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What is Immunotherapy? Immunotherapies are biological treatments that harness the immune system to prevent, control and fight diseases and other conditions. The most familiar are vaccines, which train the immune system to recognise targets such as invading pathogens. Other immunotherapies boost immune responses when they are too weak, or dampen them down when they are out of control. Still others draw on engineered immune cells or lab-made antibodies to disrupt disease processes. The Evolution of Immunotherapy Efforts to prevent disease by boosting the immune system date back thousands of years, but advanced therapies for a wide range of illnesses have come to the fore in the past two decades. A global registry of clinical trials listed 1,257 trials of immunotherapies between 2006 and 2016. The figure leapt to 4,591 in the past decade. How Do Cancer Immunotherapies Work? Cancer patients have seen great benefits from immunotherapies and dozens are now approved for more than 30 types of cancer. Some tumours evade the body’s defences by switching off immune cells, but antibody-based drugs – called checkpoint inhibitors – reactivate them so they can recognise and attack the malignancies. The Future of Immunotherapy: Beyond Cancer Researchers are now testing whether existing immunotherapies can help a broader range of patients. This includes treating allergies, infections, brain diseases, and autoimmune disorders. Some of the most exciting new immunotherapies draw on recent Nobel prizewinning work on regulatory T-cells, or Tregs, which can be used to dampen down immune responses. The Potential of Tregs in Immunotherapy Tregs are unusual immune cells that stand the immune system down once the threat has been dealt with. Therapies are in the pipeline for dementia and autoimmune diseases from type 1 diabetes and rheumatoid arthritis to lupus and chronic inflammation. The potential for Tregs is vast, and researchers believe that half of all deaths have a component that is immunological.

The Lead: Russia's Escalation and Ukraine's Counteroffensive Russia's attempts at escalation via Belarus, where it has delivered more nuclear weapons and held highly publicized joint war games, come as its ground war falters in Ukraine. Ukrainian commander-in-chief Oleksandr Syrskii reports that Ukraine has seized the tactical initiative, with Ukrainian offensive assaults now outnumbering Russian assaults on Ukrainian positions. Russia's Soldier Shortage and Recruitment Crisis Ukraine's forces have gained the upper hand because Russian forces are running out of soldiers to conduct offensive operations. According to Syrskii, "Since the beginning of 2026, the total losses of the enemy have already exceeded 141,500 people, of which more than 83,000 are irreversible." Ukraine's Foreign Intelligence Service believes Russia is unable to replenish these losses of more than 1,000 people a day, and this year is recruiting at a rate of 800-930 a day, suffering a net decrease of battlefield strength. In response, 40 Russian regions have increased sign-up bonuses by between 30 and 100 percent. Putin has also simplified citizenship procedures for Russian speakers in the Transnistrian region of Moldova, which Ukrainian President Volodymyr Zelenskyy described as "Russia looking for new soldiers." Economic Impact: Ukraine's War on Russian Oil Infrastructure Russia's economy is fraying, having run up a $78.4bn deficit in the first four months of 2026 after budgeting for a $50.5bn deficit for the entire year. "Oil dealt the main blow. Revenues from hydrocarbons fell by 38.3 percent," according to Ukraine's Foreign Intelligence Service. Ukraine has scaled up its long-range campaign against Russian refineries and oil export terminals, depriving Moscow of windfall profits from high oil prices. International Energy Agency (IEA) data shows Russia has curtailed production by 460,000 barrels per day (bpd) in April 2026 compared with April 2025. Reuters estimates that Ukrainian drone attacks knocked out about 700,000 bpd of refining capacity between January and May across 16 refineries, accounting for a quarter of Russia's refining capacity. Shift to Asymmetric Warfare: Ukraine's Strategy Evolution "Given our limited resources, to effectively resist a much larger enemy, we are trying to shift from a 'war of attrition' to an asymmetric strategy," Syrskii told the European Union Military Committee. "Our main tasks are to stop the enemy's advance and effectively counterattack, strike at the Russians' rear, including deep within their territory." Ukraine has attacked military-industrial targets in a 100km radius around Moscow, including the Angstrem semiconductor plant, the Solnechnogorsk oil pumping station, and the Moscow Refinery. Ukraine has also targeted refineries in Ryazan, Yaroslavl, Kstovo, and Sizran, as well as military hardware including helicopter gunships, amphibious craft, and anti-aircraft missile systems. Belarus Front: Russia's Nuclear Escalation and Ukraine's Warning Russia has put pressure on Belarus President Alexander Lukashenko to open a new front in the war against Ukraine. Zelenskyy stated that Russia would launch a simultaneous attack from its neighboring region of Bryansk against Chernihiv. "We know that there have been additional contacts between the Russians and Alexander Lukashenko aimed at persuading him to join new Russian aggressive operations," Zelenskyy said. Russia involved Belarus in a joint nuclear exercise with 64,000 personnel, more than 200 missile launchers, 140 aircraft, 73 surface ships and 13 submarines. Russian President Vladimir Putin confirmed that the two countries would launch ballistic and cruise missiles as part of the exercise. Russia has parked its new Oreshnik tactical nuclear missile in Belarus since last year and has threatened to attack European arms manufacturing and military sites with it.

