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For the first time, thousands of cancer patients from Black and minority ethnic backgrounds will benefit from an enhanced genetic test offered by the NHS. The new screening expands the panel of DPYD gene variants from four to five, directly addressing a long‑standing bias that left non‑white patients vulnerable to dangerous chemotherapy side‑effects. In England, patients slated for chemotherapy undergo a genetic check that can guide dose adjustments and mitigate adverse reactions such as mouth sores, hair loss, nausea, fatigue, and, in severe cases, death. Up to 40% of the 38,000 individuals receiving fluoropyrimidine‑based chemotherapy each year experience a harmful drug reaction. Previously, the test only targeted four DPYD variants common in people of European descent, meaning many Black patients received inaccurate “all‑clear” results. The addition of a fifth variant—more prevalent among African, Caribbean and other minority groups—means clinicians can now identify patients at risk who were previously missed. Since its rollout at Manchester University NHS Foundation Trust last September, three minority‑ethnic patients have had their initial chemotherapy doses adjusted, lowering their chance of a potentially fatal reaction. Dr Veline L’Esperance, senior clinical adviser at the NHS Race and Health Observatory, called the change “tangible results for patients who have historically been left behind.” She emphasized that the update shifts the discussion on ethnic health inequality from rhetoric to actionable care. Prof Habib Naqvi, chief executive of the NHS Race and Health Observatory, described the development as a “groundbreaking outcome” for chemotherapy safety, while noting that ethnic minorities remain under‑represented in genomic research and biobanks. He warned that broader inclusion is essential for the promised benefits of precision medicine to reach all communities. Prof Dame Sue Hill, chief scientific officer for NHS England, highlighted the significance of discovering the fifth variant: “Personalising chemotherapy based on genetics can save lives and reduce harmful side‑effects, especially for patients of African ancestry.” She added that the North West NHS Genomic Medicine Service has already demonstrated the practical impact of this approach. These steps come amid broader evidence that minority patients in the UK face longer diagnostic waits, more GP visits before a cancer diagnosis, and lower perceived support during treatment. The expanded DPYD test represents a concrete effort to close those gaps and ensure equitable, science‑driven care for all cancer patients.

Tottenham Hotspur have lost their captain Cristian Romero for the remainder of the 2025‑26 Premier League campaign after sustaining medial knee‑ligament damage in a clash with Sunderland striker Brian Brobbey. The injury, expected to require around eight weeks of rehabilitation, forces Romero off the pitch for the final six matches that will decide whether the club remains in the top flight.Romero left the Stadium of Light in tears after 70 minutes of a 1‑0 defeat, the goal coming from his own goalkeeper Antonín Kinský following the collision. The Argentine defender’s absence adds to an already extensive injury list that includes James Maddison, Dejan Kulusevski, Wilson Odobert and Mohammed Kudus. Goalkeeper Guglielmo Vicario is also sidelined after a hernia operation, leaving Kinský as the starter.Spurs sit 18th after a season that has seen them lose 16 league games and fail to register a domestic win in 2026. Manager Roberto De Zerbi admitted the blow could be “a big problem” but stressed the need for the squad to rally: “He’s a good guy, a top player, and we need him to finish the season and achieve our goal.”The incident also sparked a backlash against Brobbey, who was targeted with racist abuse on social media. Sunderland issued a statement pledging full support for the striker and confirming that the matter has been reported to the Premier League, relevant platforms and the police.With the relegation battle intensifying, Tottenham’s ability to replace Romero’s defensive leadership will be crucial as they fight to stay in the Premier League.

