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Scientists at London's Institute of Cancer Research and the RCSI University of Medicine and Health Sciences in Dublin have announced a new AI-driven approach to identify how patients with advanced bowel cancer will respond to bevacizumab, a drug recently introduced by the NHS. The method uses PhenMap, an AI tool that integrates complex data on the genetic makeup of tumors, allowing researchers to track patterns of how different patients react to the drug. This development aims to spare potentially thousands of patients from being given drugs that would be ineffective in fighting their cancers. In the UK alone, nearly 10,000 cases of advanced bowel cancer are identified every year, with young adults seeing a particular rise in diagnoses. Bowel cancer has the second-highest mortality rate of any cancer, behind only lung cancer. While survival rates can be as high as 98% when caught early, the five-year survival rate for advanced bowel cancer can be as low as 10%. The study tracked 117 European bowel cancer patients who had been treated with chemotherapy and bevacizumab. Researchers identified a group of patients who all had the same gene mutation and were at a high risk of having negative reactions. The scientists behind the tests now hope to expand the number of patient samples and see if the results can be used in treatments for other types of cancer. Anguraj Sadanandam, a professor in stratification and precision medicine at the ICR, said: “Once bowel cancer spreads to other parts of the body, there are very few treatment options available for patients. It is therefore positive that patients can now access the targeted drug bevacizumab on the NHS. However, we know that the majority of patients won’t benefit from the drug, meaning thousands of people in England could be facing unpleasant side effects unnecessarily.” Sadanandam added that while the findings were encouraging, the tool would need to be tested on a larger cohort to be validated. “In future, I hope this approach will lead to a test that can be used by clinicians, to ensure patients receive personalised care that has the highest chance of working against their cancer.”

Scotland staged a late comeback to beat Wales 27‑22 in what was hailed as the best match of the opening weekend of the Women’s Six Nations, played at Cardiff’s Principality Stadium. The game attracted 10,569 spectators, the highest ever attendance for a Wales‑Scotland women’s clash on Welsh soil, though the venue’s 74,500‑seat capacity meant the atmosphere fell short of the stadium’s potential. Wales, led by head coach Sean Lynn, fought back from a 24‑12 halftime hole, narrowing the gap to five points in the closing minutes. Despite a valiant effort from their own try line, a mishandled line‑out in the dying seconds denied them a first Six Nations win since their 22‑20 victory over Italy in 2024. Scotland’s triumph was especially significant for new head coach Sione Fukofuka, who secured his inaugural win since taking the reins in December. Fly‑half Helen Nelson, named player of the match, praised the team’s defensive resilience and the blend of experienced and emerging talent. The match formed part of the Welsh Rugby Union’s strategy to showcase the women’s game in the national stadium, with plans to host at least one fixture there each season, hoping larger crowds will follow. Across the tournament, England set a new attendance benchmark with 77,120 fans at Twickenham for their 33‑12 win over Ireland, while upcoming fixtures promise further milestones: Scotland will play a standalone game at Murrayfield before heading to Dublin, and France, after a strong second‑half display against Italy, now sit atop the table on points difference. Looking ahead, Wales will face France at Cardiff Arms Park, where two of the three stands are already sold out, as the team aims to build on the “fight and character” displayed in Saturday’s encounter.

Jim Jarmusch, the 73-year-old director known for his offbeat Americana films, has spent seven years crafting his latest project, 'Father Mother Sister Brother'. The film, which won the prestigious Golden Lion at the Venice film festival, is an anthology drama that explores the complexities of family relationships through three distinct stories set in New Jersey, Dublin, and Paris.Jarmusch's approach to filmmaking is characterized by his unique ability to elicit low-key performances from big stars and his focus on the quotidian aspects of life. He cites influences from filmmakers like John Cassavetes and David Lynch, but emphasizes his own humanist approach. 'I make films out of the things other people would leave out,' he notes, highlighting his attention to detail and ability to find beauty in everyday moments.The film features a star-studded cast, including Cate Blanchett, Adam Driver, Mayim Bialik, and Tom Waits. Jarmusch's process involves casting first and then writing the script quickly, often in a matter of days. 'I cast first then write fast,' he explains, showcasing his collaborative approach with actors.Jarmusch reflects on his career, mentioning the challenges of getting films made without compromising his artistic vision. 'It's harder every time to get a film made,' he acknowledges, but remains committed to his unique approach. The director also touches on themes of mortality and the cyclical nature of life, emphasizing the importance of living in the present.The film 'Father Mother Sister Brother' is set to release in UK cinemas on April 10, offering audiences a glimpse into Jarmusch's distinctive filmmaking style and thematic explorations.

