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The Breakthrough in Breast Cancer TreatmentA landmark international study has revealed that millions of women with breast cancer could safely skip chemotherapy thanks to a genomic test that determines who needs the treatment and who doesn't. The randomised trial specifically examined whether the test could identify patients who would not benefit from chemotherapy, allowing them to avoid the potentially debilitating treatment without compromising their outcomes.The Scientific Evidence Behind the TestThe results of the Optima trial, which will be presented at the American Society of Clinical Oncology's annual meeting, are being hailed by experts as gamechanging. The five-year cancer-free survival rate was 93.7% in the group that skipped chemotherapy, which was statistically non-inferior to the 94.9% rate in patients randomly assigned to receive chemotherapy.The Prosigna genomic test analyzes the activity of 50 specific genes in tumor tissue to determine the molecular subtype and develops a risk of recurrence score to help doctors decide if chemotherapy is necessary. This precision medicine approach allows for personalized treatment decisions based on the unique characteristics of each patient's cancer.A Patient's Journey to Avoiding ChemotherapyKaren Bonham, a speech and language therapist from Swansea in Wales, was one of 4,429 patients with breast cancer recruited to the trial from countries including the UK, Norway, Sweden, Australia, New Zealand and Thailand. Diagnosed with cancer in 2017 at the age of 55 after routine breast screening, Bonham described the news as shocking."It certainly propels you into a world of uncertainty. Life priorities realign – you simply want to survive," she said. Dreading chemotherapy, she agreed to join the Optima trial after undergoing surgery. She was only days away from starting treatment and had already cut her hair short when the results came back in September 2017.While taking a walk on a Welsh beach, Bonham received a phone call from her hospital informing her she had been allocated to the group of patients that would not be having chemotherapy. "How to describe the initial feeling? Immense relief? Like Christmas? Certainly a mixture of the two," she said.The Future of Personalized Cancer CareToday, Bonham, now 64, retired and living in Cardiff, is free of cancer, healthy and shows no signs of the disease coming back. "It is coming up to nine years since my diagnosis," she said. "I am mindful of my diagnosis, alert to potential changes in my body but do not feel defined by [it]. I walk, enjoy yoga and live well."While not every woman with breast cancer will be able to skip chemotherapy—the treatment remains necessary and important for many—the trial results suggest that genomic testing can safely identify those who can avoid it. This approach represents a significant shift toward personalized medicine in oncology, reducing unnecessary treatment and its associated side effects while maintaining excellent outcomes."I hope that the trial will bring positive patient outcomes to many," Bonham said, reflecting on the potential impact of this research on future breast cancer patients.

A shock government‑backed report this week warned of the danger of a “lost generation” of young people in Britain, as the number of 16‑ to 24‑year‑olds not in education, employment or training (NEETs) rose to more than 1 million, roughly 13.5% of the cohort.Rising NEET Numbers Spark Alarm in the UKOfficial UK statistics show that 13.5% of young people are not in work or college, climbing to 15.8% among 18‑ to 24‑year‑olds – nearly one in six. The report, authored by former Labour cabinet minister Alan Milburn, warns that without decisive action the country could see a sustained “lost generation”.Comparative NEET Rates: UK vs NetherlandsUK NEET rate (16‑24): 13.5% overall, 15.8% for 18‑24 year olds.Netherlands NEET rate (15‑29, adjusted): 5.3% last year, consistently below 5% for over a decade.Potential impact: Matching the Dutch rate could move 600,000 more 18‑ to 24‑year‑olds into learning or earning.Why Dutch Vocational Pathways Keep Youth EngagedThe Dutch system centres on three pillars: strong vocational secondary education (MBO), a welfare safety net that prioritises engagement and rehabilitation, and financial incentives for employers. Around 70% of Dutch 16‑ to 19‑year‑olds in upper secondary education attend an MBO school, and 35% of under‑25s later study at technical or professional universities. By contrast, only 22% of UK 18‑ to 21‑year‑olds were on vocational courses in 2024.Technical education is treated as “the foundation of the economy”, with work‑based learning embedded in curricula – many students combine four days of school with one day of on‑the‑job training.Policy Levers Behind the Dutch Low NEET RateThe 2004 Work and Social Assistance Act devolved welfare programmes to municipalities, creating personalised, localised support that addresses mental health and long‑term illness. Local councils provide tailored engagement programmes, subsidised employment, and specialised training, preventing young people on incapacity benefits from falling through the cracks.Employers receive fiscal incentives, such as payroll‑tax cuts and direct subsidies that cover up to 70% of wages for chronically unemployed youth, as highlighted by the Youth Futures Foundation. Rotterdam’s city council, led by Tim Versnel, funds up to 70% of wages for young chronically unemployed people and offers holistic support covering mental resilience, substance‑use treatment, and financial literacy.What the UK Could Adopt to Reverse the TrendTo emulate the Dutch success, the UK might consider:Expanding vocational pathways and integrating work‑based learning into secondary education.Devolving youth‑welfare services to local authorities for more personalised support.Introducing targeted fiscal incentives for businesses hiring young workers, including wage subsidies and tax relief.Adopting a whole‑of‑life approach that combines education, mental‑health services, and financial literacy for chronically unemployed youth.While cultural and structural differences mean a direct copy is impossible, the Dutch experience offers a roadmap for reducing Britain’s NEET rate and revitalising its youth labour market.

