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The Revolutionary GeneticistCraig Venter, the pioneering geneticist who revolutionized genome sequencing and challenged traditional scientific approaches, has died at age 79. His announcement at the 2001 BioVision conference that humans possess only about 30,000 genes—far fewer than the previously estimated 100,000—shattered scientific assumptions about genetic determinism. "We simply do not have enough genes for this idea of biological determinism to be right," Venter declared, emphasizing that human diversity is shaped primarily by environmental influences rather than hard-wired genetic code.The Breakthrough in Genome SequencingVenter's most significant contribution was developing the revolutionary whole genome shotgun sequencing technique, which allowed for faster, more efficient genome mapping. In 1995, his team achieved the remarkable feat of sequencing the first genome of a living organism, the bacterium Haemophilus influenzae. This breakthrough led to the founding of Celera Genomics in 1998, which aimed to sequence the entire human genome using Venter's innovative methods.The competition between Venter's privately funded Celera and the publicly funded Human Genome Project, spearheaded by the US government and UK's Wellcome Trust, created what scientists described as "testosterone-driven" rivalry. Despite tensions, this competition dramatically accelerated progress in genomics research, culminating in the announcement of the first draft human genome sequence at a White House ceremony in June 2000.The Scientific MaverickVenter was as famous for his bold personality as for his scientific achievements. A brilliant entrepreneur and unapologetic self-promoter, he enjoyed showcasing his success, private plane, yacht, and luxury watches. This flamboyant approach made him both admired and controversial. James Watson, co-discoverer of DNA's double-helix structure, compared Venter to Hitler for attempting to patent human genes, while others nicknamed him "Darth" Venter after the Star Wars villain.His tendency to break scientific protocols became evident when he revealed that much of the DNA used in Celera's human genome sequencing came from his own cells—a decision that annoyed scientists who felt he had subverted standard processes. "I've been accused of that so many times, I've got over it," Venter responded, noting that the analysis revealed he had an abnormal fat metabolism and elevated risk of Alzheimer's disease.A Life Shaped by Science and WarBorn in Salt Lake City, Utah, Venter had an unconventional path to scientific greatness. Growing up in California, he had a poor academic record and initially pursued "pursuits that involved drink, girls and bodysurfing" rather than education. His life took a dramatic turn during the Vietnam War, where he served as a senior corpsman in a naval hospital's intensive care unit in Da Nang."I witnessed several hundred soldiers die, more often than not while I was massaging their hearts – at times with my bare hand – or attempting to breathe life into them," Venter recalled. "Vietnam would teach me more than I ever wanted to know about the fragility of life." This experience sparked his interest in life sciences, leading him to study at the University of California, San Diego, where he earned a PhD in physiology and pharmacology in 1975.The Legacy of a Scientific PioneerAfter being dismissed as head of Celera in 2002, Venter used his substantial payoff to endow the J. Craig Venter Institute with $100 million. There, he pursued ambitious projects including designing energy-producing microbes and synthesizing bacterial genomes. He later founded Human Longevity and Diploid Genomics, companies that aim to combine artificial intelligence with advances in aging research and gene sequencing to extend human lifespans and improve disease diagnosis.While some of Venter's claims about the primacy of environmental influences over genetics have been questioned, his impact on genomics research remains undeniable. His revolutionary sequencing techniques transformed the field, and his competitive approach accelerated what would have otherwise been a much slower process of mapping the human genome. As the scientific community remembers Craig Venter, it acknowledges a complex figure who was simultaneously a brilliant innovator, a controversial competitor, and a transformative force in our understanding of life's fundamental building blocks.

Why Fans Are the Smart Summer Cooling ChoiceThe Guardian’s award‑winning tech journalist measured 16 fans and several evaporative coolers to see how they perform against a typical portable air‑conditioner that draws 1,000W (about 26p per hour). Fans in the test consumed between 8W and 60W, delivering a far lower electricity bill and carbon footprint while still moving enough air to make a noticeable temperature drop.Power Consumption Numbers Show Fans Beat Air‑ConditionersAirCraft Lume – 18W on top setting; could run 56 hours for the cost of one hour of air‑con.Dreo TurboCool misting fan 765S – 22W, best overall cooling performance.Devola desk fan – 12W, cheapest at £64.99.Shark FlexBreeze Pro Mist – 30W, premium misting option at £249.99.Swan Nordic evaporative cooler – 15W, lowest‑energy water‑based cooler at £69.Cooling Comfort Meets Carbon Savings for UK HouseholdsRunning a fan instead of an air‑conditioner can cut summer electricity use by up to 95 %, translating into lower bills and reduced greenhouse‑gas emissions. For a typical UK home, swapping a 1,000W air‑con for an 18W fan saves roughly £23 per month and avoids about 0.12 tCO₂ of emissions.What’s Next for Home Cooling in a Warming Climate?As heatwaves become more frequent, manufacturers are likely to focus on quieter, smarter fans with integrated sensors that adjust speed automatically. Expect more hybrid designs that combine low‑energy misting with airflow optimisation, giving consumers a wider menu of carbon‑friendly cooling solutions.

