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Business Jun 02, 2026

Alphabet to Raise $80bn for AI Spending

Alphabet plans to raise up to $80bn in equity to fund its AI infrastructure investments, including …
Introduction: Alphabet to Raise $80bn for AI Spending Alphabet, Google's parent company, has announced plans to raise up to $80bn in equity to fund its vast AI infrastructure investments. This move is one of the largest equity raisings ever and includes a $10bn share sale to investment giant Berkshire Hathaway. The AI Investment Strategy Alphabet, whose Gemini AI system has been growing its share of the AI chatbot market, says it will use the money to expand its “world-class AI compute infrastructure to meet its unprecedented customer demand.” The company stated: AI is driving an expansionary moment for Alphabet. The company is experiencing strong demand for its AI solutions and services from enterprises and consumers, at levels that are exceeding the company’s available supply. By scaling its investments, the company seeks to expand its foundational infrastructure to support the significant growth opportunity ahead. The Financial Implications However, such a huge fundraising also serves as a warning to the markets that, despite the many billions of dollars thrown at AI infrastructure, meaningful returns are limited. Jim Reid, market strategist at Deutsche Bank, noted: “Funding of the AI capex boom is becoming an increasingly key topic for markets.” The Berkshire Hathaway Partnership The decision to tap Berkshire Hathaway is eye-catching, given the company's history of providing crucial funding to companies in need. Under Warren Buffett, Berkshire made a habit of stepping in to provide important, and lucrative, funding for companies who really needed cash, such as the famous $5bn investment into Goldman Sachs at the height of the financial crisis. The Competitive Landscape Alphabet is also tapping investors before some of its largest AI rivals attempt to join the stock market. Yesterday, Anthropic, which makes the Claude chatbot, said it had filed confidentially for an initial public offering on the US stock market. Anthropic is now valued at $965bn after raising $65bn in funding, making it the world’s most valuable startup.
#Alphabet #AI #Berkshire Hathaway
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Sports Jun 01, 2026

Curaçao World Cup 2026 Team Guide

Curaçao has qualified for the 2026 World Cup, becoming the smallest nation to participate by popula…
The Road to Qualification Curaçao, a FIFA member since 2011, has spent years building towards their first World Cup appearance. As an autonomous country within the Kingdom of the Netherlands, the island has drawn on a rich pool of Dutch-raised talent with Curaçaoan roots. The Team's Strategy The team's goalkeeper, Eloy Room, mentioned that they had an advantage with the World Cup being hosted by the United States, Mexico, and Canada, as they wouldn't face them in qualifying. Curaçao played important games against Haiti, Trinidad, and Jamaica, ultimately qualifying with a goalless draw in Jamaica. Group E Fixtures 14 June v Germany, Houston (noon local, 6pm BST, 15 June 3am AEST) 20 June v Ecuador, Kansas City (7pm local, 21 June 1am BST, 21 June 10am AEST) 25 June v Côte d'Ivoire, Philadelphia (4pm local, 9pm BST, 26 June 6am AEST) The Coach Dick Advocaat, 78, will become the oldest coach to take part in a World Cup. He guided Curaçao to qualification but stepped down in February to care for his ill daughter, only to return after Fred Rutten stepped aside. Star Player Leandro Bacuna has represented Curaçao for over a decade and has played in the Premier League with Aston Villa. He is hugely popular among the local population and is known for his involvement in the community. One to Watch Livano Comenencia is a technically polished midfielder who has played for Juventus's Next Gen team and FC Zürich. He underlined his importance with a crucial goal in the 2-0 win over Jamaica. Unsung Hero Juriën Gaari is a steady presence at the back, with almost 60 games for Curaçao. He has played for several clubs, including RKC Waalwijk and Saudi clubs Al-Hazem and Abha Club.
#Curaçao #World Cup 2026 #Football
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Sports Jun 01, 2026

