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The Lead: Pakistan's Diplomatic Push in Iran CrisisPakistan's army chief, Field Marshal Asim Munir, is in Iran as part of ongoing mediation efforts to end the Israel and United States's war that began on February 28. This high-level diplomatic visit comes as the US reports slight progress in negotiations while tensions remain high in the region.The Event Details: Pakistan's Second Mediation MissionMunir arrived in Tehran on Friday, Iran's state-run IRNA news agency reported, citing the Pakistan Army. "On arrival, he was received and warmly welcomed by Iranian Interior Minister Eskandar Momeni," IRNA said, adding that "Pakistan's Interior Minister Mohsin Naqvi was also present at the reception."It is the second such trip to Tehran by Munir amid Pakistani mediation efforts to end the war. Islamabad helped secure a temporary ceasefire between the warring sides on April 8, and later hosted the highest-level talks between the US and Iran since 1979 on April 11-12.During this visit to Iran, unnamed Pakistani sources told the Anadolu news agency that Munir will discuss Iran-US talks, regional peace and stability, and other "important issues".The Data Analysis: Shifting Positions in Negotiations"The current process and the presence of senior Pakistani officials in Tehran means that we have reached a turning point or a decisive situation," Iran's Foreign Ministry spokesperson Esmaeil ⁠Baghaei said on Friday.Iranian state media quoted Baghaei as saying the gaps between Tehran and Washington are "deep and significant". "We cannot necessarily say that we have reached a point where an agreement is close," he said. "The focus of the negotiations is on ending the war. Details related to the nuclear issue are not being discussed at this stage."Speaking at the White House on Friday, US President Donald Trump said, "Iran is dying to make a deal". "We'll see what happens. But we hit them hard, and we had no choice because Iran cannot have a nuclear weapon. They cannot have it," Trump added.US Secretary of State Marco Rubio said on Friday that "slight progress" was made during talks with Iran. "I don't want to exaggerate the progress in talks, saying there had been 'a little bit of movement, and that's good'. He said the conversations were ongoing.The Impact Analysis: Regional and Global RamificationsThe Iran war and the closure of the Strait of Hormuz, which normally carries a fifth of global oil production, have sent ripples through the global economy, driving energy prices soaring.As diplomatic efforts continue, European Union nations moved towards imposing sanctions on Iranian officials and others responsible for blocking the Strait of Hormuz, the EU said on Friday. Tehran effectively closed the key shipping lane for global oil and gas supplies in retaliation for the US-Israeli war."The EU will now be able to introduce further restrictive measures in response to Iran's actions undermining the freedom of navigation in the Strait of Hormuz," the European Council representing EU nations said.Trump has repeatedly set deadlines for Tehran and then backed off. But he's also previously indicated he would hold off on military action to allow talks to continue, only to turn around and launch strikes. The US president said he called off attacks on Iran this week at the request of allies in the Middle East, including the leaders of Qatar, Saudi Arabia and the United Arab Emirates.The Prediction: Path Forward for Diplomatic SolutionsIran's ⁠Baghaei said ⁠on Friday that a Qatari delegation ‌was currently holding talks with Iran's foreign minister, ⁠but added that ⁠Pakistan remained the main ⁠mediator in ⁠the ⁠negotiations.With Pakistan intensifying its mediation process to secure a second round of direct talks between the US and Iran, the region remains on edge. While both sides report some progress, the deep gaps between Tehran and Washington suggest that a comprehensive resolution to the conflict remains elusive, with potential for both diplomatic breakthroughs and military escalation still on the table.

