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The Lead: Pakistan's Diplomatic Push in Iran CrisisPakistan's army chief, Field Marshal Asim Munir, is in Iran as part of ongoing mediation efforts to end the Israel and United States's war that began on February 28. This high-level diplomatic visit comes as the US reports slight progress in negotiations while tensions remain high in the region.The Event Details: Pakistan's Second Mediation MissionMunir arrived in Tehran on Friday, Iran's state-run IRNA news agency reported, citing the Pakistan Army. "On arrival, he was received and warmly welcomed by Iranian Interior Minister Eskandar Momeni," IRNA said, adding that "Pakistan's Interior Minister Mohsin Naqvi was also present at the reception."It is the second such trip to Tehran by Munir amid Pakistani mediation efforts to end the war. Islamabad helped secure a temporary ceasefire between the warring sides on April 8, and later hosted the highest-level talks between the US and Iran since 1979 on April 11-12.During this visit to Iran, unnamed Pakistani sources told the Anadolu news agency that Munir will discuss Iran-US talks, regional peace and stability, and other "important issues".The Data Analysis: Shifting Positions in Negotiations"The current process and the presence of senior Pakistani officials in Tehran means that we have reached a turning point or a decisive situation," Iran's Foreign Ministry spokesperson Esmaeil ⁠Baghaei said on Friday.Iranian state media quoted Baghaei as saying the gaps between Tehran and Washington are "deep and significant". "We cannot necessarily say that we have reached a point where an agreement is close," he said. "The focus of the negotiations is on ending the war. Details related to the nuclear issue are not being discussed at this stage."Speaking at the White House on Friday, US President Donald Trump said, "Iran is dying to make a deal". "We'll see what happens. But we hit them hard, and we had no choice because Iran cannot have a nuclear weapon. They cannot have it," Trump added.US Secretary of State Marco Rubio said on Friday that "slight progress" was made during talks with Iran. "I don't want to exaggerate the progress in talks, saying there had been 'a little bit of movement, and that's good'. He said the conversations were ongoing.The Impact Analysis: Regional and Global RamificationsThe Iran war and the closure of the Strait of Hormuz, which normally carries a fifth of global oil production, have sent ripples through the global economy, driving energy prices soaring.As diplomatic efforts continue, European Union nations moved towards imposing sanctions on Iranian officials and others responsible for blocking the Strait of Hormuz, the EU said on Friday. Tehran effectively closed the key shipping lane for global oil and gas supplies in retaliation for the US-Israeli war."The EU will now be able to introduce further restrictive measures in response to Iran's actions undermining the freedom of navigation in the Strait of Hormuz," the European Council representing EU nations said.Trump has repeatedly set deadlines for Tehran and then backed off. But he's also previously indicated he would hold off on military action to allow talks to continue, only to turn around and launch strikes. The US president said he called off attacks on Iran this week at the request of allies in the Middle East, including the leaders of Qatar, Saudi Arabia and the United Arab Emirates.The Prediction: Path Forward for Diplomatic SolutionsIran's ⁠Baghaei said ⁠on Friday that a Qatari delegation ‌was currently holding talks with Iran's foreign minister, ⁠but added that ⁠Pakistan remained the main ⁠mediator in ⁠the ⁠negotiations.With Pakistan intensifying its mediation process to secure a second round of direct talks between the US and Iran, the region remains on edge. While both sides report some progress, the deep gaps between Tehran and Washington suggest that a comprehensive resolution to the conflict remains elusive, with potential for both diplomatic breakthroughs and military escalation still on the table.

