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The UK medicines regulator has opened an inquiry into a growing number of clinics that sell injectable peptides while promoting them as cures for everything from ageing to injury recovery. The investigation, disclosed by the Guardian, focuses on whether these businesses are breaching the Human Medicines Regulations 2012 by making unauthorised medicinal claims. Interest in peptide‑based treatments has surged in recent years, driven by social‑media influencers, some healthcare professionals, and direct‑to‑consumer marketers. Yet the scientific foundation for most of these claims is weak, with the bulk of research confined to animal models or cell‑culture studies. According to an MHRA spokesperson, any clinic that advertises a peptide as having therapeutic benefits must treat the product as a medicine, which triggers a comprehensive regulatory framework. "If clinics offering peptide injections make medicinal claims for those treatments, the products will be considered medicines and subject to regulation," the agency warned, adding that it will act against any identified breaches. Guardian reporters identified several high‑ranking Google search results that list peptides such as Cortexin (promoted for neuroprotection), BPC‑157 (claimed to aid tissue repair), and Thymosin Alpha (advertised to boost immunity). After being contacted, one clinic removed the statements from its website. Another clinic, while acknowledging the limited human evidence, continued to market seven specific peptides, providing price lists (£350 per month for a single peptide, £450 for two) and offering delivery via vials, syringes, or pre‑filled pens for an additional fee. During a free consultation, a clinician highlighted the experimental nature of the products, noting the absence of large‑scale, randomised clinical trials and recommending a break of four to eight weeks between treatment cycles to mitigate unknown risks. The clinician suggested BPC‑157 for post‑exercise recovery, describing it as a facilitator of cellular repair and blood flow, but warned against its use in smokers or individuals with a family history of cancer due to potential angiogenic effects. The second peptide discussed was MOTS‑C, portrayed as a mitochondrial enhancer that could improve stress resilience, lower insulin resistance, and reduce visceral fat by boosting cellular energy production (ATP). The MHRA confirmed it is reviewing whether the clinician’s statements constitute medicinal claims. The clinic defended its approach, emphasizing that it clearly informs clients that the peptides are not licensed medicines and that the evidence base is largely pre‑clinical. In a broader statement, Lynda Scammell, head of borderline products at the MHRA, explained that peptide products may be marketed as cosmetics, supplements, or medicines, and each case is assessed on its intended use, pharmacological effect, and supporting evidence. She added, "We disregard claims that products are for ‘research purposes’ if it is clear that such claims are being used as an attempt to avoid medicines regulations." Peptides are short chains of amino acids, some of which occur naturally (e.g., insulin). While synthetic peptide analogues like semaglutide and tirzepatide have secured approval for weight‑loss treatments, many of the compounds promoted by these clinics remain experimental and lack the rigorous safety and efficacy testing required for medicinal products.

Liverpool's humiliating 4-0 defeat to Manchester City in the FA Cup quarter-finals has raised concerns about the team's form and manager Arne Slot's future. Slot criticized his team's performance, particularly in the 10 minutes after halftime, where he felt they lacked the 'fighting spirit' needed to compete at a high level. The manner of the defeat will heighten scrutiny of Slot's future, especially with Liverpool's upcoming Champions League quarter-final against Paris Saint-Germain. A similar performance in that tie could prove detrimental to Slot's position as manager. Erling Haaland scored a hat-trick for Manchester City, contributing significantly to their eighth consecutive FA Cup semi-final appearance. Slot emphasized the need for his team to improve defensively and show a better reaction to the loss, particularly against top-tier teams like PSG. Liverpool's Dominik Szoboszlai echoed Slot's sentiments, stating that the team's 'fighting spirit wasn't there enough.' The defeat marks Liverpool's 15th of the season, their most since the 2014-15 season. Liverpool's struggles have been compounded by Mohamed Salah's missed chances, including a penalty when City were 4-0 ahead. Slot, however, chose not to single out individuals, instead focusing on the team's overall performance and the need for improvement.

The Panama Papers, a massive leak of 11.5 million documents from Panamanian law firm Mossack Fonseca, exposed a vast network of offshore shell companies used by global elites to evade taxes and scrutiny. The leak, which involved over 350 journalists from 80 countries, revealed that hundreds of people, including over 140 politicians, were linked to offshore entities.The scandal led to significant consequences, including the resignation of Iceland's Prime Minister Sigmundur Gunnlaugsson and the disqualification of Pakistan's Prime Minister Nawaz Sharif from office. Mossack Fonseca ultimately shut down in 2018 following the leak.Governments worldwide have recovered around $2 billion in taxes, penalties, and levies since 2016, with countries like the UK, Sweden, and France each recovering between $200-250 million. However, the amount of unaccounted funds remains significantly higher.The leak has also driven regulatory changes, including the Corporate Transparency Act in the US, which requires disclosure of beneficial owners of offshore entities. The United Nations is considering a Convention on Taxation to address global tax challenges.Despite progress, gaps remain in the global tax system, allowing individuals and companies to exploit loopholes and avoid taxes. Experts stress the need for a multilateral tax convention to address tax competition and treaty shopping.

