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The Plant That Changed MedicineGoat's rue or French lilac, Galega officinalis, is a wild plant often grown in gardens for its clusters of attractive lilac or white flowers. For centuries, the plant was used to treat diabetes. Its key ingredient was later identified as galegine, which lowers blood glucose levels but has toxic side-effects.From Natural Remedy to Synthetic SolutionEventually, galegine led to the development of the synthetic drug metformin, now the classic treatment for diabetes by controlling blood sugar. Metformin has none of the toxic side effects of galegine and is now one of the most prescribed drugs in the world. For many years, however, metformin was vilified and banned in many countries because of its association with galegine.The Emergence of a Medical MultitaskerMetformin is now becoming something of a super drug for its anti-cancer effects, cardiovascular protection, delaying the onset of diabetes, and helping some people lose weight. It may even lower the risks for cognitive decline, dementia, strokes, slow aging and increase life expectancy.Understanding the MechanismExactly how metformin achieves all these remarkable wonders is not entirely understood, but it is not bad for a drug that originally came from an attractive wild plant. The scientific community continues to research the multiple pathways through which this simple compound derived from a garden plant can have such profound effects on human health.

Fernández’s Early Goal Gives Chelsea a Crucial LeadIn the 18th minute, Enzo Fernández capitalised on a left‑wing position to fire a 25‑yard effort into the top‑right corner, breaking a 40‑match win‑less streak for Tottenham at Stamford Bridge (only one win since 1990). The strike set the tone for a dominant first half.Spurs’ Late Rally Falls Short in a High‑Stakes DerbyTottenham responded with Richarlison’s 74th‑minute goal, narrowing the gap to 2‑1, but a series of missed chances—including a header from Mathys Tel and a wide effort from James Maddison—prevented an equaliser. The final whistle confirmed Chelsea’s win and left Spurs’ fate hanging.Table Implications: Survival and European Hopes at StakeTottenham now require at least a point on Sunday against Everton to avoid relegation.Chelsea move a step closer to qualifying for the Europa League with three points.Spurs possess the joint‑worst home record in the division, heightening pressure.Tottenham have won only 1 of 40 matches at Stamford Bridge since 1990, underscoring the rarity of this result.Financial and Managerial RepercussionsThe win secures vital Premier League revenue for Chelsea and bolsters coach Mauricio Pochettino’s position, while De Zerbi faces intensified scrutiny at Tottenham as the club confronts a potential drop‑down financial hit. Relegation would slash broadcast earnings and could trigger player sell‑offs.Looking Ahead: What Sunday’s Fixtures Could DecideSunday’s clash between Tottenham and Everton will be a six‑point showdown. A draw keeps Spurs in the relegation mix; a win guarantees survival. Meanwhile, Chelsea will await the outcomes of other matches to confirm their European qualification, with the league table expected to tighten further in the final round.

The LeadArsenal are Premier League champions for the first time since Arsène Wenger's Invincibles in 2004 after Manchester City drew 1-1 at Bournemouth. It caps a remarkable achievement for Mikel Arteta in his first job in management, the Spaniard having transformed Arsenal into contenders since taking over from Unai Emery in December 2019.The Championship JourneyDespite carrying the scars of previous years, Arteta's side emerged strongest from what in effect became a five-game playoff between the two contenders. City blinked first when they drew against Everton, with Arsenal recording four successive wins without conceding a goal – culminating in Monday's 1-0 victory over Burnley.The Final CountdownArteta said he expected to find it hard to watch City's game against Bournemouth given its significance but Arsenal fans had gathered in the pubs near the Emirates in anticipation of Andoni Iraola's side securing a positive result and celebrated wildly on the final whistle, spilling on the street.The Road AheadArsenal will receive the Premier League trophy at Selhurst Park on Sunday after they face Crystal Palace in their final game. Arteta will become the longest-serving manager in England's top four divisions when Guardiola's departure from City after 10 years is confirmed and has the chance to emulate his mentor by winning the Champions League when Arsenal face Paris Saint-Germain on 30 May.Historic ContextOnly on five occasions have an English team won the top division and the European Cup in the same season, with City the last to accomplish that feat in 2023. Arsenal's triumph marks the end of a 19-year wait since their last title in 2004.