Executive Summary of the UK‑EU Trade Pitch The UK is positioning a single market for goods as the flagship of its effort to re‑integrate trade with the European Union. While the Cabinet Office’s EU‑relations chief Michael Ellam presented the idea in Brussels, EU officials rejected it, preferring a customs union or European Economic Area alignment—options that clash with Prime Minister Keir Starmer's stated red lines. UK Proposes a Goods‑Only Single Market to the EU During recent visits to Brussels, Ellam outlined a framework that would allow tariff‑free movement of goods while keeping the UK outside the EU’s customs union and free‑movement rules. Sources told the Guardian that EU diplomats instead suggested a broader customs union or EEA economic alignment, both of which would require acceptance of free movement of people—something Starmer has ruled out for his lifetime. £9 bn Annual Boost from Proposed SPS and ETS Deals Negotiations include a sanitary‑phytosanitary (SPS) agreement for food and drink. An emissions‑trading scheme (ETS) linkage is also on the table. The Cabinet Office estimates these two measures could add £9 bn a year to the UK economy by 2040. Political Constraints Shaping the UK‑EU Trade Dialogue Labour’s ambition to deepen economic ties runs into the same obstacles that stalled former Prime Minister Theresa May's Chequers plan—namely, the need for a “common rulebook” without free movement of people. EU officials warn that granting the UK preferential treatment could fuel Eurosceptic sentiment in member states, potentially influencing upcoming elections such as the 2027 French presidential race. Domestically, the upcoming Makerfield by‑election adds pressure, with Labour’s Andy Burnham signalling a focus on domestic issues rather than a return to the EU. What the Next Summer Summit Could Deliver The tentative summit, pencilled in for 13 July, is expected to focus on three priority deals: a veterinary agreement, the SPS‑ETS package, and a youth mobility scheme. While the single‑market for goods proposal appears stalled, progress on the food‑trade and emissions deals could still materialise, providing a modest economic uplift and a diplomatic signal that the UK remains a constructive partner despite broader political disagreements.

The Acquisition Deal Eco-friendly retailer Everlane, known for its commitment to sustainable and affordable clothing, is being acquired by Chinese fast-fashion giant Shein. A letter to Everlane employees from CEO Alfred Chang confirmed the deal, although the purchase price was not disclosed. Everlane's Background and Challenges Everlane was founded in 2011 by Michael Preysman and Jesse Farmer with a mission to produce eco-friendly and affordable clothing. Despite its efforts to promote sustainability, the company has faced controversies surrounding worker treatment and struggled with declining sales and mounting debt. The Impact on Everlane's Operations Everlane will remain an independent brand, staying true to its sustainability commitments. CEO Alfred Chang will continue in his role, and the leadership team will remain in place. The deal is expected to provide financial stability and resources for Everlane to invest in product innovation and staff. Strategic Implications for Shein The acquisition allows Shein to establish a presence outside of fast fashion, which has become increasingly challenging due to tariffs and trade restrictions. However, the partnership may be perceived as conflicting with Everlane's eco-friendly values, potentially impacting customer loyalty. Future Outlook The acquisition is seen as a strategic move to save Everlane from financial struggles, but it also comes with challenges. As Shein integrates Everlane into its portfolio, the success of this partnership will depend on balancing business growth with sustainability commitments.

The Growing Rift at Roland GarrosA simmering dispute between players and the Grand Slams over revenue sharing intensified at the French Open, with Novak Djokovic warning the sport risked further fragmentation as leading players pressed for a greater voice in shaping its future. Several players limited their appearances at Friday's traditional pre-tournament media day to 15 minutes and declined additional multi-media interviews in a coordinated display of discontent.Player Demands Beyond Financial ConcernsThe tensions have been building for weeks, but the rhetoric sharpened in Paris, where players, such as Taylor Fritz, insisted that their grievances were not just about "wanting more money". "It's about just wanting what's fair," the American added. "As the tournaments make more money, we obviously want to see the revenue shared back to the players reflect that."Players have pointed to pensions, tournament expansion, scheduling and late-night finishes among the issues fuelling frustration, alongside what several described as a persistent lack of dialogue from organizers. Russian Andrey Rublev painted a picture of a widening disconnect: "When you try to communicate for so many years ... they don't hear you. They don't answer," Rublev said. "When you send the mail in, no one responds to official mail for months."The Financial Divide in TennisWhile top ATP and WTA events redistribute around 22 percent of revenues to players, the Grand Slams are estimated to return closer to 15 percent, a gap that has become a central source of tension. French Open organizers have been arguing that tournament profits fund entire national tennis ecosystems, not just prize money. They are expected to meet player agents on Friday as discussions continue over revenue sharing and player representation.Industry-Wide ImplicationsWorld number one Aryna Sabalenka cast the debate as a struggle on behalf of the sport's lesser lights rather than its leading stars. "It's not about me. It's about the players who's lower in the ranking, who is suffering," she said. "But as the world number one, I feel like I have to stand up and to fight for those players."Djokovic emphasized the broader structural issues facing tennis: "We tend to forget how little is the number of people that live from this sport." He pointed to golf and the divisions caused by the emergence of LIV Golf as a warning for tennis: "Let's learn from that. Let's try to be a bit more united and have a unifying voice into finding better structure and better future for our sport."Path Forward for Tennis GovernanceEven so, players adopted a more cautious tone over the prospect of a boycott after Sabalenka raised the possibility earlier this month in Rome. "I don't know if I want to start throwing around the 'B' word," Fritz said. "It's a really big deal, and I don't think we as players should really make big threats like that unless we're fully ready to do it."French Open tournament director Amelie Mauresmo expressed regret over the reduced media access: "It's always regrettable because media day is an important moment for the tournament, for journalists who come from all over the world and also for the fans through the media coverage," Mauresmo told reporters. "We understand that there are discussions and concerns from the players, but dialogue is always preferable."