The Lead: Guardiola's Legacy Beyond FootballPep Guardiola is more than a football manager, using his high-profile platform to highlight causes close to his heart. As he prepares to step away from Manchester City after 10 years and 20 trophies, the 55-year-old Spaniard leaves behind a legacy of advocacy that extends far beyond the "beautiful game."The Event Details: A Manager's Platform for Social ChangeLegendary Liverpool manager Bill Shankly may have believed football was "much, much more important" than life or death, but for Guardiola, several things outside football matter almost as much. From Palestinian children to Catalan independence and homelessness in the United Kingdom, Guardiola has strayed outside the borders of his job to advocate for a diverse range of causes during his managerial career.Guardiola has made no bones about using his position as a podium to "speak up to be a better society." His most recent foray into sensitive political territory has been his passionate embrace of the predicament of Palestinian children in Gaza during the two-year war with Israel and their suffering in the aftermath.The Data Analysis: Impact and ControversyThe war in Gaza, which began after Hamas's October 2023 attack on Israel, has killed at least 72,568 people, including children from toddlers to late teens. Hundreds of thousands of displaced people still live in tents, with conditions remaining dire despite a ceasefire that came into effect in October.Guardiola's advocacy has not been without controversy. His remarks about Palestine prompted the Jewish Representative Council of Greater Manchester and Region to write a letter to Manchester City chairman Khaldoon Al Mubarak, warning his comments put the lives of Jews in Manchester "in danger." Similarly, he was fined £20,000 ($27,000) by the Football Association in 2018 for wearing a yellow ribbon to support imprisoned politicians in his native Catalonia.The Impact Analysis: Shaping Public DiscourseWhile Guardiola's advocacy has met with criticism from some quarters, it has also sparked important conversations about global issues. His willingness to speak out on sensitive topics has demonstrated how athletes and sports figures can use their platforms to draw attention to humanitarian crises and social justice issues.Guardiola's influence extends beyond his immediate audience. When he missed a pre-match news conference to attend a charity event for Palestinian children in Barcelona, his actions garnered international attention. Similarly, his support for the Salvation Army's Partnership Trophy, a five-a-side football tournament in Manchester that raises awareness of homelessness, has helped shine a light on this often-overlooked issue.The Prediction: The Future of Athlete AdvocacyAs Guardiola transitions from his managerial role, his legacy of advocacy may inspire other sports figures to follow suit. In an era where athletes are increasingly using their platforms for social and political causes, Guardiola's approach—unapologetic, consistent, and multifaceted—could become a model for how sports figures can leverage their influence for meaningful change.His willingness to address complex geopolitical issues, from the Middle East to Ukraine and Sudan, suggests that future athlete advocates may become more engaged with global affairs, recognizing their potential to shape public discourse and bring attention to underserved communities and causes.

The Strategic Reversal in Immigration Policy The Trump administration has officially shifted the procedural landscape for permanent residency, instructing foreign nationals currently in the US on temporary visas to return to their home countries to apply for Green Cards. This directive, issued by the Department of Homeland Security (DHS) and US Citizenship and Immigration Services (USCIS), frames the policy as a necessary correction to the existing legal system. By emphasizing that "adjustment of status" is a discretionary benefit rather than an automatic right, the administration aims to deter applicants from attempting to secure permanent residency while remaining in the US. Quantifying the Crackdown: Visa Revocations This policy shift is part of a broader, aggressive enforcement strategy that has already yielded significant numbers of visa cancellations. The administration has moved to shorten the duration of visas for students, cultural exchange visitors, and media workers, signaling a zero-tolerance approach to temporary stays. Visa Revocations: Over 100,000 visas have been revoked since President Trump returned to office in January. Policy Focus: Officers are now instructed to scrutinize visa violations, unauthorised employment, and fraud more rigorously. Resource Allocation: The agency claims the new guidance helps free up resources to focus on processing other immigration cases. Humanitarian Concerns and Industry Impact While the administration argues this reinforces the rule of law, immigrant advocacy groups have raised severe concerns about the practical implications. The policy threatens to separate vulnerable populations from safety nets, potentially forcing survivors of trafficking and abused children to return to dangerous environments while their applications are pending. Future Outlook: The Dual Intent Dilemma The guidance creates a complex future for holders of "dual intent" visas, such as H-1B workers or L-1 transferees, who are legally permitted to live in the US while seeking permanent residency. Although these categories are exempt from the immediate departure requirement, the memo clarifies that this status does not guarantee approval. This suggests a future where even dual-intent holders may face increased scrutiny and procedural hurdles before being granted permanent status.

The Road to Wembley Hull City owner Acun Ilicali is set to take his team to Wembley for a chance to secure a Premier League spot. The Turkish media mogul has been at the helm of Hull since January 2022 and has overseen a tumultuous period, including multiple coaching changes and playoff battles. The Coaching Carousel Ilicali has changed coaches several times, which some attributed to his ego. However, he claims it was due to his 'lack of ego,' as he aims to correct mistakes and find success. The current coach, Sergej Jakirovic, was appointed after a series of changes, and Ilicali is optimistic about the team's chances. Overcoming Adversity The team has faced challenges, including the 'spygate' scandal involving Southampton. Despite this, Hull secured sixth place on the final day and defeated Millwall to reach the playoffs. Ilicali is proud of his team's achievement and believes they have a good chance of promotion. Financial Commitment and Future Plans Ilicali has invested significantly in the team, spending over £100m and owning every player who started the recent win against Millwall. He is committed to long-term recruitment and is optimistic about the team's future prospects. Premier League Ambitions If Hull City secures promotion, Ilicali is aware of the challenges they will face in the Premier League. He cites Sunderland as an example of a team that can survive their first season and progress. Ilicali is not afraid of failure but is focused on helping the team learn and grow.

