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Scientists have made a groundbreaking discovery, identifying a distinct 'neural fingerprint' produced by psychedelic drugs in the human brain when users experience their mind-altering effects.This breakthrough finding emerged from a comprehensive study that combined 11 brain imaging datasets from around the world, involving over 500 brain scans from 267 people in five countries. The research focused on five psychedelic substances: LSD, psilocybin, DMT, mescaline, and ayahuasca.The study revealed that these substances have a shared impact on the brain's behavior, dissolving the usual hierarchy of brain systems and flattening the hierarchy, which may underlie the raw access to one's own consciousness that some people describe during psychedelic experiences.Dr. Danilo Bzdok, a senior author on the study from McGill University in Montreal, Canada, explained that all five drugs change brain function in common ways, despite some differences in how they alter brain activity. The most striking effect was stronger communication between brain networks that engage in higher-level thinking and more primitive networks linked to vision and sensation.The research, published in Nature Medicine, provides a solid foundation for psychedelic research, which is crucial if these drugs are to become widespread therapies for mental health conditions such as depression, schizophrenia, and post-traumatic stress disorder.Dr. Emmanuel Stamatakis, a senior co-author on the study from the University of Cambridge, emphasized the importance of large-scale, coordinated evidence in the field of psychedelic research, which is moving quickly and needs to mature responsibly.

The peptide-testing industry has seen a significant surge in demand, with laboratories testing thousands of unregulated substances claiming to support weight-loss and wellness. This growth is largely driven by the injectable peptide craze, with experts warning about the lack of reliable safety data and quality control.Peptides are short chains of amino acids, which can be found naturally in the body or made synthetically in laboratories. They include active ingredients in prescription weight-loss drugs, such as Wegovy, as well as experimental compounds pushed online by the booming biohacking and anti-ageing industries.Laboratories, such as Finnrick in Texas, have reported a substantial increase in testing requests, with around 60,000 samples processed annually, including roughly 2,000 orders from the UK since 2024. About a third of the products analysed failed basic quality checks, with issues including incorrect identity, purity, and quantity.Experts, including Dr. Luke Turnock and Peter Magic, have highlighted the risks associated with these unregulated substances, including potential long-term harms such as increased cancer risk and damage to organs. The large profit margins have also drawn nefarious actors into the supply chain.The UK is a significant market for peptides, with 2,000 testing orders since 2024, tied with Canada for third place globally. The Royal Pharmaceutical Society's Prof Amira Guirguis emphasized the need for oversight, traceability, and quality assurance in the peptide market.

Iran’s sports minister, Ahmad Donyamali, warned on Sunday that his country’s participation in the 2026 World Cup remains doubtful unless FIFA agrees to shift Iran’s group‑stage fixtures from the United States to Mexico. The Iranian Football Federation (IFF) formally asked the global governing body to relocate the matches, but, according to Donyamali, it has yet to receive a definitive response. “If our request is accepted, Iran’s participation will be certain,” Donyamali told Turkey’s Anadolu news agency, underscoring the link between venue security and the team’s willingness to travel. The request comes amid heightened tensions after Israel and the United States launched attacks on Iran on February 28, sparking a broader regional conflict. Tehran retaliated with missile and drone strikes targeting Israeli sites, U.S. bases in the Middle East, and Gulf infrastructure. Iran, the first Asian nation to qualify for the tournament, is slated to play all three group matches on the U.S. West Coast – Los Angeles on June 16, Belgium in Los Angeles on June 22, and Seattle on June 26. Former President Donald Trump recently said Iran was “welcome” in the United States but added that he doubted the venue was “appropriate for their own life and safety.” In response, the Iranian team posted on social media that “no one can exclude Iran’s national team from the World Cup.” Iranian football chief Mehdi Taj echoed the sentiment, stating, “When Trump explicitly says he cannot guarantee our security, we will not travel to America.” Taj confirmed ongoing negotiations with FIFA to move the games to Mexico. FIFA, however, rejected the relocation request, reaffirming that the schedule announced last year will stand. President Gianni Infantino told IFF Vice President Mehdi Mohammad Nabi that “the matches will be played where they are supposed to be, according to the draw.” Despite the diplomatic deadlock, Donyamali affirmed that Iran’s players continue training and will be ready for the tournament, provided that adequate security guarantees are secured from the host nations. “Under these circumstances, the possibility of Iran playing in the United States is very low; if the necessary security assurances are given, our government will make the final decision,” Donyamali said, adding that former President Trump’s remarks were “morally and ethically unbalanced.” The World Cup kicks off on June 11 in Mexico, with the opening matches in the United States and Canada following on June 12. The final is set for July 19 in East Rutherford, New Jersey.

