome. She has remained in treatment‑free remission for 14 months and has largely returned to everyday activities.Prof Fabian Müller, who led the team, called the speed and depth of the response “remarkable” and said the therapy “significantly improved her quality of life.” He emphasized that clinical trials are required to determine how durable the effect is and whether it can help other autoimmune patients.The patient suffered from three distinct disorders: autoimmune haemolytic anaemia (AIHA), where rogue immune cells destroy red blood cells; immune thrombocytopenia (ITP), which depletes platelets and raises bleeding risk; and antiphospholipid syndrome (APS), which promotes dangerous blood clots. All three stem from malfunctioning B‑cells.With no conventional options left, doctors turned to CAR‑T therapy, a technique that has revolutionised treatment for certain cancers. They harvested her white‑blood cells, isolated the T‑cells, engineered them to recognise the CD19 protein on B‑cells, and reinfused the modified cells.The engineered T‑cells swiftly eliminated the pathogenic B‑cells. She received her last blood transfusion a week after treatment and was able to perform routine tasks within two weeks. Follow‑up tests showed a reconstituted, healthy B‑cell population, suggesting an immune reset. The findings were published in the journal Med.She still exhibits a mildly low white‑cell count and slightly elevated liver enzymes, which researchers attribute to the cumulative impact of prior therapies rather than the CAR‑T product.Rheumatology expert Prof Ben Parker of Manchester University NHS Foundation Trust described the case as encouraging, noting that “the prolonged response off normal therapy suggests there has been an immune reset.” However, he warned that case reports alone cannot confirm efficacy and highlighted ongoing trials for lupus, myositis, multiple sclerosis, systemic sclerosis, vasculitis, and other autoimmune conditions.

The romantic comedy 'You, Me & Tuscany' offers a wholesome and harmless meet-cute that will appeal to fans of the genre. The film stars Halle Bailey as Anna, a young woman navigating life after her mother's death, and Regé-Jean Page as Matteo, a charming Italian man who sweeps her off her feet.The movie's plot is full of familiar romantic comedy tropes, from the fake engagement to the picturesque Italian setting. However, the film's charm lies in its strong performances from the cast, particularly Bailey and Page. The chemistry between the leads is undeniable, and their romance is sweet and engaging.Despite its charm, the film has received criticism for its lack of originality and predictable plot twists. Some critics have argued that the movie relies too heavily on overused romantic comedy clichés, which detracts from its overall impact.The film's success is significant for the romantic comedy genre, as it marks a shift towards more diverse and culturally specific storytelling. The movie's diverse cast and Italian setting offer a fresh take on the traditional romantic comedy, and its positive representation of Black culture is a welcome change.Overall, 'You, Me & Tuscany' is a charming and engaging romantic comedy that is worth watching for fans of the genre. While it may not break new ground in terms of storytelling, the film's strong performances and picturesque setting make it a delightful watch.

The recent ceasefire between the United States and Iran may provide temporary relief, but the oil crisis triggered by their conflict is far from over. After 40 days of fighting, the two nations agreed to a two-week ceasefire, with negotiations set to begin in Pakistan's capital, Islamabad.One of the key points in Iran's 10-point proposal is allowing shipping to resume through the Strait of Hormuz, a critical waterway through which 20 percent of the world's oil and gas is shipped during peacetime. The strait has been effectively closed since the start of the war, causing global oil and gas prices to soar.Following the announcement, oil prices dropped to $92 on Wednesday, down from over $110 for much of the war. However, delays in restarting production and transport mean the energy crisis is far from over. For ships to continue operating, they need certainty about security during the next two weeks of the ceasefire.Even with the waterway reopened, it will take weeks for large oil tankers – now scattered thousands of miles away – to return to the Gulf to collect the millions of barrels sitting in large reservoirs. With very few tankers able to load or unload and their onshore storage full, producers began shutting wells, causing regional oil output to plummet despite efforts to reroute limited volumes via overland pipelines.Economists warn that the true impact on grocery bills will likely persist throughout 2026 and into 2027. Additionally, it will take years for the Gulf energy industry to repair facilities damaged or destroyed during the war.Shipping data shows that combined exports from Iraq, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates fell from 469 million barrels in February to 263 million barrels in March – a decline of 206 million barrels, or 44 percent. Iraq's crude exports have been hit the hardest, falling 82 percent from 94m barrels in February to 17m in March.The 206 million barrels of Gulf oil lost since the start of the war would fill approximately 103 Very Large Crude Carriers (VLCCs), the workhorse supertankers of the global energy trade. A single VLCC stretches nearly 330 metres (1,080 feet) in length, nearly the same height as the Eiffel Tower in Paris.To put that in more practical terms, if you drove a pick-up truck that averages 24 miles per gallon (or 10 litres per 100km), one barrel of crude oil would carry you about 730km or 450 miles. That is about the distance from New York City to Cleveland, Ohio.For much of the war, oil has traded above $100 per barrel, hitting a peak of nearly $128 on April 2. The value of 206 million lost export barrels at various oil prices is significant, with Brent crude being the global benchmark.

