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The Power of Negative ExpectationIn her latest book, Helen Pilcher investigates the profound connection between the mind and the body, specifically focusing on the phenomenon where negative beliefs can cause physical illness. Drawing on Roald Dahl’s The Twits, Pilcher illustrates the age-old intuition that ugly attitudes deform the face. However, her work moves beyond fiction to explore the scientific reality of the nocebo effect—a Latin term meaning "I will harm"—which occurs when a person's negative expectations lead to symptoms.Deconstructing the Nocebo EffectThe nocebo effect operates on a simple yet powerful psychological principle: the more you are warned to expect a symptom, the more likely you are to experience it. This is often described as the psychological equivalent of the "pink elephant" paradox; if you are told not to think of a pink elephant, you inevitably do. Pilcher analyzes 231 placebo-controlled clinical trials, finding that 76% of people in experimental groups reported side-effects, compared to 73% of those on a placebo. This suggests that most of us experience bodily sensations, but the nocebo effect causes us to misattribute these harmless feelings to medication.Measurable Biological ShiftsPilcher argues that the impact of the nocebo effect is not merely subjective but measurable. She highlights a striking study from Stanford where participants were told they possessed a gene associated with either high or low obesity risk, regardless of their actual genetics. The results showed that those told they had the "skinny" gene experienced a significant increase in GLP-1 (a hormone that induces satiety) after a meal, while those told they had the "fat" gene showed no change. Furthermore, Pilcher discusses research where stimulating a specific area of a mouse's brain associated with positive emotion was found to curb cancer growth, while dampening it accelerated it. This challenges the boundary between mental processes and physical disease.From Mass Panic to Medical PracticeThe book delves into the history of mass psychogenic illness (MPI), where collective anxiety spreads symptoms through a population. Historically limited by geography, MPI today can go viral due to global communication and social media. A prime example cited is the 2014 outbreak in Colombia, where social media was thought to transmit symptoms among schoolgirls who had received the HPV vaccine. Despite health officials finding no link, public confidence collapsed, dropping immunization rates from over 90% to 5%. This case underscores the vulnerability of public health to the nocebo effect at scale.The Future of Mind-Body MedicinePilcher’s work raises central philosophical questions about the nature of mind and matter. While she cautions against drawing direct parallels between mouse brain stimulation and human thought, the evidence suggests that our internal narratives can significantly alter our biology. Ultimately, understanding the nocebo effect offers a path to mitigate its negative impacts, potentially allowing individuals to avoid self-fulfilling prophecies of illness. As Pilcher notes, avoiding the nocebo effect is a "pretty good one" side-effect to have.

The Doomsday Clock: A Symbol of Humanity's Existential Threats The Earth is facing unprecedented dangers, from rising temperatures and raging conflicts to the infiltration of AI in critical decision-making processes. The Doomsday Clock, maintained by the Bulletin of the Atomic Scientists, serves as a stark reminder of these threats, currently set at 85 seconds to midnight. The Origins of the Doomsday Clock Established in 1947 by a group of Manhattan Project scientists, the Doomsday Clock was designed to symbolize the urgency of the nuclear age. The first setting was seven minutes to midnight, chosen for its aesthetic appeal. Since then, the clock has been adjusted numerous times in response to global events. Key Milestones in the Clock's History 1947: The first clock setting at seven minutes to midnight. 1949: Moved to three minutes to midnight after the Soviet Union's first nuclear test. 1953: Set to two minutes to midnight following the development of the hydrogen bomb. 2023: Set to 90 seconds to midnight, the closest to apocalypse in its history. The Current State of Global Threats According to Alexandra Bell, CEO of the Bulletin of the Atomic Scientists, the world is sleepwalking into increasing dangers. The intertwining of climate change, nuclear proliferation, and AI integration into military strategies has created a perfect storm of risks. Bell emphasizes the need for leadership and diplomatic efforts to mitigate these threats. The Future of the Doomsday Clock The Doomsday Clock is more than a symbol; it's a call to action. Its setting is determined annually by the Bulletin's science and security board, comprising leading scientists, academics, and diplomats. The clock's message is clear: humanity must act collectively to prevent its own destruction.

