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The Breakthrough prize, often referred to as the 'Oscar of science', has been awarded to a team of scientists for their groundbreaking work in gene therapy. Jean Bennett, a molecular biologist, and Albert Maguire, an ophthalmologist, who met while dissecting a brain at Harvard Medical School, have been recognized for their 25-year-long project that led to the development of Luxturna, the first approved gene therapy for blindness.The therapy has transformed the lives of people born with Leber congenital amaurosis (LCA), a genetic disorder that typically causes total blindness by early adulthood. The treatment, which smuggles a working version of the gene into retinal cells, has shown profound improvements in patients, with one patient describing seeing their child's face for the first time.The $3m prize is shared with physician Katherine High, who worked with Bennett and Maguire on the project. The couple's work is a testament to their dedication and perseverance, with Bennett noting that she was 'overwhelmed' by the news and describing it as one of the most 'miraculous eureka moments' she could imagine.Bennett also expressed concerns about the US administration's attacks on science, warning that it could 'cause damage for generations to come' and lead to a brain drain that the country would struggle to recover from.The Breakthrough prizes, founded by Silicon Valley entrepreneurs, recognize outstanding achievements in life sciences, mathematics, and physics. Other prizes awarded included work on a gene therapy for sickle cell anaemia and beta thalassaemia, and the discovery of genetic drivers of frontotemporal dementia and ALS.

Chelsea and Manchester United are set to clash at Stamford Bridge on Saturday, April 18, in a highly anticipated Premier League match. The Blues are eager to tighten their grip on a UEFA Champions League qualification spot, but their recent form has been dismal, with only one win in their last five league matches.Manchester United, currently third, is dealing with injuries and suspensions, including the absence of centre-backs Lisandro Martinez and Harry Maguire. The Red Devils are coming off a shock home defeat to Leeds United.Chelsea manager Liam Rosenior is under pressure to turn the team's fortunes around, with a protest planned by fans ahead of the match. Rosenior emphasized the importance of the game, stating, 'We have to take advantage of this moment. We're running out of time.'A win for Chelsea would close the gap to Manchester United to just four points, intensifying the race for a top-five finish and a spot in Europe's elite competition. The match could significantly impact the Premier League standings and the teams' chances of qualifying for the UEFA Champions League.

Marcus Rashford's future at Manchester United hangs in the balance as his loan spells at Aston Villa and Barcelona come to an end. The 28-year-old has not played for United since December 2024 and is currently on loan at Barcelona, who have the option to purchase him for €30m (£26m).Manchester United sit comfortably in third place in the Premier League, seven points above sixth-placed Chelsea, but will not want to see the gap close come full time at Stamford Bridge. A return to Europe's top table is vital for United, which would result in players' wages increasing, including Rashford's salary reaching £325,000 per week on his deal, which runs until 2028.Michael Carrick, United's manager, has stated that the door is not completely closed on Rashford playing for United again. 'There's decisions to be made in time on certain things, and obviously Marcus is in that situation. But at this point in time, nothing's been decided,' Carrick said. 'Certainly from my perspective, whoever's here I want to work with, make the best out of, and help them improve.'Rashford's situation is complicated by United's desire to sell him, but few clubs could match his current earnings. Carrick will want to see his team bounce back from Monday night's home defeat by Leeds, but faces a defensive crisis with Harry Maguire and Lisandro Martínez out of the lineup.

Manchester United's Harry Maguire will miss his team's upcoming match against Chelsea due to an additional one-match ban imposed by the Football Association. The ban comes as a result of Maguire's reaction to being sent off during a match against Bournemouth last month.The 33-year-old defender was shown a red card at the Vitality Stadium for a foul in the area on Evanilson, which led to Bournemouth sealing a 2-2 draw. Following the incident, Maguire allegedly made a comment towards the officials, stating they were 'a joke.'The FA's written reasons confirmed that the fourth official, Matthew Donohue, submitted an Extraordinary Incident Report Form, claiming Maguire shouted: 'You're a joke. You're all a fucking joke.' Maguire, however, claimed he said 'something along the lines of 'it is a fucking joke.''As a result, Maguire has been imposed a one-match suspension and a £30,000 fine by an independent Regulatory Commission. This suspension adds to the absence of fellow centre-backs Matthijs de Ligt and Lisandro Martínez, potentially leading to young players Ayden Heaven and Leny Yoro lining up at the heart of defence against Chelsea.

Manchester United's recent loss to Leeds United has exposed the team's shortcomings, particularly in terms of squad depth. The absence of Kobbie Mainoo and Harry Maguire was keenly felt, as their replacements struggled to make an impact.The midfield, in particular, was affected by Mainoo's absence, with Manuel Ugarte failing to live up to expectations. Ugarte, who cost £50m from Paris Saint-Germain almost two years ago, has never justified his price tag, and his performance against Leeds only added to the concerns.The team's defense was also vulnerable, with Lisandro Martínez struggling to cope with the physical threat of Leeds' Dominic Calvert-Lewin. Martínez's frustration ultimately led to his dismissal, which further compounded United's problems.The loss has highlighted the need for United to strengthen their squad, particularly in central midfield. With Casemiro's departure already confirmed and Ugarte's dependability in question, it is little wonder that United are focusing on this area. Elliot Anderson is a key target, while Carlos Baleba, Adam Wharton, and Sandro Tonali are also highly regarded at Old Trafford.Despite the setback, Michael Carrick will take comfort from seeing his team's mental resilience in tough circumstances. However, to compete on all fronts, United will require a busy summer of recruitment to address their squad shortcomings.

