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As the clock ticked down to President Donald Trump’s 8 p.m. deadline to force the reopening of the Strait of Hormuz, the six‑week Middle East conflict teetered on the brink of a far more devastating escalation.Trump’s rhetoric had escalated dramatically, with his Truth Social posts warning that the United States would unleash strikes capable of “decimating every bridge and power plant in Iran” and that “a whole civilisation will die tonight.” Legal experts labeled the language as bordering on a genocidal threat.Amid the rising tension, a series of rapid developments unfolded on Tuesday:12:06 GMT – Trump announced a plan to target Iran’s civilian infrastructure, promising total destruction of bridges and power facilities.15:21 GMT – Iranian media confirmed that US strikes hit Kharg Island, the nation’s primary oil‑export hub, but reported no significant damage.15:40 GMT – In the UN Security Council, China and Russia vetoed a Bahraini resolution aimed at protecting commercial shipping in the Strait of Hormuz, arguing the draft was biased against Tehran.16:54 GMT – Qatar’s defence ministry reported a successful missile interception, while the United Arab Emirates warned of a barrage of missile and drone attacks.18:23 GMT – Iran’s envoy to Pakistan, Reza Amiri Moghadam, signalled a “step forward” after a “critical, sensitive stage,” praising Pakistan’s “positive and productive” peace efforts.19:17 GMT – Pakistani Prime Minister Shehbaz Sharif appealed to Trump to extend the deadline by two weeks, urging Tehran to keep the Strait open as a goodwill gesture.20:25 GMT – Iran warned it would target US and Gulf‑allied energy infrastructure, threatening to block regional oil and gas supplies for years.20:41 GMT – Joint US‑Israeli airstrikes struck the Amirkabir Petrochemical Plant in Mahshahr, Iran, prompting local assessments of damage.With less than ninety minutes remaining, diplomatic channels intensified. Pakistani officials, including the military chief Asim Munir, facilitated talks that culminated in a two‑week, double‑sided cease‑fire announced by Trump at 22:45 GMT. The United States claimed to have received a “workable” 10‑point proposal from Tehran.Iranian Foreign Minister Abbas Araghchi quickly confirmed the truce, stating Iran would honor it provided attacks on its territory ceased. Sharif then invited both Iranian and US delegations to Islamabad for further negotiations aimed at a permanent settlement.Early Wednesday, Trump’s tone shifted dramatically. In a Truth Social post he hailed the cease‑fire as a potential “Golden Age for the Middle East,” celebrating the pause in hostilities and the reopening of the Strait of Hormuz.The episode underscores how last‑minute diplomacy, spearheaded by Pakistan, averted a catastrophic escalation and opened a narrow window for a broader peace process in a region long mired in conflict.

During Donald Trump’s January 2025 inauguration, Giorgia Meloni was the only European leader invited, underscoring a brief period of close personal and diplomatic ties between Italy’s right‑wing government and the new U.S. administration. A month earlier she had been photographed sharing a private conversation with Trump at the Élysée Palace while President Emmanuel Macron celebrated the reopening of Notre‑Dame. From the outset of Trump’s second term, the Italian premier was hailed by the U.S. president as a “real live wire” and the European ally who could help “straighten out the world.” Meloni embraced the role, describing Trump as a “brilliant man” and promising to "make the West great again" together. That camaraderie has now eroded. In the wake of the US‑Israeli military action against Iran, Meloni told reporters during a Gulf‑region visit that "when we don’t agree, we must say it", explicitly rejecting the war. Her stance was reinforced a week earlier when Italy denied U.S. bombers permission to refuel at a southern base. Political analysts note that Meloni’s shift marks a decisive break from Trump’s agenda. Roberto D’Alimonte, a political‑science professor at Luiss University, warned that her earlier attempt to act as a bridge between Trump and European allies has become a “liability” she now seeks to repair. Public opinion reflects the change. Recent polls show a solid majority of Italians oppose the Iran war, and support for Trump in Italy has plunged from 35 % to just 19 %. The backlash also manifested in a recent referendum on judicial reform, where 61 % of voters aged 18‑34 rejected Meloni’s proposal—a defeat analysts link more to dissatisfaction with her foreign‑policy alignment than to the reform itself. Beyond politics, the conflict threatens Italy’s economy. As the EU’s second‑largest natural‑gas consumer—accounting for roughly 40 % of its energy mix—Italy is feeling the impact of soaring energy prices caused by the near‑total shutdown of traffic through the Strait of Hormuz. The Bank of Italy now projects only a 0.5 % growth rate for 2026‑27, down from earlier forecasts, while the national statistics office reported that Italy’s fiscal deficit has breached the EU’s 3 % ceiling, limiting fiscal flexibility ahead of next year’s elections. Despite these pressures, Meloni has not completely abandoned the United States. In March she declined Trump’s request to dispatch Italian warships to the Strait of Hormuz, aligning with other European nations, yet she stopped short of condemning the US‑led operation outright. Experts argue that Meloni’s approach is deliberately cautious. “She is pragmatic and politically skilled,” D’Alimonte said. “She will continue to balance criticism of Trump’s aggressive foreign policy with the need to preserve strategic ties, moving step‑by‑step toward a stronger European alignment without burning bridges.”

