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The Breakthrough in Breast Cancer TreatmentA landmark international study has revealed that millions of women with breast cancer could safely skip chemotherapy thanks to a genomic test that determines who needs the treatment and who doesn't. The randomised trial specifically examined whether the test could identify patients who would not benefit from chemotherapy, allowing them to avoid the potentially debilitating treatment without compromising their outcomes.The Scientific Evidence Behind the TestThe results of the Optima trial, which will be presented at the American Society of Clinical Oncology's annual meeting, are being hailed by experts as gamechanging. The five-year cancer-free survival rate was 93.7% in the group that skipped chemotherapy, which was statistically non-inferior to the 94.9% rate in patients randomly assigned to receive chemotherapy.The Prosigna genomic test analyzes the activity of 50 specific genes in tumor tissue to determine the molecular subtype and develops a risk of recurrence score to help doctors decide if chemotherapy is necessary. This precision medicine approach allows for personalized treatment decisions based on the unique characteristics of each patient's cancer.A Patient's Journey to Avoiding ChemotherapyKaren Bonham, a speech and language therapist from Swansea in Wales, was one of 4,429 patients with breast cancer recruited to the trial from countries including the UK, Norway, Sweden, Australia, New Zealand and Thailand. Diagnosed with cancer in 2017 at the age of 55 after routine breast screening, Bonham described the news as shocking."It certainly propels you into a world of uncertainty. Life priorities realign – you simply want to survive," she said. Dreading chemotherapy, she agreed to join the Optima trial after undergoing surgery. She was only days away from starting treatment and had already cut her hair short when the results came back in September 2017.While taking a walk on a Welsh beach, Bonham received a phone call from her hospital informing her she had been allocated to the group of patients that would not be having chemotherapy. "How to describe the initial feeling? Immense relief? Like Christmas? Certainly a mixture of the two," she said.The Future of Personalized Cancer CareToday, Bonham, now 64, retired and living in Cardiff, is free of cancer, healthy and shows no signs of the disease coming back. "It is coming up to nine years since my diagnosis," she said. "I am mindful of my diagnosis, alert to potential changes in my body but do not feel defined by [it]. I walk, enjoy yoga and live well."While not every woman with breast cancer will be able to skip chemotherapy—the treatment remains necessary and important for many—the trial results suggest that genomic testing can safely identify those who can avoid it. This approach represents a significant shift toward personalized medicine in oncology, reducing unnecessary treatment and its associated side effects while maintaining excellent outcomes."I hope that the trial will bring positive patient outcomes to many," Bonham said, reflecting on the potential impact of this research on future breast cancer patients.

Early Reading Memories Virginia Evans shares her earliest reading memory, reading either 'The Velveteen Rabbit' by Margery Williams or poems from 'Where the Sidewalk Ends' by Shel Silverstein with her sister. Favorite Books Growing Up Evans loved mysteries and fantasy worlds, reading many Nancy Drew books, 'The Boxcar Children' by Gertrude Chandler Warner, and 'The Wind in the Willows'. She enjoyed books about things that can't exist, calling it escapism. The Book That Changed Her as a Teenager At 15, Evans read John Steinbeck's 'The Grapes of Wrath', which gave her a new understanding of what fiction can do and how words can portray complex living. The Writer Who Changed Her Mind Evans praises Joan Didion, saying every time she reads Didion's work, she is changed in some way, seeing the world, people, and politics differently. The Book That Made Her Want to Be a Writer In college, Evans read Jhumpa Lahiri's 'Interpreter of Maladies', which inspired her to write, making her think: 'I have to do this, I can do this, I will do this'. The Author She Came Back To Evans tried Jane Austen's 'Pride and Prejudice' too young, but when she came back to it in her late 20s, she enjoyed it tremendously. Books She Rereads Daphne du Maurier's 'Rebecca' Steinbeck's 'East of Eden' The Book She Could Never Read Again Evans devoured the Millennium series by Stieg Larsson but was too disturbed to read it again. The Book She Discovered Later in Life Evans didn't read 'Little Women' by Louisa May Alcott until her adult life, relating to the mother character and identifying with Jo's struggles as an author. Current and Comfort Reads Currently reading: 'While I Was Gone' by Sue Miller Comfort reads: 'The Uncommon Reader' by Alan Bennett, 'Beautiful Ruins' by Jess Walter, 'I Capture the Castle' by Dodie Smith

