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Health Apr 08, 2026

Genetic Variations May Influence Effectiveness of Weight-Loss Medications

Scientists have discovered that genetic variations in two genes involved in gut hormone pathways ma…
Researchers have made a significant breakthrough in understanding why weight-loss medications, such as GLP1 receptor agonists, work better for some individuals than others. A recent study published in Nature has identified genetic variations in two genes involved in gut hormone pathways that regulate appetite and digestion. These genetic variations may help account for different weight-loss results or side-effects when taking glucagon-like peptide 1 (GLP1) medicines, which mimic natural gut hormones to regulate appetite, insulin release, and digestion. The study analyzed data from 27,885 patients on GLP1 drugs and found that specific genetic variants were associated with slightly more weight loss or side-effects like nausea and vomiting. The findings suggest that genetic differences may contribute to why people respond differently to weight-loss jabs. However, the overall impact of genetics appeared to be modest, with non-genetic factors such as sex, drug type, dose, and duration appearing to explain a substantially larger proportion of variability. The study's results reinforce that while there is substantial variability in response to GLP1 therapies, genetics is only one part of a much more complex picture. According to Marie Spreckley, an obesity expert at the University of Cambridge, the study provides plausible evidence that genetic variants could affect outcomes. However, she notes that the magnitude of these genetic effects is small in clinical terms, and that behavioral, clinical, and treatment-related factors remain the dominant drivers of outcomes. The study's authors suggest that their findings could support future efforts to use genetic information when making treatment choices for obesity. However, Spreckley cautions that the evidence is not yet sufficient to support using genetic information to guide treatment decisions in routine clinical practice.
#GLP-1 #GIPR #GLP1R
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World Apr 08, 2026

Share Your Experience: How Have You Been Affected by the Latest Events in the Middle East?

The Guardian invites readers to share their experiences of how they have been affected by the lates…
The Guardian is calling on readers to share their personal stories of how they have been impacted by the ongoing conflict in the Middle East. With Iran and the US agreeing to a two-week conditional ceasefire, the situation remains volatile and uncertain.Whether you are living, working, or traveling in the region, or have been impacted in other ways, the Guardian wants to hear from you. Your experiences can help provide a deeper understanding of the human impact of the conflict.Please note that your security is the top priority. The Guardian recognizes it may not always be safe or appropriate to record or share your experiences, so please consider this when deciding whether to get in touch.To share your story, you can:Fill out the online form provided, which is encrypted and confidential.Message the Guardian on WhatsApp or Signal at +447766780300.The Guardian assures readers that all responses will be kept secure and anonymous if desired. The information collected will only be used for the purpose of this feature and will be deleted when no longer required.Key form fields include:NameLocationBackground information (optional)Country locatedPersonal experience with the conflictPhoto upload (optional)Publication consentContact details (optional)For more information, readers can visit the Guardian's tips guide or privacy policy.
#iran #israel #conflict
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News Apr 08, 2026

Does Tehran Mirror Trump’s Tactics in the US‑Iran Ceasefire?

The Guardian article questions whether Tehran is employing strategies reminiscent of former Preside…
The Guardian’s piece titled US‑Iran ceasefire: has Tehran played Trump? raises the provocative question of whether Tehran is adopting tactics similar to those of former President Donald Trump in the current ceasefire talks with the United States. No additional information or analysis is provided in the excerpt.
#iran #ceasefire #trump
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Politics Apr 08, 2026

Ofcom chief Ian Cheshire faces mounting pressure to enforce Online Safety Act as 2026‑27 plan rolls out