Arsenal's Bigger Cup Dreams Dashed, Fans Show Love

Arsenal's bid to win the Bigger Cup fell short, but fans showed their love and support with a massi…
The Bigger Cup Final FalloutArsenal's hopes of winning the Bigger Cup were dashed, but the team's fans showed their appreciation with a huge turnout in Islington. Despite the loss, the mood was overwhelmingly positive, with a 75-25 ratio of joy to disappointment.Debate Over Arteta's ApproachMikel Arteta's defensive strategy was questioned, with some suggesting he should have trusted his attacking players more. PSG's Vitinha criticized Arsenal's time-wasting tactics, saying they 'take a lot of time in everything.'James Milner's RetirementFormer Liverpool and Manchester City midfielder James Milner announced his retirement, ending a career with 658 Premier League appearances and numerous titles. Milner expressed gratitude to his supporters and those who challenged him.Fan Support and CelebrationDespite the loss, Arsenal fans celebrated with their team, showing love and inclusivity. The atmosphere was described as a 'welcome blend of joy, inclusivity and love.'
#Arsenal #Mikel Arteta #PSG
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Entertainment Jun 01, 2026

Rosamund Pike Criticizes Audience Member for Texting During West End Play

Rosamund Pike criticized an audience member for texting during her West End performance of Inter Al…
The Incident During the Performance Rosamund Pike has criticised an audience member for texting during the climax of her West End performance, saying she hoped the message was “very important”. After a performance of Inter Alia on Saturday, Pike returned to the stage after the final bows. She told the audience at Wyndham’s theatre in London: “I just wanted to say for anyone going to the theatre, it’s a huge thing that we’re trying to give you. I am trying to tell you a story, and I’m feeling you, and I hope you’re feeling me too.” Pike's Address to the Audience “Somebody was texting in this part,” she said, gesturing towards a section of the audience. “You know who you are and I’m not going to single you out. “Maybe it was very important, and maybe you’re a doctor, and you’re saving someone’s life, and I hope you are, but we do see these, we do feel them. I’ve got you, I feel like I’ve got to hold you all, so when I feel that and see it, it’s hard.” The Growing Trend of Actors Speaking Out Pike joins a growing number of actors who have criticised audience etiquette and phone usage during theatre performances. Last month, Lesley Manville told BBC Radio 4 that audiences should not take photos and videos during curtain calls. “Clap or don’t clap, but don’t just stick up your phone in our faces,” she said, “I find it insulting.” In April, Cynthia Erivo interrupted her performance of Dracula in the West End after spotting an audience member filming the show. During a performance of Hamlet in 2024, Andrew Scott halted the “to be or not to be” soliloquy when he saw an audience member had taken out a laptop to send emails. Background on the Play Pike, 47, won an Olivier award in April for her role as Jessica Parks in Inter Alia. The play follows Parks, a crown court judge dedicated to challenging the legal system’s approach to sexual violence, who is forced to contend with her own son being accused of rape. Inter Alia was written by the Australian playwright Suzie Miller, who also wrote one-woman-play Prima Facie starring Jodie Comer.
#Rosamund Pike #West End #Theatre Etiquette
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Environment Jun 01, 2026

