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Scientists at London's Institute of Cancer Research and the RCSI University of Medicine and Health Sciences in Dublin have announced a new AI-driven approach to identify how patients with advanced bowel cancer will respond to bevacizumab, a drug recently introduced by the NHS. The method uses PhenMap, an AI tool that integrates complex data on the genetic makeup of tumors, allowing researchers to track patterns of how different patients react to the drug. This development aims to spare potentially thousands of patients from being given drugs that would be ineffective in fighting their cancers. In the UK alone, nearly 10,000 cases of advanced bowel cancer are identified every year, with young adults seeing a particular rise in diagnoses. Bowel cancer has the second-highest mortality rate of any cancer, behind only lung cancer. While survival rates can be as high as 98% when caught early, the five-year survival rate for advanced bowel cancer can be as low as 10%. The study tracked 117 European bowel cancer patients who had been treated with chemotherapy and bevacizumab. Researchers identified a group of patients who all had the same gene mutation and were at a high risk of having negative reactions. The scientists behind the tests now hope to expand the number of patient samples and see if the results can be used in treatments for other types of cancer. Anguraj Sadanandam, a professor in stratification and precision medicine at the ICR, said: “Once bowel cancer spreads to other parts of the body, there are very few treatment options available for patients. It is therefore positive that patients can now access the targeted drug bevacizumab on the NHS. However, we know that the majority of patients won’t benefit from the drug, meaning thousands of people in England could be facing unpleasant side effects unnecessarily.” Sadanandam added that while the findings were encouraging, the tool would need to be tested on a larger cohort to be validated. “In future, I hope this approach will lead to a test that can be used by clinicians, to ensure patients receive personalised care that has the highest chance of working against their cancer.”

Tehran – Iranian officials warned that the United States must increase pressure for any peace agreement while urging their supporters to keep the streets under control.Parliament speaker Mohammad Bagher Ghalibaf said the US delegation in Islamabad “failed to gain the trust of the Iranian delegation” during the marathon talks.US President Donald Trump announced an immediate naval blockade of the Strait of Hormuz and declared that US forces are “locked and loaded” to finish Iran at the “appropriate moment.”Iran hailed the delegation’s refusal to accept Washington’s core demands – ending nuclear enrichment and relinquishing control of the Strait – as a sign of defiant resolve.Judiciary chief Gholam‑Hossein Mohseni‑Ejei thanked the Islamabad team for “guarding the rights” of government supporters, including paramilitary forces that have been gathering in Tehran’s main squares for more than six weeks.State television aired an IRGC aerospace officer urging flag‑waving crowds not to worry, stating, “If the enemy does not understand, we will make them understand,” which was met with cheers demanding more missile and drone attacks.Iranian officials blamed Trump’s “excessive demands” for the talks’ failure, noting the Ministry of Foreign Affairs did not expect an agreement after a single day of negotiations.Hard‑line parliamentarians expressed satisfaction with the stalemate, viewing Iran as holding the upper hand. Deputy speaker Hamidreza Haji‑Babaei said only a UN Security Council resolution signalling US surrender would lift sanctions on Iran.Lawmaker Amir Hossein Sabeti of the Paydari faction thanked the negotiating team for standing by red lines and called for “resistance in the field against these evildoers.”The sudden announcement of a two‑week cease‑fire left pro‑state voices disappointed; local media reported the Iranian delegation numbered over 85 members, including state‑affiliated journalists and factional analysts.The talks confirmed that a diplomatic breakthrough was not imminent and hinted at further escalation, though not necessarily a return to full‑scale fighting.National security commission head Ebrahim Azizi dismissed Trump’s blockade threats as “excessive talk.”The IRGC warned it would meet any vessel passing the Strait of Hormuz with “full force” and rejected US claims that two warships had already transited the waterway.Russian President Vladimir Putin told Iranian President Masoud Pezeshkian he remains ready to facilitate a Middle‑East peace settlement.Pezeshkian, focused on domestic affairs, reaffirmed support for Supreme Leader Ayatollah Ali Khamenei and announced that schools and universities will continue online via a limited intranet.Iran’s economy continues to suffer from chronic inflation, rising unemployment and a near‑total internet shutdown, deepening public hardship.