The Billionaire's Challenge to Women's FootballIt has been a bad week for Michele Kang, the billionaire women's football investor. On Wednesday the Uefa director of women's football, Nadine Kessler, was firm on the enforcement of rules prohibiting clubs with the same owner from playing each other in European competitions, dealing a blow to Kang, who has ambitions of taking London City Lionesses into Europe's premier competition, but also owns the tournament's most decorated side, OL Lyonnes.Then, across the weekend, Kang teams suffered two continental final defeats, with Lyonnes losing 4-0 to Barcelona in the Champions League final before her US outfit, Washington Spirit, fell short in the Concacaf W Champions Cup with a 5-3 reverse to the Mexican side Club América.Barcelona's Talent Pipeline vs. Financial MuscleSpeaking to the Catalan TV channel Esport3 in Oslo on Saturday evening, the Barcelona goalkeeper Cata Coll made some pointed remarks about money in football after their emphatic victory, and her words went viral. "There has been criticism but we have shown the team we are," she said. "Money isn't everything. We are privileged to have La Masia and all the girls that have come up to the first team: Aïcha Cámara, Carla [Julià Martínez], [Martine] Fenger, [Clara] Serrajordi, all of them. They are incredible. It says everything and that's why I say it."Many have assumed it was a jab at Kang and the use of her wealth to pursue glory in women's football, with Barcelona's talent pipeline apparently delivering an antidote to such an approach. There have been frustrations that Kang's teams have been sniffing at Barcelona's door in recent years, poaching the head coach Jonatan Giráldez, who led Barça to their second and third European titles, first planting him in post at Washington Spirit before switching him this season to Lyonnes, another of her Kynisca Sports International multi-club ownership group.The Financial Distortion in Women's FootballGiráldez isn't the only Barcelona employee to have been recruited by the big-spending Kang. The midfielder Ingrid Engen joined Lyonnes last summer and the defender Jana Fernández was acquired by London City from the Catalan club. Meanwhile, talk of potential rogue bids for Aitana Bonmatí have circulated in past seasons, while London City are believed to have made Alexia Putellas, soon to be out-of-contract, a large offer to play in the WSL.Clubs are seemingly irritated with Kang's spending because to entice superstars to fledgling projects she is offering fees and wages that are distorting the market, driving it beyond what many view as sustainable growth. Except, given the opportunity, every club would probably do it. Yes, huge men's clubs could do the same, given the large sums at their disposal, but often choose not to in the name of sustainability and gradual growth.Barcelona's Own Financial ChallengesHowever, while the constantly emerging talent from La Masia is both laudable and enviable, Barcelona are not a model women's football club, or a salve to the model being championed by Kang.Kang is one of many to have exploited the strict financial rules of La Liga, with the money trouble experienced by the men's side recently affecting every section of the club, from the women's team to the youth academy and basketball, handball and futsal teams. To lower the wage bill, players have been allowed to leave that may have been kept under different circumstances.The team that have powered Barça to four European titles contains several key players at the end of their contracts. Alongside Putellas, the quartet of Mapi León, Marta Torrejón, Salma Paralluelo and Caroline Graham Hansen are nearing the end of their deals. At some stage Barça will need to undergo their next evolution, but to what extent that is done on their terms, or forced by financial pressure, remains to be seen.The Future of Investment Models in Women's FootballSaturday's Champions League final was my eighth in nine years – the Covid-19 pandemic prevented me from attending the 2020 final between Lyon (now Lyonnes) and Wolfsburg in San Sebastián. The game has come a long way since my first, in