Iran and the United States have agreed to a two-week ceasefire, with talks set to begin in Islamabad, Pakistan, on Friday. The ceasefire comes after US President Donald Trump said he was calling off a threat to bomb Iran's power plants and bridges and suspending attacks on the country for two weeks.The truce is contingent on Iran agreeing to the 'complete, immediate and safe opening' of the Strait of Hormuz, a critical waterway through which a fifth of global oil supply passes. Iran's partial blockade of the strait has disrupted global trade, driving up oil prices and causing fuel shortages worldwide.Iran's National Security Council has confirmed that Tehran has agreed to talks based on a 10-point proposal from Iran. The proposal calls for Iranian dominance and oversight of the Strait of Hormuz, the withdrawal of all 'US combat forces' from bases in the Middle East, and a halt to military operations against allied armed groups across the region.The proposal also demands 'full compensation' for war damages, the lifting of all sanctions by the US, the United Nations Security Council, and the International Atomic Energy Agency, and the release of frozen Iranian assets abroad.Pakistan's Prime Minister Shehbaz Sharif said the warring sides had agreed to an 'immediate ceasefire everywhere', including Lebanon and elsewhere. He extended an invitation to US and Iranian delegations to Islamabad on Friday to further negotiate a conclusive agreement.

Researchers have made a significant breakthrough in understanding why weight-loss medications, such as GLP1 receptor agonists, work better for some individuals than others. A recent study published in Nature has identified genetic variations in two genes involved in gut hormone pathways that regulate appetite and digestion. These genetic variations may help account for different weight-loss results or side-effects when taking glucagon-like peptide 1 (GLP1) medicines, which mimic natural gut hormones to regulate appetite, insulin release, and digestion. The study analyzed data from 27,885 patients on GLP1 drugs and found that specific genetic variants were associated with slightly more weight loss or side-effects like nausea and vomiting. The findings suggest that genetic differences may contribute to why people respond differently to weight-loss jabs. However, the overall impact of genetics appeared to be modest, with non-genetic factors such as sex, drug type, dose, and duration appearing to explain a substantially larger proportion of variability. The study's results reinforce that while there is substantial variability in response to GLP1 therapies, genetics is only one part of a much more complex picture. According to Marie Spreckley, an obesity expert at the University of Cambridge, the study provides plausible evidence that genetic variants could affect outcomes. However, she notes that the magnitude of these genetic effects is small in clinical terms, and that behavioral, clinical, and treatment-related factors remain the dominant drivers of outcomes. The study's authors suggest that their findings could support future efforts to use genetic information when making treatment choices for obesity. However, Spreckley cautions that the evidence is not yet sufficient to support using genetic information to guide treatment decisions in routine clinical practice.

The fragile ceasefire between Iran and Israel faced a serious crisis on Wednesday as both sides presented conflicting accounts of the agreement. The development raised concerns about the potential collapse of the truce.Israel escalated its military operations in Lebanon, launching its heaviest attack yet on over 100 targets, resulting in at least 254 fatalities. This move directly contradicts the claims of Iran and Pakistan, who brokered the 11th-hour truce and asserted that the ceasefire included Lebanon.In response, Iran halted the passage of oil tankers through the Strait of Hormuz, citing an alleged Israeli breach of the ceasefire. The Fars news agency reported that oil prices had dropped sharply below $100 a barrel following the truce announcement, leading to a global stock market surge.The White House disputed Iran's claims about the closure of the Strait of Hormuz, calling the reports 'false' and stating that US President Donald Trump expected it to reopen 'immediately, quickly and safely.' The US signaled its continued adherence to the ceasefire, even as it threatened to unravel.Iran and the US have different interpretations of the agreement. Trump conveyed a version suggesting a 15-point proposal from the US, which included no enrichment of uranium and the destruction of Iran's highly enriched uranium stockpile. In contrast, Iran's 10-point plan, which Trump initially referred to as a 'workable basis for negotiation,' included the right to enrich uranium and the full lifting of sanctions.The US and Iran are set to engage in talks in Islamabad, Pakistan, this weekend, with a US negotiating team led by Vice-President JD Vance. The talks aim to cement the ceasefire into a more durable peace agreement, but significant gaps remain to be bridged.The situation in the Gulf remains fragile, with the US and Israel claiming to have destroyed Iran's industrial base and significant military assets. Iran, on the other hand, portrays the truce as a victory, with senior politician Ali Akbar Velayati stating that 'America was forced to accept a ceasefire.'