The recent ceasefire talks between the United States and Iran have ended without a breakthrough, with Iran's chief negotiator, Mohammad Bagher Ghalibaf, blaming the US for the failure of the talks held in Islamabad, Pakistan. The talks, which were the first direct engagement between the two countries at this level since the 1979 Iranian Revolution, exposed deep divisions on core issues.The US framed the lack of a breakthrough primarily around Iran's alleged refusal to meet its core demand: a firm commitment not to develop nuclear weapons. US Vice President JD Vance said Washington had made its 'red lines' clear and presented what he described as a 'final and best offer'. However, Iran downplayed expectations and blamed the US for making unreasonable demands.The main sticking points between Tehran and Washington are:Iran's nuclear programme: The US wants a clear and enforceable commitment that Iran will not develop nuclear weapons – or even the capability to do so quickly. Iran has consistently rejected accusations that it seeks to build nuclear weapons but said it is willing to negotiate limits on its nuclear activities if sanctions are removed.Strait of Hormuz: Who gets to control this strategic waterway, through which almost all of the oil and natural gas exports from the Gulf nations pass, has become a major flashpoint. Iran has floated the idea of charging transit fees to allow ships to pass through the strait, while the US is adamant the strait is reopened free of any tolls.The near shutdown of shipping through the strait has sent global energy prices soaring with many countries, especially in Asia, forced to implement unprecedented austerity measures to soften the impact of fuel shortages. Experts said the near-closure of the strait has caused the worst economic shock since the 1973 oil embargo.

In a recent Al Jazeera piece, the author stresses that "Diplomacy is not an event, it’s a process, it takes time." The statement serves as a reminder that international negotiations and diplomatic engagements unfold over extended periods, often involving incremental steps rather than abrupt breakthroughs. By framing diplomacy as a sustained effort, the commentary highlights the importance of patience, continuous dialogue, and the gradual building of trust among nations. This perspective encourages policymakers and observers alike to adopt a longer‑term view of foreign‑policy initiatives, recognizing that lasting agreements emerge from persistent, methodical work rather than isolated events.

Libya has taken a significant step towards economic stability with the approval of its first unified budget in over a decade. The Central Bank of Libya confirmed that both the eastern-based House of Representatives (HoR) and the Tripoli-based High Council of State have endorsed the budget. This development is seen as a rare moment of cooperation in a country divided by conflict since the 2014 civil war. The unified budget was signed in the capital, Tripoli, where the internationally recognized Government of National Unity is based under Prime Minister Abdul Hamid Dbeibah. Governor Naji Issa described the agreement as a 'clear declaration that Libya is capable of overcoming its differences when a unified vision for its future is forged.' Libya has remained split since the 2014 civil war, which created rival administrations in the east and west. The last time the country operated under a single national budget was in 2013. The deal brings together institutions that have long competed for authority, with representatives from both sides signing the agreement. Despite this breakthrough, political divisions remain entrenched. In the east, forces loyal to Khalifa Haftar maintain control over large parts of the country, including key oil-producing regions. The timing of the agreement is significant, given Libya's growing importance in global energy markets. Demand for its crude has increased amid disruptions linked to the Israel-US war on Iran and the blockade of the Strait of Hormuz. Libya's geographic position offers a critical advantage, as oil shipments from its ports reach European refineries quickly and avoid the risks associated with Gulf routes. Its light, sweet crude also meets the needs of European refiners facing ongoing supply challenges. This development signals a shift towards more formal cooperation, even as Libya's political fragmentation persists.

Brazilian President Luiz Inácio Lula da Silva used his Friday social‑media post to herald a new security partnership with the United States as a breakthrough in the fight against transnational crime.The agreement links the Brazilian Federal Revenue Service with U.S. Customs and Border Protection, establishing the DESARMA programme. Under DESARMA the two agencies will exchange real‑time data, apply rigorous cargo‑tracking protocols and launch joint operations to intercept illicit shipments of arms and narcotics.Finance Minister Dario Durigan called the collaboration an “important step in strengthening international cooperation”, noting that it will integrate intelligence and joint actions to curb the flow of weapons and drugs between the two nations.The pact is part of President Donald Trump’s broader “Shield of the Americas” initiative, which seeks to enlist right‑wing governments across the Western Hemisphere in a hard‑line campaign against criminal networks.Despite the cooperation, Lula’s administration has pushed back against Washington’s attempts to label Brazilian gangs such as the Primeiro Comando da Capital (PCC) and Comando Vermelho (CV) as foreign terrorist organisations. Lula and Foreign Minister Mauro Vieira have repeatedly asserted Brazil’s sovereignty and warned against external “tutelage”.In the last twelve months Brazil reported seizing 1,168 illegally imported weapons and parts, most of which originated from the U.S. state of Florida, underscoring the scale of the smuggling problem.A statement from the Revenue Service emphasized that the deal will ensure a “continuous flow of information from U.S. authorities to their Brazilian counterparts”, enhancing operational coordination.Relations remain strained: Vieira told U.S. Secretary of State Marco Rubio that Brazil opposes the terrorist‑label designation, while the Trump administration continues aggressive actions in the region, including lethal strikes on maritime vessels and a controversial raid in Venezuela.Looking ahead, Lula is expected to travel to Washington, D.C., later this year for talks with Trump, providing a diplomatic channel to manage both cooperation and disagreement.