The Arrest That Sparked International ConcernThe operation began at 9am Moscow time, but took place across all of Russia's 11 time zones. Almost simultaneously, agents of the federal security service (FSB) raided the homes and workplaces of 17 Indigenous rights activists. Officers carried out searches, confiscated laptops and phones, and arrested and interrogated activists about participation in international forums. Most were let go; many have since left the country. Others remain in Russia, but will no longer speak up.Six months later, one remains in jail. Daria Egereva, one of Russia's foremost Indigenous rights activists, is accused of membership of a terror group. No trial date has been set. Her supporters say the charges are fabricated and she has been targeted for speaking out.Egereva was not just any activist. A member of the Selkup indigenous group, from western Siberia, she was a "bright star" of Russia's indigenous rights movement. As a member of the UN's Indigenous Peoples' Coordinating Body, she had international status. Weeks before her arrest, she had played a key role at Cop30 in Brazil as co-chair of the Indigenous People's Forum on Climate Change.Her jailing has shone a spotlight on the plight of Russia's Indigenous people, threatened by authoritarianism, extractivism and climate breakdown.The Climate Crisis in Russia's Arctic"They are really seeing the worst effects of climate change," said Alicia Moncada, director of global advocacy at Cultural Survival, which campaigns for Indigenous rights. "They are on the frontline of the frontline – that's why [Egereva's] advocacy was super important."The polar north is heating faster than any other part of the planet. In recent decades, temperatures in Arctic regions have risen three to four times faster than the global average. Communities based on permafrost are seeing their world collapse around them."The elders are saying that nature has stopped trusting us," said one exiled Indigenous leader, who requested that his name be withheld. "The traditional ways of predicting nature are not working any more."Many settlements sit next to the banks of rivers and lakes. Due to the melting permafrost, those banks are beginning to crumble. "There is a real threat of destruction for a lot of those villages," said the leader, who spoke through an interpreter. And the melting ice has brought a new source of tension: newly accessible critical mineral resources.Resource Extraction and Indigenous Displacement"All these resources of the Russian Federation, a majority of them are located under the lands of Indigenous people: gold, diamonds, oil, gas, coal," the leader said. "For some people it is a treasure, but for us it is a curse."Because the companies are coming to our land for those resources and they are pushing us out. Even if they don't push us out, the environmental situation in those places will become so bad that we are unable to hunt or fish."One of the elders said that we can adapt to anything, but we will not be able to survive without our land."The Government Crackdown on Indigenous ActivismAlthough Indigenous groups maintained their identities, by the end of the Soviet era they lacked independent organisation and relied on the state. Egereva had been part of a new generation of leaders who had encouraged community self-empowerment.But this assertiveness brought them into conflict with the authorities. Even before the war in Ukraine, the Russian state claimed that its enemies were exploiting environmental and indigenous issues. Now, with the war a pretext for a crackdown on civil society, Indigenous people are among those at the sharp end.To date, 830 organisations and 20,813 individuals have been put on the "list of terrorists and extremists", according to the UN. Among them was Aborigen Forum, a network of Indigenous defenders designated an "extremist organisation" in July 2024.Russian authorities have based their charges against Egereva and her co-defendant, Natalia Leongardt, a civil rights activist, on their involvement with Aborigen. Authorities claim it is part of an anti-state "post-Russia free nations forum".International Response and Russian DefenseIn a bail hearing on 29 April, Egereva and Leongardt denied being part of any anti-state conspiracy. "I am not familiar with and do not know this organisation," Egereva told the court. "What we are being accused of is completely untrue ... I ask to be allowed to return home and embrace my children."The court refused to grant them bail, remanding them in custody until at least mid-June. The following day, Russia celebrated a new federal holiday: the "Day of Indigenous Small-Numbered Peoples".The Russian embassy told the Guardian: "The investigation concerning Daria Egereva is an internal Russian legal