Kyiv in 2018, when the host city was the same as the one for the men's Champions League final and the women's final cowered in its shadow.In Oslo the huge numbers pouring into Uefa's fan park, that featured a line of mini-pitches where girls' teams played all day, reflected the impact the final can now have on a city. Women's football has also changed a lot, but in some ways it is very similar. In 2018 Lyon lifted their fifth of what has become eight European titles, the efforts of the former club owner, men's and women's, Jean-Michel Aulas, repeatedly delivering for the French team. Aulas committed more resources to the women's team than most other European clubs and Kang is now doing the same sort of thing, but more aggressively, in a world where many of the top women's clubs are increasing investment.The problem is, there is no alternative model put forward by any of the biggest clubs. Each one walks the same path, in slightly different ways, perhaps getting annoyed at how others have gone the same route. Most men's Premier League clubs do not want an alternative funding model – because it might show fans there is another way of doing things. As it stands, those owners can take money out of clubs to boost their personal wealth.So, yes, Coll is right, but behaving like Barcelona are the morally superior club is misleading.

The Historical Detective's QuestIn the spring of 2011, author Raf Nicholson embarked on a PhD journey to document the history of women's cricket, only to find a startling lack of resources at the MCC library at Lord's. The women's cricket section contained merely three books, including Rachael Heyhoe Flint's 1978 autobiography. This discovery sparked a decade-long mission to uncover the hidden history of women's cricket, culminating in his book 'The Women in Whites: A History of Women's Cricket in England' published in June 2026.The Lancashire Cowshed TreasureThe breakthrough came when Nicholson was directed to the Women's Cricket Association archive, stored in a former cowshed in a tiny hamlet eight miles east of Blackpool. There, amidst garden furniture and farming equipment, he discovered historical treasures including minute books dating back to 1926 when the WCA was formed, scrapbooks, letters, tour diaries, and newspaper cuttings. Spending two weeks in the summer, Nicholson made daily six-mile round trips from a nearby B&B; to meticulously document these invaluable materials.Pioneers of the Women's GameThrough his research, Nicholson brought to light key figures in women's cricket history. Betty Archdale, captain of the 1934-35 Australian tour, earned the nickname 'Hitler' for her distinctive leadership style. Myrtle Maclagan, daughter of an army officer, demonstrated exceptional cricket prowess with seven for 10 in the first women's Test and the first Test hundred in women's cricket. Marjorie Pollard, the WCA founder, maintained strict dress codes that required women to play international cricket in skirts until 1997, believing 'trousers are beyond the pale'.Overcoming Financial and Social BarriersResearch revealed the constant financial struggles faced by the WCA and women's cricket players. England batter Chris Watmough described writing hundreds of letters begging for financial support for the 1968-69 tour to Australia and New Zealand, which resulted in sponsorship from lingerie brand Berlei. Coach Ruth Prideaux had so little money for the 1993 World Cup that players slept on blow-up mattresses in her living room and trained by running along Eastbourne beach. Norma Izard famously borrowed a wok from MCC kitchens to burn a miniature bat, creating the first Women's Ashes trophy in 1998.Preserving a LegacyMany of the pioneering women Nicholson researched and interviewed have since passed away, but their stories live on through his book. The research journey also led to the MCC acquiring the complete WCA archive in 2017, moving the historical materials from the Lancashire farm to Lord's. This collection now serves as a valuable resource for future researchers, ensuring that the rich history of women's cricket is preserved and accessible for generations to come.

