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Coordinated strikes by United States and Israeli forces hit Tehran, Isfahan and several other Iranian cities on Tuesday, prompting widespread power outages and extensive damage to civilian sites. The Ministry of Energy confirmed that shrapnel from the raids ruptured a primary power‑transfer line, but the outage was restored within a few hours. Among the most critical targets was the Tofigh Darou pharmaceutical complex in the Karaj industrial zone. The facility, which supplies over 90% of Iran’s domestically produced medicines—including cancer and multiple‑sclerosis treatments—sustained heavy damage from multiple projectiles. In central Iran, Isfahan endured a barrage of heavy bunker‑buster bombs over a nearby mountainous area, likely aimed at military installations. The explosions triggered secondary blasts that illuminated the night sky and produced reverberating shockwaves across the city. North‑west of Tehran, in Zanjan, a building identified as the administrative department of the Hosseinieh Azam religious centre was struck, resulting in at least four fatalities and several injuries. Iranian authorities now claim that more than 2,000 people have been killed by US‑Israeli attacks since the conflict erupted on 28 February, with residential blocks, schools, hospitals and historic sites also affected. Additional targets this week included civilian nuclear facilities, major steel producers, petrochemical plants, and the Iran University of Science and Technology, where an imaging satellite was developed. A professor linked to Iran’s missile programme and his two children were assassinated at their home in northern Tehran. U.S. President Donald Trump reiterated threats to strike Iran’s oil and gas infrastructure, power plants and water‑desalination facilities. Despite the onslaught, the Islamic Revolutionary Guard Corps (IRGC) continues to project defiance. A spokesperson for the Khatam al‑Anbiya Central Headquarters declared that Tehran’s adversaries are “humiliated and on the path of destruction,” while senior commander Ali Fadavi warned that American warships are vulnerable and allegedly transmit false transponder signals. The IRGC also released footage of ballistic missiles aimed at Israel and surrounding nations, and claimed to have downed two U.S. MQ‑9 Reaper drones, promising retaliatory strikes against technology firms linked to the United States and Israel. Domestically, the judiciary announced the execution of two members of the foreign‑based Mojahedin‑e‑Khalq (MEK) group, labeling them terrorists. This follows a series of recent executions tied to the January protests and broader dissent. Authorities also issued new indictments against roughly 200 individuals accused of assisting the U.S. and Israel, including alleged “mercenaries” who disseminated strike footage abroad. Penalties for national‑security offenses now encompass asset confiscation and capital punishment. President Masoud Pezeshkian convened his first cabinet meeting since the war’s onset in a makeshift, blue‑covered space, emphasizing that any peace negotiations will safeguard Iran’s “dignity, security and national interests.” Israel’s Channel 14 reported that Pezeshkian sought greater negotiating leverage with the United States, a request allegedly rebuffed by IRGC chief Ahmad Vahidi.

Kuwait's Ministry of Electricity confirmed that an Iranian attack on a power and water desalination plant resulted in the death of an Indian worker and significant material damage to a service building. The attack is part of Iranian aggression against Kuwait, according to the ministry.Emergency response teams were quickly dispatched to the site to manage the aftermath and ensure continued operations. The incident occurred as regional tensions spike following the start of the US-Israeli war on Iran over a month ago.Iranian forces have retaliated against Israel and countries hosting US military assets with drone and missile strikes, causing casualties and infrastructure damage. The conflict has also led to Iran effectively blocking the Strait of Hormuz, a critical passage for 20% of global oil and liquefied natural gas, driving up energy prices and unsettling financial markets.The vulnerability of critical water infrastructure in one of the world's most water-scarce regions has been exposed by the war. Kuwait has faced repeated attacks since the conflict began, including the detection of 14 missiles and 12 drones in its airspace, with several targeting a military camp and injuring 10 servicemen.The US and Israeli attacks on Iran have killed over 2,000 people, including high-ranking officials and children, and destroyed critical infrastructure. The situation remains volatile, with US President Donald Trump pausing threatened attacks on Iranian energy plants until April 6, and Iran vowing to respond to any attacks on its facilities with strikes on energy sites across the Gulf region.

The World Health Organization (WHO) has issued a dire warning about a health crisis unfolding in real time across the Middle East, emphasizing the urgent need for a complete cessation of hostilities to mitigate the humanitarian catastrophe.Dr. Hanan Balkhy, the WHO's regional director for the Eastern Mediterranean, stressed that hospitals and healthcare facilities must be treated as safe havens to protect patients and healthcare workers. The region, encompassing 22 countries and territories including Iran, Gulf states, Gaza, Sudan, Afghanistan, and Pakistan, is facing severe disruptions in healthcare services due to the ongoing conflicts.The violence has resulted in significant loss of life and displacement, with over 1,000 people killed in Lebanon, 1,500 in Iran, and 16 in Israel, alongside reports of numerous deaths in the West Bank and Gulf Arab states. Moreover, 3.2 million people have been displaced in Iran and over 1 million in Lebanon within a month, exacerbating the crisis.Balkhy expressed deep concern about the long-term impacts on maternal mortality, mental health, and the plight of orphaned children left without education. The WHO has verified dozens of attacks on healthcare facilities in Lebanon, Iran, and Israel since the conflict began, including a recent attack on a hospital in Sudan that killed at least 70 people.The organization is also preparing for potential attacks on nuclear sites and water desalination plants, which could have catastrophic health repercussions. Balkhy urged for a significant de-escalation or a permanent pause in hostilities to prevent further humanitarian disaster.