matter, conducted in full accordance with Russian law. As proceedings are ongoing, we are not in a position to comment on the specifics of the case."Russia firmly rejects any allegations of violations of Indigenous people's rights. Unlike a number of western states – including Britain in its former colonies – Russia has no history of forced assimilation of Indigenous communities. Russian law affords Indigenous peoples special legal protections, guaranteeing their collective and individual rights, cultural identity, and linguistic heritage under the constitution and in line with international norms."Russia is actively engaged in the international climate agenda, taking account of both the challenges and the economic opportunities emerging in its northern regions – including expanded access to the northern sea route and mineral resources in permafrost zones. All such projects are carried out with the aim of supporting regional development, creating jobs and attracting investment, including for the benefit of Indigenous communities in these areas."

The Nuclear Buildup in Eastern Europe Earlier this week, Belarusian President Alexander Lukashenko for the first time took part in the "rehearsal" of Russia's use of tactical and strategic nuclear weapons. Between Tuesday and Thursday, he and Russian President Vladimir Putin presided over joint military drills covering the area from Eastern Europe to the Pacific, involving hundreds of Russian missile launchers, warplanes, warships and nuclear submarines. "We threaten absolutely no one," said Lukashenko, who has helmed Belarus since 1994. "But we have such weapons, and we're ready in every possible way to defend our common fatherland from [the western Belarusian city of] Brest to [Russia's Pacific port of] Vladivostok." Russia's Nuclear Drills and Capabilities "It's important to further boost the level of readiness of strategic and tactical nuclear forces," Putin stated during the exercises. Both leaders ordered the launch of the intercontinental, hypersonic Yars missile capable of carrying three independently targetable nuclear missiles, which flew 5,750km (3,573 miles) from the Plesetsk Cosmodrome in northwestern Russia to the Pacific Kamchatka Peninsula in less than 20 minutes. As part of the drills, Moscow supplied Minsk with modified Su-25 fighter jets and Iskander-M ballistic missiles with a range of up to 500km (310 miles). Nuclear weapons are reportedly stored at the Asipovichi military range, less than 200km (124 miles) north of the Ukrainian border. Geopolitical Implications The drills come amid heightened tensions between Russia and NATO. NATO Secretary-General Mark Rutte warned that if Moscow uses nuclear weapons against Ukraine, the alliance's response would be "devastating." The exercises are clearly timed to a summit of NATO foreign ministers in Sweden's Helsingborg, a venue symbolic as Sweden joined the alliance after Russia's full-scale invasion of Ukraine. "The events develop suddenly, seemingly without any external reasons," noted Nikolay Mitrokhin, a researcher with Germany's Bremen University. "Something big is taking place, something that will be significant for international politics in general, and for mass media, including the very supply of nuclear arms." Belarus's Calculus While Belarus enjoys economic preferences and cheap hydrocarbons from Russia, Lukashenko has resisted Putin's attempts to merge Belarus with Russia as part of "union state" deals dating back to the 1990s. In recent months, ties between Belarus and the United States have also warmed, with Lukashenko joining United States President Donald Trump's Board of Peace. "We're not going to get sucked into the war in Ukraine. There's no need for it, neither civil nor military," Lukashenko stated, signaling his readiness to meet with Ukrainian President Zelenskyy. "If [Zelenskyy] wants to discuss something, seek advice, or anything else, he's welcome. I'm ready to meet him anywhere in Ukraine or Belarus." Future Scenarios Ukrainian President Zelenskyy has warned that the drills may be part of Moscow's preparations to launch a new offensive against northern Ukraine and Kyiv after Russian troops failed to capture sizeable areas in eastern and southern Ukraine this year. However, the current concentration of Russian forces in Belarus is "insufficient" for a new offensive, according to the head of the Kyiv-based Penta think tank. "Attacking Ukraine with Belarusian forces alone may end very badly for Lukashenko," said Volodymyr Fesenko. "For him, involving Belarus in the war is too big a risk." Despite this, analysts acknowledge that "unfortunately, there is such a risk" of Belarus becoming more directly involved in the conflict, though most believe Lukashenko will avoid such a development.