Occupied East Jerusalem – While Holy Week traditionally fills the Old City’s Christian Quarter with pilgrims and worshippers, the streets are now eerily quiet and storefronts remain shuttered.Palestinian shopkeeper Boulos, a man in his mid‑30s who asked to remain anonymous, still drags himself to his modest stall a few times a week, selling religious garments behind a half‑closed door to avoid Israeli orders that mandate closure of businesses in the quarter amid the ongoing US‑Israel conflict with Iran.After six years of pandemic‑related setbacks and successive wars, his business had only begun to recover when the October Gaza ceasefire was followed by a new wave of restrictions. “Before the war with Iran, we barely made enough to survive,” he said. “Now there is no income at all.”His only customer that day was an Ethiopian Christian woman buying a kilo of prayer candles for 35 shekels (about $11.20). “What can 35 shekels do for me?” Boulos lamented, underscoring the stark economic squeeze.Unlike many West Jerusalem shops, which have been allowed to stay open because of nearby bomb shelters, the Old City lacks such protection, leaving Palestinian businesses in the Christian Quarter effectively forced to shut. The area, heavily dependent on tourism, shows the least sign of life.Brother Daoud Kassabry, principal of the College des Frères school, described the scene as “the saddest Jerusalem I have ever seen.” Classes have been suspended for over a month, and the community feels the weight of an unprecedentedly difficult period.For the first time in centuries, Israeli police barred Cardinal Pierbattista Pizzaballa, the Latin Patriarch of Jerusalem, and other senior clergy from entering the Church of the Holy Sepulchre for Palm Sunday Mass. The Latin Patriarchate called the incident “unprecedented in centuries.”At a press conference, Cardinal Pizzaballa emphasized that while “all celebrations” have been cancelled for security reasons, “no one, not even the Pope, can cancel the liturgy of Easter.”Following the incident, leaders from Italy, France and the United States condemned the police action. Israeli Prime Minister Benjamin Netanyahu later defended the measure as a safety precaution, citing the absence of bomb shelters near the holy site, despite the cardinal’s residence being only metres away.Netanyahu’s justification raises questions about the long‑standing “status‑quo” arrangement that places custodianship of Christian and Muslim holy sites under the heads of their respective religious institutions and Jordan’s Waqf. Palestinian Christians interpret the rhetoric as evidence of an increasingly hostile environment under Israeli control.Bishop Emeritus Munib Younan recounted being spat on by Jewish yeshiva students in the Old City without any legal consequences. He now prefers to attend services in Bethlehem or a small church outside Jerusalem, where he feels “no one is pointing a gun at you.”“They want to show the world that this country is only meant for them – not Christians, not Muslims,” Younan said, reflecting a sentiment shared by many locals.Netanyahu later announced that religious ceremonies at the Holy Sepulchre would be permitted during Holy Week, but only for clergy, keeping the general public out. Observers noted the inconsistency, pointing out that Muslim worshippers have been barred from the Al‑Aqsa compound since late February, including during Ramadan, with only minimal international rebuke.The cumulative restrictions have crippled the already dwindling Palestinian Christian community, which now makes up less than 2 % of the population in Israel and the occupied territories. Traditional events such as the Way of the Cross procession and Holy Fire Saturday have been cancelled, eroding communal cohesion.Father Faris Abedrabbo of the Annunciation Latin Parish linked the current hardships to the Passion narrative, urging congregants to view their suffering through the lens of “steadfastness” – an active, spiritual resistance rather than passive endurance.Economic despair is prompting a new wave of emigration. Bishop Younan reported that many young Christians ask for help obtaining visas to the United States, Canada or Australia, fearing there is “no future” in Jerusalem. Boulos, the shopkeeper, admits he has considered leaving, noting that “they try to make us lose hope and abandon this land.”Despite the bleak outlook, Boulos continues to visit his shop, saying, “I come here to prove to myself that I still have hope, even if it feels endless.”

Major League Soccer (MLS) Commissioner Don Garber has expressed his approval of FIFA's dynamic pricing strategy for the upcoming World Cup, which has significantly raised ticket prices across all games. The tournament is set to take place in the US, Mexico, and Canada this summer. Garber made these comments in Miami, where he attended the inaugural fixture at Inter Miami's Nu Stadium. He suggested that the high prices resulting from FIFA's dynamic pricing model are justified by the event's exclusivity, stating that Americans are accustomed to such pricing for major events. “FIFA has been smart. They have variable ticket pricing and I'm hoping they'll be providing access to anybody that wants to buy a ticket,” Garber said. “It's not really for me to comment on pricing. [MLS] has nothing to do with that, it's FIFA's decision. But I think it's going to be a premier event and premier pricing Americans are used to.” FIFA's dynamic pricing model has been met with criticism, with some labeling it as “price gouging”. US politicians have also weighed in, writing to FIFA President Gianni Infantino. Supporters' groups have expressed outrage over the rising costs. Recently, FIFA raised the top price of a World Cup final ticket to $10,900, up from $8,600 after the finals draw in December. This represents a significant increase from the $1,600 top price for a World Cup final ticket in Qatar four years ago. Despite the controversy, Garber emphasized that MLS is working to capitalize on the tournament to showcase its growth. Many of MLS' top players, including Lionel Messi and Rodrigo de Paul, are expected to represent their nations during the World Cup. “We're going to be present during the games,” Garber added. “We've just finalized the last shoot for major advertising campaigns. It's the first time we've ever produced anything like that. We'll be advertising in the final and semi-finals with some of our biggest stars that we think will resonate around the world.”