A Tennis Legend's Academic JourneyWhen Billie Jean King left college in 1964, she had a clear purpose. Within a few years, she had become the top-ranked tennis professional in the world. Over a trailblazing career, she won 39 championships, a Presidential Medal of Freedom and a congressional Gold Medal – all while pushing publicly for gender and pay equality.Last year, she finally returned to finish the degree in history she started more than six decades ago. On Monday, she graduated at 82 years old.The Commencement Celebration"It is a privilege for me to be here as a member of your graduating class," King said at her commencement. "Yeah baby, only 61 years!"King recalled growing up in a working-class family, the daughter of a firefighter father and homemaker mother."Like so many of my fellow graduates, I am the first member of my immediate family to graduate college, like many of you," King said.Early Life and Tennis BeginningsShe chose Cal State Los Angeles, then known as Los Angeles State College, because the tennis coach, Scotty Deeds, trained men and women together. He said it would help give her the level of competition she needed to excel."Their approach to winning in tennis was revolutionary at the time," King said of Deeds and the women's coach Dr Joan Johnson. "Even today most collegiate D-1 and D-2 tennis teams do not have the women and men practice together. Scotty and Dr Johnson had it right and they took the extra step for their student athletes."King distinguished herself as a tennis champ in college, winning Wimbledon doubles while enrolled. King was 18 and her partner, Karen Hantze, was 17, making them the youngest team to win at the time.A Lifelong Commitment to EqualityBut King told the crowd that her true motivation since childhood had been to fight discrimination, a calling she first remembered feeling at age 12, when she realized that virtually everyone at the tennis clubs where she trained was white."I asked myself, where is everybody else?" King said. "From that day forward, I committed my life to equality and inclusion for all. Tennis is a global sport and it became my platform, but equality was my dream – to make the world a better place."She added: "We can never understand inclusion unless we've been excluded."King, one of the first openly gay professional athletes, founded the Women's Tennis Association in 1973 and successfully campaigned to get the US Open to pay equal purses at the US Open. That same year, she defeated Bobby Riggs in a historic match billed "The Battle of the Sexes" – a feat later dramatized in a Hollywood film staring Emma Stone and Steve Carell.Legacy and Final WordsKing ended her speech with words of advice for her fellow graduates."Have fun," King said. "Be fearless. And make history."

The Endorsement United States President Donald Trump has endorsed Texas State Attorney General Ken Paxton in the Republican run-off to represent the state of Texas in the US Senate in advance of next week's Republican primary. In a lengthy post on Truth Social, Donald Trump said that Paxton has been 'extremely loyal to me and our AMAZING MAGA MOVEMENT' while also saying that his opponent, incumbent John Cornyn, was not supportive of him when 'times were tough'. The Run-off Details In March, Trump said the candidate who did not earn his endorsement should 'DROP OUT OF THE RACE'. In order to clinch the party nomination in Texas, a candidate must win a clear majority. Neither candidate met that threshold in the state's primary election in early March. Texas also has open primaries, meaning a voter does not have to be a member of a given political party to vote in that party's primary. However, voters must pledge to vote only in one party's primary election. The Data Analysis Recent polls have the Republican run-off as a tight race. An early May poll from Texans for a Conservative Majority, a super PAC aligned with Senator Cornyn, 74, had the incumbent leading by 1 point. A Lone Star Liberty PAC poll, backed by a pro-Paxton Super PAC, showed the attorney general leading by 11 points. More independent polls, like one from the University of Houston Hobby School of Public Affairs, showed Paxton with a 3-point advantage. The Impact Analysis Texas Republicans have expressed concern about how Paxton would fare in the general election. Matt Shaheen, a Texas state representative, said that 'Ken Paxton would be a disaster for Texas conservatives!' in a post on X. The Republican nominee will face a tough general election. Polls suggest that James Talarico is either the favourite or within the margin of error. The Prediction Strategists believe this endorsement will also hurt Trump's relationship with the current Senate. 'Paxton, more likely than not, would have won without Trump's endorsement. Now Trump has alienated the Republican majority in the Senate, Senator Thune, in particular, who's been lobbying nonstop for Trump to endorse Cornyn,' Mark Jones, professor of political science at Rice University in Houston, Texas, told Al Jazeera.

