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Researchers have made a significant breakthrough in understanding why weight-loss medications, such as GLP1 receptor agonists, work better for some individuals than others. A recent study published in Nature has identified genetic variations in two genes involved in gut hormone pathways that regulate appetite and digestion. These genetic variations may help account for different weight-loss results or side-effects when taking glucagon-like peptide 1 (GLP1) medicines, which mimic natural gut hormones to regulate appetite, insulin release, and digestion. The study analyzed data from 27,885 patients on GLP1 drugs and found that specific genetic variants were associated with slightly more weight loss or side-effects like nausea and vomiting. The findings suggest that genetic differences may contribute to why people respond differently to weight-loss jabs. However, the overall impact of genetics appeared to be modest, with non-genetic factors such as sex, drug type, dose, and duration appearing to explain a substantially larger proportion of variability. The study's results reinforce that while there is substantial variability in response to GLP1 therapies, genetics is only one part of a much more complex picture. According to Marie Spreckley, an obesity expert at the University of Cambridge, the study provides plausible evidence that genetic variants could affect outcomes. However, she notes that the magnitude of these genetic effects is small in clinical terms, and that behavioral, clinical, and treatment-related factors remain the dominant drivers of outcomes. The study's authors suggest that their findings could support future efforts to use genetic information when making treatment choices for obesity. However, Spreckley cautions that the evidence is not yet sufficient to support using genetic information to guide treatment decisions in routine clinical practice.

Pakistan's diplomatic efforts have yielded a significant breakthrough, securing a temporary ceasefire between the US and Iran. The development comes after intense negotiations led by Pakistan's Prime Minister Shehbaz Sharif and Army Chief Asim Munir.The crisis had escalated to a point where Pakistan's government and military were deeply concerned about the potential consequences for the country's economy, defense, national security, and sectarian harmony. A defense pact with Saudi Arabia meant that if Riyadh entered the war, Pakistan would be drawn into it as well.Behind the scenes, Munir and Asim Malik, the country's head of army intelligence and national security adviser, played a crucial role in mediating the ceasefire. Munir's strong personal rapport with US President Donald Trump and his longstanding relationship with Iran's Revolutionary Guards were instrumental in brokering the deal.China emerged as a key player in the negotiations, with Pakistani officials claiming that Beijing directly encouraged Iran to accept a ceasefire, promising to act as a guarantor of Iran's safety in any talks. This included assurances that Iranian leaders would not be assassinated if they traveled for negotiations.The ceasefire deal was secured by 4am in Islamabad, with both the US and Iran agreeing to a temporary and fragile truce. Michael Kugelman, south Asia fellow at the Atlantic council, described it as Pakistan's 'biggest diplomatic win in years'.Pakistani officials have expressed concerns that Israel and the United Arab Emirates could still try to sabotage the peace process. However, the successful brokering of the ceasefire has been hailed as a 'shining moment' in Pakistan's history and a 'first step' towards peace.

The September 2026 Launch Window Apple is reportedly on track to debut its first foldable iPhone in September 2026, aligning with the launch of the iPhone 18 Pro and Pro Max. According to Mark Gurman of Bloomberg, the device aims to hit the market simultaneously with or shortly after the standard non-foldable models. Despite recent concerns from Nikkei Asia regarding potential delays due to engineering hurdles, the latest report suggests the timeline remains aggressive. Launch Window: Targeting September 2026 alongside iPhone 18 Pro series. Supply Constraints: Initial production volumes may be limited due to the device's complexity. Status: While six months out, the timing is not yet finalized. Engineering Breakthroughs: Durability and Display A critical factor driving this launch is Apple's reported resolution of key technical challenges that have plagued competitors. The new foldable device is said to feature significant improvements in screen quality and overall durability. Furthermore, Apple has reportedly addressed the "crease" issue, making it less visible when the device is unfolded, a common pain point for users of current foldable models. Market Implications: Entering the Foldable Wars The introduction of a foldable iPhone marks a pivotal shift in Apple's hardware strategy. For years, the company has observed the foldable market dominated by Samsung and emerging Chinese manufacturers. By entering this space, Apple aims to leverage its ecosystem lock-in and manufacturing scale to redefine the premium foldable experience. Future Outlook: Supply Chain and Adoption Analysts predict that while the September launch is the goal, supply chain bottlenecks could restrict availability. However, if Apple can deliver on its promises of a durable, high-quality foldable device, it could accelerate the mainstream adoption of foldable technology, forcing competitors to innovate further.