The Hantavirus Outbreak on the Cruise Ship The World Health Organization (WHO) has confirmed five cases of hantavirus linked to deaths aboard a cruise ship in the Atlantic Ocean. Another three cases are suspected of being linked to the Andes strain of the hantavirus. The WHO says more cases are possible, but the risk to public health remains low. Details of the Outbreak Speaking to reporters on Thursday, the UN health agency’s chief, Tedros Adhanom Ghebreyeus said the WHO had been notified by the UK of a cluster of passengers with severe respiratory illness on the Hondius cruise ship, currently sailing from Cape Verde in the Atlantic to the Spanish island of Tenerife. “While this is a serious incident, WHO assesses the public health risk as low,” Ghebreyeus told reporters. Eight cases have been reported so far, including three dead, five confirmed and three suspected, he said. Understanding Hantavirus Hantaviruses are a group of viruses carried by rodents that can cause severe disease in people. They usually get infected through contact with infected rodents, their urine, droppings or saliva. The strain of hantavirus detected on the Dutch-flagged cruise ship is the Andes virus. It has been found in Latin America and is the only hantavirus known to be capable of limited human-to-human transmission. The Investigation and Response Before boarding the ship, the first two victims had travelled in Chile, Argentina and Uruguay on a bird watching trip, which included visits to sites home to rats known to carry hantavirus. Argentine authorities are investigating the couple’s movements. The WHO informed 12 countries whose nationals disembarked in Saint Helena. They are from Britain, Canada, Denmark, Germany, the Netherlands, New Zealand, Saint Kitts and Nevis, Singapore, Sweden, Switzerland, Turkiye and the United States.

The Lead China has ordered its citizens and companies not to comply with United States sanctions against five Chinese refineries accused of handling Iranian oil, deploying a law intended to counteract 'extra-territorial' punitive measures for the first time. Understanding China's Anti-Sanctions Order China's Ministry of Commerce issued the 'prohibition order' after the US Department of the Treasury last month announced sanctions targeting one of China's biggest independently run 'teapot' refineries. The ministry stipulated that the US sanctions on Hengli Petrochemical (Dalian) refinery and four other refineries 'shall not be recognised, enforced or complied with'. The sanctions were deemed to 'improperly' restrict normal trade and business activities in violation of international law. The Data Analysis China is Iran's largest trade partner and by far the biggest buyer of Iranian oil. Chinese buyers received more than 80 percent of Iran's oil shipments in 2025, according to market intelligence firm Kpler. The US Treasury Department imposed the latest sanctions after accusing Hengli of generating hundreds of millions of dollars in revenue for Iran's military via crude oil purchases. The Impact Analysis The move signals that Beijing is taking a more assertive approach to countering sanctions. Companies risk facing the wrath of Washington or Beijing, depending on which measures they comply with. This potentially puts them in a difficult position, with firms likely to approach the competing pressures based on their respective levels of exposure to the US and Chinese markets. The Prediction China's anti-sanctions law could be seen as a model for other countries seeking to counter US pressure. However, it remains to be seen whether other countries will follow China's lead. The law's most significant long-term effect could be to inspire other powers such as Russia and the European Union to adopt similar measures.

The Escalating Protests in Bolivia Protests in Bolivia have entered the third day with three separate groups calling for reforms to agricultural, educational and labour policies. The country’s main trade union, the Bolivian Workers’ Centre (COB) union, issued a strike call last Friday, coinciding with labour reform protests around the globe to mark International Workers’ Day. The Economic Crisis Fueling the Protests The South American nation was already facing a currency shortage, causing its largest economic crisis in 40 years. On Tuesday, COB, alongside transport and education workers, took to the streets, leading to clashes with police. Law enforcement officers fired tear gas at protesters near the presidential palace in La Paz, and in nearby El Alto, public workers blocked the streets with buses, cars and trucks. The Demands of the Protesters They are demanding compensation from the government for the damage. The strikes brought public transport to a halt in several major cities around the country. Among them are the administrative capital, La Paz, as well as El Alto, Cochabamba, Oruro, and the constitutional capital, Sucre. They have created at least 70 roadway blockages, according to the Bolivia Highway Association. The Government's Response Bolivia has faced a budgetary crisis and is running low on foreign currency reserves. Last year, Paz and his centre-right government replaced socialists who had been in power for decades, and at the time, Paz said that the country was in an “economic, financial, energy, and social emergency”. When Paz took office, the country’s total debt was 95 percent of GDP, and it had consistent deficits that mirrored the country’s commodity collapse in 2014. Bolivia’s liquid reserves were less than one month of imports, according to analysis from the non-partisan global economic think tank Finance for Development Lab. The Future Outlook COB has called for an indefinite general strike. “Starting today, a general, indefinite and active strike is declared, until the government understands the people’s demands,” COB’s Secretary-General Mario Argollo told a group of 1,000 supporters on Friday amid the calls for the protest in El Alto. Among the demands are a 20 percent increase to the nation’s minimum wage, which currently sits at 3,300 bolivianos ($477.71) per month and took effect in January. That is an increase from 2,750 bolivianos ($398) set in 2025.