Protesters in Ireland and Norway have escalated demonstrations against rising fuel costs, turning major highways into blockades and prompting a convoy of lorries to converge on Oslo’s parliament. The unrest is linked to the broader spike in oil prices triggered by the conflict in the Middle East. In Dublin, hauliers, farmers and other groups have shut down motorways for the fourth consecutive day, causing fuel shortages, traffic chaos and warnings that essential supplies—food, clean water and animal feed—are at risk. The Irish police force, An Garda Síochána, described the blockades as unlawful and warned that continued defiance could lead to arrests. The Irish government has placed the army on standby to clear the obstructions, while the justice minister accused outside actors, including far‑right figures such as Tommy Robinson, of exploiting the protests for political gain. Fuel prices have surged dramatically: Irish diesel has risen from roughly €1.70 per litre to €2.17, and petrol from about €1.74 to €1.97. In Norway, despite a recent fuel‑tax cut on 1 April, diesel prices jumped 23.6 % from February to March, with overall fuel and lubricants up 17.9 %. Statistics Norway noted this as the steepest month‑on‑month increase on record, comparable only to the post‑Ukraine‑invasion spike of spring 2022. Irish Prime Minister Mícheál Martin warned that blockades of the Whitegate refinery and key depots in Galway and Foynes were pushing the country to the brink of turning away oil shipments. He called the situation “unconscionable and “illogical.” In response, Dublin unveiled a €250 million relief package that includes a temporary excise duty cut, an expanded diesel rebate for hauliers and bus operators, and an extended fuel allowance. Nevertheless, industry leaders remain skeptical about the measures’ ability to quell the unrest, and many protesters demand direct talks with ministers. Across the North Sea, Norwegian demonstrators—part of the “Dieselbrølet” (diesel roar) movement—marched a convoy of 70‑80 trucks toward the Storting. Their banners read “nok er nok!” (enough is enough). While only a few vehicles were permitted into Oslo, the show underscored hauliers’ demand for more predictable, lower fuel prices despite Norway’s status as an oil producer. Other nations have taken emergency steps: the Philippines declared a national energy emergency, and France authorized fuel tankers to operate on weekends and holidays until 11 May to stave off shortages. Back in Ireland, the blockade of the sole refinery and depots has left dozens of petrol stations empty, prompting a rush of motorists to fill up before supplies run out. Emergency services report slower response times, and the Irish Medical Organisation warns that delayed care could jeopardise patient health. Courier firm DPD has halted deliveries, and protesters have vowed to remain in Dublin for weeks, with spokesperson John Dallon stating, “If it takes a month, we are prepared to sit here.” The crisis has also forced the Irish Taoiseach to postpone a trade mission to Canada, highlighting the domestic political fallout of the fuel‑price turmoil.

Courtney Lawes has confirmed a one‑year deal with the Sale Sharks, a move that reignites hopes of a return to the England squad after two seasons in France’s Pro D2 with Brive.Approaching his 38th birthday in February, Lawes retired from Test rugby following the 2023 World Cup but insists he can still compete at the highest level. Sale’s director of rugby, Alex Sanderson, expressed enthusiasm about the former Northampton stalwart joining the Manchester‑based side.Sanderson emphasized that the signing was not driven by a paycheck: “He’s still got the ability and experience to play great rugby this season and possibly beyond.” He added that Lawes is “robust, dynamic around the park and hits hard, but his skill set makes him far more than a mere banger.”Lawes’ résumé includes 105 caps, participation in four World Cups, two Premiership titles, two Challenge Cup trophies, and three Six Nations championships. The veteran believes his body feels “good” and that retiring now would be a regretful decision.Speaking on his “un‑retirement” from international duty, Lawes said, “I’d love to play for England again, but first I want to perform well for Sale and see what happens afterward.”Sale, however, faces a potential manpower crunch ahead of their Champions Cup quarter‑final in Dublin against Leinster. England internationals Luke Cowan‑Dickie and Bevan Rodd are sidelined for the rest of the season, and hooker Nathan Jibulu awaits the outcome of a disciplinary hearing after being cited for biting former Harlequins teammate Will Hobson.The alleged incident occurred during Sale’s 26‑17 victory over Harlequins at the Twickenham Stoop. If Jibulu is suspended, Sale’s forward options will be further depleted, with brothers Tom and Ben Curry already unavailable.Despite the controversy, Jibulu remains a contender for England’s summer tour, as head coach Steve Borthwick evaluates his options ahead of the Nations Championship clash with South Africa in Johannesburg on 4 July. Sanderson praised the 23‑year‑old, noting, “He’s good now, he’ll be brilliant – he has the attributes to be an international hooker.”

