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Metabolic liver disease, or MASLD, is projected to affect 1.8 billion people worldwide by 2050, according to a recent study. This significant increase is primarily driven by rising obesity and blood sugar levels globally.MASLD, previously known as non-alcoholic fatty liver disease (NAFLD), is one of the most prevalent and rapidly growing liver conditions worldwide. The condition's prevalence has already seen a 143% increase in just three decades, from 500 million people in 1990 to 1.3 billion people in 2023.The study, published in the Lancet Gastroenterology & Hepatology journal, highlights that high blood sugar is the leading driver of MASLD-related health problems globally, followed by high BMI and smoking. These factors are strongly linked to type 2 diabetes and obesity.Regional disparities exist, with north Africa and the Middle East having disproportionately higher rates of MASLD. However, there have been sharp increases in the number of people affected in countries across the world, including the UK, Australia, and the United States.Despite the growing number of cases, the overall impact on health has remained stable, suggesting that advances in treatment and care are helping people live longer and healthier lives. However, the increasing number of cases still poses a risk of serious complications such as liver cirrhosis or cancer in the future.

Lake Erie, a vital source of freshwater for millions of people, has faced significant pollution challenges for decades. In the 1960s, the lakes and rivers around Cleveland were so polluted that they frequently caught on fire. While water quality has improved since then, the lake still struggles with poor water quality due to chemical runoff and pollution. The 2025 State of the Great Lakes report found that Lake Erie ranks poorly for pollution caused by chemical runoff and is consistently one of the top five most polluted lakes in the US. Over 5.5 billion gallons of freshwater are drawn from the lake daily to meet industrial and consumer needs, highlighting the importance of addressing these pollution issues. In response, the Cleveland Water Alliance, a non-profit organization, is working with over 300 companies, research institutions, and government agencies to develop clean water solutions for Lake Erie. The alliance has deployed hundreds of sensor buoys across the western section of the lake to observe and detect various water-related factors, including E. coli, algal blooms, and turbidity levels. Researchers at Case Western Reserve University have incubated research for a pilot program technology that can capture 90% of microplastics down to 50 microns in washing machines, preventing these materials from entering the lake. Other projects are recording solar radiation, dissolved oxygen levels, and water and air temperatures. Korean companies have also come to the area to test electrochemical water treatment methods in Lake Erie's water. The alliance's efforts aim to position Lake Erie as an open-air research facility, driving innovation and solutions to address the lake's pollution challenges. Despite these efforts, environmentalists say the challenges to cleaning up the lake are huge. A 40% reduction in phosphorus is needed to minimize blooms, with about 90% of phosphorus entering the western Lake Erie basin coming from agricultural runoff. The manure problem is also a growing concern, with the increasing number of livestock operations in the area contributing to pollution. The Cleveland Water Alliance's initiatives, such as the development of a system for making commercial-grade sodium hypochlorite on site, aim to promote technologies for wintertime monitoring of aquatic life activity and behavioral changes as well as levels of water turbidity. By leveraging data and innovation, stakeholders hope to improve the lake's water quality and mitigate the impacts of pollution.

For the first time, thousands of cancer patients from Black and minority ethnic backgrounds will benefit from an enhanced genetic test offered by the NHS. The new screening expands the panel of DPYD gene variants from four to five, directly addressing a long‑standing bias that left non‑white patients vulnerable to dangerous chemotherapy side‑effects. In England, patients slated for chemotherapy undergo a genetic check that can guide dose adjustments and mitigate adverse reactions such as mouth sores, hair loss, nausea, fatigue, and, in severe cases, death. Up to 40% of the 38,000 individuals receiving fluoropyrimidine‑based chemotherapy each year experience a harmful drug reaction. Previously, the test only targeted four DPYD variants common in people of European descent, meaning many Black patients received inaccurate “all‑clear” results. The addition of a fifth variant—more prevalent among African, Caribbean and other minority groups—means clinicians can now identify patients at risk who were previously missed. Since its rollout at Manchester University NHS Foundation Trust last September, three minority‑ethnic patients have had their initial chemotherapy doses adjusted, lowering their chance of a potentially fatal reaction. Dr Veline L’Esperance, senior clinical adviser at the NHS Race and Health Observatory, called the change “tangible results for patients who have historically been left behind.” She emphasized that the update shifts the discussion on ethnic health inequality from rhetoric to actionable care. Prof Habib Naqvi, chief executive of the NHS Race and Health Observatory, described the development as a “groundbreaking outcome” for chemotherapy safety, while noting that ethnic minorities remain under‑represented in genomic research and biobanks. He warned that broader inclusion is essential for the promised benefits of precision medicine to reach all communities. Prof Dame Sue Hill, chief scientific officer for NHS England, highlighted the significance of discovering the fifth variant: “Personalising chemotherapy based on genetics can save lives and reduce harmful side‑effects, especially for patients of African ancestry.” She added that the North West NHS Genomic Medicine Service has already demonstrated the practical impact of this approach. These steps come amid broader evidence that minority patients in the UK face longer diagnostic waits, more GP visits before a cancer diagnosis, and lower perceived support during treatment. The expanded DPYD test represents a concrete effort to close those gaps and ensure equitable, science‑driven care for all cancer patients.