Cuba’s government declared a humanitarian amnesty for 2,010 prisoners ahead of Easter’s Holy Week, a decision it says follows a careful review of each inmate’s conduct, health, and time served. The announcement, made by state media on Thursday, represents the second such amnesty this year and the fifth large‑scale pardon since 2011, bringing the total to more than 11,000 released individuals. While Havana officially denies acting under U.S. pressure, the timing aligns with what analysts describe as the most aggressive Washington campaign against the island in decades. The move comes a day after Cuba’s top diplomat in Washington invited the United States to assist in overhauling the island’s “crippled” economy, part of ongoing talks that have yet to produce concrete outcomes. U.S. officials, including President Trump’s administration, have repeatedly called for a change of government in the communist‑run state, with the president even musing about “taking” the island. Yet recent diplomatic exchanges suggest a nuanced shift: both sides have held talks, and scholars note that the amnesty could be a tangible sign of progress, however modest. University of Miami Cuban‑studies chair Michael Bustamante told AFP, “It seems not far‑fetched to think that this is a sign that some of the conversation between both governments is advancing… To where? Unclear.” He added that the political significance will depend on the profile of those released. The Cuban presidency did not disclose the names or crimes of the pardoned individuals, but indicated the group includes young people, women, and inmates over 60 who are slated for early release within the next six to twelve months. Foreign nationals and Cuban expatriates are also among those granted clemency. Importantly, the amnesty excludes anyone convicted of murder, sexual assault, drug‑related offenses, theft, illegal livestock slaughter, or crimes against state authority. Earlier in March, the government freed 51 prisoners as a “good‑will” gesture toward the Vatican, which often mediates between Washington and Havana. The current pardon is framed as part of the “humanitarian legacy of the Revolution” and is presented as customary practice during Holy Week. The release coincides with Russia’s announcement of a second oil tanker bound for Cuba, following a recent easing of the U.S. oil blockade that allowed the first shipment. Bustamante speculated that the timing may not be coincidental, suggesting a possible link between U.S. policy shifts and Cuba’s diplomatic overtures. U.S. Secretary of State Marco Rubio, a Cuban‑American critic of Havana, reiterated on Fox News that Cuba’s economic woes cannot be solved without political reform, warning that the island faces “a lot of trouble.”

Several readers have voiced alarm over the unfolding US‑Israel war on Iran, describing it as a chaotic and unjustified conflict that threatens regional stability and global order.One contributor likens the situation to a “spectacle of two rogue nations armed with nuclear weapons fighting to prevent a third from acquiring similar capabilities,” warning that the resulting chaos could embolden other territorial disputes, from China’s claim on Taiwan to Argentina’s claim on the Falklands. The writer urges individuals to emulate the anti‑apartheid boycott campaign, suggesting a coordinated boycott of US and Israeli products and a disengagement from the upcoming FIFA World Cup as potential levers to pressure the belligerents.Another letter critiques the tone of the original editorial, arguing that the war’s justification—purported nuclear compliance and regime change—was merely “grist to throw into the media mill.” The author characterises President Trump’s approach as a personal crusade, describing it as a “hyperbolic truth” that seeks to vent anger and claim divine credit, with the war ending only when Trump’s interest wanes.A third commentator questions the UK’s role, noting that despite initial resistance, British bases have quietly accommodated US and Israeli forces, mirroring the pattern seen in Gaza. The writer warns that the conflict could inflict a “disaster for our economy and that of Europe” that may last for years, calling the war both “immoral” and “illegal” and urging a policy reversal.Concern is also expressed about China’s silence. Citing a recent Guardian editorial, a reader points out that Beijing’s proclaimed “major‑country diplomacy” has not translated into constructive mediation, similar to its restrained stance on the Ukraine war. The letter argues that the global benefits of peace outweigh any short‑term advantage China might gain from allowing two wars to continue, and calls on allies of China to press the government into action.Collectively, these letters highlight a growing perception that the war in Iran is driven more by political posturing than by clear strategic objectives, and they advocate for a combination of economic pressure, public dissent, and diplomatic engagement to halt the escalation.

