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Peptides are short chains of amino acids that naturally occur in the body, acting as hormones such as insulin, oxytocin and vasopressin, or as fragments released during protein digestion.In recent years, a wave of interest has turned these molecules into purported therapeutic agents for everything from weight loss to anti‑ageing and tissue repair. Prescription drugs like semaglutide (Wegovy) and tirzepatide (Mounjaro) are synthetic peptides that have undergone rigorous clinical testing and are approved for specific medical uses.However, a large portion of the market consists of unregulated, experimental peptides sold for self‑administration. These products often bypass the strict approval processes required for medicines, raising serious safety concerns.Who is using these products? Initially confined to a niche of powerlifters and bodybuilders in the 2010s, the audience has expanded dramatically. Influential figures such as podcaster Joe Rogan have promoted combinations like the “Wolverine stack” (BPC‑157 and TB‑500) for injury recovery, while other compounds—CJC‑1295, MK‑677, ipamorelin, and GHK‑Cu—are marketed for muscle growth and anti‑ageing. Social media platforms are now flooded with instructions on purchasing and injecting these substances.Scientific backing is scant. Reviews of the literature reveal that most experimental peptides have only been tested in animal or cell models. For example, BPC‑157 shows promise for tendon and muscle repair in pre‑clinical studies, but no randomized human trials have validated these effects. Similarly, TB‑4 and its synthetic analogue TB‑500 have demonstrated limited blood‑vessel formation in laboratory settings, yet human data are absent and both are listed as prohibited substances by the World Anti‑Doping Agency.Researchers also highlight a critical knowledge gap: dosage, frequency and treatment duration remain undefined, making self‑administration a gamble.Legal landscape in the UK is clear that peptides not classified as medicines fall outside the Medicines and Healthcare products Regulatory Agency’s (MHRA) remit. If a seller makes medicinal claims, the product must hold a marketing authorisation under the Human Medicines Regulations 2012. The MHRA warns that labeling items as “research use only” does not shield vendors from enforcement when evidence shows the products are intended for human consumption.Health risks are multi‑fold. Experts caution that benefits observed in animal studies do not guarantee safety in humans. Contamination with harmful impurities or bacterial endotoxins can trigger severe reactions, including septic shock. Injecting excess natural peptides may disrupt the body’s tightly regulated hormonal balance, potentially affecting multiple physiological pathways.There is also theoretical concern that augmenting peptide levels could accelerate tumour growth, as some cancers over‑express certain peptide pathways. While no direct cases have been documented, the possibility underscores the need for caution.Additional dangers include improper injection techniques (e.g., air embolism), unknown interactions with existing medications, and the lack of systematic monitoring of long‑term effects. As one researcher put it, “If something goes wrong, users may never notice until irreversible damage has occurred.”