Breaking Down the Complex Language of AI Artificial intelligence is changing the world, and simultaneously inventing a whole new language to describe how it’s doing it. Spend five minutes reading about AI and you’ll run into LLMs, RAG, RLHF, and a dozen other terms that can make even very smart people in the tech world feel insecure. This glossary is our attempt to fix that. We update it regularly as the field evolves, so consider it a living document, much like the AI systems it describes. Artificial General Intelligence (AGI) Artificial general intelligence, or AGI, is a nebulous term. But it generally refers to AI that’s more capable than the average human at many, if not most, tasks. OpenAI CEO Sam Altman once described AGI as the “equivalent of a median human that you could hire as a co-worker.” Meanwhile, OpenAI’s charter defines AGI as “highly autonomous systems that outperform humans at most economically valuable work.” Google DeepMind’s understanding differs slightly from these two definitions; the lab views AGI as “AI that’s at least as capable as humans at most cognitive tasks.” Confused? Not to worry — so are experts at the forefront of AI research. AI Agent An AI agent refers to a tool that uses AI technologies to perform a series of tasks on your behalf — beyond what a more basic AI chatbot could do — such as filing expenses, booking tickets or a table at a restaurant, or even writing and maintaining code. However, as we’ve explained before, there are lots of moving pieces in this emergent space, so “AI agent” might mean different things to different people. Infrastructure is also still being built out to deliver on its envisaged capabilities. But the basic concept implies an autonomous system that may draw on multiple AI systems to carry out multistep tasks. API Endpoints Think of API endpoints as “buttons” on the back of a piece of software that other programs can press to make it do things. Developers use these interfaces to build integrations — for example, allowing one application to pull data from another, or enabling an AI agent to control third-party services directly without a human manually operating each interface. Most smart home devices and connected platforms have these hidden buttons available, even if ordinary users never see or interact with them. As AI agents grow more capable, they are increasingly able to find and use these endpoints on their own, opening up powerful — and sometimes unexpected — possibilities for automation. Chain-of-Thought Reasoning Given a simple question, a human brain can answer without even thinking too much about it — things like “which animal is taller, a giraffe or a cat?” But in many cases, you often need a pen and paper to come up with the right answer because there are intermediary steps. For instance, if a farmer has chickens and cows, and together they have 40 heads and 120 legs, you might need to write down a simple equation to come up with the answer (20 chickens and 20 cows). Coding Agent This is a more specific concept that an “AI agent,” which means a program that can take actions on its own, step by step, to complete a goal. A coding agent is a specialized version applied to software development. Rather than simply suggesting code for a human to review and paste in, a coding agent can write, test, and debug code autonomously, handling the kind of iterative, trial-and-error work that typically consumes a developer’s day. Compute Although somewhat of a multivalent term, compute generally refers to the vital computational power that allows AI models to operate. This type of processing fuels the AI industry, giving it the ability to train and deploy its powerful models. The term is often a shorthand for the kinds of hardware that provides the computational power — things like GPUs, CPUs, TPUs, and other forms of infrastructure that form the bedrock of the modern AI industry. Deep Learning A subset of self-improving machine learning in which AI algorithms are designed with a multi-layered, artificial neural network (ANN) structure. This allows them to make more complex correlations compared to simpler machine learning-based systems, such as linear models or decision trees.