The Government's Intervention in Food PricingUK supermarkets have been asked by the government to consider putting a price freeze on some essential foodstuffs to protect the public from inflation fuelled by the Middle East conflict. This proposal comes amid growing concerns about the cost of living, with Chancellor Rachel Reeves having met supermarket bosses last month to discuss potential impacts on household expenses.The measure follows the Scottish National party's pledge to use its devolved public health powers to fix prices on 20 to 50 items such as bread, milk, cheese, eggs, rice and chicken because their rising cost was "impacting our nation's nutrition." However, the UK government is framing its approach as voluntary rather than mandatory price controls.Supermarket Industry PushbackRetailers have firmly rejected the government's plan, criticising its potential costs amid rising taxes, fuel and energy expenses. Supermarket executives have been particularly vocal in their opposition, with one calling the idea "completely mad" and another describing it as "an unnecessary, unwanted and unjustified intervention in the market."The British Retail Consortium, which represents all the big supermarkets, argues that the UK already has "the most affordable grocery prices in western Europe thanks to the fierce competition between supermarkets." Instead of price controls, the trade body urges the government to focus on reducing "public policy costs which are pushing up food prices in the first place."Operational Challenges of Price ControlsSupermarket sources reveal that while no formal requests have been made, discussions have centered around requiring retailers to stock at least one version of basic items such as bread, milk and butter at a set low price. This would ensure constant availability of these products, but could lead to unintended consequences.Ensuring such availability might require branded or more expensive lines to be discounted to the set price if cheaper varieties run out. "The cost of doing something like this is huge," one supermarket source said. "It would be a huge amount of work as we don't sell every [version of a product] in every store."The Scottish Devolution AngleThe SNP made its eye-catching price-fixing pledge at the launch of its manifesto for the Scottish parliament election, in which it won a record fifth term after securing 58 of Holyrood's 129 seats. However, the proposal was immediately dismissed as a "potty gimmick" by retailers and may put the party on a collision course with the UK government.The SNP's approach could breach the Scotland Act of 1998 that created the devolved parliament, potentially creating a constitutional crisis. A UK government source clarified that while the SNP favored government-mandated caps, the UK government was only proposing a voluntary price freeze, with talks still at an early stage.Market and Consumer Impact AnalysisRetail executives argue that a price freeze on essential items would likely have "unintended consequences on items they might not consider essential but might be for some families" as businesses sought to recover lost profits elsewhere. The plan might depress prices on the 20 or so items covered but could lead to increases in other product categories.UK retailers, farmers and food producers have warned that without help from the government there will be price rises and potential shortages. This creates a complex balancing act for policymakers seeking to address immediate cost concerns without disrupting the broader food supply chain.Policy Outlook and Next StepsChancellor Reeves is due to announce measures to help households with the cost of living, with the price cap proposal potentially being part of this announcement. However, according to sources close to the talks, there has yet to be any agreement on the specifics of such a policy.The Treasury has declined to comment on the ongoing discussions, leaving the market uncertain about the government's next moves. As the cost of living crisis continues to impact households, the debate over price controls is likely to intensify, with potential implications for supermarket profitability, consumer choice, and the broader UK economy.

The LeadThe upcoming US midterm elections may be influenced as much by how electoral maps are drawn as by voter preferences. Redistricting, the process of redefining electoral boundaries, has become a powerful tool that can determine which party controls Congress and state legislatures.The Art of Map DrawingRedistricting occurs every decade following the census, when states redraw congressional and legislative district lines to account for population changes. This process, intended to ensure equal representation, has increasingly become a battleground for political advantage. Through techniques like packing (concentrating opposing voters in a few districts) and cracking (spreading opposing voters across many districts), parties can create maps that favor their candidates even when they don't have majority support.The Data Behind District DesignStudies have shown that gerrymandering can have significant impacts on election outcomes. In the 2022 midterms, for example, Republicans won 54% of House seats despite receiving only 49% of the popular vote. Similarly, in some states with Democratic-controlled redistricting, Democrats have won disproportionate representation. The efficiency gap—a metric measuring how wasted votes are distributed between parties—has been used in court cases to challenge extreme partisan gerrymanders.Impact on American DemocracyThe practice of gerrymandering raises fundamental questions about democratic representation. When districts are drawn to favor one party, it can lead to uncompetitive elections, reduced voter choice, and diminished accountability. Many argue that this contributes to political polarization, as elected officials cater to their party's base rather than moderate voters. The issue has sparked numerous legal battles, with the Supreme Court ruling in 2019 that federal courts cannot hear challenges to partisan gerrymandering, leaving the issue to state legislatures.Future of Fair DistrictsAs the 2026 midterms approach, several states are experimenting with independent redistricting commissions to reduce political influence in map drawing. Technology has also emerged as both a tool for gerrymandering and a solution for transparency, with software helping to identify potential partisan gerrymanders. While the Supreme Court has largely stepped back from regulating partisan gerrymandering, state courts and constitutional amendments in some states continue to provide checks on extreme map manipulation. The battle over district shapes will likely remain a central feature of American politics for years to come.