The relationship between the United States and Iran appears to be on the brink of a critical juncture. Recent statements from US officials suggest a potential military strike against Iran's power infrastructure, a move that could have far-reaching consequences for the region. The threat, as reported, has heightened concerns about the stability of the Middle East and the potential for widespread disruptions to Iran's energy sector. This development comes at a time when diplomatic efforts to ease tensions between the US and Iran have been under intense scrutiny. Iran, a significant player in the global energy market, relies heavily on its power plants to support both domestic needs and international oil exports. Any disruption to these facilities could lead to significant economic and geopolitical repercussions, affecting not only Iran but also the broader region and global markets. The situation remains fluid, with international observers closely monitoring developments for signs of escalation or potential diplomatic breakthroughs. The possibility of military action against Iran's power plants raises critical questions about the future of US-Iran relations and the impact on regional stability.

Arsenal broke a spell of anxiety at the Estádio José Alvalade, edging Sporting CP 1‑0 in the Champions League quarter‑final first leg. Kai Havertz delivered the decisive goal after Gabriel Martinelli’s cross found him unmarked, allowing the German forward to finish past Rui Silva.The match was a grinding affair; Arsenal completed 488 passes but struggled to create clear-cut chances. Early opportunities were limited to set‑piece scrambles and long‑range attempts, with Noni Madueke’s corner rattling the bar and Leandro Trossard’s speculative 40‑yard effort failing to find the net.Arsenal’s breakthrough came in added time of the second half. Substituting Martin Ødegaard in the 70th minute, Arteta introduced Havertz, who slipped into a support‑striker role and, moments later, slotted home the winner. The goal not only secured the lead but also provided a psychological lift as the season’s final weeks loom.Equally pivotal was goalkeeper David Raya’s performance. The Spaniard produced three major saves, including a fingertip parry that kept a Geny Catamo header off the line and a double‑save sequence against Catamo and Luis Suárez. His interventions were described as “nothing will ever get past him,” underscoring the importance of elite goalkeeping in high‑stakes fixtures.Sporting CP pressed in the closing stages, with Ousmane Diomande threading a pass behind Ben White and Maxi Araújo forcing a near‑miss that only Raya’s fingertips prevented. Yet Arsenal’s defensive shape and Raya’s reflexes held firm, allowing the Gunners to head into the second leg with a valuable advantage.Arteta’s side has faced criticism for recent goalkeeping choices, notably starting Kepa Arrizabalaga in the Carabao Cup final against Manchester City, a decision that backfired after an error led to City’s opener. The contrast with Raya’s composure highlights the impact of recruitment decisions on match outcomes.While the win injects optimism, Arsenal remain nine points clear at the top of the Premier League and must translate this European momentum into domestic consistency. As Arteta cautioned, “don’t panic,” the onus now lies on Havertz to maintain composure and on the squad to capitalize on the platform Raya helped secure.