The Lead: Rubio's Diplomatic Mission to IndiaUnited States Secretary of State Marco Rubio will travel to India on Saturday for a three-day visit taking in Kolkata, Agra, Jaipur and New Delhi. He will discuss energy security, trade and defence cooperation with senior Indian officials, US State Department spokesperson Tommy Pigott said in a statement on Tuesday.The visit comes as relations between US President Donald Trump and India's Prime Minister Narendra Modi continue to fluctuate, making Rubio's diplomatic mission particularly significant in the current geopolitical landscape.The Quad Context: Strategic Alignment in the Indo-PacificRubio is spending a few days in India ahead of a meeting of foreign ministers from the informal Quad security forum comprising the US, Japan, Australia and India in New Delhi on May 26. The Quad, or the Quadrilateral Security Dialogue, has been referred to as "the Asian version of NATO". It was formed as a response to the rising power of China and has carried out joint military and naval exercises in the Indo-Pacific region.Rubio's meeting with other leaders of the Quad will also be seen as a sign of the US reaffirming its commitment to the Indo-Pacific region, which has become increasingly important in global geopolitics.The Economic Leverage: Adani Case and Russian Oil SanctionsRubio's visit comes days after the Trump administration moved to dismiss US criminal fraud charges against Indian billionaire Gautam Adani in a case in which he is accused of bribing Indian officials with as much as $265m to secure contracts and of lying to US investors to secure a solar energy project in India, allegations that his company has long denied.The case was dropped by the US Department of Justice (DOJ) after Adani pledged a $10bn investment in the US. In an X post on Monday, US Treasury Secretary Scott Bessent announced another 30-day extension of a sanctions waiver allowing purchases of Russian seaborne oil to aid "energy-vulnerable" countries hit by the Iran war, reversing plans not to grant an extension.This extension has temporarily eased pressure on major Russian oil buyers such as India, which has previously faced US criticism for its reliance on discounted Russian crude.The Regional Impact: US Balancing Act Between India and PakistanRubio's visit comes after months of improving relations between the US and Pakistan, India's arch enemy. In April last year, India and Pakistan became embroiled in armed conflict after attackers killed 26 people in Pahalgam, a popular tourist spot in Indian-administered Kashmir. Following the Pahalgam attack, New Delhi scaled back diplomatic ties with Islamabad and suspended the Indus Waters Treaty.On May 7, India struck nine sites in Pakistan and Pakistan-administered Kashmir with missiles, which Islamabad said killed dozens of civilians. A ceasefire – for which Trump claimed credit – was eventually brokered on May 10. However, tensions between the South Asian neighbours continue to simmer."PM Modi told President Trump clearly that during this period, there was no talk at any stage on subjects like India-US trade deal or US mediation between India and Pakistan," Indian Foreign Secretary Vikram Misri said last June.The Future Outlook: Navigating Complex Geopolitical WatersAnalysts say that Rubio's visit to India is part of Washington's attempt to mend bilateral ties with New Delhi following tension between Trump and Modi last year. Sadanand Dhume, senior fellow for India, Pakistan and South Asia at the Council on Foreign Relations (CEFR), wrote in an article for the CEFR website on Thursday that Rubio is going to India in "repair" mode.Last October, Indian Foreign Secretary Shyam Saran told The Wire: "The 25-year upward trajectory of India-US relations has certainly plateaued, if not started declining". The coming months will be crucial in determining whether Rubio's visit can successfully reset the relationship or if the current tensions will continue to define US-India relations.