The UK medicines regulator has opened an inquiry into a growing number of clinics that sell injectable peptides while promoting them as cures for everything from ageing to injury recovery. The investigation, disclosed by the Guardian, focuses on whether these businesses are breaching the Human Medicines Regulations 2012 by making unauthorised medicinal claims. Interest in peptide‑based treatments has surged in recent years, driven by social‑media influencers, some healthcare professionals, and direct‑to‑consumer marketers. Yet the scientific foundation for most of these claims is weak, with the bulk of research confined to animal models or cell‑culture studies. According to an MHRA spokesperson, any clinic that advertises a peptide as having therapeutic benefits must treat the product as a medicine, which triggers a comprehensive regulatory framework. "If clinics offering peptide injections make medicinal claims for those treatments, the products will be considered medicines and subject to regulation," the agency warned, adding that it will act against any identified breaches. Guardian reporters identified several high‑ranking Google search results that list peptides such as Cortexin (promoted for neuroprotection), BPC‑157 (claimed to aid tissue repair), and Thymosin Alpha (advertised to boost immunity). After being contacted, one clinic removed the statements from its website. Another clinic, while acknowledging the limited human evidence, continued to market seven specific peptides, providing price lists (£350 per month for a single peptide, £450 for two) and offering delivery via vials, syringes, or pre‑filled pens for an additional fee. During a free consultation, a clinician highlighted the experimental nature of the products, noting the absence of large‑scale, randomised clinical trials and recommending a break of four to eight weeks between treatment cycles to mitigate unknown risks. The clinician suggested BPC‑157 for post‑exercise recovery, describing it as a facilitator of cellular repair and blood flow, but warned against its use in smokers or individuals with a family history of cancer due to potential angiogenic effects. The second peptide discussed was MOTS‑C, portrayed as a mitochondrial enhancer that could improve stress resilience, lower insulin resistance, and reduce visceral fat by boosting cellular energy production (ATP). The MHRA confirmed it is reviewing whether the clinician’s statements constitute medicinal claims. The clinic defended its approach, emphasizing that it clearly informs clients that the peptides are not licensed medicines and that the evidence base is largely pre‑clinical. In a broader statement, Lynda Scammell, head of borderline products at the MHRA, explained that peptide products may be marketed as cosmetics, supplements, or medicines, and each case is assessed on its intended use, pharmacological effect, and supporting evidence. She added, "We disregard claims that products are for ‘research purposes’ if it is clear that such claims are being used as an attempt to avoid medicines regulations." Peptides are short chains of amino acids, some of which occur naturally (e.g., insulin). While synthetic peptide analogues like semaglutide and tirzepatide have secured approval for weight‑loss treatments, many of the compounds promoted by these clinics remain experimental and lack the rigorous safety and efficacy testing required for medicinal products.

In the devastated streets of Gaza City's Tuffah neighborhood, residents are taking matters into their own hands to rebuild their homes. Mohammed al-Jadba, a 31-year-old father of 10, is using stones from the rubble of his destroyed house and mud to construct a new shelter. His home, once a four-storey building, was reduced to rubble during Israel's genocidal war on Gaza.With Israeli restrictions on imports preventing the entry of essential construction materials like cement, Gaza residents are forced to get creative. Mohammed has been collecting iron, window frames, and door frames from his old house to use in his new build. The mud, mixed with human hair collected from barbershops, is being used to stick everything together.The United Nations estimates that it will cost $70bn to fully reconstruct Gaza, with 92% of residential buildings damaged or destroyed. An urgent $20bn is needed within the first three years to initiate basic recovery and restore essential services. However, reconstruction efforts have been hindered by continued Israeli restrictions on the entry of construction materials and heavy machinery.As a result, Palestinians in Gaza have focused on partial reconstruction, using available materials to make damaged homes habitable. The United Nations Development Programme (UNDP) has worked on over 230 housing units, benefiting more than a thousand people. However, these interventions are temporary solutions, and the real solution remains elusive.Abdel Nasser al-Jalousi, a 55-year-old resident of Khan Younis, has benefited from partial rehabilitation projects. His heavily damaged home has been made habitable with tarpaulins used as substitutes for walls, doors, and room partitions. However, he stresses that these materials are not a long-term fix and will need to be replaced every season.The scale of the crisis remains severe, with over 213,000 families living in tents and widespread damage during winter storms. The situation highlights the need for political will and massive resources to rebuild Gaza and provide sustainable solutions for its residents.

Iranian military units have launched a coordinated search for the two pilots of a United States F‑15 fighter jet that was struck by an Iranian air‑defence system over the country's southwest region. The operation, reported by the state‑run Fars news agency, is the first documented crew‑recovery effort since the US‑Israeli war with Iran began on 28 February. State media released images showing the aircraft's wreckage, including an ejection seat attached to a parachute, underscoring the seriousness of the incident. Reuters cited two U.S. officials confirming that a fighter jet was downed and that a search‑and‑rescue mission is underway for any survivors. Iranian Parliament Speaker Mohammad‑Bagher Ghalibaf used the event to mock President Donald Trump’s repeated claims of victory, posting on social media that the conflict had been reduced from "regime change" to a plea for the location of the pilots. According to Iranian reports, the downed aircraft was an F‑15 likely crewed by two pilots. The Pentagon and U.S. Central Command (CENTCOM) have not issued an immediate comment, a pattern consistent with past Iranian claims that CENTCOM swiftly denied. Local Iranian television broadcast footage of the jet's debris, and officials appealed to civilians to remain vigilant for any survivors. The governor of Kohgiluyeh and Boyer‑Ahmad province announced that anyone who captures the crew would receive special commendation, as relayed by the semi‑official ISNA news agency. U.S. lawmakers responded with statements of support. Senate Minority Leader Chuck Schumer posted on X, "I’m praying for the safe return of the crew aboard the fighter jet and all of those working to rescue them in these dangerous conditions." Since the war's onset, the United States has reported the loss of three F‑15s in a friendly‑fire incident over Kuwait and a refuelling aircraft that crashed in Iraq, killing six crew members. Iran, meanwhile, claims to have downed dozens of U.S. drones and continues to assert that its new air‑defence system, introduced after the 12‑day war, remains operational. While President Trump and his advisers repeatedly assert that the United States has neutralised Iran’s air‑defences, the downing of the jet and the ensuing search highlight the ongoing volatility of the conflict.