The United States and Iran have agreed to a two-week ceasefire, with Iran reopening the strategic Strait of Hormuz and talks set to begin in Islamabad, Pakistan. The agreement was reached after a request from Pakistan's Prime Minister Shehbaz Sharif and pressure from China.Iran's Minister of Foreign Affairs, Abbas Araghchi, confirmed that safe passage through the Strait of Hormuz will be ensured for two weeks through coordination with the country's armed forces. Under the agreement, Iran and Oman will be allowed to charge transit fees on passing ships, with Tehran planning to use the revenue for post-war reconstruction.The ceasefire was agreed upon just an hour before US President Donald Trump's deadline to escalate the conflict expired. Trump's move followed a request from Pakistan's Prime Minister, who urged Washington to extend its deadline for a deal and called on Iran to reopen the strait. The breakthrough came after talks with Pakistan's leadership, which had pushed for a ceasefire.Iran has proposed a 10-point peace plan, which includes lifting sanctions, creating a war-loss fund, a potential US troop withdrawal from the Gulf, and recognition of Iran's right to enrich uranium in exchange for a pledge not to build nuclear weapons. However, it is unclear whether the US has agreed to any of these proposals.The ceasefire has triggered street celebrations in Tehran and Baghdad, with Iranian leaders declaring the conflict is ending 'on Iran's terms'. However, some citizens remain skeptical, warning the US and Israel may be using the pause to 'buy time' and regroup.The agreement has also had an impact on the global economy, with crude prices falling below $100 after Trump's announcement. However, analysts remain cautious, with markets in 'wait-and-see mode' as a 'big gap' remains in negotiations.

Cheng Li-wun, chairwoman of Taiwan’s main opposition party the Kuomintang (KMT), used a high‑profile trip to mainland China to advocate for renewed dialogue with Beijing. On Wednesday she laid a wreath at Sun Yat‑sen’s mausoleum in Nanjing, invoking the revolutionary’s legacy of “equality, inclusiveness and unity” as a moral foundation for cross‑strait reconciliation. Her visit marks the first time a KMT leader has set foot in China in ten years. Cheng said the core values of Sun’s ideal—"all under heaven are equal"—should guide efforts to promote reconciliation and regional prosperity across the Taiwan Strait. During the trip Cheng also expressed hopes to meet Chinese President Xi Jinping, framing the potential encounter as a diplomatic test that could demonstrate the effectiveness of dialogue over deterrence. The timing of the trip is notable. It comes amid heightened friction between Taipei and Beijing, with China continuing to assert sovereignty over Taiwan while refusing to engage with President William Lai Ching‑te, whom it labels a “separatist”. Amid concerns that a distracted United States may be less able to guarantee Taiwan’s security, some Taiwanese voters view a thaw in relations as attractive. Wen‑ti Sung, a non‑resident fellow at the Atlantic Council’s Global China Hub, told Al Jazeera that a cordial photo‑op between Cheng and Xi could bolster the KMT’s argument that dialogue is more effective than military deterrence. Domestically, Cheng’s outreach occurs as Taiwan’s opposition‑controlled parliament has stalled a proposed $40 billion increase in defence spending. She acknowledged Taiwan’s democratic evolution, referencing the legacy of the “White Terror” period, while also praising China’s recent development achievements. The governing Democratic Progressive Party (DPP) sharply criticized the trip, accusing the KMT of undermining national security. Party spokesperson Wu Cheng argued that if the opposition truly seeks stability, it should stop blocking the defence budget increase. Neither Beijing nor Taipei formally recognises the other’s government, leaving any dialogue fragile and heavily politicised. Cheng’s visit therefore represents both a symbolic gesture toward historic ties and a contested move within Taiwan’s polarized political landscape.