The Schreiber family, presiding over a nationwide commercial portfolio via the Midos Group, is at the center of a growing controversy involving two distinct business models: aggressive tax avoidance and the profiteering from the UK's housing crisis. The Dual Nature of the Schreiber Business Empire The investigation reveals a complex web of family-owned entities that appear to operate on opposite ends of the social spectrum. On one side, the Midos Group is accused of exploiting a controversial tax scheme to avoid business rates on empty commercial properties. On the other, a similarly named but ostensibly separate entity, Midos Management Co, is profiting from the UK's chronic shortage of social housing by arranging temporary accommodation for homeless residents. Midos Group: Accused of using the 'faith room' scheme to avoid rates on empty units. Midos Management Co: Collecting fees for arranging temporary accommodation for councils. Key Figures: David Schreiber (Midos Group) and Elizabeth Endzweig (Midos Management Co). Financial Impact of the 'Faith Room' Tax Loophole The core of the tax avoidance allegations centers on a provision that exempts property owners from paying business rates if the space is made available for religious worship. The 'faith room' scheme, marketed by Verity, allegedly involves minimal activity—such as placing a notice and a staff member reading scripture—to create the appearance of worship. Total Savings: Landlords have saved at least £18m through this scheme. Specific Case: Dover District Council is suing for £1.7m of unpaid tax. Properties Involved: Discovery Park in Kent and a disused pub in Clapham, London. Profiting from the Homelessness Crisis While the family allegedly avoids taxes on empty buildings, they are simultaneously capitalizing on the housing emergency. Midos Management Co acts as an intermediary, matching councils with private landlords to house homeless residents. Despite claims of separation, evidence suggests significant overlap between the two entities. Revenue Collected: At least £43m collected on behalf of landlords since 2019. Client Base: Lambeth council and at least four other councils. Directorship Overlap: Elizabeth Endzweig, daughter of David Schreiber, is a co-director of multiple companies sharing the same address as Midos Group. The Future of UK Property Tax Compliance The revelations highlight a growing tension between private profit and public service obligations. With MPs and councils increasingly scrutinizing these arrangements, the 'faith room' exemption is likely to face tighter regulatory oversight. The case sets a precedent for how closely connected family businesses can be without violating anti-avoidance rules, potentially leading to stricter audits of corporate structures in the property sector.

The Surge in Anti-Foreign Business ViolenceSouth Africa is currently facing a wave of violent attacks targeting foreign-owned shops and businesses, with reports of looting, arson, and intimidation spreading across several provinces. The violence, which appears to be fueled by xenophobic sentiments, has raised serious concerns about the safety of immigrant entrepreneurs and the stability of local markets.Escalating Attacks on Immigrant-Owned EnterprisesThe recent spate of violence has seen numerous foreign-owned retail establishments being targeted, with many shopkeepers reporting threats and physical attacks. Witnesses describe coordinated attacks where groups of individuals descend on shopping areas, systematically targeting businesses owned by immigrants from other African nations. South African authorities have deployed additional police forces to affected areas, but the violence continues to flare up in different regions.Economic Toll of the UnrestThe attacks are taking a significant economic toll, with estimates suggesting millions of dollars in damages to foreign-owned businesses. Shop owners report complete losses of inventory and property, with many fearing they may never be able to reopen. Local economies in affected areas are also suffering, as these businesses often serve as vital retail hubs for surrounding communities, providing essential goods and services.Regional Implications and Social TensionsThe violence against foreign-owned businesses is exacerbating already strained social relations in South Africa. The attacks reflect deep-seated economic frustrations and xenophobic attitudes that have been building for years. This situation threatens South Africa's reputation as a relatively stable economy in the region and could impact diplomatic relations with neighboring countries whose citizens are being targeted.Path Forward for Business Safety and Community RelationsExperts predict that without immediate intervention, the violence could escalate further, potentially leading to broader social unrest. Government officials are calling for dialogue between local communities and foreign business owners, while also addressing the root economic grievances that fuel such attacks. Long-term solutions may include better economic opportunities for local populations and strengthened protection for all businesses regardless of ownership nationality.