Guinea's Bauxite Boom: Mining Wealth vs. Local Livelihoods

Guinea's vast bauxite reserves have attracted global mining interests, but local communities face e…
The Global Bauxite Rush and Guinea's ContradictionIn the small village of Bembou Silaty, northwestern Guinea, 38-year-old Mamadou Aliou embodies the central contradiction of Guinea's bauxite boom. Working in the environmental health and safety department for a mining company while simultaneously advocating for his community's rights, Aliou represents the complex relationship between global resource demands and local realities."Before these companies arrived, we cultivated our land, and it sustained us," Aliou told Al Jazeera. "We could cover our daily needs, especially food. But now, when a piece of land is registered and belongs to a mining company, you have nothing there any more."The Strategic Value of Guinea's Bauxite ReservesGuinea holds the world's largest reserves of bauxite, the ore that becomes alumina and ultimately aluminum—a metal essential for car and aircraft frames, windows, wind turbines, and solar panels. Over the past three decades, the country has multiplied its bauxite production tenfold, with more than a dozen ongoing projects currently operating.As the global energy transition demands ever more aluminum, Guinea has found itself in a strategically crucial position. Approximately 75 percent of the bauxite exported by the country over the past decade has ended up in China, which produces 60 percent of the world's aluminum. Companies from Russia, the United States, and the United Arab Emirates have also established significant operations in the country to secure this valuable resource.Economic Disparities and Compensation ChallengesIn the traditional bauxite heartlands of Kindia and Boke, the main roads are notably well-maintained, and steady jobs in technical roles or transport logistics have created economic opportunities for some Guineans. In Bembou Silaty, however, the situation remains starkly different—a quiet village without electricity, where farming methods remain untouched by mechanization.People working in technical roles at the mine can earn up to about $300 a month, a significant sum in Guinea. For other locals who make a living from farming, most don't have a regular wage and rely on the yield from their crops. Across Guinea, an estimated half of the population depends on agriculture for their livelihood.Locals in Bembou Silaty say every hectare claimed by mining is a hectare lost to farming, in a country that spent more than $500m importing rice in 2024. "They give you compensation for your land, but it's not enough, and in the end, it's mismanaged," Aliou said. "Within a month or two, someone who received 50 or 100 million Guinean francs ($5,700-11,400) has nothing left. No land, no money. They have to start over, from below zero."Environmental Degradation and Water ContaminationThe environmental impact of bauxite mining in communities like Bembou Silaty has been profound. Not all homes in the village of about 5,000 have indoor toilets and plumbing. While a new water point serves nearly all residents, the water contains iron contamination.In neighboring villages, the situation is even more dire. "Since the mining companies came, we've had this problem with the water. The children get sick, and the parents too," said Mariama Kindi Diallo, a farmer. "The doctors tell us not to drink the rain or river water. There are no roads, no school, no phone signal. What are we supposed to do? We are asking for help to have a dignified life."Environmental concerns extend beyond water contamination. Surgical holes drilled into the ground mark where mining companies have tested for bauxite—a reminder to farmers that the impact on the land is felt even before extraction begins. In a recent report, Djami Diallo, the Guinean minister of the environment and sustainable development, stated that each year, certain companies had their impact studies and evaluation reports rejected for failing to comply with environmental standards.The Government's Push for Value AdditionTo address these challenges and increase the benefits for Guinea, the government of Mamady Doumbouya, which came to power in a 2021 coup, is attempting to reorganize the mining sector. It is pressing investors to process bauxite within Guinea, ensuring a portion of the value stays in the country.Processing bauxite into aluminum can multiply its price by 37 times. Instability in Iran amid the US and Israel's war has contributed to rising aluminum prices, which surpassed $3,600 per tonne in April. Doumbouya is set to lead the country for the next seven years, after winning the December 2025 elections with nearly 87 percent of the vote.Achieving this transformation, however, requires a huge increase in electricity generation—power that is non-existent in villages like Bembou Silaty and unreliable even in the capital, Conakry. Guinea is working with neighboring Senegal on a solution: Using Senegalese gas to generate enough electricity to process its bauxite on African soil.The Global Trail of Bauxite and MigrationThe story of Guinea's bauxite extends far beyond its borders. More than 3,000km away, in Parets del Valles, Spain, the journey's end plays out. For Spain, Europe's largest consumer of Guinean bauxite, more than 90 percent of its imports come from Guinea.The aluminium produced there feeds the automotive industry and serves both industrial and domestic purposes. In Spain, there is light, hot water, paved roads—all the base elements of a decent life that remain elusive in many parts of Guinea.Increasingly, more boats are leaving directly from Guinea, towards the Canary Islands and on to mainland Europe. According to Frontex, the European Union border security agency, more Guineans arrived in the Canary Islands, Spain, in 2023 (2,324) than in the previous 13 years combined. In 2024 and 2025 combined, another 6,000 Guineans arrived.Many left, following the bauxite trail, hoping to find something more in the places where their resources are both enjoyed and exploited. "If you compare the bauxite we export with what we get in return, the difference is enormous," Aliou reflects. "We gain almost nothing. Just enough to survive."
#Guinea #Bauxite Mining #Environmental Impact
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Sports Jun 01, 2026