Wrexham pulled off a stunning comeback to draw 2-2 against West Brom, significantly boosting their chances of securing a Championship playoff spot. The match saw Isaac Price's deflected free-kick and Josh Maja's penalty give West Brom a strong lead heading into halftime.However, Wrexham mounted an impressive second-half recovery. Josh Windass scored a spectacular goal from 20 yards just two minutes after the restart, and Lewis O'Brien and George Dobson were involved in a controversy that led to an own goal, leveling the score for Wrexham.This draw propels Wrexham into sixth place, just a point above Southampton, who have a game in hand. The two teams are set to face each other in north Wales on Tuesday in a crucial matchup.In other matches, Hull drew 1-1 at Oxford, with Mo Belloumi scoring early in his return from injury. Leicester came from behind to draw 2-2 against Preston, with Patson Daka scoring twice after returning from international duty.Blackburn secured a vital 1-0 win over Birmingham thanks to Todd Cantwell's 69th-minute goal, moving six points clear of the relegation zone. Portsmouth boosted their survival hopes with a 1-1 draw at Norwich, while QPR beat Watford 2-1.In a thrilling match, Swansea came from two goals down to draw 3-3 at Sheffield United. Stoke secured a comfortable 2-0 victory over already-relegated Sheffield Wednesday, extending their unbeaten home run to five matches.

Chris Haskins, Lord Haskins, who has died at the age of 88, was a highly influential figure in British business and politics. He was a key supporter of Tony Blair's New Labour project and played a crucial role in advising on regulatory reform and rural affairs. Early Life and Career Born in Dublin, Ireland, Haskins studied modern history at Trinity College Dublin, where he developed a reputation as a radical. He began his career in journalism, covering the Aldermaston marches for the Irish Times, before moving into business. In 1959, he traveled to England, married Gilda Horsley, and joined his father-in-law's company, Northern Dairies, which later became Northern Foods. Business Achievements Under Haskins' leadership, Northern Foods grew into Britain's leading food manufacturer. He was instrumental in developing chilled food techniques, which enabled the mass production of ready meals and convenience foods. A significant partnership with Marks & Spencer was established, which became a cornerstone of the company's success, generating annual sales of half a billion pounds. Public Service and Politics Haskins was a vocal advocate for various public causes, including European monetary union, English regional devolution, and the reduction of subsidies to British agriculture. He served as a 'rural tsar' during the foot and mouth outbreak of 2001 and authored a rural recovery report for Defra, which proposed a shift towards environmental concerns and a long-term reduction in subsidies. Legacy Throughout his life, Haskins was known for his 'no-nonsense approach' and his commitment to telling the truth as he saw it. He was a passionate advocate for regional devolution and took an active role in various Yorkshire economic bodies. Despite facing disappointment as governments wound down bodies he chaired, Haskins remained dedicated to his causes, reflecting on his life's work: 'Most of the campaigns of my life have failed, largely, I comfort myself, because I have been ahead of my time.' He is survived by his wife, Gilda, their five children, nine grandchildren, and a great-granddaughter.