The Lead: This Week's Entertainment HighlightsThis week's entertainment landscape offers a diverse array of critically acclaimed shows and films, from hilarious comedies to chilling horror. Channel 4's "Make That Movie" stands out as one of the funniest shows of the year, while Netflix's "The Four Seasons" returns with a brilliant second season. Horror fans can explore the disturbing world of "Backrooms," while Marvel offers a stylish take with "Spider-Noir."TV Comedy Gold: Make That MovieChannel 4Summed up in a sentence Last One Laughing finalist delivers one of the funniest shows of the year, with this mockumentary about a director who makes awful films.What our reviewer said "So ostentatiously silly that it deserves to be paraded around the streets." Stuart HeritageRead the full reviewFurther reading "People are like: you're a crackpot": how Sam Campbell became comedy's oddball superstarNetflix Triumph: The Four Seasons ReturnsNetflixSummed up in a sentence Tina Fey triumphs again with the return of this comedy about a group of middle-aged friends who reunite during holidays throughout the year.What our reviewer said "Even more perspicacious, poignant and hilarious than the first." Chitra RamaswamyRead the full reviewMarvel's Stylish Take: Spider-NoirPrime VideoSummed up in a sentence In Marvel's witty homage to the hard-boiled films and fictions of the 40s – which can be watched in colour or black-and-white – Nicolas Cage plays Ben Reilly, who gave up being superhero "the Spider" five years ago.What our reviewer said "Everything is shot with style and confidence." Lucy ManganRead the full reviewFurther reading The life of PIs: the strange case of 2026's resurgence of hard-boiled detectivesHidden Gem: PoniesNow/Sky AtlanticSummed up in a sentence Emilia Clarke and Haley Lu Richardson have heaps of fun as two widows who become cold war spies in this espionage comedy-drama.What our reviewer said "It's a mashup of genres and tropes, but it is its own thing too – and an unexpected treat at that." Lucy ManganRead the full reviewHorror Innovation: BackroomsIn cinemas nowSummed up in a sentence A debut from 20-year-old director Kane Parsons that examines memory, reality and fear in an icily disturbing horror, in which Chiwetel Ejiofor accesses an infinite series of hidden rooms that all feel creepily askew.What our reviewer said "Backrooms progressively raises its game towards the big finish with jump scares, squirm scares and tiny shiver scares. There is real fascination in exploring this vast, invisible city state of fear." Peter BradshawRead the full reviewFurther reading Are you sitting uncomfortably? How Backrooms upended the horror movieMusic and Bromance: Power BalladIn cinemas nowSummed up in a sentence Nick Jonas and Paul Rudd star in a comedy of bromance and betrayal from Irish writer-director John Carney that brilliantly brings together Rudd's washed-up wedding singer and Jonas's insecure ex-boyband superstar.What our reviewer said "Power Ballad is about making it and dreaming big, about every busker never giving up on hopes of one day being mega. But as so often with Carney, it's about something else, usually left unacknowledged in movies about music or any sort of show business: the terrible binary of success and failure." Peter BradshawRead the full reviewUnexpected Pairing: TunerIn cinemas nowSummed up in a sentence Playing a piano tuner with super-sensitive hearing, Leo Woodall's relationship with Dustin Hoffman is a tender highlight in this safe-cracking thriller.What our reviewer said "What a pair they are; they are a real pleasure to watch in an easy, unforced drama that mixes romcom moments with a relaxed crime thriller. It's like the Safdie brothers in chill-out mode." Cath Clarke

The Lead: Arsenal's European QuestSince Arsenal's euphoric Premier League win last week, north London has been in a state of celebration. Now, with the Gunners poised to play in the Uefa Champions League final in Budapest, Gooner fever is spreading across the continent. Arsenal fans are embarking on extraordinary journeys to witness their team's first Champions League final appearance in 20 years, demonstrating the remarkable dedication of the club's supporters.The Travel Challenge: Trains, Planes and AutomobilesWith all 13 of Wizz Air's Budapest-bound flights from London sold out by Friday, and the last available ticket priced at £407 one way according to Skyscanner, Arsenal fans have become creative travelers. Darren Cornish, a 53-year-old IT manager from Hemel Hampstead, exemplifies this resourcefulness: "We'll get there by train, plane and automobiles," he said. After securing return flights to Linz, Austria for £150, he plans to take a three and a half hour train to Budapest on Saturday morning.Many fans are taking indirect routes through Vienna, Bratislava, Rome, and other European cities to avoid the exorbitant flight prices. Ben Boxhall and two friends from Essex flew to Kraków instead, paying £170 for return flights, then plan to catch a 5am bus to Budapest, arriving around midday. They haven't booked a hotel, intending to join thousands of fans at the Uefa meeting point before pulling an all-nighter and catching the first bus back.The Fan Experience: Generations of CelebrationThe journey to Budapest represents different things to different generations of Arsenal supporters. For younger fans like Ben Boxhall, 23, this is their first Premier League victory they can remember: "We were 18 months old when they won the league in 2004. This is the first one that we remember and celebrating with our parents and friends."Older fans like Neil Roberts, who has attended matches for 25 years, appreciate the rarity of this moment: "When you haven't had success for so long, when it does come around it's magical." This generational divide creates a unique atmosphere where older fans savor the moment while younger fans experience the thrill of success for the first time.The Financial Impact: Cost of Champions League GloryThe financial commitment from Arsenal supporters is substantial. While some fans found relatively affordable options like Cornish's £150 return flights to Austria, others are paying significantly more. Ollie Laurence, 23, knows "people who are paying north of a grand" on flights to get to Budapest. Ticket prices for the final itself are equally staggering, with some tickets reportedly available for around £2,500.This financial investment reflects the high stakes and emotional value of the occasion. For many fans, the cost is secondary to the opportunity to witness history, especially after a 20-year absence from the Champions League final.The Historical Context: A Free Hit at GloryArsenal's return to the Champions League final after two decades has created a unique psychological dynamic among supporters. With the Premier League title already secured, many fans view the final as a "free hit," as Darren Cornish explains: "This game is a free hit. If we lose, we've still got the premiership. If we win, it'll be the best thing ever. There's no pressure on these boys."This perspective contrasts with previous finals where the weight of expectation might have been heavier. The combination of already achieved success and the potential for a historic double has created an atmosphere of celebration rather than anxiety, allowing both players and fans to enjoy the occasion without the usual pressure of a must-win situation.

