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The Breakthrough in Breast Cancer TreatmentA landmark international study has revealed that millions of women with breast cancer could safely skip chemotherapy thanks to a genomic test that determines who needs the treatment and who doesn't. The randomised trial specifically examined whether the test could identify patients who would not benefit from chemotherapy, allowing them to avoid the potentially debilitating treatment without compromising their outcomes.The Scientific Evidence Behind the TestThe results of the Optima trial, which will be presented at the American Society of Clinical Oncology's annual meeting, are being hailed by experts as gamechanging. The five-year cancer-free survival rate was 93.7% in the group that skipped chemotherapy, which was statistically non-inferior to the 94.9% rate in patients randomly assigned to receive chemotherapy.The Prosigna genomic test analyzes the activity of 50 specific genes in tumor tissue to determine the molecular subtype and develops a risk of recurrence score to help doctors decide if chemotherapy is necessary. This precision medicine approach allows for personalized treatment decisions based on the unique characteristics of each patient's cancer.A Patient's Journey to Avoiding ChemotherapyKaren Bonham, a speech and language therapist from Swansea in Wales, was one of 4,429 patients with breast cancer recruited to the trial from countries including the UK, Norway, Sweden, Australia, New Zealand and Thailand. Diagnosed with cancer in 2017 at the age of 55 after routine breast screening, Bonham described the news as shocking."It certainly propels you into a world of uncertainty. Life priorities realign – you simply want to survive," she said. Dreading chemotherapy, she agreed to join the Optima trial after undergoing surgery. She was only days away from starting treatment and had already cut her hair short when the results came back in September 2017.While taking a walk on a Welsh beach, Bonham received a phone call from her hospital informing her she had been allocated to the group of patients that would not be having chemotherapy. "How to describe the initial feeling? Immense relief? Like Christmas? Certainly a mixture of the two," she said.The Future of Personalized Cancer CareToday, Bonham, now 64, retired and living in Cardiff, is free of cancer, healthy and shows no signs of the disease coming back. "It is coming up to nine years since my diagnosis," she said. "I am mindful of my diagnosis, alert to potential changes in my body but do not feel defined by [it]. I walk, enjoy yoga and live well."While not every woman with breast cancer will be able to skip chemotherapy—the treatment remains necessary and important for many—the trial results suggest that genomic testing can safely identify those who can avoid it. This approach represents a significant shift toward personalized medicine in oncology, reducing unnecessary treatment and its associated side effects while maintaining excellent outcomes."I hope that the trial will bring positive patient outcomes to many," Bonham said, reflecting on the potential impact of this research on future breast cancer patients.

The Historical Detective's QuestIn the spring of 2011, author Raf Nicholson embarked on a PhD journey to document the history of women's cricket, only to find a startling lack of resources at the MCC library at Lord's. The women's cricket section contained merely three books, including Rachael Heyhoe Flint's 1978 autobiography. This discovery sparked a decade-long mission to uncover the hidden history of women's cricket, culminating in his book 'The Women in Whites: A History of Women's Cricket in England' published in June 2026.The Lancashire Cowshed TreasureThe breakthrough came when Nicholson was directed to the Women's Cricket Association archive, stored in a former cowshed in a tiny hamlet eight miles east of Blackpool. There, amidst garden furniture and farming equipment, he discovered historical treasures including minute books dating back to 1926 when the WCA was formed, scrapbooks, letters, tour diaries, and newspaper cuttings. Spending two weeks in the summer, Nicholson made daily six-mile round trips from a nearby B&B; to meticulously document these invaluable materials.Pioneers of the Women's GameThrough his research, Nicholson brought to light key figures in women's cricket history. Betty Archdale, captain of the 1934-35 Australian tour, earned the nickname 'Hitler' for her distinctive leadership style. Myrtle Maclagan, daughter of an army officer, demonstrated exceptional cricket prowess with seven for 10 in the first women's Test and the first Test hundred in women's cricket. Marjorie Pollard, the WCA founder, maintained strict dress codes that required women to play international cricket in skirts until 1997, believing 'trousers are beyond the pale'.Overcoming Financial and Social BarriersResearch revealed the constant financial struggles faced by the WCA and women's cricket players. England batter Chris Watmough described writing hundreds of letters begging for financial support for the 1968-69 tour to Australia and New Zealand, which resulted in sponsorship from lingerie brand Berlei. Coach Ruth Prideaux had so little money for the 1993 World Cup that players slept on blow-up mattresses in her living room and trained by running along Eastbourne beach. Norma Izard famously borrowed a wok from MCC kitchens to burn a miniature bat, creating the first Women's Ashes trophy in 1998.Preserving a LegacyMany of the pioneering women Nicholson researched and interviewed have since passed away, but their stories live on through his book. The research journey also led to the MCC acquiring the complete WCA archive in 2017, moving the historical materials from the Lancashire farm to Lord's. This collection now serves as a valuable resource for future researchers, ensuring that the rich history of women's cricket is preserved and accessible for generations to come.

