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The Cultural Phenomenon Returns On a chilly morning at a Silvertown studio behind London City airport, the sunburst intro to Jimmy Cliff's The Harder They Come is on repeat. Dancers run through a routine studded with reggae and dancehall moves. "Get high," commands associate choreographer Neisha-yen Jones with a smile. "Get low!" The ensemble rise and dip. They do the bogle and whine around each other as their watchful director Matthew Xia nods along. They circle Natey Jones who breaks out the opening line: "Well, they tell me of a pie up in the sky." In the distance, a plane leaves the ground. From Film to Theatrical Celebration It's eight months since The Harder They Come's full-throttle takeoff at Stratford East, where the musical was so popular that it is now returning for a second run which will also serve as a eulogy for Cliff who died in November. Playwright Suzan-Lori Parks' adaptation of Perry Henzell's 1972 Jamaican film is bolstered by a handful of her own songs as well as classics including Israelites and Wonderful World, Beautiful People – plus every number on the film's monumental soundtrack. Jones is reprising the role of Ivan (played on screen by Cliff and inspired by real-life outlaw Rhyging), who arrives in Kingston from the country and is dismissed and exploited, before becoming both a hit singer and a fugitive. The Evolution of a Cultural Narrative The original was akin to cinéma vérité, directly evoked spaghetti westerns and veered into blaxploitation territory; Ivan's tale has gained greater warmth, humour and protest spirit on stage. It was the best musical I saw in 2025. "The story is a tragedy but the theatrical event is a celebration," says Xia of his production. Twenty years ago, the film was adapted as a musical with a book by Henzell, also at Stratford East. "It all started at Ivan's Nine Night," Xia recalls. "There was a massive poster of Ivan on the wall, with everyone coming, and it was told in retrospect with vignettes." Choreography and Cultural Connection Shelley Maxwell, recently arrived from Jamaica, was watching the musical in the audience one night and has since become the choreographer of the new production. She has fused the folk dance forms of revivalism and pocomania, learned in her childhood, with reggae, dancehall and moves that today's teenagers can recognise. "I wanted to tap into the youth market," she says. It's brought some enthusiastic feedback from audience members who may not know the film. "Like: 'Oh my God, they did that step I always do at a party!' It allows them to form a connection." Authenticity and Cultural Representation Xia, wearing trainers in the Jamaican flag's colours, and Maxwell, whose tracksuit has the same black, green and gold trim, were intent on instantly transporting their audience to Kingston. The opening, says the director, is an "establishing shot" with characters coming and going on Simon Kenny's magnificent multi-level set, accompanied by Toots and the Maytals' hit Funky Kingston. To borrow from its lyrics, you really can believe everything they do. Even each move in the dominoes game we see is scripted, explains Maxwell, who mapped out the market scene with precision: "Where are you going to? How heavy is the item that you're holding? This is the swing of the hips." Social Commentary Through Performance Xia, whose father came to England from Jamaica in the 1970s, praises the freewheeling realism of the film. "Lots of the background performers are just whoever happened to be in the market that day, or walking through the shantytown. Lots of the actors were people that Perry knew, they had no training." Henzell, says Xia, showed "the part of Jamaica that had always been hidden, people living hand to mouth". The musical depicts a "quartet of oppression" against Ivan, as he takes a stand against individuals representing hypocrisies of the church, law, drugs trade and music industry. Universal Themes and Contemporary Relevance The Harder They Come was both a pioneering example of independent film-making for Jamaicans and a portrait of a newly independent country. Maxwell, who grew up glued to Hollywood musicals, says it was empowering to discover a film full of the Jamaican songs she loved. "I was probably way too young when I saw it. But what I saw was the world around me." She traces how different forms of music played a pivotal part in the country establishing its identity, moving from African forms and American R&B; to mento, ska, rocksteady, reggae and the rise of Bob Marley and Jimmy Cliff. Maxwell captures that chain reaction with a tantalizing question: "What's this groove becoming?" Transforming the Narrative for Modern Audiences The musical also makes its hero's actions more understandable. "In the film, Ivan becomes a kind of wanton murderer," says Xia. In the musical, "he accidentally shoots a police officer when he's under threat, is remorseful, yet also knows that if he gives himself in then that's the end of his journey". Another significant change is the depth given to the principal women – Ivan's mother Daisy and Elsa, with whom he falls in love under the eye of her authoritarian guardian, the preacher. "The moral heart of the piece now resides in those two women," says Xia. Maxwell transforms a brief sequence from the film, in which Ivan imagines a tryst with the devout Elsa, into a floor-trembling set piece when the preacher's congregation lose their robes to indulge in lustful fantasy. The male gaze of the original scene is duly excised: "it had to be like it was both of them in partnership in that fantasy world," says Maxwell, who adds that the nature of dancehall – "grinding, gyrating on another body" required her to use her skillset as an intimacy director.