Historic peace talks between Iran and the US commenced in Islamabad, Pakistan, marking the first face-to-face meeting between senior negotiators from both countries since 1979. The discussions, facilitated by Pakistani mediators, took place in a positive atmosphere despite continued fighting in Lebanon.The US delegation, led by Vice-President JD Vance, and Iran's negotiators, headed by Mohammad Bagher Ghalibaf and Abbas Araghchi, engaged in two rounds of talks. The discussions covered key topics such as security, finance, and the Strait of Hormuz.Pakistani sources confirmed that Pakistan's army chief, Asim Munir, was present in the room, having played a crucial role in brokering a ceasefire earlier in the week. Pakistan's Prime Minister, Shehbaz Sharif, hosted dinner for the delegations at his residence.The Iranian negotiators initially demanded a ceasefire in Lebanon, reparations, and a commitment to unblock frozen assets as part of a peace deal. However, the US warned against attempts to manipulate the negotiations, with Vance stating that the US would not be receptive to such tactics.The talks have sparked optimism, with a senior Pakistani official expressing hope for a breakthrough. The discussions have also drawn attention from other countries, with reports suggesting that China may offer guarantees to secure a deal.Meanwhile, Israel's military actions in Lebanon have escalated tensions, with Hezbollah firing rockets at Israeli cities. The Lebanese army has deployed troops to maintain stability amid internal tensions.

Brian Cox’s latest live show, ‘Emergence’, draws its spark from Johannes Kepler’s 1609 treatise ‘The Six‑Cornered Snowflake’. Cox explains that Kepler’s wonder at the symmetry of snowflakes, written during a Prague snowstorm, embodies the modern scientific quest to understand the origins of patterns we observe.He says the show explores three realms: what we know, what we don’t know, and what may remain unknowable. This framework sets the stage for his reflections on the biggest unanswered questions in science.If he could answer any scientific mystery, Cox would choose the existence of life beyond Earth. He points to current missions—two spacecraft heading to Jupiter’s moons and the James Webb Space Telescope probing exoplanet atmospheres—as promising avenues that might soon reveal a biosignature.When asked about the future of technology, Cox warns that the trajectory of artificial intelligence is still opaque, making it both thrilling and potentially hazardous. He adds that quantum computing is another frontier with wildly divergent timelines—some experts see breakthroughs within five years, others doubt they’ll arrive in a lifetime—highlighting the revolutionary yet unpredictable nature of these tools.Cox also reflects on his shifting stance toward social media. He admits moving from early optimism about its democratizing power to a more critical view of its noise and misinformation, while acknowledging its complex impact on politics and public discourse.On personal advice, Cox stresses the importance of following one’s passion: “Do what you most enjoy,” he says, recalling his own journey from a teenage musician to a celebrated astronomer, supported by parents who encouraged his interests.He shares a memorable fan encounter: at an ELO concert, a man introduced himself as Paul McCartney after asking a question about Saturn’s moon Enceladus—an encounter that left Cox “overwhelmed” as a lifelong Beatles fan.When asked about a pop‑culture stance, Cox admits he is largely out of touch, but notes that musical innovation seems to have plateaued since the 1980s, contrasting the rapid evolution of earlier decades.One of his favorite astronomical facts is the staggering number of observable galaxies: about two trillion. He highlights how, within a century, humanity moved from debating whether other galaxies existed to quantifying an immense cosmos, also measuring its age at roughly 13.8 billion years.Brian Cox will tour ‘Emergence’ across Australia from 5 to 30 May 2026.

The scheduled talks between the United States and Iran in Islamabad have drawn intense international attention, as both sides seek to address lingering tensions and explore avenues for de‑escalation. Key issues expected on the table include regional security, nuclear safeguards, and the release of detained nationals. Analysts note that the neutral venue of Pakistan could provide a diplomatic cushion, potentially easing the hardline stances that have hampered previous rounds.While the United States aims to secure concrete commitments on Iran's nuclear program, Tehran is likely to push for the lifting of economic sanctions that have strained its economy. The outcome could reshape trade flows and investment prospects across the Middle East, influencing global energy markets and regional stability.Observers caution that any breakthrough will depend on the willingness of both parties to make reciprocal concessions. Failure to achieve a consensus may reinforce existing geopolitical fault lines, prompting further diplomatic maneuvering by regional powers.