The Lead Declan Rice has promised that Arsenal “are coming back for more” next season after putting aside their disappointment at losing on penalties in the Champions League final by parading the Premier League trophy in north London. Arsenal's Champions League Final Disappointment Paris Saint-Germain retained their European crown after a nail-biting shootout in Budapest, which ended with Gabriel Magalhães missing the decisive spot kick. Arsenal – who have played more games in the competition without winning it than any other club – reached the Champions League final for the first time since 2006 having made steady progress under Mikel Arteta in recent seasons. The Data Analysis Rice scored in the shootout and chanted “Set-piece FC” on a microphone as Arsenal showed off the Premier League trophy they won for the first time since 2004. Rice is set to miss England’s first warm-up game for the World Cup against New Zealand on Saturday as he has a few days off before linking up with Tuchel’s training squad in Miami. The Impact Analysis Rice believes the best is still to come from a squad that includes the exciting 16-year-old Max Dowman. “Speaking to the players, obviously the manager, there is no reason why we are stopping here,” he said. “Next season we are going to go even stronger and we are going to be ready again so it is exciting times for this club.” The Prediction “To see the joy we can give people is crazy. Next year, we’re coming back for more.” Arteta briefly addressed the crowd before four open-top buses also carrying the women’s team – who paraded the Fifa Champions Cup they won in February – started the five-mile loop around the streets of north London, with hundreds of thousands of supporters estimated to have turned out.

The Visa Delay CrisisThe South African squad's departure for the FIFA World Cup has been delayed due to a hold-up in the visas for Mexico, whom they face in the tournament's opening game in 11 days, the South African Football Association (SAFA) has confirmed. Bafana Bafana, as South Africa's national men's football team is known, were scheduled to depart on a chartered flight from Johannesburg to Mexico City on Sunday morning, but remained grounded as visas for the cohost nation for some squad members were delayed.World Cup Opening Match in JeopardyMexico will host South Africa in the World Cup's opening game at the Estadio Azteca on June 11, making this delay particularly concerning. "The South African senior men's national team has experienced challenges regarding visas for some players and officials, and as a result the group could not travel to North America this morning as originally planned," SAFA said in a media release. The association emphasized that they are "working around the clock to ensure that the team travels to Mexico City as soon as possible ahead of the opening match."Squad and Tournament ScheduleHugo Broos announced his 26-man squad on Wednesday, which included two uncapped players. South Africa will warm up for the World Cup with a friendly against Jamaica on June 5. After taking on the cohosts in their opening group clash, they meet Czechia on June 18 and South Korea on June 24. The squad was given a grand public sendoff in Johannesburg on Saturday before their first appearance in the tournament since hosting it in 2010, but the flight from OR Tambo airport to Mexico City was postponed.Official Response and CriticismSAFA said it had called an emergency committee meeting later on Sunday to discuss the issue following a vociferous condemnation from Sports Minister Gayton McKenzie, who termed it "embarrassing and grossly unfair." "We are being made to look like fools," McKenzie said on social media platform X. Amid speculation about the visa bungle, several social media users questioned why the team paraded in Johannesburg before their departure if team officials were aware that players had not been issued visas yet.Broader Visa Challenges at World CupSouth Africa are not the first team to run into visa-related logistical issues at the World Cup. Members of Iran's World Cup squad have also not been issued visas for the United States, where they play their opening game against New Zealand on June 15 and two other group matches thereafter. According to Iranian state media reports on Saturday, FIFA has informed the Football Federation Islamic Republic of Iran (FFIRI) vice president Mahdi Mohammadnabi that administrative work is in progress and the visas will be issued this week. Iran relocated its team's base camp from Arizona, US, to Mexico last week.