Kang's Spending Sparks Debate: Barcelona's Model vs. Financial Power in Women's Football

Billionaire investor Michele Kang's spending in women's football has sparked resentment despite Bar…
The Billionaire's Challenge to Women's FootballIt has been a bad week for Michele Kang, the billionaire women's football investor. On Wednesday the Uefa director of women's football, Nadine Kessler, was firm on the enforcement of rules prohibiting clubs with the same owner from playing each other in European competitions, dealing a blow to Kang, who has ambitions of taking London City Lionesses into Europe's premier competition, but also owns the tournament's most decorated side, OL Lyonnes.Then, across the weekend, Kang teams suffered two continental final defeats, with Lyonnes losing 4-0 to Barcelona in the Champions League final before her US outfit, Washington Spirit, fell short in the Concacaf W Champions Cup with a 5-3 reverse to the Mexican side Club América.Barcelona's Talent Pipeline vs. Financial MuscleSpeaking to the Catalan TV channel Esport3 in Oslo on Saturday evening, the Barcelona goalkeeper Cata Coll made some pointed remarks about money in football after their emphatic victory, and her words went viral. "There has been criticism but we have shown the team we are," she said. "Money isn't everything. We are privileged to have La Masia and all the girls that have come up to the first team: Aïcha Cámara, Carla [Julià Martínez], [Martine] Fenger, [Clara] Serrajordi, all of them. They are incredible. It says everything and that's why I say it."Many have assumed it was a jab at Kang and the use of her wealth to pursue glory in women's football, with Barcelona's talent pipeline apparently delivering an antidote to such an approach. There have been frustrations that Kang's teams have been sniffing at Barcelona's door in recent years, poaching the head coach Jonatan Giráldez, who led Barça to their second and third European titles, first planting him in post at Washington Spirit before switching him this season to Lyonnes, another of her Kynisca Sports International multi-club ownership group.The Financial Distortion in Women's FootballGiráldez isn't the only Barcelona employee to have been recruited by the big-spending Kang. The midfielder Ingrid Engen joined Lyonnes last summer and the defender Jana Fernández was acquired by London City from the Catalan club. Meanwhile, talk of potential rogue bids for Aitana Bonmatí have circulated in past seasons, while London City are believed to have made Alexia Putellas, soon to be out-of-contract, a large offer to play in the WSL.Clubs are seemingly irritated with Kang's spending because to entice superstars to fledgling projects she is offering fees and wages that are distorting the market, driving it beyond what many view as sustainable growth. Except, given the opportunity, every club would probably do it. Yes, huge men's clubs could do the same, given the large sums at their disposal, but often choose not to in the name of sustainability and gradual growth.Barcelona's Own Financial ChallengesHowever, while the constantly emerging talent from La Masia is both laudable and enviable, Barcelona are not a model women's football club, or a salve to the model being championed by Kang.Kang is one of many to have exploited the strict financial rules of La Liga, with the money trouble experienced by the men's side recently affecting every section of the club, from the women's team to the youth academy and basketball, handball and futsal teams. To lower the wage bill, players have been allowed to leave that may have been kept under different circumstances.The team that have powered Barça to four European titles contains several key players at the end of their contracts. Alongside Putellas, the quartet of Mapi León, Marta Torrejón, Salma Paralluelo and Caroline Graham Hansen are nearing the end of their deals. At some stage Barça will need to undergo their next evolution, but to what extent that is done on their terms, or forced by financial pressure, remains to be seen.The Future of Investment Models in Women's FootballSaturday's Champions League final was my eighth in nine years – the Covid-19 pandemic prevented me from attending the 2020 final between Lyon (now Lyonnes) and Wolfsburg in San Sebastián. The game has come a long way since my first, in Kyiv in 2018, when the host city was the same as the one for the men's Champions League final and the women's final cowered in its shadow.In Oslo the huge numbers pouring into Uefa's fan park, that featured a line of mini-pitches where girls' teams played all day, reflected the impact the final can now have on a city. Women's football has also changed a lot, but in some ways it is very similar. In 2018 Lyon lifted their fifth of what has become eight European titles, the efforts of the former club owner, men's and women's, Jean-Michel Aulas, repeatedly delivering for the French team. Aulas committed more resources to the women's team than most other European clubs and Kang is now doing the same sort of thing, but more aggressively, in a world where many of the top women's clubs are increasing investment.The problem is, there is no alternative model put forward by any of the biggest clubs. Each one walks the same path, in slightly different ways, perhaps getting annoyed at how others have gone the same route. Most men's Premier League clubs do not want an alternative funding model – because it might show fans there is another way of doing things. As it stands, those owners can take money out of clubs to boost their personal wealth.So, yes, Coll is right, but behaving like Barcelona are the morally superior club is misleading.
#Michele Kang #Barcelona FC #Women's Football
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Science Jun 01, 2026