Early Reading Memories Virginia Evans shares her earliest reading memory, reading either 'The Velveteen Rabbit' by Margery Williams or poems from 'Where the Sidewalk Ends' by Shel Silverstein with her sister. Favorite Books Growing Up Evans loved mysteries and fantasy worlds, reading many Nancy Drew books, 'The Boxcar Children' by Gertrude Chandler Warner, and 'The Wind in the Willows'. She enjoyed books about things that can't exist, calling it escapism. The Book That Changed Her as a Teenager At 15, Evans read John Steinbeck's 'The Grapes of Wrath', which gave her a new understanding of what fiction can do and how words can portray complex living. The Writer Who Changed Her Mind Evans praises Joan Didion, saying every time she reads Didion's work, she is changed in some way, seeing the world, people, and politics differently. The Book That Made Her Want to Be a Writer In college, Evans read Jhumpa Lahiri's 'Interpreter of Maladies', which inspired her to write, making her think: 'I have to do this, I can do this, I will do this'. The Author She Came Back To Evans tried Jane Austen's 'Pride and Prejudice' too young, but when she came back to it in her late 20s, she enjoyed it tremendously. Books She Rereads Daphne du Maurier's 'Rebecca' Steinbeck's 'East of Eden' The Book She Could Never Read Again Evans devoured the Millennium series by Stieg Larsson but was too disturbed to read it again. The Book She Discovered Later in Life Evans didn't read 'Little Women' by Louisa May Alcott until her adult life, relating to the mother character and identifying with Jo's struggles as an author. Current and Comfort Reads Currently reading: 'While I Was Gone' by Sue Miller Comfort reads: 'The Uncommon Reader' by Alan Bennett, 'Beautiful Ruins' by Jess Walter, 'I Capture the Castle' by Dodie Smith

Lead: A Milestone Reflection on Climate ActionIn its 250th edition, the Guardian's Down to Earth newsletter pauses to assess how the world's fight against climate change has unfolded since the high‑water mark of Cop26 in Glasgow, 2021.Looking Back: Cop26’s Promise and the Five‑Year Journey2021‑2022: Nations pledged to limit warming to 1.5°C, set net‑zero targets and pledged to phase out coal.2022‑2023: The Russian invasion of Ukraine and the Iran‑oil conflict drove crude prices above $100 /barrel, exposing fossil‑fuel vulnerabilities.2024‑2025: Populist governments rolled back environmental regulations, while renewable technology became cheaper and more widespread.Numbers That Matter: Public Awareness and Emissions GapsThe “Covering Climate Now” survey found that 80‑89 % of the global public recognise the climate threat and demand government action.Current national plans still point to a projected warming of about 2.8 °C, well above the agreed target.Renewable energy costs have fallen by roughly 70 % since 2020, making clean power “cheap, widely available and overwhelmingly popular.”Why the Momentum Slowed: Geopolitics, Economics and PopulismWar‑driven spikes in oil prices, the re‑election of climate‑skeptical leaders and the rise of populist rhetoric have eroded the optimism that surrounded Cop26, pushing many countries to backtrack on commitments.What Lies Ahead: Hopeful Trends and Persistent ChallengesDespite setbacks, advances in clean‑tech, growing public pressure and emerging green‑economy initiatives suggest a pathway forward, but the intertwined climate‑biodiversity‑economy crises demand coordinated global action.

The State of Great Barrier Reef Island Resorts Kerry Outerbridge's recent visit to Brampton Island in the Great Barrier Reef revealed a resort in a state of disrepair. The once-thriving tourism destination now lies abandoned, with damaged infrastructure and overgrown vegetation. The Impact of Extreme Weather Events The resort was severely damaged by Cyclone Yasi in 2011, which is a prime example of the series of extreme weather events that have affected the Great Barrier Reef island resorts. At least six resorts have been abandoned, and many more are struggling to recover. The Economic Challenges The rising cost of diesel and skyrocketing insurance costs driven by the climate crisis have added to the economic challenges faced by the resorts. Additionally, investors are seeking to 'land bank' resorts without operating them, further exacerbating the issue. The Future of Tourism in the Great Barrier Reef The Queensland government has launched a campaign to attract domestic tourists, and there are plans to revitalize some of the abandoned resorts. However, the future of these island paradises remains uncertain, and it is unclear whether they will be able to recover from the damage and neglect. The Push for Restoration and Accountability The Queensland government is taking steps to force the restoration or sale of abandoned resorts, including Brampton Island. This move aims to prevent future resorts from languishing unbuilt or being left in disrepair, ensuring that these unique island ecosystems are protected for future generations.