Study Shows Fetal Exposure to Vegetable Flavours Influences Post‑Birth PreferencesThe research team gave pregnant volunteers powdered kale or carrot capsules during the third trimester and later measured their children’s facial reactions to the same smells. Reactions were recorded via ultrasound before birth, repeated at three weeks, and again when the children were about three years old.Methodology: Kale and Carrot Powder Capsules Administered to Expectant MothersParticipants were asked to swallow a capsule each day containing either kale or carrot powder. The study avoided large volumes of juice, which many volunteers found unpalatable, opting for a low‑cost capsule format.Capsules administered in late pregnancy (around 32 weeks gestation).Initial chemosensory response captured with ultrasound imaging.Follow‑up assessments at 3 weeks and 3 years post‑birth.Sample Size and Observed Reactions Reveal Early Flavor MemoryAlthough the cohort was modest, the findings were consistent:12 children were observed at age three.Infants exposed to carrot powder smiled when presented with a carrot scent and grimaced at kale, and vice‑versa for the kale group.The same preference pattern was evident in the ultrasound scans before birth.These results suggest that flavour exposure in utero can create a durable chemosensory memory.Potential Public‑Health Benefits of Early Dietary ConditioningIf replicated on a larger scale, the approach could offer a low‑cost strategy for improving population nutrition:Reducing childhood resistance to vegetables may lower long‑term risks of obesity and diet‑related diseases.Capsules are inexpensive and could be integrated into routine prenatal supplements.The concept is adaptable to different cultural diets, as noted by the researchers’ interest in fish‑rich Japanese diets.Next Steps: Larger Trials and Cross‑Cultural ApplicationsThe authors acknowledge the need for a bigger, funded study to confirm the effect across diverse populations. Future research aims to:Expand the sample size to hundreds of mother‑child pairs.Test additional flavours and odourants, including artificial sweeteners.Explore policy pathways for incorporating flavour‑exposure capsules into prenatal care guidelines.Published in Developmental Psychobiology, the paper titled “Do Human Fetuses Form Long‑Lasting Chemosensory Memories?” opens a new avenue for early nutritional interventions.

The Lead A recent study has provided evidence that crickets may experience pain in a similar way to humans and other animals. Researchers at the University of Sydney have found that crickets exhibit behaviors that resemble pain responses when injured, such as stroking and grooming a sore antenna. Cricket Pain Response Study Associate Professor Thomas White, an entomologist from the University of Sydney, led the study, which was published in Proceedings of the Royal Society. The researchers applied a heated soldering iron to the antennae of dozens of crickets, causing a temporary but unpleasant sensation. The crickets that received the hot probe 'overwhelmingly' directed their attention to the affected antenna, grooming it more frequently and for a longer period than those that did not receive the treatment. The Data Analysis The study found that: Crickets that received the hot probe directed their attention to the affected antenna. They groomed the antenna more frequently and for a longer period. The soldering iron was set to 65C, hot enough to be unpleasant but not causing lasting harm. The Impact Analysis This research has significant implications for our understanding of insect cognition and pain. The study's findings suggest that insects may be capable of experiencing pain, which challenges traditional views of their cognitive abilities. This has important implications for animal welfare, particularly for insects that are farmed for food, feed, and research. The Prediction As science continues to reveal more about insect brains, behavior, and experiences, it is likely that our understanding of their capacity for pain and consciousness will evolve. This may lead to changes in animal welfare laws and our treatment of insects in various industries. Ultimately, this research encourages us to reevaluate our relationship with insects and consider their well-being.

The Sudden Passing of Brandon Clarke Memphis Grizzlies forward Brandon Clarke has died at the age of 29, his sports agency has confirmed. “We are beyond devastated by the passing of Brandon Clarke,” Priority Sports said. “He was so loved by all of us here, and everyone whose life he touched. He was the gentlest soul who was the first to be there for all of his friends and family. Our hearts are so broken as we think about his mom, Whitney, his entire family and all of his friends. From high school to San Jose State to Gonzaga to the Grizzlies, Brandon impacted everyone who was part of his life.” Clarke's Basketball Career and Community Impact Clarke had a standout college career with San Jose State and Gonzaga before he was picked by the Oklahoma City Thunder with the 21st overall selection of the 2019 draft. He was named to the NBA All-Rookie team in his first season in Memphis. He signed a four-year extension with the Grizzlies in 2022 but missed most of the past season after undergoing knee surgery. Clarke was born in Vancouver before his family moved to the United States when he was a child. He was active in the Memphis community and celebrated his 29th birthday by donating books and resources to a local elementary school. Clarke's Legacy and Off-Court Contributions “Every time I talk to kids, I try to get that in their minds that school is important, teachers are important and grades matter,” Clarke told the Memphis Commercial Appeal. “I couldn’t have made it here without locking in on reading, writing and all of that stuff.”