When the sanctioned Russian tanker Anatoly Kolodkin docked at Matanzas and off‑loaded roughly 700,000 barrels of crude, observers were left questioning why Washington had temporarily lifted its oil embargo on the island.Just weeks earlier, President Donald Trump had taken to social media to declare an end to any oil or cash flowing to Cuba. Yet, in a stark reversal, he later told reporters he had no objection to oil shipments reaching the country, allowing the Russian vessel to pass.Adding to the intrigue, Cuban authorities announced the release of 2,010 prisoners as a “humanitarian gesture” for Holy Week. Analysts quickly linked the pardons to the tanker’s arrival, interpreting both moves as evidence of ongoing, albeit secret, talks between Washington and Havana.The U.S. oil blockade has already pushed Cuba’s fragile economy to the brink: tourism has all but vanished after airlines from Canada, Russia, China and France withdrew, with Iberia set to exit by the end of May. Most petrol stations are shuttered and blackouts have become a daily reality.Population estimates now sit at 9.5 million, down from a pre‑crisis peak after a two‑million‑person exodus over the past five years. Citizens describe a systemic collapse of health, education and transport services.With official channels silent, Cubans are piecing together fragmented leaks—largely from the U.S. side—to gauge the direction of the negotiations.The dialogue pits Trump’s hard‑line rhetoric, which vows to “take” the island, against Cuba’s insistence that its political system is non‑negotiable.One diplomat suggested the tanker’s arrival could be a tactical humanitarian showcase, but also noted it might serve as a confidence‑building measure. The simultaneous prisoner release leans toward the latter interpretation.Professor William LeoGrande of American University observed that such reciprocal gestures often precede substantive diplomatic progress.Meanwhile, another Russian‑flagged tanker, the Sea Horse, carrying about 200,000 barrels, was sighted moving toward Venezuela, hinting at a coordinated “carrot” strategy aimed at both Havana and Caracas.Although oil alone is unlikely to compel the Cuban regime to relinquish power, the recent events suggest a more transactional pathway may be emerging.Since 2021, Cuba has nurtured a private sector of over 10,000 small‑ and medium‑sized enterprises (Mipymes), spawning a new class of affluent Cubans often tied to the regime and the army’s economic arm, Gaesa.Negotiations appear to be led by Raúl Guillermo Rodríguez Castro, a grandson of former President Raúl Castro and son of the late Gaesa chief Luis Rodríguez López‑Calleja.In a recent CNN interview, Fidel Castro’s grandson Sandro Castro, a 33‑year‑old influencer and businessman, argued that the majority of Cubans now favor a capitalist model over communism.His open criticism of President Miguel Díaz‑Canel—calling his performance “unsatisfactory”—would normally trigger state security action, yet appears tolerated, suggesting the U.S. may be leveraging Díaz‑Canel’s vulnerability in the talks.Analysts speculate a possible outcome where Cuba’s economy opens to foreign investment while senior Castros retain political influence, aligning with Trump’s expressed desire for a “friendly” transition reminiscent of recent moves in Venezuela.One senior diplomat in Havana noted that the United States might permit existing private businesses to continue operating, provided they also open markets to U.S. interests.The prospect of any Castro family member retaining authority is likely to provoke fierce opposition from hard‑line Cuban‑American groups, epitomized by figures like Marco Rubio, who have long advocated for the Castros’ removal.Perhaps the greatest concern remains the roughly 40 % of Cubans who are not part of the private sector and rely on state support; many are elderly and now face the very real threat of starvation.

Italian football fans are being encouraged to put their national team's World Cup 2026 qualification failure behind them – by backing co-hosts Canada instead. Canada Soccer, the national governing body for the sport, is offering a free jersey swap on Saturday for fans in Toronto's Little Italy district.“Dear Italian soccer fans, Don't wait four more years. Swap your jersey for Canada,” read a post on X. The initiative aims to tap into Canada's large Italian diaspora, with around 1.5 million Canadians having either full or partial Italian ancestry.Italy would have faced Canada in Group B had they won their qualifying playoff against Bosnia and Herzegovina – but the Azzurri lost on penalties, missing out on the men's World Cup finals for the third tournament in succession. Instead, Jesse Marsch's team will face Bosnia and Herzegovina, Qatar, and Switzerland in their group games.“Canada Soccer is inviting Italian-Canadians to get behind the home team,” read a further statement. “On Saturday 4 April from 10am to 2pm (EST), Canada Soccer will be outside Cafe Diplomatico on College Street in Toronto, offering fans the chance to swap their Italy colours for a Canada jersey and join the momentum heading into the Fifa World Cup 2026.”T icket prices for Canada's World Cup opener against Bosnia and Herzegovina on 12 June have soared, with all unsold tickets listed at $3,125 and most resale seats costing a similar price. Saturday's free jersey swap may be the most affordable way that local Italian fans can get involved with the World Cup this summer.