Euphoria's third season has been a long-awaited return, but unfortunately, it's absolutely not worth the wait. The show's creator, Sam Levinson, has taken a darker and more desperate approach, focusing on the characters' bleak lives and struggles with sex work, drugs, and trauma.The season picks up five years after the end of season two, with recovering addict Rue (Zendaya) drawn into the world of drug dealer Laurie (Martha Kelly). Her life as a mule between Mexico and the US is depicted in gritty and intense cinematic sequences, drawing on westerns and blaxploitation.Meanwhile, Cassie (Sydney Sweeney) is on the cusp of trad wifedom with toxic jock Nate (Jacob Elordi), but their relationship is marred by Nate's crumbling business and Cassie's OnlyFans content. The show's handling of her cam girl ambitions feels bafflingly dated and voyeuristic.The performances are mostly good, with standout performances from Zendaya, Sweeney, and Adewale Akinnuoye-Agbaje. However, the show's grim and humorless tone makes it feel like a chore to watch.Levinson's approach to exploring the devastating impact of synthetic opioids on ordinary Americans feels heavy-handed and desperate. The show's focus on brainrot bimbo-ism and male perversion also detracts from its once unapologetically queer heart.Overall, Euphoria season three is a disappointing and grubby addition to the series, feeling like a contractual obligation rather than a passion project.

On a recent weekday evening, a special bus tour whisked art lovers through over twelve galleries and museums that stayed open until midnight, offering a late‑night glimpse of the Abidjan Art Week programme.The after‑hours event, dubbed the Night of the Galleries, was first trialled in January 2024 alongside the Africa Cup of Nations – a tournament that Côte d’Ivoire both hosted and won – and has become a staple of the festival’s third edition, which ran from Tuesday to Sunday.Since its inception, the week has broadened its footprint, moving beyond the city centre to include venues such as the La Rotonde des Arts contemporary‑arts hub in the Plateau district and the Adama Toungara Museum of Contemporary Cultures (MuCAT) in the working‑class neighbourhood of Abobo.Local collectors are emerging in force. MuCAT has hosted the Africa Foto Fair each year since 2022, and the Marché des Arts du Spectacle d’Abidjan – the city’s answer to the Dakar Biennale – is set to launch its 14th edition later this month.A graffiti festival launched two years ago has transformed the perception of street art, with vibrant murals now adorning the façade of the La Pyramide building and several upscale hotels in Plateau.Organisers stress that the festival’s growth should be independent of external validation. This year’s roster featured artists from Cameroon, the Democratic Republic of the Congo and Mali, and the number of participating galleries more than doubled compared with previous editions.Founder Yacouba Konaté, who also directs La Rotonde des Arts, highlighted the festival’s commitment to accessibility, arguing that art should not be seen as an elite pastime.The opening tribute honoured Simone Guirandou‑N’Diaye, a pioneering Ivorian art historian whose legacy lives on through Galerie LouiSimone Guirandou, now run with her daughter Gazelle.Among the week’s highlights, MuCAT presented Murmures d’Archives, a quieter, archival‑focused exhibition that concluded with an artists’ workshop and a DJ set.In the upscale Cocody district, New York‑based artist Ouattara Watts staged a solo show at Galerie Cécile Fakhoury, drawing the Ivorian diaspora into dialogue with the local scene. Watts explained that his work aims to transcend borders, describing it as “a vision that goes beyond any map – it is the cosmos that I paint.”