The ongoing conflict in the Middle East has taken a significant turn as foreign ministers from Arab and Muslim countries gathered in Riyadh for urgent discussions. The meeting, which included representatives from 12 countries, aimed to muster a common response to Iran's increasing retaliation against US assets and infrastructure in the region.The talks were held as Iran targeted several energy facilities across Saudi Arabia, the United Arab Emirates, and Qatar in retaliation against Israel's strike on the South Pars gasfield, Iran's biggest source of energy. This escalation comes after a series of Israeli assassinations of top Iranian security officials.The joint statement issued on Thursday confirmed that the countries present at the meeting, including Qatar, Azerbaijan, Bahrain, Egypt, Jordan, Kuwait, Lebanon, Pakistan, Saudi Arabia, Syria, Turkiye, and the United Arab Emirates, asserted the right of states to defend themselves, citing Article 51 of the United Nations Charter on defensive action.The foreign ministers condemned deliberate Iranian attacks with ballistic missiles and drones that have struck various targets, including residential areas, water desalination plants, oil facilities, airports, and diplomatic positions. They called on Iran to:Halt its attacks.Stop "provocative actions or threats" aimed at its neighbours.Cease supporting, financing, and arming pro-Iran proxy groups based in Arab states.Refrain from actions or threats aimed at blocking the Strait of Hormuz or threatening maritime security in the Bab al-Mandeb strait.The meeting yielded a unified response to Iran's increasingly unpredictable behaviour, but the joint statement was vague about how countries would follow this up. Saudi Foreign Minister Faisal bin Farhan Al Saud emphasized his country's right to defend itself and hinted that Saudi Arabia and other Gulf states would act if necessary, adding that they have "very significant capacities and capabilities that they could bring to bear should they choose to do so".The Iranian leadership's response to these developments remains unclear, with New Supreme Leader Mojtaba Khamenei having not been seen in public since his appointment. The Islamic Revolutionary Guard Corps (IRGC) issued a statement saying that Iranian forces had responded to the "deceiving and lying enemy" that had targeted energy facilities in the country, and that they had "entered a new phase of warfare" to defend Iran's infrastructure.

US President Donald Trump has ordered a pause in attacks on Iran's power infrastructure for five days. The move comes after Trump issued a 48-hour ultimatum to Iran to reopen the critical shipping route through the Strait of Hormuz or risk US attacks on its power plants.Iran's Response to US Ultimatum: Iran threatened to attack power plants in Israel and the Gulf if its own power plants were targeted. The Islamic Revolutionary Guard Corps (IRGC) stated that it would hit power plants in Israel as well as any supplying electricity to military bases hosting US troops and assets in the region.Potential Targets: Iran could target Israeli power plants, including Orot Rabin north of Tel Aviv, with a capacity of around 3,900 megawatts, and Rutenberg in Ashkelon, with a capacity of around 2,250 megawatts. Iran also mentioned that it would target financial entities that finance US military assets, including US Treasury bonds.Energy Infrastructure: Iran's attacks on energy infrastructure in the Gulf have already had significant impacts. Qatar's state-run energy firm, QatarEnergy, halted LNG production following Iranian attacks on its operational facilities, causing an estimated $20bn in lost annual revenue. Saudi Arabia also shut down operations at the Ras Tanura plant, its biggest domestic oil refinery.Financial and Corporate Entities: Iran could target large US companies with Israeli links, including Google, Microsoft, Palantir, IBM, Nvidia, and Oracle. Iranian officials also mentioned that they would target US Treasury bonds and entities that finance US military assets.Other Critical Infrastructure: Iran's foreign minister accused the US of striking a desalination plant on Qeshm Island off the coast of Iran, cutting off the water supply to 30 villages. Bahrain also reported that an Iranian drone caused material damage to one of its desalination plants.

Iran has issued a stark warning to Gulf countries, threatening 'irreversible destruction' of their water infrastructure if the US follows through on its threat to attack Iran's electricity grid. This move has raised fears of a severe disruption to water supplies in the region, which heavily relies on desalination plants for drinking water.The Gulf countries, including Saudi Arabia, United Arab Emirates, Qatar, Bahrain, Kuwait, and Oman, are highly dependent on these plants, with some countries relying on them for up to 90% of their water supply. For example, Kuwait gets 90% of its water from desalination plants, while Saudi Arabia relies on them for around 70%.Desalination plants are considered critical civilian infrastructure in the Gulf, as they turn seawater into drinking water through a process called reverse osmosis. These plants are situated on the coast, making them an easy target for an Iranian attack, and disabling them would have a significant impact on civilian populations and industries.Iran has already followed through on a similar threat in the past, targeting a desalination plant in Bahrain after one of its own plants was hit. Analysts have warned that any disruption to water infrastructure could trigger a major escalation in the conflict, given the potential economic and civilian impact.The impact of targeting desalination plants would be severe, with most Gulf countries only having water reserves to last around a week. If plants are struck and capacity is taken out, the impact would be quick and severe, potentially wiping out water supplies to major cities in a matter of days.