The British Solving Championship: An Opportunity for Chess Enthusiasts This week’s puzzle is a chance to enter an annual national competition in which Guardian readers ­traditionally perform well and in ­considerable numbers. White in the diagram, ­playing as usual up the board, is to play and checkmate in two moves, against any black defence. The Event Details The puzzle is the first stage of the annual Winton British Solving Championship, organised by the British Chess Problem Society and sponsored by the investment ­managers ­Winton. This competition is only open to ­British ­residents and entry is free. To take part, simply send White’s first move by post to Nigel Dennis, Boundary House, 230 Greys Road, Henley-on-Thames, Oxon RG9 1QY, or by email to [email protected]. Entry Requirements and Deadline All entries must be postmarked or emailed no later than 31 July 2026. Entrants must provide their name and home address. Juniors under 18 on 31 August 2025 must also give their date of birth. The Competition Structure The best 15-20 players from the postal round, plus the best juniors, will be invited to the final at Harrow school on Saturday 13 February 2027, where the prize money is expected to be at least £1,600. The winner of the final will have the right to represent Great Britain at the 2027 world ­solving championships, an event where GB are often medal contenders. A Note on Chess and Professionals Back in the 1950s most top English players were amateurs, often civil servants or teachers, who competed in tournaments during their vacations. After the 1970s Fischer boom and English successes brought an influx of sponsors, chess professionals could earn a decent living, but the tide turned again during the 1990s. The breakup of the Soviet Union brought harder international competition, while Nigel Short’s world title defeat and the move to screen rather than print marketing drove sponsors away. A New Grandmaster: Harry Grieve Harry Grieve became England’s latest grandmaster on Tuesday when the 25-year-old, who was British champion in 2022 and helped CSC/Kingston finish second in this season’s UK 4NCL League, won first prize in Budapest with a 7/9 total.

Phyllida Barlow's Disruptor Exhibition at Wolterton Hall Phyllida Barlow's exhibition 'Disruptor' at Wolterton Hall in Norfolk is a thought-provoking showcase of her unconventional sculptures and installations. The exhibition challenges the traditional grandeur of the stately home, transforming it into a space for contemporary art. The Exhibition's Concept and Curation The exhibition is curated by Simon Oldfield, Wolterton's artistic director, who has reinvented the space to make room for new ideas. Barlow's works, which seem to take on a life of their own, are a perfect fit for this vision. Her exhibition begins at the entrance with the installation 'Untitled: Stacked Chairs', a cacophony of red plywood chairs that feels like a statement about throwing things out and starting again. Barlow's Sculptures and Installations Throughout the exhibition, Barlow's sculptures and installations are displayed in various rooms of the stately home. Her works are made from unconventional materials such as latex, cement, hessian scrim, plaster, and rope. One of her early works, 'Loaf', is a tar-black glass and paper coated with latex, resembling a loaf of bread. Her recent wall sculptures, cobbled together with cement, hessian scrim, plaster, and other materials, look like big gobs of bubblegum stuck rudely to the wall. The Impact of Barlow's Work Barlow's work is about what materials communicate. The house says, 'I am here, I'm important – Barlow says, everything is precarious, nothing goes as planned.' Her works are a commentary on the impermanence of things and the challenge to traditional notions of art and architecture. The Future of Wolterton Hall The exhibition is part of Wolterton Hall's ongoing transformation into a space for contemporary art. The hall's owners, the Ellis family, have been working to reinvent the space, and Barlow's exhibition is a key part of this vision. The exhibition runs until 31 October and is a must-see for anyone interested in contemporary art and the transformation of traditional spaces.