Lead: SpaceX’s $1.75 trillion IPO filing pulls back the curtain on lofty ambitions and hidden costsThe rocket‑builder released a sprawling investor prospectus that blends trillion‑dollar valuation hopes with concrete details: $131 m spent on Cybertrucks, $4.9 bn loss in 2025, and a promise of a million‑person Mars colony. At the same time, the document warns of AI‑related liabilities from the Grok chatbot and escalating personal‑security expenses for Elon Musk.Inside the 300‑Page Prospectus: Mars Colonies and Cybertruck PurchasesThe filing repeatedly stresses the mission to "extend the light of consciousness to the stars" and to establish permanent human settlements on the Moon and Mars. It also reveals that SpaceX bought roughly $131 million worth of Cybertrucks in 2025 – enough for at least 1,300 vehicles, representing a sizable slice of Tesla’s total sales that year.Cybertruck spend: $131 m (2025)Estimated units: ≥1,300Tesla total Cybertruck sales 2025: 20,237 unitsFinancial Highlights: Billions in Losses and $131 m Cybertruck SpendKey numbers from the prospectus illustrate the scale of SpaceX’s cash burn:$4.9 bn net loss in 2025$4.3 bn loss in Q1 2026$506 m paid to Tesla for Megapack batteries in 2025$191 m paid to Tesla for Megapack batteries in 2024These figures underscore the interdependence of Musk’s ventures and the financial pressure ahead of the IPO.Strategic Risks: AI Chatbot Grok and Security ExpendituresThe risk section flags several non‑financial threats:Grok’s “spicy” and “unhinged” modes could generate explicit, misleading, or non‑consensual content, exposing SpaceX to litigation and regulatory scrutiny.Investigations by U.S., U.K. and EU authorities into alleged sexual‑image generation by Grok.Security spending for Musk’s personal protection rose to $4 m in 2025, with an additional $1 m in the first quarter of 2026.What the IPO Could Mean for SpaceX’s Multiplanetary FutureIf the offering proceeds, the capital influx could fund the ambitious Mars‑colony target – a million‑person settlement that would trigger a 1 bn‑share award to Musk. However, sustained losses, AI‑related legal exposure, and the need for continual heavy investment in experimental technologies raise questions about long‑term profitability.Analysts will watch whether the market rewards the visionary narrative or penalizes the financial volatility and regulatory headwinds embedded in the filing.