The Final Episode of The Late Show Celebrities, politicians, and New Yorkers paid their respects to Stephen Colbert as the Late Show aired its final episode on Thursday. The long-running chat show, which started back in 2015, was cancelled last year by CBS, purportedly because of a financial decision. But many believed it was a result of the network's increasing closeness with Donald Trump, who Colbert regularly criticised. A Bittersweet Goodbye Last night's episode saw the host bid an emotional farewell with the help of celebrity guests including Paul McCartney, Paul Rudd, Ryan Reynolds, and Bryan Cranston. "We love doing the show for you but what we really love is doing the show with you," he said to the audience at home. Colbert hosted more than 1,800 episodes of the Late Show, taking over the mantle from David Letterman. Tributes from Around the World Former president Joe Biden, who had previously guested on the show, also joined the chorus this week with a tribute on Instagram. "There aren't many who can make people think and laugh at the same time," he wrote. "For years, Stephen brought wit, heart, and honesty to late night television. America could always count on a laugh – and sometimes a needed reality check. Congrats on an incredible run, my friend." The Impact of Colbert's Comedy Jane Fonda was among celebrities featured in a video put together by her newly relaunched Committee for the First Amendment. "He made us laugh and he never flinched," the Oscar-winning actor said. "We've watched this administration suppress dissent repeatedly." Colbert already has his next gig lined up with the long-term JRR Tolkien fan set to co-write a new Peter Jackson-produced film tentatively titled The Lord of the Rings: Shadow of the Past. The Future of Late-Night Television The Late Show is being replaced by Comics Unleashed, an unscripted comedy series from comedian and media mogul Byron Allen. The entire set from the show is being donated to the Museum of Broadcast Communications in Chicago.

What is Immunotherapy? Immunotherapies are biological treatments that harness the immune system to prevent, control and fight diseases and other conditions. The most familiar are vaccines, which train the immune system to recognise targets such as invading pathogens. Other immunotherapies boost immune responses when they are too weak, or dampen them down when they are out of control. Still others draw on engineered immune cells or lab-made antibodies to disrupt disease processes. The Evolution of Immunotherapy Efforts to prevent disease by boosting the immune system date back thousands of years, but advanced therapies for a wide range of illnesses have come to the fore in the past two decades. A global registry of clinical trials listed 1,257 trials of immunotherapies between 2006 and 2016. The figure leapt to 4,591 in the past decade. How Do Cancer Immunotherapies Work? Cancer patients have seen great benefits from immunotherapies and dozens are now approved for more than 30 types of cancer. Some tumours evade the body’s defences by switching off immune cells, but antibody-based drugs – called checkpoint inhibitors – reactivate them so they can recognise and attack the malignancies. The Future of Immunotherapy: Beyond Cancer Researchers are now testing whether existing immunotherapies can help a broader range of patients. This includes treating allergies, infections, brain diseases, and autoimmune disorders. Some of the most exciting new immunotherapies draw on recent Nobel prizewinning work on regulatory T-cells, or Tregs, which can be used to dampen down immune responses. The Potential of Tregs in Immunotherapy Tregs are unusual immune cells that stand the immune system down once the threat has been dealt with. Therapies are in the pipeline for dementia and autoimmune diseases from type 1 diabetes and rheumatoid arthritis to lupus and chronic inflammation. The potential for Tregs is vast, and researchers believe that half of all deaths have a component that is immunological.

The Legacy of Mohamed Salah at Liverpool Mohamed Salah's departure from Liverpool marks the end of an era for the Egyptian forward, who has been a key player for the club since his arrival in 2017. With 257 goals and 441 appearances, Salah has cemented his place in Liverpool's history books. A Career of Achievements Third-highest goalscorer in Liverpool's history Won the Premier League title, Champions League, and numerous other honors Four-time Premier League Golden Boot winner Hat-trick of clean sweeps of the Professional Footballers' Association and Football Writers' Association footballer of the year awards The Impact of Salah's Departure Salah's departure has been marked by controversy, with the player publicly criticizing manager Arne Slot and the team's style of play. However, it is seen as a necessary move for both parties, with Salah seeking a new challenge and Liverpool looking to refresh their squad. The Future for Salah and Liverpool As Salah moves on to a new chapter in his career, Liverpool will look to build on the foundations he has helped establish. With a legacy that will be remembered for generations to come, Salah's impact on the club will not be forgotten.