The Appeal of Period Homes with Modern ExtensionsPeriod properties in England continue to capture the imagination of homebuyers seeking a blend of historical character and contemporary living. The trend of adding stylish extensions to these heritage homes has created a unique niche in the property market, offering the best of both worlds – original features with modern functionality.Architectural Harmony: Blending Old with NewSuccessful period home extensions require careful consideration of architectural harmony. Leading architects specializing in heritage properties emphasize the importance of respecting the original building's character while introducing modern elements that complement rather than compete with the existing structure. This approach has resulted in some stunning transformations across England's historic towns and cities.Market Value and Premium PricingProperties that successfully blend period charm with contemporary living spaces command premium prices in England's real estate market. Recent sales data indicates that well-designed extensions can increase a property's value by 15-25%, with some exceptional cases achieving even higher returns. This financial incentive has driven many homeowners to invest in thoughtful extensions that enhance both lifestyle and investment potential.Popular Extension Styles and FeaturesThe most sought-after extensions include open-plan kitchen-dining areas that flow seamlessly from original reception rooms, glass-walled extensions that flood interiors with natural light while preserving sightlines of period features, and orangery-style spaces that bridge the gap between traditional and contemporary design. Modern amenities under these historic roofs often include underfloor heating, energy-efficient glazing, and smart home technologies discreetly integrated into the original fabric.Regional Hotspots for Period Home ExtensionsCertain areas of England have become particularly known for their innovative period home extensions. London boroughs like Camden and Richmond see frequent transformations of Victorian and Georgian properties, while cities such as Bath, York, and Cambridge showcase remarkable blends of architectural heritage with contemporary design. The Cotswolds and other rural areas also feature prominently, with barn conversions and farmhouses receiving sensitive yet modern updates.Future Trends in Period Property RenovationAs sustainability becomes increasingly important in the property sector, period home extensions are evolving to incorporate eco-friendly features. From solar panels integrated into roofs sympathetic to the original style to heat pumps disguised within period-appropriate outbuildings, the future of period home renovation lies in sustainable modernization. Additionally, there's growing interest in multi-generational living solutions, with extensions designed to accommodate extended families while maintaining the property's historical integrity.

The onset of the Iran war in February 2026 has derailed expectations of a 2026 UK interest‑rate cut, pushing mortgage rates higher and leaving many prospective home‑buyers scrambling.Iran War Triggers Higher UK Mortgage RatesBank of England analysts now anticipate at least one rate rise this year, reversing earlier forecasts of cuts in 2026. The conflict has reignited inflation concerns, keeping mortgage costs elevated for longer.Rising Rates Push Monthly Payments Up 20%Panos (36, executive sous‑chef) saw his five‑year fixed rate climb from 4.18% to 5.22%, lifting his monthly payment from £2,600 to £3,100 – a 20% increase.Jonathan (49, academic) had a rate of 3.6% withdrawn and secured a new 5.2% fixed deal, adding roughly £150 per month and extending his repayment horizon to 2049 (age 72).Average mortgage‑rate expectations for first‑time buyers have risen by over 1 percentage point since February, according to the Guardian survey.First‑Time Buyers Forced into Renting and Delayed HomeownershipPersonal testimonies illustrate the broader trend:Edward (47, Staffordshire) sold his home, only to face a Section 21 eviction and a drying rental market, while mortgage‑rate spikes made his target purchase unaffordable.Grace (27, NHS employee) saw her approved loan cut from £188,000 to £134,000, then to a reduced offer of £170,000 at 5.2%, forcing her to postpone buying.Across the sample, borrowers report a shift from buying to extended renting, with many extending tenancy periods beyond original plans.Outlook: Prolonged Rate Environment and Policy UncertaintyAnalysts expect the Bank of England to maintain a tighter monetary stance for the remainder of 2026, given persistent inflationary pressure linked to global conflict. Without a clear resolution to the Iran war, mortgage rates are likely to stay above pre‑war levels, keeping first‑time buyers on the sidelines and pressuring the UK housing market to adapt to a higher‑cost financing regime.