The Department for Culture, Media and Sport, acting on Historic England’s advice, has awarded Grade II* listed status to a limestone rubble barn on a grassy knoll in the Lake District, joining an elite roster that includes Battersea Power Station and the London Coliseum.Dubbed “Henry’s Castle,” the structure was most recently used as a shelter for livestock, but research suggests it may date back to the 14th century and originally served a high‑status function that remains unknown.Only 5.8% of England’s listed buildings achieve the Grade II* level, indicating they possess “more than special interest.” The barn’s unusual features – a corbelled chimney stack, a stepped garderobe, and a plastered interior showing signs of fire – set it apart from ordinary field barns.Historic England’s listing team leader, Sarah Charlesworth, described the building as “one of those rare structures that raises more questions than it answers,” underscoring its intrigue for scholars and visitors alike.Lake District National Park’s built‑environment adviser, Rose Lord, recalled her 2022 visit, noting that despite layers of animal manure the barn’s architecture hinted at something “very special” – a construction far beyond typical agricultural outbuildings.Four years of meticulous work by archaeologists, architects, and conservation engineers have restored the barn’s most striking element: an oak roof featuring a hand‑finished, chamfered and pegged central truss, a technique associated with high‑quality carpentry of the 14th or 15th centuries.Experts speculate on the barn’s original purpose, ranging from a defensive lookout or hunting lodge to a luxurious summer house. Historic England notes similarities to bastles – fortified farmhouses common along the Anglo‑Scottish border – though the building’s location south of the border makes a strict classification unlikely.Originally converted to domestic use in the 16th or 17th century and later repurposed as a field barn by the 19th century, the structure takes its name from former owner farmer Henry Willison.Lord called the new listing the “cherry on the cake” for the restoration project, highlighting that most buildings of comparable significance have already been recorded in earlier surveys. Interpretation panels and an owl‑nesting box are slated for installation in the coming weeks, adding educational and ecological value to the site.

The highly anticipated third and final season of Euphoria premieres on Monday at 9pm on Sky Atlantic. The series, created by Sam Levinson, follows the lives of a group of high school students as they navigate love, friendship, and identity.The new season stars Zendaya, Jacob Elordi, and Sydney Sweeney, who have all become major Hollywood stars since the show's debut. The story picks up five years after high school, with the characters now in their early 20s. Previews are scarce, but it's known that Cassie and Nate are married, Jules is in art school and is a 'sugar baby', and Rue is involved in some shady business in Mexico.Other TV shows airing tonight include Miriam Margolyes Made Me Me on BBC Two, Great Japanese Railway Journeys on BBC Two, Missed Call on Channel 5, Charmain and the Prophet on BBC Two, and DTF St Louis on Sky Atlantic.

Rescuers are frantically digging through the rubble in south Lebanon after a series of deadly Israeli strikes hit the region. The attacks have left a trail of destruction, with many lives lost and communities affected.The situation on the ground remains dire as emergency responders work tirelessly to search for survivors and recover the bodies of those killed. The impact of these strikes has been severe, exacerbating tensions in an already volatile region.International concern is growing over the escalation of violence, with calls for restraint and a return to diplomatic efforts to resolve the conflict. The incidents have sparked widespread condemnation and highlighted the urgent need for a peaceful resolution.

The article from Al Jazeera outlines the people who lost their lives in Lebanon as a result of Israeli military action on a single day, emphasizing the personal tragedies behind the headline numbers. By naming each victim, the report seeks to humanize the casualties and draw attention to the broader humanitarian consequences of the ongoing hostilities between Israel and Lebanon.While specific details such as ages, occupations, or hometowns are listed in the original piece, the overarching message is clear: the conflict’s impact is deeply personal, affecting families and communities across the region. These individual stories serve as a stark reminder of the cost of continued violence and underscore calls for de‑escalation and protection of civilians.