President Donald Trump used his social‑media platform on Thursday to declare that the United States will send an extra 5,000 troops to Poland, a move that overturns a prior decision to reduce the American footprint in Europe. Trump’s Surprise Troop Deployment to Poland The announcement was framed as a personal endorsement of Poland’s newly elected president, Karol Nawrocki, whom Trump praised for his “friendship” and “shared security vision.” Polish Foreign Minister Radek Sikorski welcomed the decision, saying it would keep the U.S. presence “more or less at previous levels.” Details of the 5,000‑Soldier Reinforcement Date of announcement: Thursday, 22 May 2026 Units involved: Not specified; Pentagon has not clarified whether the troops are redeployed from Germany or newly assigned. Previous plan: A scheduled deployment of 4,000 troops was scrapped a week earlier; an earlier proposal to withdraw 5,000 troops from Germany was also announced. Polish reaction: President Nawrocki and Foreign Minister Sikorski praised the move as a sign of “good alliances based on cooperation, mutual respect, and shared security.” Numbers Behind the Move: Troop Levels and Funding While the exact financial outlay was not disclosed, Warsaw traditionally contributes a significant share of the cost for U.S. forces on its soil. Analysts note that maintaining an additional 5,000 troops could increase Poland’s annual contribution by several hundred million dollars, depending on the force composition. Current U.S. troop presence in Poland: Approximately 4,000–5,000 personnel. Potential total after deployment: Up to 10,000 U.S. soldiers. Comparison with Germany: The Pentagon recently announced a reduction of combat brigades in Europe from four to three, signaling a broader re‑balancing of forces. Strategic Ripple Effects Across NATO The abrupt policy shift fuels uncertainty among NATO allies that have already expressed frustration with Trump’s “America First” stance, especially his criticism of European defence spending and the U.S.–Israeli war on Iran. NATO Secretary‑General Mark Rutte welcomed the Polish reinforcement but warned Europe must become less dependent on U.S. troops. Swedish Foreign Minister Maria Malmer Stenergard described the situation as “confusing” for both allies and U.S. officials. U.S. Secretary of State Marco Rubio is slated to discuss NATO burden‑sharing at the upcoming foreign‑ministers meeting. European concerns now extend to other U.S. statements, such as threats to annex Greenland, further straining alliance cohesion. What Comes Next for Transatlantic Defense Analysts predict a short‑term scramble within NATO to clarify the composition and timeline of the Polish deployment. Potential scenarios include: Redeployment of troops from Germany to Poland, solidifying a forward‑focused posture on the Eastern flank. Gradual scaling back of U.S. forces in Central Europe, paired with increased European defence investments. Intensified diplomatic efforts by the Pentagon and State Department to reassure allies ahead of the NATO foreign‑ministers summit. In the coming weeks, the alliance’s ability to present a unified response to Russian aggression in Ukraine will hinge on how quickly Washington can translate the announced numbers into a clear, predictable force structure.

The Lead: US-Cuba Relations Reach Critical PointUnited States President Donald Trump and Secretary of State Marco Rubio have issued new threats of military action against Cuba, escalating tensions between the two nations. The Trump administration, with Cuban-American Rubio at the forefront, has been increasing pressure on the communist-led island in what appears to be an attempt to institute "regime change," including a fuel blockade that has pushed the Cuban economy toward collapse.The Escalation: Military Buildup and Legal ActionsThe push against Cuba has accelerated in recent days, with the US indicting Cuba's former President Raul Castro and gathering military forces in the Caribbean. Since returning to office, Trump has implemented numerous sanctions against Cuba, including a fuel blockade that has caused blackouts and protests across the island.On Thursday, Adys Lastres Morera – sister of a high-ranking executive of the Grupo de Administracion Empresarial SA (GAESA) conglomerate, controlled by Cuba's military – was arrested. The US military has also announced that several navy ships, including an aircraft carrier, have arrived in the Caribbean to participate in maritime exercises with partners in Latin America.The Rationale: National Security ConcernsRubio told reporters that Cuba has been a national security threat for years due to its ties with US adversaries Russia and China. Rejecting suggestions of "nation building," Rubio emphasized that the issue is one of "national security." While stating that a negotiated agreement is the US "preference," he indicated that the path of diplomacy with Cuba is "not high.""Their economic system doesn't work. It's broken, and you can't fix it with the current political system that's in place," Rubio said. He added that Cuba has historically "bought time and waited out" previous administrations, but "they're not going to be able to wait us out or buy time. We're very serious, we're very focused."The Presidential Stance: Trump's Personal CommitmentPresident Donald Trump separately told reporters that US presidents have considered intervening in Cuba for decades, but that he appears likely to be "the one that does it." Trump expressed willingness to take action, stating he would be "happy" to intervene militarily in Cuba if necessary.International Response: Condemnation and SupportIn response to the US actions, Cuban Foreign Minister Bruno Rodriguez criticized Rubio for falsely labeling Cuba a threat. "The US secretary of state lies once again to instigate a military aggression that would provoke the shedding of Cuban and American blood," Rodriguez said.Both China and Russia have criticized the US pressure on Cuba. China stated it "firmly supports" Cuba and urged the US to de-escalate tensions and "stop threatening force." Kremlin spokesperson Dmitry Peskov commented that "under no circumstances should such methods – which border on violence – be used against either former or current heads of state."Historical Context: The Venezuela PrecedentAnalysts suggest that Trump and Rubio may be considering a similar approach in Cuba to the regime change operation conducted in Venezuela earlier in 2026. In January, Venezuelan President Nicolas Maduro and his wife were kidnapped in a military operation and brought to the US, where Maduro was charged with "narcoterrorism."Future Outlook: Aid Offers and Potential EscalationRubio noted that Cuba had tentatively accepted an offer of $100 million in aid in return for reforms, though it remains unclear if the US would accept Cuba's terms, as Washington insists on circumventing the military-backed conglomerate GAESA. The situation remains volatile, with both sides digging in their positions as the US continues its military buildup in the region.