Recent CDC data reveal a dramatic 1,200% increase in kratom‑related poisonings across the United States over the last ten years, with the most pronounced surge recorded in 2025. Researchers link this rise to the growing presence of 7‑hydroxymitragynine (7‑OH), a synthetically produced compound that mimics kratom’s effects but carries opioid‑like risks. Walter Prozialeck, pharmacology professor at Midwestern University, said the trend was expected, noting that the synthetic alkaloid has entered the market through energy drinks and other products since 2024. Christopher McCurdy of the University of Florida warned that marketing 7‑OH as “enhanced kratom” blurs the line for consumers, turning poison‑control calls into a conflated metric for both natural and synthetic products. By contrast, natural kratom (Mitragyna speciosa)—a Southeast Asian plant used for centuries as a pain reliever—has demonstrated a relatively favorable safety profile in animal and human studies. A 2018 statement from then‑HHS Secretary Brett Giroir rejected the DEA’s push to schedule kratom as a Schedule I substance, citing insufficient evidence of harm. Despite the scientific distinction, several states have moved to implement or propose blanket bans on all kratom products, prompting concern from clinicians and patient advocates. A recent user survey indicated that about 50% of respondents rely on kratom for chronic pain, while roughly 40% use it during addiction recovery. Personal testimonies underscore the plant’s therapeutic role. Jeff Maslan, a 68‑year‑old Californian with severe osteoarthritis, credits kratom with easing opioid withdrawal after multiple surgeries. Similarly, “Steven,” a disabled California resident, describes how kratom eliminated unbearable oxycodone withdrawal symptoms without producing the euphoric “warm fuzzy” feeling typical of opioids. Researchers emphasize that 7‑OH carries genuine opioid hazards, including addiction, severe withdrawal, and respiratory depression that can lead to fatal overdose. In animal models, 7‑OH demonstrated the same respiratory‑depression risk as classic opioids, whereas kratom’s primary alkaloid did not. Prozialeck and colleagues explain that kratom’s pharmacology is more nuanced: it partially activates opioid receptors while also engaging adrenergic and serotonin pathways, resembling a hybrid of a weak opioid and an SNRI‑type antidepressant. This multimodal action likely accounts for its lower euphoric potential and the reported boost in energy among users. Nevertheless, experts caution that kratom is not without risk. Fatal poisonings often involve co‑ingestion of potent opioids such as fentanyl, suggesting that some users may cycle between kratom and stronger substances, raising overdose danger due to reduced opioid tolerance. Additionally, heavy‑metal contamination has been detected in certain kratom batches, though the source—soil, processing, or storage—remains unclear. Given these complexities, the consensus among scholars like Austin Zamarripa (Johns Hopkins) is that natural kratom should remain accessible, while concentrated 7‑OH products merit stricter regulation. “These products may offer meaningful benefits to some individuals, and those benefits could be lost if access is restricted too broadly,” Zamarripa said, urging a differentiated policy approach. As the debate unfolds, patients like Steven worry that a sweeping ban would ignore the nuanced safety profile of the plant. “There’s corn on the cob, there’s high‑fructose corn syrup, there’s whiskey— all derived from corn but fundamentally different,” he remarked, highlighting the need for targeted, evidence‑based regulation rather than a one‑size‑fits‑all prohibition.

Scientists at London's Institute of Cancer Research and the RCSI University of Medicine and Health Sciences in Dublin have announced a new AI-driven approach to identify how patients with advanced bowel cancer will respond to bevacizumab, a drug recently introduced by the NHS. The method uses PhenMap, an AI tool that integrates complex data on the genetic makeup of tumors, allowing researchers to track patterns of how different patients react to the drug. This development aims to spare potentially thousands of patients from being given drugs that would be ineffective in fighting their cancers. In the UK alone, nearly 10,000 cases of advanced bowel cancer are identified every year, with young adults seeing a particular rise in diagnoses. Bowel cancer has the second-highest mortality rate of any cancer, behind only lung cancer. While survival rates can be as high as 98% when caught early, the five-year survival rate for advanced bowel cancer can be as low as 10%. The study tracked 117 European bowel cancer patients who had been treated with chemotherapy and bevacizumab. Researchers identified a group of patients who all had the same gene mutation and were at a high risk of having negative reactions. The scientists behind the tests now hope to expand the number of patient samples and see if the results can be used in treatments for other types of cancer. Anguraj Sadanandam, a professor in stratification and precision medicine at the ICR, said: “Once bowel cancer spreads to other parts of the body, there are very few treatment options available for patients. It is therefore positive that patients can now access the targeted drug bevacizumab on the NHS. However, we know that the majority of patients won’t benefit from the drug, meaning thousands of people in England could be facing unpleasant side effects unnecessarily.” Sadanandam added that while the findings were encouraging, the tool would need to be tested on a larger cohort to be validated. “In future, I hope this approach will lead to a test that can be used by clinicians, to ensure patients receive personalised care that has the highest chance of working against their cancer.”