The Lead: Demands for Transparency on £5m Gift The defence secretary, John Healey, has urged Nigel Farage to provide transparency about the £5m gift he received from a billionaire businessman, in particular over whether any of the sum could have been linked to Russia-connected profits. In a letter to the Reform UK leader, Healey also asked him to address the possibility that the war against Iran might boost the revenues of AML Global, an aviation fuel company owned by Christopher Harborne, who gave Farage the £5m in 2024. Farage initially supported the US-Israeli attacks on Iran. The Financial Inquiry: Scrutinizing the Gift's Origins The letter, seen by the Guardian, asked Farage to confirm that none of the sum was "derived from transactions with Russian state-linked energy companies", and to give assurances that AML Global had complied fully with all sanctions on Russian energy since the full-scale invasion of Ukraine in 2022. In a statement to the Guardian, AML Global said it had complied fully with all UK and international sanctions, and screened any business partners to ensure the same. The Political Fallout: Investigation and Disclosure The Guardian revealed last month that shortly before the 2024 general election, Farage was given £5m by Harborne, a British-Thai dual citizen based in Thailand. Farage did not disclose the money at the time, and it only emerged when the Guardian reported it. He has argued that because it was an unconditional gift, and received before he announced he would run for parliament, there was no need to declare it once he did become an MP. However, after a complaint from the Conservatives, Farage faces a formal investigation by the parliamentary standards watchdog, Daniel Greenberg, into whether he should have done. The Geopolitical Concerns: Russia and Iran Connections In the letter, Healey noted that AML Global supplies jet fuel through a network of "main and regional oil companies" covering more than 1,200 locations worldwide, including central Asia, the Gulf and eastern Europe. Healey asked Farage to confirm that none of the profits which helped finance the £5m gift came from transactions with Russian state-linked energy companies, that AML Global had fully complied with all Russia sanctions, and that "no fuel sourced from Russian-controlled refineries has passed through its supply chain". The Public Interest: Demands for Open Books Citing previous comments by Farage about Russia – for example, that Nato "provoked" Russia's invasion of Ukraine by expanding eastwards – Healey said this wider situation "places Reform UK under a Russian cloud that only transparency can lift". On Iran, the letter asked Farage to say whether he was aware of a potential benefit to Harborne's company from rising aviation fuel prices when he made supportive comments about the attack on Iran, which led to Iran blockading the strait of Hormuz. Healey added: "The public is entitled to ask whether your financial interests were impacting on your political positioning and your initial support for throwing the UK armed forces headlong into a war in the Middle East without a plan."

The Churchill Exhibition: War Leader's Artistic EscapeBritain's eloquent war leader kept himself sane by puffing on cigars, swilling brandy – and painting the world around him. The Wallace Collection in London is hosting "Winston Churchill: The Painter" from 23 May to 29 November, offering a rare glimpse into the artistic side of the historical figure.New Voices in Contemporary ArtThe London art scene is buzzing with new exhibitions featuring contemporary artists:Kira Freije presents hollow metal people at Modern Art Oxford, showing shadows of Berlin Dada in her work. The exhibition runs from 23 May to 16 August.Miriam Elia, known for her witty take on Ladybird books, turns her eye towards Moses in this exhibition for Jewish Cultural Month at JW3, until 30 June.Liam Young offers futuristic but lo-fi worlds you can walk through at the Barbican, until 6 September, with installations finding hope for our planet.Zsuzsi Ujj presents her first UK solo show at Arcadia Missa, from 22 May until 18 July, establishing her presence from Hungary's dissident art and underground music scenes.Remembering Valie ExportThe art world mourns the passing of Austrian feminist artist and film-maker Valie Export, who died this week. Her 1968 performance piece "Tapp und Tastkinema" (Tap and Touch Cinema) is highlighted as typically provocative but playful, giving people the opportunity to interact with and appraise a real female body: her own. Export's fearless approach to challenging beauty standards continues to influence contemporary artists.Notable Art News and DevelopmentsThe week brought several significant stories from the art world:Taiba Akhuetie makes wild creations out of hair – Rihanna and Cate Blanchett are fansWhistler should have used better paint to capture his motherNina Simone's chewing gum is going on show in a new exhibition celebrating the superfanChristo made the invisible visibleGrayson Perry's life story is to be made into a musicalFlorentina Holzinger rocked this year's Venice Biennale with naked jetskiers, human bells and urine diversGen Z can't get enough of the king of colour, Mark RothkoSanya Kantarovsky's paintings of Christian iconography and children will haunt youMasterpiece of the Week: The Judgement of ParisJoachim Wtewael's "The Judgement of Paris" (1615) stands as this week's masterpiece. The painting depicts the moment when Trojan prince Paris foolishly rates the beauty of Minerva, Venus, and Juno, giving the prize to Venus in return for her helping him seduce Helen. This decision sparked the Trojan War, with the Greeks supported by the furious Juno. Wtewael's mannerist style, with its bony, angular forms and deliberate distortions, creates an overabundance that presages doom, reflecting the war-torn Europe of the 1600s. The painting is on display at the National Gallery in London.