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An Iranian missile has struck central Tel Aviv, causing widespread damage to buildings and vehicles, and injuring at least six people. The attack has led to a significant escalation of tensions in the region, with Israeli Prime Minister Benjamin Netanyahu vowing to continue striking Tehran and Lebanon.“There’s more to come,” Netanyahu said in remarks that appeared to corroborate those of three Israeli officials who told Reuters they thought it was improbable that Iran would accept US demands in any new round of negotiations. This development has dimmed hopes of de-escalation after US President Donald Trump played up the chances of a deal to end the conflict.In a statement released on Tuesday, Iran’s Islamic Revolutionary Guard Corps said it would launch heavy missile and drone attacks at Israeli troops in northern Israel and the area near Gaza “without restraint” unless Israel ceased attacks in Lebanon and Palestine. The threat has raised concerns about the potential for further escalation in the region.Police said an Iranian munition carrying a substantial explosive payload struck the central city, causing widespread damage to buildings and vehicles. At least six people were lightly injured. Several buildings were damaged across Tel Aviv, with emergency services reporting casualties at one of the impact sites. One building and the adjacent road were heavily affected, with cars set ablaze.Israel’s health ministry reports 4,829 injured people have been brought to hospitals since the onset of the war. Of those people, 111 remain in hospital and 12 are in a serious condition. The strikes were the latest in a cycle of retaliation after Israeli operations announced on Monday.About 40 minutes after Trump said he would delay action against Iran’s power infrastructure, Israel said on X that it had “just begun another wave of strikes targeting infrastructure of the Iranian terror regime across Tehran”. The Israel Defense Forces said energy facilities would be spared, suggesting that Israel may be aligning with Washington in suspending attacks on Iranian power plants and related sites.The US-based Human Rights Activists’ News Agency said in the previous 24 hours it had recorded at least 206 attacks across 15 provinces in Iran, resulting in at least four casualties (killed and injured, both civilian and military). At least six people were killed in strikes on homes in the city of Tabriz, according to Iran’s Fars news agency.Since US-Israeli bombs started falling on Iran, estimates of total deaths (military and civilian) in the country have exceeded 1,500, with some rights groups reporting figures as high as 3,230 as of 21 March. The escalation has also spilled beyond Israel, with Iranian strikes extending into Gulf states.

Pakistan and Afghanistan have agreed to a temporary ceasefire during the Muslim holiday of Eid al-Fitr, which begins on Thursday and lasts until Tuesday. The decision was made amid weeks of deadly violence between the neighboring countries.Pakistani Information Minister Attaullah Tarar announced that the ceasefire was requested by Saudi Arabia, Qatar, and Turkey. He stated that Pakistan is offering this gesture in good faith and in keeping with Islamic norms.However, Tarar also warned that if there are any cross-border attacks, drone attacks, or terrorist incidents inside Pakistan, military operations will immediately resume with renewed intensity.The Taliban government in Afghanistan also confirmed that it would temporarily suspend military operations against Pakistan.The ceasefire comes after Afghanistan accused Pakistan of killing hundreds of people in an air strike on a drug rehabilitation center in Kabul. Pakistan has strongly rejected these claims, stating that it only targets terrorist infrastructure and military locations.The United Nations reported 143 deaths in the incident at the Omar Addiction Treatment Hospital, a 2,000-bed facility. The conflict has led to repeated cross-border clashes and air strikes inside Afghanistan, despite international calls for a ceasefire and concerns about a widening displacement crisis.The World Health Organization (WHO) chief, Tedros Adhanom Ghebreyesus, urged all parties to de-escalate and prioritize peace and health, noting that at least six health facilities in Afghanistan have been affected by the violence since late February.The Qatari Ministry of Foreign Affairs welcomed the temporary truce as a positive gesture that contributes to de-escalation and promotes calm between the two sides. They hope the pause in fighting will pave the way for a return to a sustainable ceasefire agreement that spares civilian lives and achieves security and stability.