By the time head coach Jesse Marsch concluded the March international window, the clock was ticking toward April, leaving Canada with more questions than answers ahead of the 2026 World Cup. The Toronto friendly against Tunisia turned into an “odd” afternoon, with a sudden lightning delay pushing the match’s finish to 11 p.m. and forcing fans to follow the action on mobile devices while rain hammered the city. While many had imagined a Canada‑Italy opener after the December draw, the draw against Bosnia and Herzegovina proved a relief. Swapping a potential clash with the world’s 12th‑ranked side for a match against the 65th‑ranked Bosnia is now viewed as a fortunate turn, yet the Bosnian squad displayed a relentless mid‑press that tested Canada’s defensive organization. Bosnia’s pressing generated 30 shots and a torrent of crosses, with veteran striker Edin Džeko looming as a threat and young forwards Esmir Bajraktarević and Kerim Alajbegović showcasing high energy. Marsch noted, “These kids grew up in a war‑torn country; they have resilience that showed in the last week.” Defensive depth emerged as a glaring issue. Centre‑back Moïse Bombito returned to training but remains sidelined with a Nice injury, while regulars Alfie Jones, Derek Cornelius and Luc de Fougerolles were unavailable. MLS pair Joel Waterman and Kamal Miller displayed “ill‑timed jitters,” raising concerns about the back line’s stability. Offensively, Canada’s output was blunt. Across two matches only two Jonathan David penalties found the net; forwards Cyle Larin and Tani Oluwaseyi failed to create a decisive spark. Larin’s last goal for Canada came in October 2024, and Oluwaseyi has scored just two times in 22 caps. Moreover, the team has failed to score from open play in six of their last seven internationals, recording three 0‑0 draws on home soil. Amid the gloom, 22‑year‑old winger Marcelo Flores offered a glimpse of optimism. The former Tigres talent, recently cleared to represent Canada after switching from Mexico, dazzled with dribbles and quick pivots, prompting calls to elevate Juventus striker Promise David and position Flores in a more creative role. The final, lingering question concerns the starting goalkeeper for the June 12 opener. Marsch has oscillated between Maxime Crépeau and Dayne St Clair for two years, and injuries have prevented a decisive choice. Both keepers remain fit, leaving the coach “as close as it’s always been” to a decision. Predicted squad Goalkeepers: Dayne St Clair, Maxime Crépeau, Owen Goodman. Defenders: Moïse Bombito, Derek Cornelius, Luc de Fougerolles, Joel Waterman, Alistair Johnston, Niko Sigur, Richie Laryea, Alphonso Davies. Midfielders: Steph Eustaquio, Ismaël Kone, Mathieu Choinière, Nathan Saliba, Jonathan Osorio, Tajon Buchanan, Ali Ahmed, Liam Millar, Marcelo Flores, Jacob Shaffelburg. Forwards: Jonathan David, Cyle Larin, Tani Oluwaseyi, Daniel Jebbison, Promise David.

The United Kingdom has taken the lead in gathering foreign ministers from 40 countries to discuss strategies for reopening the Strait of Hormuz, a vital shipping route that has been blocked by Iran's actions.UK Foreign Secretary Yvette Cooper emphasized that Iran's blockade of the waterway is threatening global economic security. The virtual meeting, which included countries like France, Germany, Italy, Canada, Japan, and the United Arab Emirates, resulted in a joint statement demanding that Iran cease its attempts to block the strait and pledging to ensure safe passage through the waterway.The coalition's efforts are seen as a response to US President Donald Trump's comments that securing the strait is not the US's responsibility. The meeting is considered a first step, to be followed by working-level meetings to hammer out details.Al Jazeera's Rory Challands noted that while the coalition is broad, involving countries from various regions, there are questions about the naval capacity of these countries to enforce the reopening of the strait. British Prime Minister Keir Starmer has emphasized the need for non-military solutions, and French President Emmanuel Macron has suggested that talking directly to Iran is the best approach.The closure of the Strait of Hormuz has had significant economic impacts, including soaring petroleum prices and disruptions to global oil supplies. There have been 23 direct attacks on commercial vessels in the Gulf since the conflict began, resulting in 11 crew members killed.