The Lead OpenAI CEO Sam Altman took the stand to defend himself against Elon Musk's lawsuit challenging OpenAI's corporate structure. Musk's lawsuit alleges that OpenAI's founders "stole a charity" when they launched a for-profit subsidiary. Musk's Allegations and Altman's Response Altman described Musk's allegations as "difficult to wrap my head around" and emphasized that OpenAI's foundation, with $200 billion in assets, is doing "incredible work." Musk's attorneys pointed out that OpenAI's foundation didn't have full-time employees until earlier this year, but OpenAI board chair Bret Taylor explained that this was due to the challenge of converting equity to cash. The Safety Commitment Debate Musk's lawyers questioned whether OpenAI's commitment to safety had been compromised as its commercial power grew. Altman revealed that in 2017, Musk's "specific plans on safety made me worry." He described a pivotal moment when Musk suggested that OpenAI should pass to his children if he were to die. Altman's Concerns About Musk's Management Altman testified that Musk's management tactics, which might have worked for engineering and manufacturing, didn't suit OpenAI. He claimed that Musk had demotivated key researchers and damaged the organization's culture. Altman defended the "sweat equity" of fellow cofounders Greg Brockman and Ilya Sutskever. The Aftermath and Current Lawsuit Musk ultimately left OpenAI's board and started competing AI initiatives. OpenAI's lawyers noted that Musk had been kept up to date and asked to participate in investments, which his lawsuits now claim corrupted the non-profit. A 2018 discussion about a Microsoft investment was described as a "good vibes meeting" where Musk shared memes on his phone.

The Orbital Data Center Partnership Google and SpaceX are in talks to launch orbital data centers in space, according to a report from The Wall Street Journal citing sources familiar with the matter. This potential collaboration comes as both tech giants position themselves at the forefront of next-generation computing infrastructure. SpaceX's Ambitious IPO Strategy The potential deal coincides with SpaceX's preparations for its $1.75 trillion IPO later this year. The company is selling investors on the vision that data centers in space will become the most cost-effective locations for AI compute within the next few years. This orbital data center concept represents a significant shift from traditional ground-based infrastructure to space-based solutions. Financial Implications and Previous Investments SpaceX's orbital data center ambitions follow its recent deal with Anthropic to use computing resources from xAI's data center in Memphis, Tennessee, with potential future collaboration on orbital facilities. (SpaceX acquired xAI in February.) Meanwhile, Google has previously invested $900 million in SpaceX back in 2015, according to regulatory filings, demonstrating the long-term strategic relationship between the two companies. Google's Broader Space Infrastructure Plans Google is reportedly in discussions with other rocket-launch companies beyond SpaceX, indicating a multi-faceted approach to space-based infrastructure. The company has also announced Project Suncatcher, an initiative with plans to launch prototype satellites by 2027. This suggests Google is hedging its bets and exploring various pathways to space-based data solutions. The Economics of Orbital vs. Terrestrial Data Centers Elon Musk has actively created hype around orbital data centers, claiming they are cheaper to operate than their Earth-based counterparts. Proponents also highlight that space-based facilities would be free from the local community backlash that often accompanies U.S. ground-based data center expansions. However, as TechCrunch recently reported, today's terrestrial data centers remain significantly more cost-effective than orbital ones when satellite construction and launch expenses are factored into the equation. The Future of Space-Based Computing As the race for AI compute resources intensifies, the concept of orbital data centers represents both a bold vision and significant technical challenges. While current economics favor ground-based facilities, advances in rocket technology and satellite manufacturing could potentially shift this balance in the coming decades. The discussions between Google and SpaceX underscore the growing interest in space as a frontier for technological infrastructure development.