Jaume Guardeno, a 23‑year‑old rider for the Spanish Caja Rural‑RGA squad, was airlifted to Hospital Taulí in Sabadell on Tuesday after a training accident that ended in a collision with a car.The team confirmed that Guardeno suffered a serious head injury when his bike hit a stone, causing him to lose control and strike the vehicle. He was immediately transferred by helicopter to the intensive‑care unit, where he remains under close observation.Guardeno had just completed the Tour of Catalonia, finishing 29th, and previously placed 14th in last year’s Vuelta a España, marking him as a promising talent in Spanish road cycling.“We want to express all our support and strength to Jaume and his family during this time, wishing him a speedy and full recovery,” the Caja Rural‑RGA team statement read.In related cycling news, former Olympic champion Richard Carapaz announced that he has undergone surgery for a perineal condition ahead of the upcoming Giro d'Italia. The 32‑year‑old Ecuadorian, who won the Giro in 2019 and secured podium finishes in 2022 and 2023, said the procedure was handled "in the best possible way" and that he is now focused on recovery.Carapaz, a gold‑medalist from the Tokyo Olympics, missed the Tour de France and Vuelta a España last season due to illness. He aims to return to peak form in time to contest a fourth Giro podium.

NASA's Artemis II space mission has successfully launched from Florida, embarking on a historic journey around the moon with four astronauts on board. This mission marks a significant milestone in the United States space agency's plan to return humans to the moon and eventually send astronauts to Mars.The 32-storey rocket rose from NASA's Kennedy Space Center in Cape Canaveral, where tens of thousands gathered to witness the liftoff. The Artemis II crew, consisting of NASA astronauts Reid Wiseman, Victor Glover, and Christina Koch, and Canadian Space Agency astronaut Jeremy Hansen, are set for a nearly 10-day journey around the moon and back.“On this historic mission, you take with you the heart of this Artemis team, the daring spirit of the American people and our partners across the globe, and the hopes and dreams of a new generation,” said Charlie Blackwell-Thompson, the launch director. “Good luck, Godspeed Artemis II. Let’s go.”During the mission, the astronauts will spend the first one to two days in high Earth orbit carrying out extensive systems checks. They will then perform a critical engine burn known as translunar injection, which will send the spacecraft out of Earth's orbit and onto a trajectory towards the moon.The journey will take several days, during which the crew will continue monitoring spacecraft systems as they travel farther from Earth. Orion will then fly behind the moon on a free-return trajectory, a path that naturally swings the spacecraft back towards Earth using the gravity of both the moon and Earth, with minimal fuel required.After the lunar flyby, the crew will spend several days traveling back to Earth while carrying out additional deep-space tests on power systems, thermal controls, and crew operations. As Orion approaches Earth, the capsule will re-enter the atmosphere at speeds of about 40,233km per hour (25,000 miles per hour), before splashing down in the Pacific Ocean, where recovery teams will retrieve the crew.

Tiger Woods, the renowned golf superstar, has made a significant decision to step down as the US captain for the 2027 Ryder Cup. This move allows him to focus on his health and well-being, following a recent court ruling that granted him permission to travel abroad for comprehensive inpatient treatment.A Florida judge approved Woods's request, citing his need for an “intensive, highly individualized and medically integrated program” away from media scrutiny. Woods's lawyer argued that his client's complex clinical presentation required a level of care that couldn't be safely provided in the United States.The decision comes on the heels of Woods's recent misdemeanor driving under the influence (DUI) charges following a rollover crash in Jupiter, Florida. Woods had pleaded not guilty to the charges, which included property damage and refusal to submit to a urinalysis. The incident revealed that Woods had been swearing profusely, showed signs of lethargy, and had extremely dilated pupils.Woods has been open about his need for treatment, stating that he aims to achieve lasting recovery. In a public statement, he expressed his commitment to prioritizing his health and seeking the necessary support. The PGA of America, PGA Tour, and Augusta National Golf Club have all offered their support for Woods during this challenging time.The PGA of America has announced that they will provide further updates on the Ryder Cup Captaincy when appropriate. For now, Woods's focus remains on his health and well-being, and the golf community rallies around him in support of his journey toward recovery.