The economic consequences of an Iran war could have devastating effects on global poverty, with 32 million people at risk of being pushed into poverty worldwide. The United Nations Development Programme (UNDP) warns that developing countries will bear the brunt of this impact. In a report released amid concerns over a fragile ceasefire, the UNDP highlights a 'triple shock' affecting energy, food, and economic growth. This conflict is reversing international development gains, with uneven regional impacts expected. Alexander De Croo, UNDP administrator and former Belgian prime minister, emphasizes that even if the war ends, its impact will persist, especially in poorer countries where people may be pushed back into poverty. He notes that those who had previously escaped poverty are now at risk of falling back into it. The report outlines three scenarios for the war's impact. In the worst-case scenario, involving six weeks of major disruption to oil and gas production and eight months of higher costs, 32.5 million people globally could fall into poverty. The UNDP uses the upper-middle-income poverty line, an international standard defined as income below $8.30 per person per day, calculated by the World Bank. To mitigate these effects, the UNDP suggests targeted and temporary cash transfers to protect vulnerable households in developing nations, estimating a cost of about $6 billion to neutralize the shocks for those falling below the poverty line. The agency also recommends interventions like temporary subsidies or vouchers for essential services. The news comes as Western governments face criticism for cutting aid spending amid economic pressures and increased defense spending. The UNDP and other international agencies stress the importance of maintaining or increasing development aid to support countries hardest hit by the economic fallout.

The Pivot from Vision Pro to Everyday WearablesApple is reportedly preparing to enter the smart glasses market with a product launch targeted for 2027, signaling a significant strategic shift away from its ambitious mixed reality ambitions.Four Distinct Design PrototypesRectangular Frames: Ranging from large to slim, potentially mimicking the style of CEO Tim Cook.Oval/Circular Frames: Available in both larger and smaller sizes.Color Options: Black, ocean blue, and light brown.A Strategic Retreat from High-End ARThis move represents a retreat from the complex Vision Pro ecosystem, which faced delays and lukewarm reception. Instead, Apple is betting on a simpler form factor similar to Meta’s Ray-Ban glasses.The 2027 Roadmap: Simplicity Over ImmersionThe upcoming device will lack displays, focusing instead on camera lenses for photos, videos, calls, and music. It will also integrate with the long-promised Siri upgrade, aiming to capture the mainstream market rather than the niche enthusiast base.

“The world is grown so bad that wrens make prey where eagles dare not perch,” wrote Shakespeare in *Richard III*. The line now echoes a hopeful development: the iconic golden eagle could once again soar over England after more than a century and a half of absence. The golden eagle, a bird with a wingspan of roughly 2 metres, was a common sight in Shakespeare’s England, yet it has been effectively extinct in the country since the death of the last native individual in 2015. Centuries of persecution by gamekeepers and farmers, who feared predation on lambs and game birds, drove the species to the brink. A feasibility study commissioned by Forestry England and released on Sunday pinpoints eight potential “recovery zones”—predominantly in northern England—where the habitat could sustain a viable eagle population. The report cautions that establishing breeding pairs may take **more than a decade**. In response, Environment Secretary Emma Reynolds announced an additional £1 million in species‑recovery funding. The money will underwrite a programme that could see juvenile eagles, aged six to eight weeks, released into the wild as early as next year. Reynolds said, “This government is committed to protecting and restoring our most threatened native wildlife – and that includes bringing back iconic species like the golden eagle. Backed by £1 million of government funding, we will work alongside partners and communities to make the golden eagle a feature of English landscapes once again.” Across the border, golden eagle numbers in southern Scotland have surged to record levels thanks to a major restoration project. Satellite tracking shows that some translocated Scottish birds are already venturing into northern England, offering a natural source of future colonisers. The new funding will support these cross‑border movements and enable targeted reintroductions. While experts anticipate that golden eagles could be regularly observed across northern England within 10 years, establishing a self‑sustaining breeding population will require a longer horizon. Mike Seddon, chief executive of Forestry England, explained, “The detailed findings of our feasibility study will guide us, with our partners at Restoring Upland Nature, to take the next steps toward recovering golden eagles in northern England. This DEFRA funding means we can build on the good work we have begun, engaging local communities, landowners and conservation organisations.” The £1 million allocation forms part of a broader £60 million species‑recovery fund announced by DEFRA. It aligns with the UK’s legally binding commitment to halt the decline in species abundance by 2030 and to reduce extinction risk by 2042 relative to 2022 levels.