New Ofcom chief Ian Cheshire inherits a sprawling 2026‑27 agenda, but the Online Safety Act will do…
Ian Cheshire steps into the helm of Ofcom with a comprehensive 2026‑27 plan that spans telecoms, broadband, postal services, broadcast media and the digital sphere. While the breadth of responsibilities is vast, the regulator’s work on the Online Safety Act (OSA) is set to dominate his tenure.The OSA, the UK’s flagship legislation governing social‑media, search and video platforms, has become a flashpoint between internet‑safety advocates and free‑speech proponents. Campaigners such as Ian Russell – father of Molly Russell, whose tragic suicide highlighted online harms – and filmmaker Beeban Kidron are urging a tougher regulatory stance.Last year, Russell publicly called for a change in Ofcom’s leadership, citing the watchdog’s failure to block an online suicide forum accessible to UK users. At the same time, Technology Secretary Liz Kendall wrote to Ofcom expressing “deep concern” over delays in rolling out key OSA provisions.Although updating the act is a parliamentary responsibility, Cheshire’s close ties to government could accelerate ministerial action. The OSA, passed in 2023, only began substantive implementation under chief executive Dame Melanie Dawes, with the introduction of rigorous age‑gating measures last year marking the first tangible impact on users.Beyond online safety, Ofcom must continue its core duties established in 2003: supervising public‑service broadcasting, ensuring impartial news, maintaining universal postal delivery six days a week, and monitoring broadband and mobile‑phone coverage across the UK. The government’s expectation is clear – the regulator must move faster on digital safety without neglecting these legacy functions.A looming test of the OSA’s strength is the investigation into the partial nudification of women and girls by Elon Musk’s AI tool Grok. The outcome will signal how effectively Ofcom can enforce the act against emerging AI‑driven harms.The 2026‑27 plan lists projects such as preventing illegal content from going viral, measuring harmful material encountered by children, and assessing the effectiveness of age‑gating. Additional measures targeting major platforms like Google and Instagram remain stalled due to ongoing court proceedings.Recent incidents – from misinformation spikes following the Southport killings to AI‑generated misogyny on X – underscore the urgency. While the legislation provides Cheshire with a framework, the patience of campaigners and policymakers is wearing thin.
#Ofcom #Ian Cheshire #Online Safety Act
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Politics Apr 08, 2026

Istanbul's Israeli Consulate Shooting: Key Details Emerge

A shooting incident occurred at Istanbul's Israeli consulate, with details still emerging.
A shooting incident has taken place at Istanbul's Israeli consulate. The event has garnered significant attention, but specifics regarding the incident, including casualties or motives, remain unclear.The source of this information is Al Jazeera, a reputable news organization. However, due to the lack of detailed information in the provided content, a comprehensive analysis or further details about the incident cannot be accurately provided at this time.
#Israeli Consulate #Istanbul #Turkey
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Video Apr 07, 2026

Iran Reports US-Israeli Projectile Strikes Synagogue in Tehran

Iran has reported that a projectile believed to be of US-Israeli origin has struck a synagogue in T…
Iranian authorities have confirmed that a synagogue in Tehran was hit by a projectile they believe was of US-Israeli origin. The incident has heightened tensions in the region, with Iran attributing the attack to its longstanding adversaries.The attack on the synagogue in the Iranian capital has sparked concerns about escalating conflicts in the Middle East. Iran has been at odds with both the US and Israel for decades, with periodic escalations in tensions and conflicts.The Iranian government has not provided detailed information on the extent of the damage or any casualties resulting from the attack. However, the incident is seen as a significant development in the region's geopolitical landscape.
#iran #says #us-israeli
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Politics Apr 07, 2026

Australian Ex‑Special Forces Officer Ben Roberts‑Smith Charged with Five Afghanistan War Crimes

Former Australian special‑forces soldier Ben Roberts‑Smith was arrested at Sydney Airport and faces…
Ben Roberts‑Smith, a former Australian special‑forces operative, was taken into custody at Sydney Airport on Tuesday after the Australian Federal Police (AFP) announced he faces five separate war‑crime counts linked to the killing of five individuals in Afghanistan from 2009 to 2012. The charges, each punishable by life imprisonment, allege that the victims were unarmed civilians who were not engaged in hostilities at the time of their deaths. AFP Commissioner Krissy Barrett told reporters that the prosecution will argue the victims were shot either directly by Roberts‑Smith or by subordinates acting on his orders while he was present. Barrett emphasized that the accusations stem from a "complex" investigation conducted jointly by the AFP and the Office of the Special Investigator, a probe that began in 2021. The New South Wales Local Court has scheduled a bail hearing for Roberts‑Smith on Wednesday, where he will appear before a magistrate. This arrest follows a high‑profile legal defeat for Roberts‑Smith: an Australian judge in 2023 ruled that journalists who reported he was "complicit in and responsible for the murder" of unarmed Afghan men had not defamed him, a decision upheld by the Full Court of the Federal Court in May of the previous year. Rawan Arraf, executive director of the Australian Centre for International Justice, described the development as a "significant and long‑awaited step for victims and affected communities" in Afghanistan. She added that prosecuting alleged war crimes by Australian special‑forces personnel is essential for delivering justice and for Australia to meet its international law obligations. Since the 2001 NATO‑led intervention, roughly 39,000 Australian soldiers have served in Afghanistan, supporting operations against the Taliban and other armed groups. Roberts‑Smith, who previously received the Victoria Cross for his fifth tour, was regarded as the most‑decorated living Australian war veteran before the charges. The case also revives attention on former army lawyer David McBride, who remains incarcerated for disclosing information about alleged Australian war crimes in Afghanistan. In response to Roberts‑Smith’s arrest, Senator David Shoebridge posted a brief message on X urging the release of McBride.
#Ben Roberts‑Smith #Australian Defence Force #Afghanistan War
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Tech Apr 07, 2026