The recent escalation between the US and Iran has brought the world to the edge of a potentially devastating conflict. US President Donald Trump's threat to attack Iran if it didn't reopen the Strait of Hormuz sparked a global outcry and raised concerns of a wider conflict.Trump's public threat to commit genocide sent shockwaves through the United States, with over 70 Democratic members of Congress calling for his removal from office. The Iranian government and people were also shocked, with thousands forming human chains around bridges and power stations that Trump might strike.Faced with the prospect of a catastrophic war, Trump chose to back away from his threat and instead claimed that he had granted Pakistan's request for a two-week ceasefire. However, the Iranian foreign minister tweeted that Trump had agreed to accept Tehran's 10-point plan as a general framework for negotiations.The chasm between the two sides remains vast, with major differences on issues such as sanctions relief and Iran's ballistic missile stocks. A mega-deal remains the only path to averting a return to full-scale war, but it will require compromises and adept diplomacy from both sides.If there's no firm deal, the conflict will almost certainly reignite. The US and Iran have agreed to a temporary ceasefire, but Iran still controls the Strait of Hormuz and retains the military muscle to spark a worldwide recession.

At a Pentagon briefing, Defense Secretary Pete Hegseth asserted that Iran’s request for a temporary cease‑fire was a direct result of the United States’ intensive air campaign, which he described as having reduced Iran’s weapons factories to rubble and rendered its military ineffective for years to come. Hegseth, standing beside Joint Chiefs Chairman Dan Caine, said the final wave of strikes before President Donald Trump announced a two‑week pause had completely destroyed Iran’s defense industrial base. While Iran can still fire from existing stockpiles, it can no longer replace lost munitions, according to the secretary. President Trump posted on Truth Social that he had agreed to suspend hostilities less than two hours before his self‑imposed deadline to “decimate the entirety of Iranian civilization.” The decision followed a last‑minute diplomatic push by Pakistan’s Prime Minister Shehbaz Sharif and army chief Gen Asim Munir. Iran’s foreign minister Abbas Araghchi confirmed Tehran’s acceptance of the pause, and the country’s supreme national security council announced it would send a delegation to Islamabad for formal talks starting Friday. Both sides claimed victory: Iran’s security council said it had achieved “nearly all the objectives of the war,” while the United States highlighted the crippling of Iran’s military capabilities. The cease‑fire ends a conflict that began on 28 February, when the U.S. and Israel launched nearly 900 strikes in a 12‑hour window against Iranian military infrastructure, missile sites, and leadership. The opening day saw the death of Supreme Leader Ali Khamenei, with his son Mojtaba Khamenei named successor on 8 March. Hegseth warned that the United States had prepared additional strikes on Iran’s power plants, bridges and energy infrastructure—targets he said Iran could not defend or rebuild for decades—if Tehran had refused the pause. According to Joint Chiefs Chairman Caine, 13 U.S. service members were killed during the fighting. Total casualties across the region exceed 5,000, including over 1,600 Iranian civilians and at least 1,497 deaths in Lebanon. By the sixth day of the war, U.S. military spending had reached roughly $12.7 billion, with a pending supplemental request of $200 billion before Congress. The future of a lasting settlement remains uncertain. Trump later announced that Iran would hand over its enriched uranium and cease all enrichment activities, while Iran’s supreme national security council released a 10‑point counter‑proposal that explicitly demands the right to continue enrichment. Disagreements also persist over the cease‑fire’s scope. Israel maintains that the pause does not apply to Lebanon, where ground and air campaigns are at their most intense since Israel’s northern invasion. Both Pakistan and Iran, however, have stated that Lebanon is included in the cease‑fire. Subsequent reports indicated Iranian missile and drone attacks on Kuwait and the United Arab Emirates, as well as strikes on Iran’s oil infrastructure on Lavan Island. Iran’s supreme national security council warned that its forces remain on high alert, stating, “our hands are on the trigger, and any mistake by the enemy will be met with full force.” When asked about the long‑term U.S. presence in the region, Hegseth replied unequivocally: “We’re not going anywhere.”