The Resurgence of Ebola in Central AfricaThe current outbreak in the Democratic Republic of Congo and Uganda represents a significant breach in regional containment efforts. Unlike previous years, this resurgence involves complex logistical challenges, including the movement of populations and the potential for cross-border transmission. The WHO's intervention highlights that the virus has adapted to evade standard containment protocols, forcing a re-evaluation of current safety measures.The Economic and Social Toll of a Global Health EmergencyDeclaring a Global Health Emergency triggers a cascade of international interventions, including emergency funding and medical supplies, but also imposes heavy economic costs on affected regions. The disruption to healthcare systems and trade routes in Central Africa creates a ripple effect that extends far beyond the immediate patient count. The financial burden of managing a cross-border outbreak often outweighs the cost of preventative measures, making rapid response critical.Shifting Dynamics in Global Health SecurityThis event underscores a growing vulnerability in global health infrastructure. The ability of the WHO to act swiftly highlights the importance of rapid response mechanisms, yet the persistence of the virus suggests that previous containment strategies may be insufficient against evolving viral strains. The situation in 2026 serves as a stark reminder that infectious diseases remain a persistent threat to global stability.Containment Challenges in 2026Looking ahead, the containment of this outbreak will likely depend on the success of international vaccination campaigns and the stabilization of local security conditions. Without decisive action, the risk of the virus spreading to urban centers remains a persistent threat to global stability. The coming months will determine whether the international community can contain the spread before it becomes a pandemic-level crisis.

Eight students were taken into custody on May 29, 2026 following a fatal fire that engulfed a dormitory at a Kenyan school, killing several occupants. The arrests mark a swift legal response to a tragedy that has shocked the nation. Fatal Dormitory Blaze Claims Lives at Kenyan School The fire erupted in the student residence, rapidly spreading due to the building's wooden structure and limited fire‑suppression systems. Emergency services arrived within minutes, but the blaze had already caused multiple fatalities and injuries. Arrests of Eight Students Spark Legal Scrutiny Eight students detained on suspicion of negligence, arson, or other related offenses. Implications for School Safety Standards in Kenya The incident has reignited debate over the adequacy of safety regulations in Kenyan educational facilities. Critics argue that overcrowded dormitories, outdated wiring, and insufficient fire exits contributed to the disaster. Potential Reforms and Future Oversight Government officials have pledged a review of school infrastructure standards and stricter enforcement of fire‑safety codes. Civil society groups are calling for independent audits of all boarding schools to prevent similar tragedies.

The Lead The World Health Organization (WHO) chief has embarked on a critical visit to the Democratic Republic of Congo (DRC) as the region grapples with an ongoing Ebola crisis. WHO's Response to the Ebola Outbreak The WHO Director-General's visit underscores the organization's commitment to supporting the DRC in its fight against the Ebola outbreak. The WHO has been working closely with local health authorities to contain the spread of the disease. The Current Situation in DRC The Ebola outbreak in the DRC has presented significant challenges, including insecurity in the affected areas and the risk of the virus spreading to neighboring countries. The WHO's visit aims to bolster the response efforts and ensure a coordinated approach to tackling the crisis. The Impact on Global Health The Ebola crisis in the DRC has implications for global health security, highlighting the need for continued vigilance and cooperation among nations to prevent the spread of infectious diseases. Future Outlook The WHO's efforts, in collaboration with local and international partners, are crucial in controlling the outbreak and preventing future health crises. The organization's visit to the DRC is a significant step towards achieving this goal.