The Modernist Comedian's Journey How has it come to this? That's what new show Tilting at Windmills finds John Kearns asking, and – after a fashion – it's what TS Eliot asked in The Waste Land, the modernist poem Kearns deploys here as an unlikely motif. After the breakup of a 12-year relationship with the mother of his son, we find the 39-year-old angrier than usual, and unmoored: flat-hunting pessimistically while living back home with mum and dad, roaming the streets of London having fled a disappointing walking tour based on Eliot's verse. High Culture Meets Everyday Life Sound clips of the poem, read by Alec Guinness, punctuate the show. They infuse it (as Van Gogh's Starry Night did with its predecessor, The Varnishing Days) equally with awe, at life's ineffable mysteries, and bathos – at the contrast between high literary culture and the humdrum realities of our host's life. Here he is shopping in Aldi with his mum; there he is naked and not very wet under a dripping shower. A remark about washing machines by a newspaper columnist induces a bout of class anxiety; an awkward teenage meeting is recalled with then-PM Tony Blair, who came to see Kearns' school play. Existential Questions and Personal Struggles Under Jon Brittain's direction, this all comes at us in Eliot-alike fragments, as Kearns bounces between existential conjecture (an encounter with ventriloquist Nina Conti has him wondering "am I my own puppet?!") and sadness at the wreckage of his domestic dreams. We're not let deeply into all that: no oversharer he. But if his real feelings are woven obliquely into this tapestry of a Streatham clown adrift, they remain palpable, not least in the surprising ferocity this usually low-key act brings to his dialogues with dimwit estate agent Connor, say, or with two poetry scholars in a pub over an illicit packet of prawn cocktail crisps. A Poignant Reflection on Modern Life Maybe its sharp edges, that sense of real hurt beneath the (very funny) gags about Kearns' limited commercial reach, forestall hilarity. But there's no resisting the care, the craft and the many beautifully turned phrases of a comic who "feels like he's being CC'ed into his own life". At its best, this show about The Waste Land itself aspires to wonderstruck, workaday poetry. Show Information Artist: John Kearns Show: Tilting at Windmills Director: Jon Brittain Touring to 6 November

The LeadCarlos Alcaraz, the world's second-ranked men's tennis player and defending Wimbledon champion, has officially withdrawn from this year's Wimbledon Championships and the preceding Queen's Club tournament due to a persistent right wrist injury. The 23-year-old seven-time Grand Slam champion, who completed the career Grand Slam earlier this year with his Australian Open victory, has not competed since withdrawing from the Barcelona Open last month.The Injury DetailsAlcaraz confirmed his withdrawal in a statement posted on X, explaining that while his recovery is progressing well, he is still not ready to compete on grass courts. "My recovery is going well and I feel much better, but unfortunately I'm still not ready to be able to play, and that's why I have to withdraw from the grass-court swing at Queen's and Wimbledon," the two-time Wimbledon champion wrote.The injury, which also forced him out of the French Open, has sidelined the Spanish star for consecutive major tournaments, disrupting what had been a promising start to his 2026 season.Career Impact AnalysisAlcaraz's withdrawal represents a significant setback in his quest to become the youngest player in the Open Era to complete the calendar-year Grand Slam. Having already won the Australian Open earlier this year, the grass court season at Wimbledon and the subsequent hard courts at the US Open presented a clear path to tennis immortality.The 23-year-old's absence also means he will be unable to defend the 2,000 ATP ranking points he earned by winning Wimbledon in 2023 and 2024, potentially impacting his position in the world rankings and his seeding for future tournaments.The Rivalry ImpactAlcaraz's withdrawal creates a significant void in the men's draw, particularly in light of his compelling rivalry with Italian Jannik Sinner. The pair contested an epic French Open final last year, with Alcaraz coming back to win the title before Sinner turned the tables to take the Wimbledon crown.Without Alcaraz, the narrative of their ongoing battle for supremacy in men's tennis is temporarily paused, disappointing fans and broadcasters who had anticipated another potential final showdown between the two young stars.Future OutlookWhile Alcaraz expressed optimism about his recovery progress, the timeline for his return to competitive play remains uncertain. The focus will now shift to the US Open in September, where the Spaniard will aim to make his comeback and continue his pursuit of tennis history.In his absence, the Wimbledon field becomes more open, with players like Novak Djokovic, Jannik Sinner, and others presented with an opportunity to claim the prestigious title on the grass courts of the All England Club.