The world of Major League Baseball has witnessed a significant transformation in pitching, with velocity and accuracy reaching unprecedented levels. This arms race is largely attributed to advances in pitching analytics, often developed by individuals without a traditional baseball background.Rob Friedman, known as PitchingNinja online, has authored a new book titled 'Unhittable: How Technology, Mavericks and Innovators Engineered Baseball's New Era of Pitching Dominance.' The book explores how technology and data analysis have revolutionized the art of pitching.In the past, pitchers like Bob Feller were renowned for their speed, but today's pitchers routinely exceed triple digits on the radar gun. Friedman notes that technology brings out the best in everybody, allowing pitchers to refine their skills and achieve remarkable results.The use of heat maps, slow-motion cameras, and AI has become commonplace in analyzing pitching performance. These tools help quantify not just velocity but also accuracy, enabling pitchers to deliver the ball to the plate with precision.Paul Skenes of the Pittsburgh Pirates, last year's National League Cy Young winner, and Nolan McLean of the New York Mets are examples of pitchers benefiting from analytics. Friedman praises McLean's exceptional skills, describing his stuff as 'absolutely nasty.'The debate surrounding pitcher-friendly conditions continues, with some arguing that the game has become too favorable to pitchers. Friedman counters that pitchers are on offense, and their performance is a reaction to the hitter's actions.Injuries to pitchers are on the rise, and while there is no consensus on the cause, Friedman suggests that excessive velocity may contribute to the problem. He cites Trevor Bauer as an example of a pitcher who successfully adopted analytics and training methods to enhance his performance.The intersection of analytics and tradition remains a contentious issue, with some players and coaches skeptical of data-driven approaches. Friedman advocates for a bridge between both sides, emphasizing that analytics provide valuable information to inform pitching decisions.

At least 43 civilians were killed and 44 houses set ablaze during an assault by the Allied Democratic Forces (ADF) in Bafwakoa, located in Mambasa territory of Ituri province, according to the Congolese army.Lieutenant Jules Tshikudi Ngongo, the army’s regional spokesperson, said the attack occurred on Thursday and that the death toll could rise as search operations continue.The ADF, a rebel outfit that pledged allegiance to ISIL, has been increasingly targeting civilians in Ituri and the neighboring North Kivu province, despite joint Congolese‑Ugandan military campaigns launched in 2021.Witnesses reported that victims were killed with machetes, some perished in house fires, and two individuals were abducted, according to local customary official Christian Alimasi.The incident underscores the army’s difficulty in containing the ADF, which operates alongside other insurgent groups such as the Rwandan‑backed M23, responsible for seizing the major eastern city of Goma last year.Data from research firm Insecurity Insight indicates the ADF accounted for roughly 25% of civilian‑targeted violence in eastern DRC between 2020 and 2025, reflecting its significant presence in the region.Last year, the ADF’s attacks resulted in 66 deaths and multiple abductions, signalling a troubling escalation in its campaign against local populations.

Legal groups in Uganda have strongly condemned the arrival of a dozen deportees from the United States, calling the deportation process 'undignified, harrowing and dehumanising'. The Uganda Law Society and the East Africa Law Society have taken the matter to court, seeking relief to halt what they describe as 'patent international illegality'.The deportation marks the first confirmed instance of deportees being transferred from the US to Uganda. The 12 individuals reportedly landed at Entebbe International Airport by private aircraft. No identifying information about the deportees has been provided.The deportation is part of President Donald Trump's efforts to offload immigrants to 'third countries' where they have no personal connections. Uganda is one of several countries that have agreed to accept deported foreigners, including Equatorial Guinea, Ghana, Rwanda, Eswatini, and South Sudan.The deal with Uganda was confirmed by the country's Ministry of Foreign Affairs last August, stating it was a 'temporary arrangement' with priority given to deportees from other African countries. Unaccompanied children and people with criminal records are excluded from the deal.Critics have raised concerns about the safety of countries receiving US deportees, citing human rights abuses in Uganda. The US has previously criticised Uganda for 'significant human rights abuses', including extrajudicial killings, life-threatening prison conditions, and torture.The Trump administration has defended the deportations as legal under the US Immigration and Nationality Act, citing diplomatic assurances from 'third countries' that deportees would not face persecution. However, the policy has faced numerous legal challenges, with concerns about immigrants' due process rights.

Al Jazeera presents an in‑depth look at Mohamed Salah, exploring the intertwining of his football achievements, personal faith, and the evolving public narrative surrounding elite athletes. The piece highlights how Salah’s on‑field success—marked by record‑breaking goal tallies and pivotal titles—has become a platform for discussing broader cultural themes. His openness about his religious beliefs offers a rare glimpse into the personal convictions that shape his professionalism. By examining Salah’s influence beyond the pitch, the article underscores a changing perception of sports figures: no longer seen solely as entertainers, but as individuals capable of driving social dialogue and challenging stereotypes. Through interviews, match footage, and commentary from peers, the feature illustrates how Salah’s story resonates with fans worldwide, fostering a deeper appreciation for the role of faith and identity in modern football.