The Guardian's Exclusive: A Family's Quest to Save Europe's Endangered Glutinous Snail

Ian Hughes and his family have dedicated themselves to saving Europe's endangered glutinous snail. …
The Family's Mission to Save the Glutinous Snail Ian Hughes and his son, Ben, are driving through the hills of north Wales with an array of homemade animal artefacts. They finally reach Llyn Tegid – Bala Lake, where, knee-deep in the water, Ian brandishes two glutinous snails. The snails have been driven to extinction in England by poor water quality. Pollutants from agriculture and industry have ruined their habitats in ponds, ditches, lakes, and streams. The lake in Gwynedd hosts the last remaining wild population of glutinous snails in Britain. The Conservation Efforts Hughes has dedicated more than a decade to conserving the tiny mollusc and other rare species. This year, the Department for Environment, Food and Rural Affairs (Defra) has listed the snail as one of the threatened species that will benefit from a £60m government funding boost. With the funding, the British and Irish Association of Zoos and Aquariums will receive support to build ark populations of the glutinous snail, while the Freshwater Habitats Trust hopes to use new resources to find locations suited to wild reintroductions. The Impact of Conservation Hughes's passion for invertebrates extends to convincing other people to care about them. He writes children's books, which Ben illustrates, about the species he has studied, and the pair sell T-shirts showcasing their wildlife drawings. Ben says, 'Well, why do we matter? We're part of a huge living system. If you take a cog out of a machine, it doesn't work any more.' The Future of the Glutinous Snail Now, Hughes hopes the Defra funding will help the conservation efforts he has long championed. The goal is to keep the snails moving and preserve their population. By continually moving snails from one container to another, Hughes and his family aim to prevent the water from becoming polluted and ensure the survival of the species.
#Glutinous Snail #Conservation #Ian Hughes
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Sports May 31, 2026