Iran and the United States announced a two‑week ceasefire that will also guarantee safe navigation through the strategically vital Strait of Hormuz, a chokepoint through which roughly 20% of the world’s oil supply moves.The pause comes as the conflict entered its 40th day, with hopes now fixed on a diplomatic breakthrough during talks scheduled to begin in Pakistan on Friday.President Donald Trump declared that the truce would be activated once Tehran fully reopened the waterway, linking the cessation of hostilities to the restoration of a critical global supply route.Celebrations erupted across Iran, and numerous world leaders publicly welcomed the development, describing it as a step toward broader regional stability.The fighting, which has drawn in virtually the entire Middle East, saw Iran claim to target U.S. assets in several Gulf Cooperation Council (GCC) states, while Gulf nations accused Tehran of striking civilian infrastructure.Hezbollah’s March 2 attacks on Israel pulled Lebanon into the war, and although Israel has signaled support for the ceasefire, it warned that the agreement does not extend to Lebanon.Against this backdrop, Gulf and neighboring states have issued statements outlining their positions on the ceasefire:Saudi Arabia welcomed the truce, urging an immediate end to regional attacks and calling for the Strait of Hormuz to be reopened, emphasizing that the ceasefire should lead to a “comprehensive sustainable pacification.”Qatar described the ceasefire as an “initial step toward de‑escalation,” stressing the need for rapid implementation, full adherence by Iran, and the protection of maritime security and international trade under international law.United Arab Emirates diplomatic adviser Anwar Gargash hailed the outcome as a victory for a war the UAE sought to avoid, claiming the nation now possesses greater leverage and capacity to shape regional affairs.Oman expressed appreciation for Pakistan’s mediation and called for intensified efforts to address the root causes of the conflict, aiming for a permanent end to hostilities.Iraq welcomed the ceasefire but urged the United States and Iran to launch “serious and sustainable dialogue” that tackles underlying disputes and rebuilds mutual trust.Egypt framed the truce as a crucial opportunity for negotiations, diplomacy, and dialogue, insisting that any lasting peace must respect freedom of navigation and consider the legitimate security concerns of Gulf states.Turkey supported the ceasefire and pledged backing for the upcoming Islamabad talks, emphasizing the importance of full ground‑level implementation and strict adherence by all parties.Sudan called the two‑week pause a “positive step toward de‑escalation,” highlighting its potential to foster diplomacy and regional stability.

Mircea Lucescu, a Romanian football great and serial trophy winner as a player and coach, has passed away at the age of 80. Lucescu's death was confirmed by the Bucharest University Emergency Hospital, where he was admitted after reportedly suffering a heart attack on Friday morning.Lucescu was one of the most successful Romanian football coaches and players, known for being the first to qualify the Romanian national team for a European Championship in 1984. He had a lengthy coaching career spanning almost half a century, from the late 1970s to World Cup 2026 qualifying.As a player, Lucescu captained his country at the 1970 World Cup. His coaching career included stints with Shakhtar Donetsk, where he won the UEFA Cup in 2009 and accumulated 22 trophies, making him the most successful manager in the club's history.Lucescu also coached Turkish and Romanian national teams and had spells with Italian clubs such as Pisa, Brescia, Reggiana, and Inter Milan. His contributions to Romanian football have been widely praised, with Romanian President Nicusor Dan paying tribute to him as "one of the most respected figures in the history of Romanian and European football".UEFA President Aleksander Ceferin remembered Lucescu as "one of the game's true originals – a man of rare football intellect, remarkable dignity and passion". Lucescu's legacy continues to inspire generations of football players and fans.