Hospital Fire Halts Ebola Care in North KivuOn 21 May 2026, a fire destroyed a dedicated Ebola treatment centre in the North Kivu province of the Democratic Republic of Congo (DRC), cutting off inpatient care for patients amid a rapidly expanding outbreak.Location: North Kivu, DRCFacility: Ebola treatment hospital operated by MSFCause: Under investigation, preliminary reports suggest accidental ignitionImpact: All beds, equipment, and stored medical supplies lostOutbreak Numbers Reveal Escalating ThreatThe DRC health ministry reported over 1,200 confirmed cases and approximately 800 deaths since the outbreak began earlier this year, marking the deadliest Ebola wave in the country’s history.Case fatality rate remains above 65%Transmission clusters expanding to three new districtsVaccination campaign has reached 45% of target populationRegional Health System Strains Under CrisisWith the loss of the treatment centre, the DRC’s already stretched health infrastructure faces a critical gap. Neighboring facilities are operating at over 90% capacity, and international partners are scrambling to deploy mobile units.WHO pledges emergency funds for temporary isolation wardsLogistical challenges include road insecurity and limited power supplyCommunity trust erodes after repeated incidents, hindering contact tracingWhat the Next Weeks Could Hold for DRC's Ebola ResponseExperts warn that without rapid replacement of treatment capacity, the outbreak could accelerate, potentially adding several hundred cases. Immediate actions include:Deploying modular treatment units within 48 hoursAccelerating vaccine rollout to reach 70% coverage by end‑JulyStrengthening surveillance in bordering provinces to prevent cross‑border spread

The Shifting Tides of Trump's Iran Policy In a week that began with Donald Trump revealing he was just an hour away from 'making the decision' to resume attacks on Iran, the United States president has oscillated between expressing hope for a lasting ceasefire and threatening military escalation. Diplomacy and Threats Trump's mixed messaging has also coincided with a renewed flurry of diplomacy, with Iran as of Thursday saying it had received and was reviewing Washington's response to Tehran's latest ceasefire proposal. The Hawkish Advisers Trump, meanwhile, appeared to indicate an appetite for a third option: a prolonged, grinding conflict. On Thursday, he reposted a New York Post op-ed by Richard Goldberg, a senior adviser at the Foundation for Defense of Democracies, a pro-Israel think tank that has long supported military action against Tehran. Trump's Statements This Week The Trump administration has continually sent broad and at times contradictory messages on Iran, even preceding the war. On Sunday, Trump threatened that the 'clock is ticking' for Iran, the latest instance of the US signalling an end to the current halt to fighting, which has run parallel to an ongoing naval blockade of Iran's ports. The Strategic Dilemma While Trump's supporters have characterised his everything-on-the-table approach as part of a wider 'mad man' foreign policy approach, others have said it reflects the president's entrenched dilemma as he tries to claim a convincing victory in the conflict.