Malina Lee, a 31‑year‑old wedding baker from San Antonio, joined TikTok in 2020 to pass the lockdown‑induced boredom and promote her business. Four years later, an anonymous commenter called “PickleFart” noticed an asymmetrical neck in one of her videos and suggested she check for a goiter.The tip proved accurate: doctors confirmed thyroid cancer. Lee received prompt treatment and, within a year, was declared cancer‑free. She told the outlet that her oncologist was amazed at how early the disease was caught, crediting the TikTok comment as the catalyst.Lee’s experience is part of a growing trend where TikTok’s hyper‑targeted algorithm surfaces health‑related content that resonates with users’ unnoticed symptoms. In several cases, community members have flagged potential conditions that clinicians initially missed.The “PickleFart” persona belongs to Billie Jean Tuomi, who calls herself the “thyroid avenger.” A thyroid‑cancer survivor herself (diagnosed in 2012), Tuomi now scans videos for neck asymmetry and gently advises creators to seek a thyroid panel—a blood test measuring hormone levels and antibodies. The American Thyroid Association recommends adults start routine thyroid testing at age 35, or annually for high‑risk individuals.Tuomi estimates she has flagged dozens of videos, with at least four confirmed serious thyroid issues, including Lee’s. She stresses she does not claim to diagnose, merely urges viewers to consult a physician. After a viral comment, she received a flood of private messages with neck photos, prompting her to change her username.Lee, inspired by Tuomi’s intervention, has begun commenting on other users’ videos, helping one individual discover an enlarged thyroid that required removal. She describes the process as a “domino effect” of community‑driven health awareness.Medical professionals acknowledge the double‑edged nature of this phenomenon. Craig Mittleman, director of emergency services at Lawrence + Memorial Hospital, notes a rise in patients arriving with self‑diagnoses sourced from social media. While this can empower patients to ask informed questions, it also burdens clinicians with debunking misinformation.Gender disparities amplify the issue: research shows women are more likely to seek health information online, often after feeling dismissed by traditional providers. TikTok user Tori Mosser, a 23‑year‑old filmmaker, credits a direct message suggesting chronic appendicitis for prompting surgery that resolved her chronic vomiting episodes.Both Lee and Mosser emphasize the therapeutic value of finding a supportive community on TikTok, especially for invisible or chronic illnesses that are frequently minimized in clinical settings.

The world's finance ministers and central bank governors are gathering in Washington for the half-yearly meetings of the International Monetary Fund and the World Bank, with the global economy in a perilous spot. The US-Israeli war on Iran, coming soon after the Covid pandemic and Russia's invasion of Ukraine, has triggered significant economic turbulence.Even if a durable peace deal in the Middle East can be reached, there will still be permanent economic scars. The conflict has caused damage to infrastructure, heaping further pressure on already struggling households. This is the biggest energy shock of the modern age, with oil and gas prices surging, inflation rising, and borrowing costs increasing.The IMF has said it will cut its growth forecasts for 2026 when it publishes its flagship world economic outlook. In every scenario, growth is slower and inflation higher. Households worldwide will feel the pain, with the world's poorest bearing the brunt.The fund's managing director, Kristalina Georgieva, has urged officials to work together, warning that "go-it-alone actions" may have appeal but would ultimately make matters worse. The IMF cautions that any energy support should be targeted and temporary to limit the costs of blanket support and avoid stoking inequality.For central banks, the fund urges them to remain vigilant, with financial markets expecting interest rates to be kept on hold or raised to prevent high inflation from becoming entrenched. The economic problems are interlinked with political instability, making it a challenging situation for governments worldwide.