The United Nations has recorded 143 deaths in an air strike on a drug rehabilitation centre in Kabul, significantly lower than the figure offered by Afghanistan's Taliban government.The attack on Kabul's Omar Addiction Treatment Hospital on Monday night has sharpened a bitter dispute between Pakistan and Afghanistan, with the Taliban putting the casualties at more than 400 people killed and about 265 wounded.The UN Assistance Mission in Afghanistan provided its figure to the Reuters news agency on Wednesday. The gap between the two counts underscores the difficulty of verifying casualty figures in the conflict as competing claims frequently come from Kabul and Islamabad.Afghanistan's Taliban administration has blamed Pakistan for the attack on the drug rehabilitation centre, a 2,000-bed facility, and Pakistan has denied carrying out the strike. Hamdullah Fitrat, a deputy spokesman for the Taliban administration, said the strike hit the hospital, destroying large sections of the building and triggering fires that rescue teams worked through the night to contain.Afghan government spokesperson Zabihullah Mujahid accused Pakistan of deliberately hitting civilian infrastructure and called the assault a “crime against humanity”. Mujahid said those killed and wounded were patients undergoing addiction treatment at the time of the strike.Pakistan's information minister, Attaullah Tarar, denied the allegation, insisting his country “only targeted terrorist infrastructure and military locations”. The strike is the latest in a widening confrontation between the two neighbours, who have engaged in repeated cross-border clashes.At the heart of the dispute is a long-running Pakistani accusation that the Taliban government shelters the Pakistan Taliban, known as Tehrik-i-Taliban Pakistan, as well as outlawed Baloch separatist groups responsible for attacks on Pakistani soil. Kabul has consistently denied providing sanctuary to the groups.

US lawmakers, including Senator Chris Murphy and Representative Greg Casar, are taking steps to regulate prediction markets by introducing the Banning Event Trading on Sensitive Operations and Federal Functions (BETS OFF) Act. This legislation seeks to prohibit wagers on sensitive events such as government actions, terrorism, war, assassination, and events where an individual knows or controls the outcome. The proposed bill comes in response to concerns that betting platforms like Kalshi and Polymarket have allowed users to profit from geopolitical conflicts, including the US and Israel's joint strikes against Iran and the abduction of Venezuelan President Nicolas Maduro. Critics argue that these platforms enable individuals with insider knowledge to influence government decisions and profit from them. Murphy emphasized that the legislation aims to prevent the monetization of sensitive events, stating, "What happens to us spiritually when every moral question in this country becomes a market?" He added that certain matters should not be influenced by the potential for profit. The lawmakers cited examples of significant profits made by users on Polymarket, including a $500,000 profit from a bet on Iran's supreme leader being out of power hours before a strike. They suggested that such trades may have been made by individuals with insider knowledge from within the White House or close to the administration. The BETS OFF Act is part of a broader effort to regulate the prediction market industry. Other proposed legislation includes measures to establish federal consumer protections, ban elected officials from profiting from prediction markets, and impose age verification for users.

US President Donald Trump has claimed he is having 'productive' conversations with Iran, leading to a five-day pause in US strikes on Iranian power plants and energy infrastructure. However, Tehran denies these talks exist, casting doubt on the situation.If real, these talks would be a welcome de-escalatory step, but they also indicate that Trump's threat of war risked severe consequences that could damage more than just the intended target.Meanwhile, Israel is advancing measures in the West Bank that shift its occupation to annexation. The Israeli cabinet approved land registration in roughly half of the West Bank, which could lead to large-scale dispossession of Palestinians. This move is illegal under international law, according to the Israeli liberal advocacy organization Peace Now.Settlers have been reported to have imposed a reign of terror in the West Bank, with Israeli forces seemingly turning a blind eye. The Guardian reported coordinated settler attacks across Palestinian villages, including arson and violent assaults.The article suggests that Israel's moves may be driven by a desire to consolidate territorial control while US support is still available. With many Americans questioning the cost of the alliance, Israel may be trying to lock in favorable outcomes before the situation changes.