The Struggle of Working-Class Artists The Tara Clerkin Trio, consisting of Tara Clerkin, Sunny Joe Paradisos, and Pat Benjamin, has been making waves in the underground music scene with their eclectic sound, which blends elements of minimalist jazz, avant-pop, and trip-hop. Despite their growing success, the band members, who are all working-class artists, share their struggles in the UK's music industry. The Band's Unique Sound Their music is characterized by happy accidents and incidental noises, which they incorporate into their tracks. The band's sound is shaped by their use of loop pedals, sampling, and a variety of instruments, some of which they don't play properly. This unique approach has charmed fans across the music spectrum, including jazz enthusiasts. The Challenges of Making Music The band members discuss the difficulties of making a living as working-class artists in the UK. They highlight the struggle to balance touring, working, and making music, often having to juggle multiple jobs to make ends meet. The situation is further complicated by the fact that touring three times a year doesn't pay enough to support their living expenses. The New Album: Somewhere Good Their second album, 'Somewhere Good', is their most pop-oriented record yet, featuring more structured songwriting and storytelling. The album was written and recorded in precarious circumstances, with the band members working and touring simultaneously. Despite the challenges, the album captures a sense of optimism and positivity, with songs that address themes of loss, grief, and gentrification. The Future of Independent Music The Tara Clerkin Trio's experience reflects the broader challenges faced by working-class artists in the UK. They chose to release their album on the in-house label of east London record shop World of Echo, rather than signing with a bigger label, to maintain creative control and avoid giving away their rights. As they continue to make music, they hope to inspire others to do the same, despite the difficulties.

The Legacy of the White Hotel The White Hotel, a Salford venue housed in a former MOT garage, has been a generator for underground culture in the north-west for over a decade. Its programme has spanned classical music ensemble the Manchester Collective, a celebration of Bertolt Brecht, and Andy Weatherall's last ever DJ set. The Event Details The White Hotel will shut up shop in January due to its location in a flood-risk zone. The venue's artistic director, Austin Collings, and caretaker, Ben Ward, decided it was better to close on their own terms rather than risk becoming a museum. The Data Analysis The White Hotel has hosted sold-out gigs from notable acts such as Damo Suzuki and William Basinski. The venue has a 300-capacity space that was overwhelmed by a 2015 gig with Detroit legend DJ Stingray. The Impact Analysis The White Hotel's closure will erase a rare club built from the ground up, fueled by a spirit of experimentation and collaboration, disregarding the profit motive. However, its spirit will mutate, and the team behind the venue are celebrating its legacy with a new three-day festival, the Black Lights, in venues around Blackpool. The Prediction The team behind the White Hotel are launching a film production company, with Collings' directorial debut, a short titled Wild Bodies, set to go on the festival circuit with a soundtrack by the Coral. The future of the Black Lights festival is dependent on ticket sales, but it aims to continue the White Hotel's legacy of experimental and underground culture.

The LeadSimon Rogers, Google's data editor, presents a fascinating exploration of human curiosity through the lens of search queries in his book 'What We Ask Google.' The compilation of anonymized search data from 2004 to the present offers a unique mirror into our collective concerns, from parenting questions to existential queries, though the review suggests the book presents a somewhat rose-tinted view of technology's role in our lives.The Book OverviewRogers, a former Guardian journalist who joined Google in 2015, organizes the search data into themed chapters that blend statistics with personal anecdotes. The book traces search trends back to 2004, when internet access was limited to less than half of UK households. Rogers posits that our search queries reveal something 'real and deep and meaningful about who we are as humans,' arguing that even brief searches indicate genuine care and concern.The Data InsightsThe book reveals intriguing patterns in human search behavior. Parenting-related queries like 'Why do babies get hiccups?' and 'How to tell kids about divorce?' appear frequently. Notably, in early 2023, searches for 'take care of parents' surpassed 'take care of kids,' reflecting the demographic pressures on the sandwich generation. The data also highlights geographical peculiarities, such as Austrians, Nigerians, and Canadians most frequently asking about back pain at night, and Americans in Kansas struggling to spell 'chaos' while their Missouri neighbors are stumped by 'unconscious.'The Critical PerspectiveThe review identifies significant limitations in Rogers' approach. As a 'company man' who joined Google from Twitter, the book presents an overly optimistic view of the internet and Google's role in society. There's minimal acknowledgment of the AI revolution's impact on search behavior and its consequences for content creators. The book also avoids addressing darker aspects of human nature reflected in search histories, political influences like Donald Trump, and how big tech may actually amplify parenting anxieties rather than alleviate them.The Cultural ImpactDespite its limitations, the book offers a diverting window into collective curiosity. It demonstrates how our search habits reflect societal concerns, from the practical ('How to fold a burrito') to the profound ('How often can you donate plasma?'). The reviewer notes that Rogers interprets this latter query as evidence of altruism rather than recognizing it as a symptom of US healthcare inequities. The book ultimately serves as an interesting, if selective, cultural artifact that captures our digital age's peculiarities and preoccupations, even if it doesn't fully confront the complexities of our relationship with technology.