Toronto Neighbourhood Divided Over AI-Powered Surveillance Plan

A Toronto neighbourhood is divided over a plan to use AI-powered surveillance to create a 'virtual …
A controversy has erupted in Toronto's affluent Rosedale neighbourhood over a proposed AI-powered surveillance system aimed at curbing the area's high property crime rates. The plan, championed by resident Craig Campbell, involves installing cameras that scan licence plates to identify suspicious vehicles.The system, developed by US-based company Flock, uses AI to learn which cars belong to residents and which are potentially suspicious. The technology has sparked concerns about privacy, bias, and surveillance. While some residents see it as a necessary measure to enhance safety, others are worried about the implications of such a system.Rosedale has experienced a significant rise in home invasions, with robbers targeting the neighbourhood at a rate more than double the city average. Crime rates in Toronto as a whole have been declining, but residents are seeking solutions to address their concerns. Campbell, who runs a security company and holds the Canadian licensing rights for Flock, proposed the plan as a way to create a 'virtual gated community.'The system would involve an initial group of 100 residents paying a C$200 monthly subscription to access the technology. The cameras collect licence plate data, which is retained for 30 days, and police can only access the data with legal authorization. While the system does not use facial recognition, concerns about AI bias and profiling have been raised.Flock claims its network of over 90,000 cameras has helped reduce crime by up to 70% in some communities. However, the company has faced scrutiny in the US for its collaboration with law enforcement and allegations of mass surveillance. In Canada, privacy laws are stricter, and regulators are likely to view the network as a data collection system subject to the Personal Information Protection and Electronic Documents Act (Pipeda).The Toronto police have acknowledged residents' concerns about safety but have not commented on the legality of the proposed system. The city's privacy commissioner has emphasized the need for companies to inform individuals and obtain consent before collecting and using personal information.
#Toronto #AI-powered surveillance #virtual gated community
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Technology Apr 07, 2026

Former Meta Engineer Accused of Stealing 30,000 Private Facebook Photos, Prompting Police Probe and Security Overhaul

A former Meta employee in London is under criminal investigation for allegedly downloading about 30…
A former Meta employee based in London is being investigated by the Metropolitan Police’s cybercrime unit for allegedly downloading roughly 30,000 private Facebook images while employed by the company.According to court documents obtained by the Press Association, the suspect is said to have created a script designed to circumvent Meta’s internal detection systems, allowing him to access and extract the images without triggering security alerts.Meta confirmed that the breach was discovered more than a year ago. The company immediately terminated the employee, notified the affected users, and referred the matter to UK law enforcement. It also announced that its security infrastructure has been enhanced to prevent similar incidents.The individual remains on police bail, with magistrates requiring him to report to officers in May and to disclose any plans for foreign travel.Legal experts note that while the rogue employee could face charges under data‑protection and computer‑misuse laws, Meta’s liability hinges on whether it had “appropriate technical and organisational measures” in place. As senior data‑protection specialist Jon Baines of Mishcon de Reya explains, “If the employer has sufficient safeguards, the law does not punish the organisation for the actions of a rogue employee.” However, a finding that Meta’s safeguards were inadequate could expose the company to substantial fines or damages.The Information Commissioner’s Office (ICO) acknowledged the incident, emphasizing that “social media users should be able to trust that their personal information is handled responsibly.”Meta’s challenges come amid broader scrutiny of major platforms. Last month, a Los Angeles court held both Meta and Google liable for a woman’s childhood social‑media addiction, a ruling that could reshape platform accountability.
#meta #facebook #cybercrime
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