Liverpool's Post-Slot Era: Key Challenges for the New Manager

Liverpool faces significant challenges as they prepare for life after Arne Slot, with the new manag…
The Lead: Liverpool at a CrossroadsAs Liverpool prepares for life after Arne Slot, the club faces significant challenges that will define their immediate future. The Dutchman's tenure ended without the dominance expected, leaving a squad in need of strategic overhaul both on and off the pitch. The new manager inherits a team that must rediscover its identity while addressing key personnel departures and tactical shortcomings.Style Evolution: From Heavy Metal to Soft RockPerhaps Mohamed Salah's style of communication wasn't the slickest, but he was correct that Liverpool need to redefine the style of football they play. Everything on the pitch last season under Arne Slot felt very placid as Liverpool failed to dominate opponents and were often found overrun. The new head coach will want to demonstrate his plans and implement an attacking style to best use what is available to him. Anfield does not want to witness back-foot football, fans want to see a swagger to those in red. Supporters and Slot suffered from a disconnect in the final months. The Dutchman was hindered by not possessing the vivacious personality of Jürgen Klopp nor the results in the end, and the aforementioned tedious style. The successor will want to put fans at the forefront and build a strong bond between stands and dugout, built on a platform of attractive play.Investment Analysis: Underperforming Key SigningsAfter spending heavily last summer trying to build a squad capable of dominating the Premier League for years to come, it was difficult to pick out someone who thrived. Hugo Ekitiké was the best of the new arrivals but record signings Florian Wirtz and Alexander Isak barely made the season's footnotes. Isak could at least attribute his struggles to fitness and injury problems, including a leg fracture, but the German's first taste of English football was a sour one. He never looked comfortable as a No 10, physically finding it tough going as speed on the ball and strength in battle were lacking. Getting the best out of a clearly talented player must be a priority, because Wirtz has the capabilities to open defences and help Liverpool control games but needs a confidence boost and an arm around the shoulder.Structural Impact: Midfield Deficiencies and Leadership VacuumWirtz is part of a wider midfield issue that lacks physicality and an obvious No 6. Ryan Gravenberch was elected as the man for the role by Slot, which worked well when the possession stats were in Liverpool's favour but finding someone who can break things up effectively is advisable. Every other team have someone who can break up play but Liverpool lack someone in that role. Not since Georginio Wijnaldum or Fabinho have the club possessed someone capable of overwhelming opponents with their physical attributes and in an evolving sport, this oversight must end. Dominik Szoboszlai being moved around the pitch was unhelpful because he can be one of the best central midfielders in the world but needs a defined position to make his own.The players departing Anfield are weighed down with individual and team trinkets, thanks to the success they have enjoyed with Liverpool. Arguably, the influence of Salah and Andy Robertson on the pitch waned in their final season with the club but their experience and winning mentality will be a huge loss to the dressing room and training ground. Ibrahima Konaté is another exiting, providing a recruitment headache the club were not fully anticipating. It does beg the question if it is the right time to allow Alisson Becker, who has suffered from injury problems in recent times, to be sold and allow a new generation to start afresh, with Virgil van Dijk leading the transition. There are plenty of potential internal candidates who can take on greater responsibility but it may require a change in transfer strategy to acquire players in their late-20s with Champions League experience to help give the right balance.Defensive Rebuild: Addressing Key DeparturesKonaté's contract expiration will be softened by Jérémy Jacquet's impending arrival but further investment is required. Van Dijk's longevity is unknown so finding a partnership for the long term will be critical; a more rugged centre-back like Nottingham Forest's Murillo could be an ideal choice to offer balance and greater aggression. Competition for Milos Kerkez will be important, but if Andoni Iraola does take the job the reunion could get the best out of the Hungarian and get him to flourish after a mixed first year on Merseyside. On the opposite side, continuity would help everyone because Slot was forced to trying numerous people in the role, many out of position. Ideally, Conor Bradley or Jeremie Frimpong can make it their own, having struggled to replace Trent Alexander-Arnold, although both have suffered with injury problems. If they can stay fit, they both possess the quality to be a solution, especially if clever coaching can embrace their attacking prowess and incorporate more defensive discipline.Future Outlook: Rebuilding the AttackSlot insisted that new wingers would change the dynamic next season but he will not be the one to benefit. Salah is off, Federico Chiesa cannot carry on as a bit-part, so will almost certainly leave too, freeing up some space on the flanks. Rio Ngumoha offered brief teenage glimpses of excitement as someone with the pace and trickery to get past full-backs. Frimpong, brought in as a right-back, was more often found on the wing because he possessed the speed Slot desired in those areas, while also offering a further indication that the transfer dealings left a lot to be desired. They did not replace the maverick tendencies of Luis Díaz and Cody Gakpo has never looked a natural winger. Targeting new wide men will be imperative. RB Leipzig's Yan Diomande, Brighton's Yankuba Minteh or Athletic Club's Neco Williams would be ideal candidates to bring thrust to a side lacking dynamism and get supporters off their seats.
#Liverpool FC #Arne Slot #Premier League
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Health May 31, 2026