Chris Haskins, Lord Haskins, who has died at the age of 88, was a highly influential figure in British business and politics. He was a key supporter of Tony Blair's New Labour project and played a crucial role in advising on regulatory reform and rural affairs. Early Life and Career Born in Dublin, Ireland, Haskins studied modern history at Trinity College Dublin, where he developed a reputation as a radical. He began his career in journalism, covering the Aldermaston marches for the Irish Times, before moving into business. In 1959, he traveled to England, married Gilda Horsley, and joined his father-in-law's company, Northern Dairies, which later became Northern Foods. Business Achievements Under Haskins' leadership, Northern Foods grew into Britain's leading food manufacturer. He was instrumental in developing chilled food techniques, which enabled the mass production of ready meals and convenience foods. A significant partnership with Marks & Spencer was established, which became a cornerstone of the company's success, generating annual sales of half a billion pounds. Public Service and Politics Haskins was a vocal advocate for various public causes, including European monetary union, English regional devolution, and the reduction of subsidies to British agriculture. He served as a 'rural tsar' during the foot and mouth outbreak of 2001 and authored a rural recovery report for Defra, which proposed a shift towards environmental concerns and a long-term reduction in subsidies. Legacy Throughout his life, Haskins was known for his 'no-nonsense approach' and his commitment to telling the truth as he saw it. He was a passionate advocate for regional devolution and took an active role in various Yorkshire economic bodies. Despite facing disappointment as governments wound down bodies he chaired, Haskins remained dedicated to his causes, reflecting on his life's work: 'Most of the campaigns of my life have failed, largely, I comfort myself, because I have been ahead of my time.' He is survived by his wife, Gilda, their five children, nine grandchildren, and a great-granddaughter.

Peter Whelan and the Irish Baroque Orchestra have returned Handel’s Messiah to Dublin, the city of its 1742 debut, with a landmark recording that is the first period‑instrument rendition by an Irish ensemble. The project seeks to echo the original performance at the Fishamble Street music hall, where audience etiquette was so strict that women were asked to forgo hoop skirts and men to leave their swords at home.The album features a cast of historically informed singers. Helen Charlston delivers the contralto arias once associated with the scandal‑ridden Susannah Cibber, her voice described as firm, slightly metallic and unflaggingly expressive. A rare duet‑and‑chorus version of “How Beautiful Are the Feet,” originally written for two Dublin cathedral countertenors, showcases Alexander Chance in buoyant form, while soprano Hilary Cronin provides a sweet‑sounding contrast.Whelan draws a fleet‑footed performance from a modest 13‑member choir and the orchestra, resulting in vocal lines that are light, precise, and at times almost conversational. Formerly a bassoonist with the orchestra, Whelan is poised to succeed Nicholas McGegan as music director of San Francisco’s Philharmonia Baroque, cementing his status as a rising star in the baroque world.Listeners can stream the recording on Apple Music or Spotify.