Washington, D.C. – President Donald Trump declared a two‑week ceasefire with Iran on Tuesday, just hours after threatening a massive attack on the country. The pause will allow Iran to reopen the strategic Strait of Hormuz while both sides negotiate a longer‑term settlement. Republican Senator Lindsey Graham, a noted Iran hawk, welcomed the diplomatic move but stressed extreme caution. He praised the “hard work” of negotiators but warned that any agreement must be scrutinized, noting that Iran’s 10‑point plan reportedly offers sanctions relief and permits Tehran to retain control of the strait. Graham also warned that Iran must not be rewarded for its earlier attacks on the strait, writing on X: “We must remember that the Strait of Hormuz was attacked by Iran after the start of the war, destroying freedom of navigation. Going forward, it is imperative Iran is not rewarded for this hostile act against the world.” Democratic senators, while relieved that U.S. forces would be out of immediate danger, seized the moment to demand accountability. Senator Ruben Gallego said, “Stopping war is good… we can criticize why we got into this war, the illegality of it and hold the Trump admin accountable. But right now I am relieved.” Other Democrats, including Senator Ed Markey and Congresswoman Alexandria Ocasio‑Cortez, warned that the ceasefire does not erase the fact that the conflict was launched without congressional authorization and that targeting civilian infrastructure may constitute war crimes. Ocasio‑Cortez wrote, “The President has threatened a genocide against the Iranian people… launched a massive war… without reason, rationale, nor Congressional authorization – which is as clear a violation of the Constitution as any.” Critics on the right, such as far‑right activist Laura Loomer and commentator Mark Levin, dismissed the truce as a temporary pause, predicting the war will resume. Loomer warned, “The negotiation is a negative for our country… I don’t know why people are acting like this is a win.” Levin added, “This enemy is still the enemy; they’re still surviving.” The conflict, which began on February 28 without a congressional war declaration, has already seen high‑profile strikes, including an attack that the article claims killed Iranian Supreme Leader Ayatollah Ali Khamenei and a devastating strike on a girls’ school in Minab that killed over 170 civilians, mostly children. Economically, the closure of the Strait of Hormuz earlier in the war sent oil and gas prices soaring, underscoring the strategic importance of the waterway. Senator Chris Murphy (D) warned that allowing Iran to control the strait would be a “history‑changing win” for Tehran. Across the aisle, lawmakers agree that the ceasefire is not a clean slate. Advocacy director Raed Jarrar of DAWN urged an immediate congressional investigation into the war’s origins, funding, and accountability for civilian casualties. As the two‑week pause unfolds, U.S. officials and legislators will closely monitor negotiations, with the broader debate over war powers, constitutional authority, and potential impeachment of President Trump remaining front and center in Washington.

The documentary series 'Trust Me: The False Prophet' has shed light on the sinister activities of a polygamous Mormon cult led by Samuel Bateman, who is currently serving a 50-year sentence for luring minors into criminal sex acts.Director Rachel Dretzin, a former investigative journalist for Frontline, worked on the series, which follows a pair of documentary filmmakers, Christine Marie and Tolga Katas, who embedded themselves in Utah's Fundamentalist Church of Jesus Christ of Latter-day Saints (FLDS) community. They earned the trust of the cult members and were invited into Bateman's home, where he presided over 20 'wives', many of them underage.The filmmakers' incriminating footage and witness testimony were essential to the FBI's case against Bateman and other men charged with crimes. The series transcends the true crime genre's typical sensationalism, presenting its revelations thoughtfully and honestly.Dretzin notes that documentary filmmaking can be more effective than the legal system in effecting change, particularly in cases like this where the community is fiercely insular. The series raises questions about the ethics of documentary filmmaking and the blurred lines between observer and participant.The story also highlights the manipulation and indoctrination of young women within the cult, including Naomi, a young woman who becomes a pivotal witness. Her aunt Carole, who defected from the FLDS, shares her insights on how the cult grooms girls for exploitation.Dretzin believes that the story has echoes in our ordinary lives and political landscape, particularly in the era of 'fake news' and echo chambers. The series serves as a reminder of the dangers of closed systems and the importance of critical thinking.