The United Kingdom’s cyber‑defence agency has issued a stark warning: Russian‑affiliated hackers are targeting everyday internet routers to conduct espionage operations. By compromising these edge devices, attackers can steal user credentials, redirect traffic to fraudulent sites, and potentially infiltrate other connected gadgets such as smartphones and computers. According to the National Cyber Security Centre (NCSC), the campaign appears opportunistic, casting a wide net before filtering for high‑value intelligence targets. This mirrors a broader trend where threat actors focus on hardware that bridges users to the cloud, often overlooking the security of routers and network cameras. Professor Alan Woodward of the University of Surrey emphasized that routers are frequently forgotten, becoming weak points in home and small‑business networks. "If a router is compromised, attackers can reroute users to fake banking sites, establish persistence on the network, and probe connected devices for further vulnerabilities," he explained. The NCSC attributes the activity to the notorious group APT28, also known as Fancy Bear, which is almost certainly linked to Russian intelligence services. APT28 previously orchestrated high‑profile attacks, including the 2015 breach of the German parliament that exposed confidential emails and legislators' schedules. In a parallel move, the U.S. Federal Communications Commission has prohibited the sale of all consumer‑grade routers manufactured outside the United States, citing "unacceptable risks to national security." The FCC warned that foreign‑made routers have been exploited to facilitate espionage, disrupt networks, and steal intellectual property. While most routers are produced in China or Taiwan, exceptions like Elon Musk’s Texas‑made Starlink devices are unaffected. Privacy specialists caution that a blanket ban will not resolve existing vulnerabilities, especially for legacy routers that no longer receive security patches. Woodward urged small businesses and individuals to keep firmware up to date and monitor network activity for anomalies. The article also revisits the 2016 Bangladesh central bank heist, where hackers siphoned $80 million by exploiting cheap, second‑hand routers that were exposed to the internet. Investigators believe a North Korean state‑linked group was behind that attack, illustrating how compromised routers can serve as gateways to critical financial systems. Overall, the NCSC’s alert underscores a growing geopolitical cyber‑threat landscape, where state‑sponsored actors leverage everyday hardware to gather intelligence and disrupt adversaries.

Arthur Rosenfeld, 73, and Meryl Tankard, 70, open the performance by introducing themselves as “sprightly old geezers,” setting a tone of candid humor that runs through the evening. The production, ‘Kontakthof – Echoes of 78,’ is a fresh staging of Pina Bausch’s iconic 1978 work, now re‑imagined by Australian choreographer Meryl Tankard. Unlike the 2010 London run that split the piece between teenagers and senior amateurs, this rendition features the eight surviving members of the original cast—all now in their late sixties to early eighties—performing the very roles they created half a century ago. A ninth dancer was absent due to illness. Their live movements are mirrored on a large screen by the black‑and‑white film of the 1978 performance, creating a visual palimpsest where past and present dance together. The choreography, set to 1930s dance‑hall songs, remains a wry commentary on courtship, power dynamics and consent. Tankard’s direction emphasizes the passage of time, allowing audiences to witness the same steps executed by bodies that have aged, yet retain a striking vitality. Dancers such as Josephine Ann Endicott, now in her seventies, glide across the stage in silk dresses, their frames more fragile but their confidence undiminished. Moments of poignancy arise when the film shows cast members who have since passed away. Onstage, John Giffin reaches for his late partner’s face, only to grasp empty air—a visual metaphor for loss that resonated deeply with the audience. Personal revelations punctuate the performance: Beatrice Libonati, 71, describes herself as “paranoid and a misanthrope,” while Tankard admits, “I wish I’d had children; I miss my mother every day,” underscoring the undercurrent of longing that runs through the piece. Beyond its narrative, the production offers a meditation on continuity. Bausch’s signature walking patterns—slow circles and linear traverses—are repeated, suggesting that despite changing bodies, the human species continues to tread familiar social routes. The music, unchanged from the original, carries on until the final dancer pauses, symbolising the inevitable end of the dance of life. The show runs at Sadler’s Wells, London through 11 April, offering a rare glimpse into how art can bridge generations and celebrate the endurance of the human spirit.