The Historic AppointmentJo Yapp has been named the head coach for the first women's British & Irish Lions tour, which will travel to New Zealand in 2027. The former England captain is currently the head of the women's pathway at the Rugby Football Union and previously led Australia to the quarter-finals of last year's Rugby World Cup.Yapp was preferred for the role over England head coach John Mitchell, who led England to World Cup glory in 2025 and had publicly expressed interest in the Lions position. The 46-year-old will work part-time for the Lions from July before taking a sabbatical from her RFU role next year to commit fully to the position.Coaching CredentialsAfter retiring from playing in 2009, Yapp built an impressive coaching career. She started with England Under-20s before becoming skills coach at Worcester's women's side, later being promoted to head coach until the side folded in 2023. Her most recent role was as head coach of Australia, making her the first woman to lead the Wallaroos.With Australia, Yapp led them to the WXV2 trophy in 2024, securing their place at the 2025 World Cup where she was one of only three female head coaches at the tournament. The Wallaroos reached the quarter-finals but were knocked out by eventual runners-up Canada. As a player, Yapp was capped 70 times for England and represented her country at three World Cups.The Tour DetailsThe Lions will tour New Zealand in September 2027, with the schedule including three Tests against the Black Ferns. New Zealand will be led by Whitney Hansen, who took over in December 2025. The rest of the coaching staff, selected from the four home nations (England, Ireland, Scotland, and Wales), has yet to be confirmed."To lead the first British & Irish Lions women's team is an incredible honour and something I'm immensely proud of," Yapp said. "The Lions represents the very best of our sport and this tour to New Zealand is an opportunity to create something truly special and help shape the future of women's rugby for years to come."Significance for Women's RugbyThis appointment marks a significant milestone for women's rugby, with Carol Isherwood, chair of the Lions women's committee, calling it "a hugely significant appointment for women's rugby and an exciting new chapter in Lions history."Ben Calveley, Lions chief executive, emphasized the importance of the selection process: "The selection process was rigorous, competitive and international in scope as befitting the significance of this historic appointment. For a moment that represents such a step forward for the game, it was important to us that this appointment serves our desire to grow and support all aspects of the women's game including the promotion of female coaches."Yapp's experience facing the Black Ferns as a player—losing to them in World Cup finals in 2002 and 2006—gives her unique insight: "I know from experience how challenging it is to face the Black Ferns on home soil, but that challenge is exactly what makes this tour so exciting."

Olly Murs Steps Into the Unknown for Soccer AidOlly Murs recently completed a brutal 400km journey from Old Trafford in Manchester to the London Stadium by running, cycling and rowing – and raised £830,000 for Unicef. On Sunday, he will take part in the 20th annual Soccer Aid match, along with Jill Scott, Tom Hiddleston, Wayne Rooney, Jermain Defoe, Owen Cooper and Angry Ginge.Under the VinesPressing concerns: the first season of this breezy wine-making daytime drama saw chalk-and-cheese step-cousins Louis (Charles Edwards) and Daisy (Rebecca Gibney) grow close after jointly inheriting a kaput New Zealand vineyard. But as this second run begins, Louis seems set on heading back to London with his ex.Gardeners' WorldWith summer making an early appearance, now is the time to embrace Monty Don’s colourful, bold flowers. Only got a patio to play with? Rekha Mistry has big plans for a small space. And Carol Klein is discovering the science of what happens to a seed from the very moment it is sown.Hunting Britain’s Fugitives: DispatchesHow many people are at large in the UK, guilty of serious crimes, but on the run and easily evading the authorities? Lawbreakers may think justice will never catch up with them, but some are less successful at escaping the attentions of reporter Matt Shea, who takes it upon himself to track them down and, in spite of the potential threat of violence, confront them.PoniesAmerican widows Bea (Emilia Clarke) and Twila (Haley Lu Richardson) have made an impactful debut as spies in Moscow in 1977: they’ve burned down a pub. How can they top that? A confident comedy drama fleshes out its two protagonists by giving Bea a new mission that requires her to toughen up, while Twila benefits from letting her guard down.Smoggie QueensLike a more chaotic, camper Beautiful People, the series ends with a bang as the gang, through flashbacks, recount a cheating scandal that happened during the final of the Mr Teesside competition. Expect several unreliable narrators, fake chest hair and “Detective Sexy” (AKA Dickie wearing fake breasts and a Sherlock cap).Film choiceFuze (David Mackenzie, 2025), 6.15am, 12.10pm, 8pm, Sky Cinema Premiere. Two of the bookies’ favourites to be the next James Bond go head to head in David Mackenzie’s tense, rug-pulling thriller. Aaron Taylor-Johnson stars as no-nonsense army bomb disposal major Will Tranter, called to defuse a second world war bomb in central London.