The LeadRobert Smith, a distinguished pharmacologist and professor at St Mary's medical school in London (now part of Imperial College), has died aged 92. His groundbreaking work on how genetic variations affect drug responses helped shape the field of personalized medicine.The Discovery of Debrisoquine PolymorphismBob became well known for his role in the discovery of "debrisoquine polymorphism." In 1975, as one of five volunteer researchers who took debrisoquine, a blood pressure medication, he was the only one to suffer adverse effects (hypotension) and collapse. This led to the discovery of a genetic polymorphism where certain individuals cannot break down specific drugs efficiently. While Bob described this as an "accident waiting to happen," it positioned him at the forefront of pharmacogenetics.Awards and RecognitionSmith's contributions to pharmacology were formally recognized when he became the first recipient of the Paton prize in 1998 for his work in understanding how genes affect drug response. His academic achievements included becoming professor of pharmacology in 1978 and serving as deputy dean of the medical school from 1980-88.Impact on Medicine and SportsSmith's research fundamentally changed how medical professionals understand drug responses, paving the way for personalized medicine approaches. Beyond human medicine, he applied these principles to horse racing, chairing the UK Horserace Scientific Advisory Committee (1979-99) and its pan-European equivalent (1992-2005). He also served as a director of the Horseracing Forensic Laboratory in Newmarket during the 1990s, helping shape anti-doping protocols.Enduring LegacySmith never fully retired, continuing his research as emeritus professor until publishing his last paper in 2020. His legacy extends beyond scientific contributions to include the principles, warmth, kindness and generosity he embodied throughout his career. His work continues to influence pharmacology and personalized medicine, ensuring his impact will be felt for generations to come.

The Devastating Impact on Lebanese Education Israel's war in Lebanon has created a 'lost generation' of students, widening societal disparities and damaging national unity, experts have warned. The conflict has destroyed schools across southern Lebanon and displaced hundreds of thousands of students, with many educational institutions turned into makeshift shelters for displaced people. The Scale of the Crisis According to UNESCO, 339 schools are located in warzones in Lebanon, while hundreds more are acting as collective shelters, affecting access to education for another 250,000 children. Since March, Israeli attacks have displaced more than 1.2 million people in Lebanon, including 500,000 school-aged children. The Shift to Online Learning Some schools have turned to online learning, but experts say this has its drawbacks, particularly for students from lower-income families. Limited internet access, electricity shortages, and lack of devices have hindered students' ability to access education. The Long-Term Consequences Experts warn that the crisis will have long-term consequences, including increased inequalities, child labor, and child marriage. The economic crisis in Lebanon has already led to a significant erosion of the middle class, with the country's Gini coefficient rising from 0.32 in 2011 to 0.61 in 2023. The Need for Urgent Intervention Experts stress the need for urgent and sustained intervention to address the crisis, including out-of-the-box thinking to support students and teachers. The fear is that without serious nationwide intervention, these disparities will have long-term consequences and leave an entire generation further behind.

The Lead The hantavirus outbreak on the MV Hondius cruise ship has sparked fears, but health experts emphasize that it is distinct from COVID-19 in several critical ways. As the last passengers are evacuated and quarantined, researchers are working to understand the origins of the outbreak and mitigate its spread. What is the Hantavirus? Hantaviruses are a family of viruses that cause two main illnesses in humans: hantavirus pulmonary syndrome (HPS) and haemorrhagic fever with renal syndrome (HFRS). The viruses are transmitted to humans by rodents, primarily through their urine, saliva, and droppings. HPS has a high fatality rate of about 40%, while the death rate for HFRS varies from 1% to 15%. Can Hantavirus Spread from Person to Person? The Andes strain of the hantavirus, which causes HPS, is the only hantavirus clearly shown to spread from person to person, but only to a limited extent. This transmission occurs through close, prolonged contact, such as within a household or intimate contact. It does not spread like an airborne virus through casual social contact. The Event Details The MV Hondius cruise ship, which departed from South America on April 1, had 150 people from 23 countries on board. Three people have died in the outbreak on the ship. The European Centre for Disease Prevention and Control (ECDC) hypothesizes that some passengers caught the hantavirus while in Argentina, where the virus is endemic. The Data Analysis 11 confirmed hantavirus infections from the MV Hondius outbreak 3 deaths reported 94 people evacuated and repatriated to about 20 countries 18 American passengers evacuated, with 1 testing positive in a biocontainment unit in Nebraska The Impact Analysis The hantavirus outbreak highlights the need for vigilance and proper public health measures. While the risk of a pandemic is low due to the limited human-to-human transmission, experts stress the importance of monitoring for symptoms and quarantine measures for those exposed. The Prediction Experts believe that the chances of hantaviruses causing the next pandemic are low due to their transmission dynamics. The risk to the general population in Europe remains low, and widespread transmission is not expected. Proper precautions, including quarantine and protective gear for healthcare workers, are crucial to controlling the spread.