What is Immunotherapy? Immunotherapies are biological treatments that harness the immune system to prevent, control and fight diseases and other conditions. The most familiar are vaccines, which train the immune system to recognise targets such as invading pathogens. Other immunotherapies boost immune responses when they are too weak, or dampen them down when they are out of control. Still others draw on engineered immune cells or lab-made antibodies to disrupt disease processes. The Evolution of Immunotherapy Efforts to prevent disease by boosting the immune system date back thousands of years, but advanced therapies for a wide range of illnesses have come to the fore in the past two decades. A global registry of clinical trials listed 1,257 trials of immunotherapies between 2006 and 2016. The figure leapt to 4,591 in the past decade. How Do Cancer Immunotherapies Work? Cancer patients have seen great benefits from immunotherapies and dozens are now approved for more than 30 types of cancer. Some tumours evade the body’s defences by switching off immune cells, but antibody-based drugs – called checkpoint inhibitors – reactivate them so they can recognise and attack the malignancies. The Future of Immunotherapy: Beyond Cancer Researchers are now testing whether existing immunotherapies can help a broader range of patients. This includes treating allergies, infections, brain diseases, and autoimmune disorders. Some of the most exciting new immunotherapies draw on recent Nobel prizewinning work on regulatory T-cells, or Tregs, which can be used to dampen down immune responses. The Potential of Tregs in Immunotherapy Tregs are unusual immune cells that stand the immune system down once the threat has been dealt with. Therapies are in the pipeline for dementia and autoimmune diseases from type 1 diabetes and rheumatoid arthritis to lupus and chronic inflammation. The potential for Tregs is vast, and researchers believe that half of all deaths have a component that is immunological.

Palantir Accuses Mayor of Prioritising Politics Over SafetyPalantir says London mayor Sadiq Khan is “politicising procurement” by blocking a two‑year, £50 million AI contract for the Metropolitan Police, arguing the move jeopardises public safety.Mayor Blocks £50m AI Procurement Deal with Met PoliceKhan’s office cited a “clear and serious breach” of procurement rules and rejected the plan for the Met to use Palantir’s AI to process intelligence in criminal investigations. The decision was first reported by the Guardian on 21 May 2026.Financial Stakes: £50m Contract and Wider Government Deals£50 million – value of the blocked Met Police contract.£330 million – NHS England deal with Palantir.£240 million – Ministry of Defence agreement.Less than £500,000 – earlier separate AI pilot with the Met to detect rogue officers.Political Fallout and Policing Implications in LondonThe move has split Labour MPs: Rosena Allin‑Khan and Clive Lewis praised the block, while Stella Creasy condemned Palantir’s CEO for “using sexual‑abuse allegations to attack the mayor”. The Metropolitan Police Federation called the AI system “big brother”. Business Secretary Peter Kyle defended Palantir’s capabilities and urged Khan to explain his decision.Future of AI Procurement and Domestic Tech AlternativesKhan’s stance may encourage a shift toward British‑owned AI solutions, echoing Kyle’s call for more investment in domestic firms. Ongoing debates about foreign AI providers could reshape how UK public services adopt advanced technology, with potential impacts on policing effectiveness and public trust.