On Halloween night in 2022, the 33‑year‑old Los Angeles‑based musician Angelo De Augustine collapsed at home, experiencing a cascade of sensory failures that left him unable to see, hear or move properly. Family members rushed him to the hospital, where doctors ran extensive tests but could not pinpoint a diagnosis, ultimately sending him home with a warning to return only if he became completely deaf or blind. Faced with a semi‑incapacitated body, De Augustine’s sole focus became completing the album he had been crafting for the previous year, Toil and Trouble. He admits he believed he might not survive the illness, yet he pushed through the pain, hoping to finish the record before his presumed death. De Augustine’s career had been gaining momentum. After his 2014 debut Spirals of Silence, he joined Sufjan Stevens’ label Asthmatic Kitty for 2017’s Swim Inside the Moon and later co‑produced the acclaimed 2021 collaboration A Beginner’s Mind. A 2019 track, “Time,” from the album Tomb, amassed over 31 million streams after featuring in Zach Braff’s film A Good Person, but the artist was too ill to capitalize on its success. Recovery was gradual and arduous. Over three years De Augustine relearned basic functions—walking, speaking, hearing, and playing instruments. Those challenges informed his newest work, Angel in Plainclothes, an album that contemplates mortality and the fleeting nature of life through ethereal soundscapes. Musically, the record draws on influences ranging from Nick Drake’s wistfulness to early Paul Simon’s lyricism. Tracks such as “Spirit of the Unknown” celebrate simple joys, while the lead single “Mirror Mirror” uses a reflective metaphor to describe his feeling of being a ghost watching life from the sidelines. He records from a studio he calls “A Secret Place,” emphasizing the intimate, introspective tone of the project. Recent research, De Augustine notes, suggests that chronic stress can overload the central nervous system, causing the body to shut down—a possible explanation for his 2022 episode. He points to the relentless pressures of the music industry as a likely source of that prolonged anxiety. Born to musical parents—his mother Wendy Fraser sang on the Dirty Dancing soundtrack—De Augustine originally pursued soccer before injuries redirected him toward music. Largely self‑taught, he began writing original material without formal lessons, a factor he believes gives his songs a distinctive edge. During his convalescence he moved back in with his mother, unable even to prepare meals. A breakthrough came when he discovered that immersion in water alleviated his symptoms, prompting a deeper awareness of his stress levels. A disciplined regimen of physical and mental exercises helped rewire his nervous system, gradually restoring his ability to play guitar and sing. When his health permitted, De Augustine returned to the studio, this time enlisting collaborators such as string arranger Oliver Hill, harpist Leng Bian, producer Thomas Bartlett (aka Doveman), and his mother on percussion. Drummer Jonathan Wilson contributed drums and offered his Topanga Canyon studio for the track “The Cure,” a song that likens illness to addiction. The album’s sonic palette is enriched by antique instruments—a bowed psaltery, aquarion, Marxophone, bass recorder, train whistle, 1960s German guitaret, miniature accordion, and a 1990s synthesiser version of a Japanese koto harp—underscoring De Augustine’s penchant for unconventional textures. After a five‑year hiatus from live performance, he returned to the stage last year, describing the experience as “amazing” despite its challenges. Though he acknowledges he is not yet fully healed, he feels he is emerging as a blend of his former self and a newly humbled individual who no longer takes life for granted. Reflecting on his journey, De Augustine says, “For so long my only focus was to be a great songwriter, and perhaps I paid the price for that. Now I’m trying to live a good life rather than chase outcomes.” Angel in Plainclothes was released via Asthmatic Kitty on 24 April, offering listeners a glimpse into his renewed perspective and artistic resilience.

Researchers at Rothamsted Research in Harpenden, Hertfordshire, have made a groundbreaking discovery in the field of food safety. By utilizing Crispr genome editing, they have successfully developed wheat that can be used to make bread with reduced levels of acrylamide, a toxic compound classified as a probable carcinogen.The innovation lies in the reduction of free asparagine, an amino acid in wheat that converts into acrylamide when bread is toasted, fried, or baked. Field trials over two years demonstrated that gene-edited wheat can have significantly lower concentrations of free asparagine without impacting crop yields. This translates into lower acrylamide formation in food products, making toasted bread safer for consumption.In tests, bread and biscuits made from the edited wheat showed substantially reduced acrylamide levels, with some bread samples having concentrations below detectable limits even after toasting. The Crispr editing targeted the gene responsible for asparagine production, achieving a reduction of up to 93% in free asparagine in dual-edited lines.Compared to conventional methods that achieved a 50% reduction in free asparagine but resulted in a 25% yield penalty, the Crispr-edited wheat offers a more efficient and effective solution. Dr. Navneet Kaur, a lead researcher, highlighted the potential of Crispr technology to deliver precise, beneficial changes in crop genetics, emphasizing the importance of supportive regulatory frameworks to unlock benefits for agriculture and food systems.The UK has become a global hub for gene editing research since Brexit, with the Genetic Technology (Precision Breeding) Act of 2023 facilitating the development and marketing of genetically modified crops. However, the future of these advancements may be influenced by negotiations with the EU over sanitary and phytosanitary agreements.Prof. Nigel Halford, who led the study, noted that low-acrylamide wheat could help food businesses meet safety standards without compromising product quality or incurring major costs, ultimately reducing consumers' dietary exposure to acrylamide.