The AI-Driven Economic Surge Taiwan's economy is booming, with a growth rate that would be the envy of any country. The AI boom sweeping Taiwan has made it an exciting time to work in tech, particularly in the semiconductor industry, which produces about 90 percent of the most advanced chips used to power leading AI models. The Semiconductor Industry's Dominance Taiwan is a semiconductor powerhouse, with Taiwan Semiconductor Manufacturing Company (TSMC) accounting for more than 40 percent of the value of the island's stock market. Semiconductors alone account for more than 20 percent of Taiwan's GDP. The Uneven Distribution of Benefits Despite the impressive economic growth, concerns are rising about the uneven distribution of benefits. Many industries unrelated to tech do not seem to be feeling the benefits, with some individuals experiencing stagnant pay and rising living costs. The semiconductor industry employs only about 300,000 people in a workforce of 11 million. The Risk of a 'Dual Society' Economists warn that Taiwan's economic model has left it at risk of becoming a 'dual society' where tech sweeps up talent, funding, and resources at the expense of other industries. The wealth divide has grown over the decades, with Taiwan's Gini coefficient increasing from 0.308 in 1980 to 0.341 in 2024. The Future Outlook As Taiwan's economy continues to grow, the government faces challenges in addressing the uneven distribution of benefits and ensuring that the growth is inclusive and sustainable. The country's reliance on a single industry for growth marks a shift from the Asian Tiger era, when Taiwan's economy was driven by hundreds of thousands of small and medium-sized enterprises.

The Lead: Trump's Decision Point on IranUnited States President Donald Trump has announced he is meeting in the Situation Room to make a "final determination" on a possible deal with Iran that could extend the ceasefire and reopen the Strait of Hormuz. The announcement comes amid deep mistrust between the two sides, with Iran's top negotiator emphasizing that Tehran will judge any agreement by actions rather than promises.The Proposed Deal: Conditions and ConcessionsIn his latest post on the Truth Social platform, Trump outlined numerous conditions for Tehran to accept, including: never developing a nuclear weapon, ensuring the Strait of Hormuz remains open in both directions without tolls, removing any remaining mines in the Strait, and allowing the US to unearth and destroy Iran's enriched uranium. Trump also noted that ships caught in the Strait due to the US naval blockade "may start the process of 'heading home!'" and that "no money will be exchanged until further notice."The Diplomatic Context: Uncertainty and Mixed SignalsUncertainty about the details of a memorandum of understanding (MOU) has grown over the past week amid ongoing distrust between the US and Iran as they seek to end the three-month-long war. While White House sources indicated that the US and Iran had reached a tentative agreement to extend the ceasefire by 60 days, Trump has yet to sign off. Iranian state news outlet Fars reported that the agreement was in its final stages of ratification, but stressed there were no provisions about destroying Iran's nuclear materials in the MOU.The Iranian Position: Actions Over PromisesIran's top negotiator, Mohammad Bagher Ghalibaf, emphasized Tehran's position that "no action will be taken before the other side acts," stating that "guarantees and words, only actions are the criterion." He added that "the winner of any agreement is the one who is better prepared for war the day after," highlighting the deep-seated mistrust that continues to plague negotiations between the two nations.The Regional Implications: Strait of Hormuz and BeyondThe potential reopening of the Strait of Hormuz represents a significant development in the region, with arrangements potentially including monitoring and inspection of ships. This critical waterway is vital for global oil supplies, and its closure has had substantial economic impacts. Any agreement that successfully reopens the Strait would mark a major diplomatic achievement, though the long-term sustainability of such an agreement remains questionable given the history of mistrust between Washington and Tehran.The Path Forward: Final Decision and Implementation ChallengesAs Trump prepares to make his "final determination," the coming days will be crucial in determining whether this potential deal can move from tentative agreement to formal implementation. Al Jazeera's Patty Culhane noted that in the past, the Trump administration has indicated that a deal has been reached, only to later find out it has not. If this deal were to materialize, it would represent "the entire wishlist of what the US was demanding and none of the concessions that Iranian were asking for," suggesting significant challenges in achieving a balanced agreement that satisfies both sides.