The Disco Legend Returns to the SpotlightLost in Music, He's the Greatest Dancer, Thinking of You and We Are Family – many artists would long for just one of these songs at any time in their career, but for Sister Sledge they all appeared on a single side of one of their albums. As she brings these and the rest of the disco group's still-sensational catalogue to the Electric Paradise festival this summer, Kathy Sledge will be joining us to answer your questions.The Rise of Sister SledgeKathy is one of four Sledge sisters along with Debbie, Joni and Kim, who formed the group as children in the mid-1960s, picking up gigs at churches and local events in their home city of Philadelphia as the Sledge Sisters. After flipping the name around, they got a record deal and their first chart success came in the UK in 1973, with the Top 20 hit Mama Never Told Me.The Chic Collaboration That Defined an EraFurther commercial success eluded them for a few years – though that's no reflection on the quality of early disco material such as Pain Reliever – until their label paired them with Chic's Nile Rodgers and Bernard Edwards. Sister Sledge's poise and charisma shone from the aforementioned hits the pair wrote for them, collected on the album We Are Family. The title track reached No 2 in the US and it, along with the others, endure as pinnacles of the disco era.Chart Success Through the DecadesRemixed versions of those songs came back around in 1984 and 1993, each to great success particularly in the UK, though the group's only UK No 1 single was in a very different style in 1985, with the swaying neo-60s pop of Frankie.A Solo Career and Continued PerformancesKathy took the lead vocal on some of their biggest hits, and after Sister Sledge went on hiatus in 1987, she had a solo career interspersed with occasional Sister Sledge reunions, and later – amid some legal wrangles with her sisters – solo tours of Sister Sledge material. Next up she'll perform at Electric Paradise in Milton Keynes, on 8 August, alongside other legends of the era such as Grace Jones, Candi Staton, Kool and the Gang and more.Your Questions for the Disco IconNow 67, Kathy has been in countless nightclubs and recording studios around the world across her multi-decade career, so there's plenty to ask her. Post your questions in the comments below before 6pm GMT on Wednesday, and we'll publish her answers later in the week.

Lead: Guardiola’s Transformative Tenure at Manchester CityWhen Pep Guardiola took charge in February 2016, he inherited a squad in transition. Over the next four seasons the club evolved into a dominant force, redefining Premier League standards and setting new statistical benchmarks.2016‑17: Building the Blueprint – A Trophy‑Free InceptionThe inaugural season was a learning curve. City finished third in the league and exited the Champions League in the last‑16 to Monaco. The campaign highlighted the emerging influence of Kevin De Bruyne in midfield, laying the tactical foundations for future success.2017‑18: The 100‑Point Milestone and Domestic SupremacyGuardiola’s second season delivered historic numbers:100 points – a Premier League record at the time106 goals scoredLeague title secured with a 19‑point margin over Manchester UnitedLeague Cup triumph over ArsenalDespite a 5‑0 victory over Liverpool early on, City were eliminated by the same opponents in the Champions League quarter‑finals.2018‑19: Securing the Domestic Treble Amidst European FrustrationCity’s third campaign saw a slight dip in points (98) and goals (95), but the season culminated in a historic domestic treble:Premier League championsLeague Cup winnersFA Cup winnersEuropean ambitions were thwarted when Tottenham knocked City out on away‑goals in the Champions League quarter‑finals.2019‑20: Covid‑Era Setback and Cup ConsolationThe pandemic‑disrupted season saw City finish second, 18 points behind Liverpool. A memorable 4‑2 aggregate win over Real Madrid hinted at European progress, but a one‑off quarter‑final loss to Lyon ended the run. The club salvaged silverware with a League Cup victory over Aston Villa.Financial and Brand Impact of City’s SuccessGuardiola’s trophy haul has driven commercial growth:Global sponsorship deals expanded, boosting revenue by an estimated £200 million annually.Matchday attendances consistently topped 55,000, reinforcing the Etihad’s status as a premier venue.Merchandise sales surged, with the 2017‑18 season alone generating record shirt sales worldwide.Strategic Implications for English Football and EuropeCity’s dominance has forced rivals to rethink recruitment, tactical flexibility and financial investment. The club’s emphasis on possession‑based, high‑pressing football has become a benchmark for Premier League aspirants, while the continued European shortfall underscores the tactical gap between English and continental powerhouses.Future Outlook: What Lies Ahead for Guardiola and CityLooking forward, Guardiola aims to convert domestic supremacy into Champions League success, likely by further strengthening the squad’s depth and adapting to evolving European tactics. With a solid financial base and a clear footballing philosophy, Manchester City is positioned to remain at the forefront of both English and European competition for years to come.