The Limited Time Offer Only two days are left to secure a spot at TechCrunch Disrupt 2026 with a 50% discount on a second pass. This offer is available for all types of passes, including Founder, Investor, Attendee, Non-profit, and Expo+. The Benefits of Attending Disrupt 2026 Attendees will have access to high-impact programming, unparalleled networking opportunities, and real-time insights from industry leaders. The event features a range of sessions, including the Startup Battlefield 200, where founders pitch live in front of seasoned VC judges and a global audience. The Importance of Bringing a Second Person Bringing a co-founder, operator, or partner can accelerate clarity and decision-making. Attendees can compare interpretations in real-time, challenge assumptions, and make better decisions while the context is still fresh. Pass Options Founder Pass: Access investor meetings, Deal Flow Café, curated networking, and programming on scaling, fundraising, and growth. Investor Pass: Connect directly with founders, access curated deal flow, and participate in investor-focused sessions and networking. Attendee Pass: Full access to stages, breakouts, roundtables, and networking to understand what's working across the ecosystem. Non-profit Pass: Explore how emerging tech applies to mission-driven organizations and connect with builders and partners. Expo+ Pass: Focused access to the Expo Hall, breakouts, and networking. Don't Miss Out The offer ends on May 8 at 11:59 p.m. PT. Register now to secure your spot and bring someone with you at 50% off.

The Lead At the Milken Institute Global Conference, leaders from across the AI supply chain gathered to discuss the current state and future of artificial intelligence. They touched on various challenges, including chip shortages, energy constraints, and the potential for new AI architectures. The Bottlenecks in AI Development The discussion highlighted several bottlenecks in AI development. Christophe Fouquet, CEO of ASML, noted that despite efforts to accelerate chip manufacturing, the market will likely remain supply-limited for the next two to five years. Francis deSouza, COO of Google Cloud, pointed out the immense demand for AI infrastructure, with Google Cloud's revenue growing 63% and its backlog nearly doubling to $460 billion. The Data and Energy Constraints Qasar Younis, co-founder and CEO of Applied Intuition, emphasized that the bottleneck for his company is not silicon but data gathered from the real world, which is essential for training physical AI models. The energy required to power AI infrastructure is also a significant concern. deSouza mentioned that Google is exploring data centers in space to address energy constraints, although this comes with its own set of challenges. New AI Architectures and Their Implications Eve Bodnia, founder of Logical Intelligence, discussed a different approach to AI, focusing on energy-based models (EBMs) that aim to understand the underlying rules of data, similar to human brain function. This approach could be particularly useful for applications requiring an understanding of physical rules, such as chip design and robotics. The Future of AI: Agents, Guardrails, and Trust Dmitry Shevelenko, chief business officer of Perplexity, talked about the evolution of its search product into a 'digital worker' called Perplexity Computer. This tool is designed to act as a staff that a knowledge worker can direct, raising questions about control and security. Shevelenko emphasized the importance of granularity in permissions and actions to ensure trust and security. The Geopolitical and Generational Impact The discussion also touched on the geopolitical implications of physical AI and its impact on national sovereignty. Younis noted that physical AI manifests in the real world in ways that governments can't ignore, leading to questions about safety, data collection, and control. Regarding the impact on the next generation, the panelists were optimistic, highlighting the potential for AI to help address significant problems and unleash new levels of creativity and opportunity.

The Disappointment of a Missed Opportunity Millwall's dreams of automatic promotion to the Premier League were short-lived, lasting only three minutes into their match against Oxford. The Lions were eager to capitalize on Ipswich's result against QPR, but the news of Ipswich's goal quickly dampened the atmosphere at The Den. The Event Details The match against Oxford was a strange occasion, with Millwall needing a better result at home than Ipswich to secure promotion. However, with Ipswich taking the lead against QPR, the pressure was off, and the game became more about securing a playoff spot. Millwall's manager, Neil, had emphasized the importance of focusing on their own game rather than results elsewhere. The Data Analysis Millwall finished third in the Championship, securing a playoff spot. Although they did not achieve automatic promotion, their third-place finish and participation in the playoffs come with a significant prize. The exact financial details of the prize were not specified, but it is a notable reward for the team's performance. The Impact Analysis The disappointment of missing out on automatic promotion will linger, but Millwall can take pride in their performance throughout the season. The team's players, mostly EFL old hands, understand the significance of this opportunity. A successful playoff run could still lead to promotion, providing a chance for the players to experience the top tier. The Prediction While Millwall's automatic promotion hopes are dashed, their focus will shift to the playoffs. A strong performance in the playoffs could still secure a Premier League spot, providing a thrilling conclusion to the season. The team's manager, Neil, expressed pride in his team's performance, and with the right mindset, they can still achieve their goal.