The Uncertain World Cup Match New Zealand will play their first World Cup game in 16 years with much of the planet watching what is surely the biggest event of the group stage. But little attention will be on whether New Zealand can record their first World Cup win with Iran their opposition on 15 June. The Event Details Ever since the US and Israel attacked Iran on 28 February, there has been uncertainty surrounding this World Cup fixture in Los Angeles. There were conflicting signals whether the Islamic Republic of Iran would allow the national football team to travel to the home of its attacker, and whether the US would welcome Team Melli. The Current Status With kick-off now weeks away, it appears the game will go ahead as planned. Still, there is the possibility of protests by the large local Iranian population in “Tehrangeles”, many of whom fled the 1979 revolution, and acts of defiance by players. The Impact Analysis New Zealand, who also face Egypt and Belgium in their group, are very much the supporting cast in this drama. It is an unusual situation for any team to be in but that has been the case for the past three months with Bazeley never quite sure who the opposition would be for New Zealand's biggest game since 2010. The Prediction “Right now we’re still continuing as though we’re playing Iran,” Bazeley said in March. “They’re the team that qualified and we got drawn against them. That’s still the fixture and until we get told otherwise, we’ll ‌continue ⁠with that preparation. Obviously, if things change, then we’ll deal with that.”

The Rise of Tim Payne New Zealand defender Tim Payne has become an unlikely star after an influencer from Argentina called on his followers to unite and make the little-known 32-year-old a “hero” of the upcoming World Cup. The Social Media Campaign El Scarso, a football influencer also known as Valen Scarsini, identified Payne as the least-known player at the World Cup in Canada, the United States and Mexico based on his small social media following. Payne had around 4,700 followers on Instagram earlier this week, but his following has grown at a rate of almost 1,000 per minute to more than a million by Friday. The Impact on Payne's Fame Payne’s following is now six times greater than New Zealand’s captain and best-known player, Nottingham Forest forward Chris Wood. Scarsini, who has more than 500,000 followers, implored his base to “start mentioning Tim Payne everywhere.” The Future of Tim Payne's Career Now there is even a song supporting Payne, who recently made his 50th appearance for New Zealand after making his debut at 18. Payne, who plays his club football for Wellington Phoenix in the A-League Men, responded Friday to his new-found social media fandom, expressing his gratitude to Scarsini and his fans.

The US Visa Conundrum Iran's football team is facing difficulties in obtaining US visas, which has affected their training and preparation for the World Cup. The team's ambassador to Mexico, Abolfazl Pasandideh, expressed concerns about the team's participation in the tournament. Training Camp Relocation The Iranian team was originally scheduled to train in Tucson, Arizona, but they have relocated to Tijuana, Mexico, due to visa issues. Pasandideh visited the training camp and expressed frustration about the situation. The Impact on Iran's World Cup Campaign Pasandideh stated that Iran is not participating in the World Cup on "equal terms" due to the visa issues. The team will play their group games in Los Angeles and Seattle. The Iranian Football Federation is hopeful that the players will be granted multiple entry visas. Upcoming World Cup Matches Iran will play against New Zealand on June 15 in Los Angeles. Iran will play against Belgium on June 21 in Los Angeles. Iran will play against Egypt on June 26 in Seattle. The Diplomatic Efforts Iranian diplomats have been involved in efforts to resolve the visa issue. They visited the stadium where the team is training and met with local security officials.