Scientists have made a groundbreaking discovery, identifying a distinct 'neural fingerprint' produced by psychedelic drugs in the human brain when users experience their mind-altering effects.This breakthrough finding emerged from a comprehensive study that combined 11 brain imaging datasets from around the world, involving over 500 brain scans from 267 people in five countries. The research focused on five psychedelic substances: LSD, psilocybin, DMT, mescaline, and ayahuasca.The study revealed that these substances have a shared impact on the brain's behavior, dissolving the usual hierarchy of brain systems and flattening the hierarchy, which may underlie the raw access to one's own consciousness that some people describe during psychedelic experiences.Dr. Danilo Bzdok, a senior author on the study from McGill University in Montreal, Canada, explained that all five drugs change brain function in common ways, despite some differences in how they alter brain activity. The most striking effect was stronger communication between brain networks that engage in higher-level thinking and more primitive networks linked to vision and sensation.The research, published in Nature Medicine, provides a solid foundation for psychedelic research, which is crucial if these drugs are to become widespread therapies for mental health conditions such as depression, schizophrenia, and post-traumatic stress disorder.Dr. Emmanuel Stamatakis, a senior co-author on the study from the University of Cambridge, emphasized the importance of large-scale, coordinated evidence in the field of psychedelic research, which is moving quickly and needs to mature responsibly.

Jamie Dimon, chairman and chief executive of JPMorgan Chase, used his highly‑watched annual letter to shareholders to press the White House to strengthen economic cooperation with U.S. allies, warning that a decline in shared prosperity could produce "truly adverse consequences" for democratic nations.His message arrives as the Iran‑Israel conflict enters its sixth week, a war that has already rattled global energy markets. Economists cited in the letter caution that prolonged fighting could push oil prices above $170 a barrel, a level capable of triggering a worldwide recession.Dimon’s appeal is widely read as a thinly‑veiled rebuke of President Donald Trump. Earlier this year, Trump filed a $5 billion lawsuit against Dimon and JPMorgan, accusing the bank of “de‑banking” him. The timing of Dimon’s comments—just days after Trump’s aggressive rhetoric urging foreign governments to "go get your own oil"—underscores the growing rift between the bank’s leadership and the administration."Economic weakening of the world’s democracies or a fragmentation of their economic bonds could lead to truly adverse consequences," Dimon wrote. He warned that adversarial states aim to make allies less dependent on the United States, potentially turning them into economic “vassals” of hostile regimes.Beyond geopolitics, Dimon highlighted the broader macro‑economic outlook. He warned that the war could generate "sticky" inflation, higher commodity prices, and disrupted supply chains, which together may force interest rates higher than markets currently anticipate. He echoed other economists in warning that inflation could rise rather than fall in 2026.Despite these challenges, Dimon expressed optimism about the U.S. economy, affirming his belief that "the American Dream is alive." He also turned to emerging technology, noting that artificial intelligence could deliver breakthroughs in healthcare, manufacturing, and safety, ultimately shortening the work week and extending life expectancy.Dimon’s annual letter—spanning nearly 50 pages and more than 20,000 words—remains a barometer for Wall Street sentiment. In it, he also critiqued the administration’s tariff policy, arguing that while tariffs have forced renegotiations, a comprehensive foreign‑economic strategy should promote growth both for the United States and its partners.As transatlantic relations strain under soaring energy costs and divergent trade policies, Dimon’s call for a coordinated economic front underscores a pivotal moment: the United States must decide whether to lead a cohesive democratic coalition or risk ceding influence to autocratic powers.