Breakthrough Cancer Jab Shows Unprecedented Results in Eradicating Tumors

A revolutionary cancer treatment called amivantamab has shown unprecedented results in clinical tri…
The Lead: Unprecedented Cancer Treatment SuccessDoctors have hailed "unprecedented" trial results that show a triple-action cancer jab can eradicate entire tumours in patients. In an international trial spanning 11 countries, the injection was offered to patients whose cancer had spread or come back and whose disease had failed to respond to other treatments.The Breakthrough: Amivantamab's Triple-Action ApproachThe jab, called amivantamab, shrank the tumours of more than a third of patients, with dramatic changes seen within weeks. In 15 of them, doctors found the drug had melted away their tumours altogether.The smart jab targets cancer in three ways. It blocks both EGFR (epidermal growth factor receptor), a protein that helps tumours grow, and MET, a pathway that cancer cells often use to escape treatment. It also helps activate the immune system to attack the tumour.The Clinical Trial Data: Impressive Response RatesIn the trial, 102 patients with head and neck cancer, the world's sixth most common cancer, were given the jab. Tumours shrank or disappeared completely in 43 patients, including 28 whose tumours shrank significantly and 15 who saw them eradicated entirely.Patients receiving amivantamab lived for a median of 12.5 months overall after starting treatment, despite having a form of cancer with very poor outcomes, once standard treatments stop working.The Impact Analysis: New Hope for Treatment-Resistant CancersKevin Harrington, professor in biological cancer therapies at the Institute of Cancer Research, London (ICR), said: "These are unprecedentedly strong responses in patients whose disease has become resistant to both chemotherapy and immunotherapy. This is a group of patients for whom treatment options are extremely limited, so seeing this level of benefit is very striking."Researchers also highlighted that the trial focused on people with head and neck cancers that did not include those with human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma. That is particularly significant, they said, since head and neck cancers not caused by HPV are usually harder to treat, making progress in this group hugely important.The Patient Experience: Transforming Quality of LifeOne of the first patients to benefit was Carl Walsh, 56, who was diagnosed with tongue cancer in May 2024 and joined the OrigAMI-4 trial at the Royal Marsden in July 2025. "I was initially treated with both chemotherapy and immunotherapy, which unfortunately were not successful," he said. "At that point, I was recommended for the OrigAMI-4 trial. I'm now on my 17th cycle of treatment and I'm very pleased with the progress so far."Unlike many cancer treatments, amivantamab is given as a tiny jab under the skin rather than via an intravenous drip, making treatment quicker and more convenient for patients and much easier to deliver in outpatient clinics.The Future Outlook: Expanding Treatment ApplicationsThe results will be presented on Sunday in Chicago at the world's largest cancer conference, the annual meeting of the American Society of Clinical Oncology (Asco).Amivantamab, developed by Johnson & Johnson, is now being evaluated in about 60 clinical trials, primarily for lung cancer, but also for colorectal, brain and gastric cancers.Prof Kristian Helin, the chief executive of the ICR, said: "This study demonstrates how the development of new treatments through rigorous cancer research may lead to meaningful advances, even for patients with very limited treatment options. Achieving this level of tumour response and encouraging survival outcomes in such a challenging-to-treat group represents a significant step forward."
#Cancer #Amivantamab #Johnson & Johnson
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