According to the latest Tottenham Hotspur financial statements, former executive chair Daniel Levy received £5.76 million in remuneration for the year ending 30 June 2025. That figure represents a 54% increase on his 2024 earnings and, as noted by football‑finance analyst Kieran Maguire, made him the highest‑paid director in the Premier League for the season. In stark contrast, the club’s women’s team—comprising 64 players and staff—had a combined salary and bonus total of £3.73 million, a 23% rise from the previous year. After accounting for social security and pension contributions, the overall wage bill reached £4.3 million, with an average annual earnings of roughly £58,000 per employee. This places Tottenham Women below several WSL rivals that have disclosed their 2024‑25 accounts, such as Brighton (£5 million), Manchester United (£5.88 million), and Arsenal (£11.3 million), but above Liverpool (£3.12 million). The women’s side recorded a post‑tax loss of £2.83 million, marginally higher than the £2.73 million loss reported in 2024. The deficit persisted despite a notable surge in commercial revenue, which more than doubled from £1.46 million to £3.34 million. Broadcast income remained static at £267,414, while prize‑money earnings fell by approximately £600,000. On the pitch, Tottenham Women finished the 2024‑25 campaign in 11th place in the Women’s Super League. However, the current 2025‑26 season shows a marked turnaround, with the team sitting fifth with three matches remaining and having nearly doubled their league victories compared with the previous term. Sources indicate that an internal review has repositioned women’s football as a strategic priority for the club, a shift that is expected to be reflected in the forthcoming 2025‑26 accounts.

Manchester United interim manager Michael Carrick strongly criticized the red card decision given to defender Lisandro Martínez during the team's 2-1 loss to Leeds United at Old Trafford. Martínez was sent off in the 56th minute for pulling the hair of Dominic Calvert-Lewin, a decision Carrick described as 'shocking' and one that may prompt an appeal.The red card could result in a three-match ban for Martínez, potentially sidelining him for United's upcoming fixtures against Chelsea, Brentford, and Liverpool. This comes at a critical time as Harry Maguire is also facing a possible suspension for his second yellow card in as many games.Carrick questioned the severity of the red card, stating, 'The arm [is] in the face of Lisandro and he is off balance and grappling. He goes to touch his shirt and gets a red card for it.' He emphasized that the incident did not constitute aggressive behavior, adding, 'It is not aggressive, there is no jolt, no tug.'The manager also expressed concern over another incident involving Noah Okafor's goal for Leeds, suggesting that Dominic Calvert-Lewin impeded Leny Yoro in the buildup. 'The goal, Leny Yoro gets a forearm smash in the back of the head. I don’t know how that doesn’t get overturned,' Carrick remarked.Leeds United's manager, Daniel Farke, reflected on the historic victory, stating, 'I feel tired, relieved, proud of the boys. The first league win here in over 40 years is amazing.'

Harry Magunei believes the relentless spotlight at Manchester United would have broken many players, noting that the club’s demanding environment can overwhelm even seasoned professionals.After signing a new one‑year contract with an option for a further season, the 33‑year‑old defender extended a tenure that began with a then‑world‑record £80 million fee paid to Leicester in 2019.During his 266 appearances for United, Maguire helped the club win the FA Cup and Carabao Cup, captained the side from 2020 under Ole Gunnar Solskjær, and endured a dip in form that saw him lose his place after Erik ten Hag took over. He even flirted with a move to West Ham in the summer of 2023 before re‑establishing himself as a key figure.“I see a lot of players come into this club and, frankly, it’s just too big for them,” Maguire said. “The eyes on you, the scrutiny, the analysis… there are ex‑players commenting on every goal. That’s part and parcel of playing for this club.”He added that many would have quit early under such pressure: “Probably. I think there’ll be a lot who want to close the book and restart their career. It’s probably broken them a little bit earlier.”Reflecting on his own ordeal, Maguire described the period of intense mockery and abuse as a low point that forced him to adopt a “laid‑back attitude” and ignore outside noise to regain form.Since Erik ten Hag’s appointment, United have climbed to third place in the Premier League, reviving hopes of Champions League qualification. Maguire is optimistic about the club’s trajectory: “If we get the recruitment right and keep the momentum, there’s no ceiling to where we can reach. We have to be in the conversation for the big trophies.”On the international stage, Maguire hopes to feature for England at the 2026 World Cup. Although manager Thomas Tuchel currently ranks him behind Ezri Konsa, Marc Guéhi, John Stones and the injured Trevoh Chalobah, Maguire remains determined: “I’m desperate to go, whether I start or come on late. I still believe I’m arguably one of the best defenders in the world in both boxes.”

Harry Maguire has committed his future to Manchester United by signing a contract extension that will keep him at the club until 2027, with the option for a further year. The defender, who joined from Leicester in 2019, was due to reach the end of his deal this summer.Maguire expressed his delight in extending his stay at the club, stating: “Representing Manchester United is the ultimate honour. It is a responsibility that makes myself and my family proud every single day. I am delighted to extend my journey at this incredible club to at least eight seasons and continue to play in front of our special supporters to create more amazing moments together.”He also highlighted the club's ambition, saying: “You can feel the ambition and potential of this exciting squad. The determination throughout the whole club to fight for major trophies is clear for everyone to see and I am confident that our best moments together remain ahead of us.”