The Champions Cup’s single‑leg knockout stage has historically favoured hosts – only two of the 24 matches since the format’s introduction three years ago have seen the home side lose. This weekend’s fixtures threaten to upend that trend.Defending champions Bordeaux Bègles have been quoted at 1‑100 odds to defeat a severely weakened Leicester Tigers on Sunday – a price more suited to a two‑horse race. The Tigers will be without key internationals Ollie Chessum, Joe Heyes and Nicky Smith, all ruled out for the match.Coach Geoff Parling has elected to rest his forward trio to preserve a top‑four finish in the domestic league, a decision that underscores the growing difficulty English clubs face in juggling league ambitions with European knockout demands.Parling’s dilemma echoes a similar scenario a year ago when Saracens rested their stars and suffered a crushing 72‑point defeat to Toulon. Alongside Saracens, Harlequins, Leicester and Sale collectively conceded 215 points and exited the competition without a whisper of a fight. Only Bath Rugby has managed to maintain sufficient squad depth to compete on both fronts.The competition’s structure is locked in until 2030, with a 2028 twist that will see the eight quarter‑finalists face seven Super Rugby Pacific teams and one Japanese side, aiming to crown a true world club champion every four years. Yet the packed calendar – culminating in the 2027 World Cup and the 2028 Six Nations – raises serious questions about player availability.“I just don’t know how you fit everything in,” Parling admitted. “The game is very physical now. We all want the best versus the best, but it is what it is.”Knockout success now demands back‑to‑back weekend victories. For example, if Northampton Saints overcome Castres on Friday night, they will face a fully‑strengthened Bath the following week, unless Saracens can engineer a dramatic turnaround after their recent 62‑15 Premiership loss at the Rec.Other clubs face similar uphill battles: Harlequins could earn a Dublin trip after beating Sale, only to recall their heavy 62‑0 defeat to Leinster in April; Bristol might pull off a miracle in Toulouse but would likely meet Bordeaux in the last eight.South African provinces are gathering momentum, with the Stormers and Bulls arguably better placed to silence home crowds in Glasgow and Toulon than earlier in the season. Stormers coach John Dobson quipped, “What will it take us to win? Venus to align with Uranus and Saturn.”Meanwhile, Glasgow Warriors have become notoriously difficult to beat at Scotstoun. If any of the traditional powerhouses – Northampton, Bath, Toulon, Glasgow, Toulouse, Harlequins, Bordeaux or Leinster – fail to reach the quarter‑finals, their conquerors will have defied the odds.

Irish MEP Barry Andrews toured makeshift shelters in Beirut last month, where displaced families are living on dirty mattresses and blankets and suffering from infections. The conditions, he said, are worse than during Israel’s 2024 incursion, underscoring the human cost of Israel’s retaliatory strikes after Hezbollah fired rockets into Israel.On returning to Dublin, Andrews became one of the first European lawmakers to urge the European Union to revive sanctions against Israel. He argued that the EU must also address state‑backed settler violence in the West Bank, attacks on health workers in Gaza, and Israel’s recent move to reinstate the death penalty for Palestinians convicted of terrorism.The EU’s leverage lies in its association agreement with Israel, a commerce and cooperation accord that underpins a €68 billion (€59 bn) trading relationship and includes cooperation on energy and scientific research. Former EU representative to the Palestinian territories, Sven Kühn von Burgsdorff, says the bloc should suspend this agreement, halt all military aid, and cease trade with illegal settlements, warning that inaction will further damage the EU’s reputation.Andrews described the EU’s reaction to the Iran‑Israel‑Lebanon war as “weak and pathetic,” adding that it effectively gives Israel a “permission slip for endless war crimes.” The European Commission condemned the Knesset’s death‑penalty vote as “very concerning” and a “clear step backwards,” while the Council of Europe called it a “legal anachronism” incompatible with modern human‑rights standards.Human‑rights figures note that in the past four weeks more than 1,240 people have been killed in Lebanon—including at least 124 children—and over 1.1 million have been displaced. In Gaza, the death toll has risen by 673 since the October ceasefire, bringing the total to 72,260 deaths.EU leaders have been divided on how to respond. Former Commission President Ursula von der Leyen proposed unprecedented sanctions last September, citing a “man‑made famine” in Gaza, but the proposal failed to secure a majority in the Council of Ministers, losing momentum after the U.S. announced a cease‑fire plan.Member states also differ: Ireland, Spain and Slovenia champion the Palestinian cause, whereas Germany, Austria and Hungary—led by Viktor Orbán, a close ally of Prime Minister Benjamin Netanyahu—have resisted measures such as sanctions on West Bank settlers.Despite these divisions, a senior EU diplomat warned in mid‑March that the bloc may need to “increase pressure on Israel again,” citing the “highly problematic” situation in Gaza and the West Bank. Another diplomat highlighted the importance of engaging with Israeli civil society, noting an open letter from 600 Israeli security officials urging an end to the Gaza war.In a recent statement, a Commission spokesperson reiterated that diplomatic engagement with Israel continues, describing it as the standard approach when partners “do not see developments eye to eye.” Yet former EU envoy Kühn von Burgsdorff cautioned that the EU cannot appear as a “sidekick” to an “erratic, unreliable” U.S. president or a “warmongering, annexationist” Israeli prime minister, as such a stance would undermine Europe’s global standing.